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Article: Serving on the FDA oncologic drugs advisory committee.

Hoffman, Philip C

Clinical advances in hematology & oncology : H&O

2022 Volume 20, Issue 11, Page(s) 649–651

MeSH term(s)	Humans ; United States ; Advisory Committees ; United States Food and Drug Administration ; Medical Oncology
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Interview
ZDB-ID	2271951-9
ISSN	1543-0790
ISSN	1543-0790
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Article: Physical meat quality characteristics of Angolan giraffe (Giraffa giraffa angolensis) as affected by sex and muscle

Hoffman, Louwrens C. / Silberbauer, Bianca L. / Needham, Tersia / Bureš, Daniel / Kotrba, Radim / Strydom, Philip

Elsevier Ltd Meat science. 2022 Oct., v. 192

2022

Abstract: Giraffe numbers grow exponentially when farmed, necessitating periodic culling. This study quantified the effect of sex and muscle on the physical quality characteristics of eight giraffe muscles. The Warner-Bratzler shear force (WBSF) was the only ... ...

Abstract	Giraffe numbers grow exponentially when farmed, necessitating periodic culling. This study quantified the effect of sex and muscle on the physical quality characteristics of eight giraffe muscles. The Warner-Bratzler shear force (WBSF) was the only parameter to be affected by an interaction between sex and muscle (P < 0.001), although the interaction for the CIE L* values tended towards significance (P = 0.054). Cooking loss (male = 41.6 ± 0.35%; female = 40.7 ± 0.33%; P = 0.024) and CIE L* values (male = 38.8 ± 0.23; female = 37.3 ± 0.27; P = 0.039) were both affected by sex. Muscle had an effect on all physical parameters. The ultimate pH of all muscles was 5.5–5.9; the average WBSF of <43 N for all muscles indicates giraffe meat in this study is tender. This study shows that yield and physical characteristics of giraffe meat are favourable, and the results may be useful for the marketing of giraffe meat.
Keywords	Giraffa ; females ; males ; meat ; meat quality ; muscles ; pH ; shear stress
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2022.108911
Database	NAL-Catalogue (AGRICOLA)

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Article: The origins of Western mind-body exercise methods.

Hoffman, Jonathan / Gabel, C Philip

Physical therapy reviews : PTR

2016 Volume 20, Issue 5-6, Page(s) 315–324

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2016-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1432030-7
ISSN	1743-288X ; 1083-3196
ISSN (online)	1743-288X
ISSN	1083-3196
DOI	10.1080/10833196.2015.1125587
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Article: Validation of a novel mobile phone application for type 2 diabetes screening following gestational diabetes mellitus.

Gomez Slagle, Helen B / Hoffman, Matthew K / Caplan, Richard / Shlossman, Philip / Sciscione, Anthony C

mHealth

2022 Volume 8, Page(s) 12

Abstract: Background: We sought to determine if using fasting blood glucose (FBG) through text-based care is an effective screening tool for type 2 diabetes in the postpartum period compared to in-person, 2-hour oral glucose tolerance testing (2hr OGTT).: ... ...

Abstract	Background: We sought to determine if using fasting blood glucose (FBG) through text-based care is an effective screening tool for type 2 diabetes in the postpartum period compared to in-person, 2-hour oral glucose tolerance testing (2hr OGTT). Methods: This was a single-center interventional study that included individuals diagnosed with gestational diabetes. Patients were enrolled in standard, office-based 2hr OGTT in combination with text-based remote diabetes screening. Study participants were instructed to record FBG for 3 consecutive days using a mobile application. We assessed agreement with 2hr OGTT using sensitivity, specificity, positive and negative predictive value with exact binomial 95% confidence intervals. Results: A total of 446 individuals diagnosed with gestational diabetes met inclusion criteria, 239 of which were enrolled in standard office-based screening and 207 were enrolled in dual screening using standard 2hr OGTT testing combined with text-based remote FBG screening. A FBG value less than 100 mg/dL had 100% sensitivity (86-100%), 86% specificity (77-93%) with a 100% (94-100%) negative predictive value and 71% (54-85%) positive predictive value. Follow-up was significantly higher among individuals enrolled in remote text-based screening compared to standard in-office screening (48% Conclusions: Text-based screening may be a feasible alternative to in-office screening. A mobile-based system using FBG successfully screened all patients with type 2 diabetes in the postpartum period with 100% sensitivity and negative predictive value. Remote telehealth screening significantly increased follow-up with type 2 diabetes screening.
Language	English
Publishing date	2022-04-20
Publishing country	China
Document type	Journal Article
ISSN	2306-9740
ISSN	2306-9740
DOI	10.21037/mhealth-21-36
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Article ; Online: Physical meat quality characteristics of Angolan giraffe (Giraffa giraffa angolensis) as affected by sex and muscle.

Hoffman, Louwrens C / Silberbauer, Bianca L / Needham, Tersia / Bureš, Daniel / Kotrba, Radim / Strydom, Philip

Meat science

2022 Volume 192, Page(s) 108911

Abstract	Giraffe numbers grow exponentially when farmed, necessitating periodic culling. This study quantified the effect of sex and muscle on the physical quality characteristics of eight giraffe muscles. The Warner-Bratzler shear force (WBSF) was the only parameter to be affected by an interaction between sex and muscle (P < 0.001), although the interaction for the CIE L* values tended towards significance (P = 0.054). Cooking loss (male = 41.6 ± 0.35%; female = 40.7 ± 0.33%; P = 0.024) and CIE L* values (male = 38.8 ± 0.23; female = 37.3 ± 0.27; P = 0.039) were both affected by sex. Muscle had an effect on all physical parameters. The ultimate pH of all muscles was 5.5-5.9; the average WBSF of <43 N for all muscles indicates giraffe meat in this study is tender. This study shows that yield and physical characteristics of giraffe meat are favourable, and the results may be useful for the marketing of giraffe meat.
MeSH term(s)	Animals ; Cooking ; Female ; Giraffes ; Male ; Meat/analysis ; Muscle, Skeletal/physiology ; Ruminants
Language	English
Publishing date	2022-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	753319-6
ISSN	1873-4138 ; 0309-1740
ISSN (online)	1873-4138
ISSN	0309-1740
DOI	10.1016/j.meatsci.2022.108911
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Brief Report: Discordance Between Liquid and Tissue Biopsy-Based Next-Generation Sequencing in Lung Adenocarcinoma at Disease Progression.

Tran, Misha C / Strohbehn, Garth W / Karrison, Theodore G / Rouhani, Sherin J / Segal, Jeremy P / Shergill, Ardaman / Hoffman, Philip C / Patel, Jyoti D / Garassino, Marina C / Vokes, Everett E / Bestvina, Christine M

Clinical lung cancer

2023 Volume 24, Issue 3, Page(s) e117–e121

MeSH term(s)	Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Adenocarcinoma of Lung/genetics ; Biopsy ; Disease Progression ; High-Throughput Nucleotide Sequencing ; Biomarkers, Tumor ; Mutation
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2023.01.003
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Zs.A 5893: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Tryptophan Metabolites And Their Predicted Microbial Sources In Fecal Samples From Healthy Individuals.

Chappell, Cynthia L / Hoffman, Kristi L / Lorenzi, Philip L / Tan, Lin / Petrosino, Joseph / Gibbs, Richard / Muzny, Donna / Doddapaneni, Harshavardhan / Ross, Matthew C / Menon, Vipin K / Surathu, Anil / Javornik Cregeen, Sara Joan / Reyes, Anaid G / Okhuysen, Pablo C

bioRxiv : the preprint server for biology

2024

Abstract: Gut microbiota produce tryptophan metabolites (TMs) important to homeostasis. However, measuring TM levels in stool and determining their microbial sources can be difficult. Here, we measured TMs from the indole pathway in fecal samples from 21 healthy ... ...

Abstract	Gut microbiota produce tryptophan metabolites (TMs) important to homeostasis. However, measuring TM levels in stool and determining their microbial sources can be difficult. Here, we measured TMs from the indole pathway in fecal samples from 21 healthy adults with the goal to: 1) determine fecal TM concentrations in healthy individuals; 2) link TM levels to bacterial abundance using 16S and whole genome shotgun (WGS) sequencing data; and 3) predict likely bacterial sources of TM production. Within our samples, we identified 151 genera (16S) and 592 bacterial species (WGS). Eight TMs were found in ≥17 fecal samples, including four in all persons. To our knowledge, we are the first to report fecal levels for indole-3-lactate, indole-3-propionate, and 3-indoleacrylate levels in healthy persons. Overall, indole, indole-3-acetate (IAA), and skatole accounted for 86% of the eight TMs measured. Significant correlations were found between seven TMs and 29 bacterial species. Predicted multiple TM sources support the notion of a complex network of TM production and regulation. Further, the data suggest key roles for Collinsella aerofaciens and IAA, a metabolite reported to maintain intestinal homeostasis through enhanced barrier integrity and anti-inflammatory/antioxidant activities. These findings extend our understanding of TMs and their relationship to the microbial species that act as effectors and/or regulators in the healthy intestine and may lead to novel strategies designed to manipulate tryptophan metabolism to prevent disease and/or restore health to the dysbiotic gut.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.20.572622
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Nationwide Survey Study of Recovery Community Centers Supporting People in Recovery From Substance Use Disorder.

Hoeppner, Bettina B / Simpson, Hazel V / Weerts, Catherine / Riggs, Marion J / Williamson, Alivia C / Finley-Abboud, Diadora / Hoffman, Lauren A / Rutherford, Philip X / McCarthy, Patty / Ojeda, Julia / Mericle, Amy A / Rao, Vinod / Bergman, Brandon G / Dankwah, Akosua B / Kelly, John F

Journal of addiction medicine

2024

Abstract: Objective: The medical community has become aware of its role in contributing to the opioid epidemic and must be part of its resolution. Recovery community centers (RCCs) represent a new underused component of recovery support.: Methods: This study ... ...

Abstract	Objective: The medical community has become aware of its role in contributing to the opioid epidemic and must be part of its resolution. Recovery community centers (RCCs) represent a new underused component of recovery support. Methods: This study performed an online national survey of all RCCs identified in the United States, and used US Census ZIP code tabulation area data to describe the communities they serve. Results: Residents of areas with RCCs were more likely to be Black (16.5% vs 12.6% nationally, P = 0.005) and less likely to be Asian (4.7% vs 5.7%, P = 0.005), American Indian, or Alaskan Native (0.6% vs 0.8%, P = 0.03), or live rurally (8.5% vs 14.0%, P < 0.0001). More than half of RCCs began operations within the past 5 years. Recovery community centers were operated, on average, by 8.8 paid and 10.2 volunteer staff; each RCC served a median of 125 individuals per month (4-1,500). Recovery community centers successfully engaged racial/ethnic minority groups (20.8% Hispanic, 22.5% Black) and young adults (23.5% younger than 25 years). Recovery community centers provide addiction-specific support (eg, mutual help, recovery coaching) and assistance with basic needs, social services, technology access, and health behaviors. Regarding medications for opioid use disorder (MOUDs), RCC staff engaged members in conversations about MOUDs (85.2%) and provided direct support for taking MOUD (77.0%). One third (36.1%) of RCCs reported seeking closer collaboration with prescribers. Conclusions: Recovery community centers are welcoming environments for people who take MOUDs. Closer collaboration between the medical community and community-based peer-led RCCs may lead to significantly improved reach of efforts to end the opioid epidemic.
Language	English
Publishing date	2024-03-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000001285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparison of the EXtracorporeal TReatments In Poisoning (EXTRIP) and Paris criteria for neurotoxicity in lithium poisoned patients.

DiSalvo, Philip C / Furlano, Emma / Su, Mark K / Gosselin, Sophie / Hoffman, Robert S

British journal of clinical pharmacology

2021 Volume 87, Issue 10, Page(s) 3871–3877

Abstract: Aims: Two guidelines for haemodialysis in lithium poisoning, one from the Extracorporeal TReatments in Poisoning (EXTRIP) workgroup and a single centre retrospective one (Paris) differ. We compared outcomes in lithium poisoning based on these criteria ... ...

Abstract	Aims: Two guidelines for haemodialysis in lithium poisoning, one from the Extracorporeal TReatments in Poisoning (EXTRIP) workgroup and a single centre retrospective one (Paris) differ. We compared outcomes in lithium poisoning based on these criteria with a primary outcome of worsening neurological symptoms in patients for whom EXTRIP and Paris criteria were discordant. Methods: Poison centre data were queried for lithium poisoned patients for whom haemodialysis was either recommended or performed. Patients were categorized according to EXTRIP and Paris criteria and excluded if the peak lithium concentration was <1.2 mmol/L or if neurological follow-up was unavailable. Comparative analyses were only performed when both criteria could be assessed. Results: In total, 219 patients were analysed. Paris criteria were met in 70 and EXTRIP criteria in 178. Forty two patients were excluded because Paris criteria could not be evaluated. When Paris and EXTRIP both supported haemodialysis, 50/57 (88%) of patients who received haemodialysis improved, as did all 3 who did not receive haemodialysis. When Paris and EXTRIP did not support haemodialysis, all nondialysed patients did well. Among the 86 patients for whom EXTRIP supported haemodialysis but Paris did not, 4/19 (21%) patients not dialysed deteriorated (P = .02; odds ratio = 8.7, 95% confidence interval = 1.5-51.8), 1 of whom died. All 8 patients for whom Paris criteria supported haemodialysis but EXTRIP did not were dialysed and improved. Conclusions: When the EXTRIP and Paris criteria are discordant, EXTRIP criteria outperforms the Paris criteria at identifying potentially ill patients who might benefit from haemodialysis.
MeSH term(s)	Drug Overdose ; Humans ; Lithium ; Paris ; Poisons ; Retrospective Studies
Chemical Substances	Poisons ; Lithium (9FN79X2M3F)
Language	English
Publishing date	2021-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.14802
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Article ; Online: The Impact of Global Collaboration on the Academic Focus of the West African College of Surgeons: Are Worldwide Efforts Aligning with Local Priorities?

Hoffman, Gary S / Parvin-Nejad, Fatemeh P / Linz, Matthew S / Salter, S Elina / Goydos, Christopher / Padmanaban, Vennila / Nwomeh, Benedict C / Mshelbwala, Philip M / Sifri, Ziad C

World journal of surgery

2023 Volume 47, Issue 10, Page(s) 2319–2327

Abstract: Background: Global collaboration has the potential to induce a shift in research focus away from the priorities of those in low- and low-middle-income countries (LICs and LMICs). This study quantified international collaboration among surgery ... ...

Abstract	Background: Global collaboration has the potential to induce a shift in research focus away from the priorities of those in low- and low-middle-income countries (LICs and LMICs). This study quantified international collaboration among surgery publications by Fellows of the West African College of Surgeons (WACS) and investigated if collaboration with upper-middle-income and high-income countries (UMICs and HICs) decreases the homophily of research focus. Methods: Publications by WACS surgery Fellows from 1960 to 2019 were characterized as local WACS publications, collaborative publications without UMIC/HIC participation, or collaborative publications with UMIC/HIC participation. Research topics were determined for each publication, and topic percentages were compared between collaboration groups. Results: We analyzed 5065 publications. Most (3690 publications, 73%) were local WACS publications, while 742 (15%) were collaborative publications with UMIC/HIC participation and 633 (12%) were collaborative publications without UMIC/HIC participation. UMIC/HIC collaborations contributed to 49% of the increase (378 out of 766 publications) from 2000 to 2019. Topic homophily was significantly lower between local WACS publications and collaborations with UMIC/HIC participation (differed in nine research topics) than it was between local WACS publications and collaborations without UMIC/HIC participation (differed in two research topics). Conclusions: Publications without international collaboration comprise most WACS research, but the rate of UMIC/HIC collaborations is rapidly increasing. We found that UMIC/HIC collaborations decreased the homophily of topic focus in WACS publications, indicating that global collaborations need to have greater emphasis on the priorities of those in LICs and LMICs.
MeSH term(s)	Humans ; Developing Countries ; Surgeons
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-023-07075-5
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