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Article ; Online: Efficient Hydrogen Evolution Reaction with Bulk and Nanostructured Mitrofanovite Pt 3 Te 4

Gianluca D’Olimpio / Lixue Zhang / Chia-Nung Kuo / Daniel Farias / Luca Ottaviano / Chin Shan Lue / Jun Fujii / Ivana Vobornik / Amit Agarwal / Piero Torelli / Danil W. Boukhvalov / Antonio Politano

Nanomaterials, Vol 12, Iss 558, p

2022 Volume 558

Abstract: Here, we discuss the key features of electrocatalysis with mitrofanovite (Pt 3 Te 4 ), a recently ... by 47% owing to the partial replacement of Pt with Te. Remarkably, the Tafel slope in nanostructured ...

Abstract	Here, we discuss the key features of electrocatalysis with mitrofanovite (Pt 3 Te 4 ), a recently discovered mineral with superb performances in hydrogen evolution reaction. Mitrofanovite is a layered topological metal with spin-polarized topological surface states with potential applications for spintronics. However, mitrofanovite is also an exceptional platform for electrocatalysis, with costs of the electrodes suppressed by 47% owing to the partial replacement of Pt with Te. Remarkably, the Tafel slope in nanostructured mitrofanovite is just 33 mV/dec, while reduced mitrofanovite has the same Tafel slope (36 mV/dec) as state-of-the-art electrodes of pure Pt. Mitrofanovite also affords surface stability and robustness to CO poisoning. Accordingly, these findings pave the way for the advent of mitrofanovite for large-scale hydrogen production.
Keywords	metal chalcogenides ; hydrogen evolution reaction ; electrocatalysis ; Chemistry ; QD1-999
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CHA

Su, Chun-Hung / Tsao, Teng-Fu / Chen, An-Chih / Chang, Kai-Wei / Yang, Yi-Sun / Ueng, Kwo-Chang / Tsai, Chin-Feng

European journal of clinical investigation

2018 Volume 48, Issue 3

Abstract: Background: The CHADS: Materials and methods: This prospective study included all 1494 patients who had acute ischaemic stroke without haemorrhagic transformation which was evidenced with magnetic resonance (MR) imaging during hospitalization. Total ... ...

Abstract	Background: The CHADS Materials and methods: This prospective study included all 1494 patients who had acute ischaemic stroke without haemorrhagic transformation which was evidenced with magnetic resonance (MR) imaging during hospitalization. Total infarction volume and arterial stenosis score were calculated based on MR imaging. National Institutes of Health Stroke Scale scores (NIHSSs) were obtained at admission and discharge by board-certified neurologists. The clinical outcomes were defined as composite endpoints of restroke and mortality and were recorded with the mean follow-up period of 37.5 months. Results: There were 195 (13.1%) patients with AF. The patients with AF had significantly higher median CHADS Conclusions: Prestroke CHA
MeSH term(s)	Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/mortality ; Brain Infarction/mortality ; Brain Infarction/prevention & control ; Constriction, Pathologic/etiology ; Constriction, Pathologic/prevention & control ; Female ; Humans ; Magnetic Resonance Angiography ; Male ; Prognosis ; Prospective Studies ; Risk Assessment/methods ; Severity of Illness Index ; Stroke/mortality ; Stroke/prevention & control
Language	English
Publishing date	2018-01-29
Publishing country	England
Document type	Evaluation Studies ; Journal Article
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.12884
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Article ; Online: Effect of coffee, tea and alcohol intake on circulating inflammatory cytokines: a two sample-Mendelian randomization study.

He, Yuan / Zhu, Shuang / Zhang, Yu / Tan, Chin Ping / Zhang, Jianbin / Liu, Yuanfa / Xu, Yong-Jiang

European journal of clinical nutrition

2024

Abstract: Background: Despite the abundance of research examining the effects of coffee, tea, and alcohol ... cytokines.: Methods: Information regarding the consumption of coffee, tea, and alcohol was collected ... 95% CI 0.06 ~ 0.8; p = 0.023) levels. Conversely, tea intake was potentially correlated ...

Abstract	Background: Despite the abundance of research examining the effects of coffee, tea, and alcohol on inflammatory diseases, there is a notable absence of conclusive evidence regarding their direct causal influence on circulating inflammatory cytokines. Previous studies have primarily concentrated on established cytokines, neglecting the potential impact of beverage consumption on lesser-studied but equally important cytokines. Methods: Information regarding the consumption of coffee, tea, and alcohol was collected from the UK Biobank, with sample sizes of 428,860, 447,485, and 462,346 individuals, respectively. Data on 41 inflammatory cytokines were obtained from summary statistics of 8293 healthy participants from Finnish cohorts. Results: The consumption of coffee was found to be potentially associated with decreased levels of Macrophage colony-stimulating factor (β = -0.57, 95% CI -1.06 ~ -0.08; p = 0.022) and Stem cell growth factor beta (β = -0.64, 95% CI -1.16 ~ -0.12; p = 0.016), as well as an increase in TNF-related apoptosis-inducing ligand (β = 0.43, 95% CI 0.06 ~ 0.8; p = 0.023) levels. Conversely, tea intake was potentially correlated with a reduction in Interleukin-8 (β = -0.45, 95% CI -0.9 ~ 0; p = 0.045) levels. Moreover, our results indicated an association between alcohol consumption and decreased levels of Regulated on Activation, Normal T Cell Expressed and Secreted (β = -0.24, 95% CI -0.48 ~ 0; p = 0.047), as well as an increase in Stem cell factor (β = 0.17, 95% CI 0.02 ~ 0.31; p = 0.023) and Stromal cell-derived factor-1 alpha (β = 0.20, 95% CI 0.04 ~ 0.36; p = 0.013). Conclusion: Revealing the interactions between beverage consumption and various inflammatory cytokines may lead to the discovery of novel therapeutic targets, thereby facilitating dietary interventions to complement clinical disease treatments.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-024-01438-4
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Article ; Online: Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort.

Vollstedt, Eva-Juliane / Schaake, Susen / Lohmann, Katja / Padmanabhan, Shalini / Brice, Alexis / Lesage, Suzanne / Tesson, Christelle / Vidailhet, Marie / Wurster, Isabel / Hentati, Faycel / Mirelman, Anat / Giladi, Nir / Marder, Karen / Waters, Cheryl / Fahn, Stanley / Kasten, Meike / Brüggemann, Norbert / Borsche, Max / Foroud, Tatiana /

Tolosa, Eduardo / Garrido, Alicia / Annesi, Grazia / Gagliardi, Monica / Bozi, Maria / Stefanis, Leonidas / Ferreira, Joaquim J / Correia Guedes, Leonor / Avenali, Micol / Petrucci, Simona / Clark, Lorraine / Fedotova, Ekaterina Y / Abramycheva, Natalya Y / Alvarez, Victoria / Menéndez-González, Manuel / Jesús Maestre, Silvia / Gómez-Garre, Pilar / Mir, Pablo / Belin, Andrea Carmine / Ran, Caroline / Lin, Chin-Hsien / Kuo, Ming-Che / Crosiers, David / Wszolek, Zbigniew K / Ross, Owen A / Jankovic, Joseph / Nishioka, Kenya / Funayama, Manabu / Clarimon, Jordi / Williams-Gray, Caroline H / Camacho, Marta / Cornejo-Olivas, Mario / Torres-Ramirez, Luis / Wu, Yih-Ru / Lee-Chen, Guey-Jen / Morgadinho, Ana / Pulkes, Teeratorn / Termsarasab, Pichet / Berg, Daniela / Kuhlenbäumer, Gregor / Kühn, Andrea A / Borngräber, Friederike / de Michele, Giuseppe / De Rosa, Anna / Zimprich, Alexander / Puschmann, Andreas / Mellick, George D / Dorszewska, Jolanta / Carr, Jonathan / Ferese, Rosangela / Gambardella, Stefano / Chase, Bruce / Markopoulou, Katerina / Satake, Wataru / Toda, Tatsushi / Rossi, Malco / Merello, Marcelo / Lynch, Timothy / Olszewska, Diana A / Lim, Shen-Yang / Ahmad-Annuar, Azlina / Tan, Ai Huey / Al-Mubarak, Bashayer / Hanagasi, Hasmet / Koziorowski, Dariusz / Ertan, Sibel / Genç, Gençer / de Carvalho Aguiar, Patricia / Barkhuizen, Melinda / Pimentel, Marcia M G / Saunders-Pullman, Rachel / van de Warrenburg, Bart / Bressman, Susan / Toft, Mathias / Appel-Cresswell, Silke / Lang, Anthony E / Skorvanek, Matej / Boon, Agnita J W / Krüger, Rejko / Sammler, Esther M / Tumas, Vitor / Zhang, Bao-Rong / Garraux, Gaetan / Chung, Sun Ju / Kim, Yun Joong / Winkelmann, Juliane / Sue, Carolyn M / Tan, Eng-King / Damásio, Joana / Klivényi, Péter / Kostic, Vladimir S / Arkadir, David / Martikainen, Mika / Borges, Vanderci / Hertz, Jens Michael / Brighina, Laura / Spitz, Mariana / Suchowersky, Oksana / Riess, Olaf / Das, Parimal / Mollenhauer, Brit / Gatto, Emilia M / Petersen, Maria Skaalum / Hattori, Nobutaka / Wu, Ruey-Meei / Illarioshkin, Sergey N / Valente, Enza Maria / Aasly, Jan O / Aasly, Anna / Alcalay, Roy N / Thaler, Avner / Farrer, Matthew J / Brockmann, Kathrin / Corvol, Jean-Christophe / Klein, Christine

Movement disorders : official journal of the Movement Disorder Society

2023 Volume 38, Issue 2, Page(s) 286–303

Abstract: Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of ... ...

Abstract	Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
MeSH term(s)	Humans ; Parkinson Disease/genetics ; Mutation
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29288
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Monitoring and evaluating the dietary risk of trace elements content in bottled and hand-shaken tea in Taiwan.

Chin, Wei-Shan / Chien, Ling-Chu / Kao, Ho-Ching / Chuang, Yung-Ning / Liao, Kai-Wei

Environmental science and pollution research international

2023 Volume 30, Issue 19, Page(s) 55716–55729

Abstract: Tea is the most frequently consumed beverage worldwide and is obtained from the leaves ... Camellia sinensis. The traditional way of tea consumption through brewing is gradually being replaced ... by the consumption of bottled and hand-shaken tea. Despite the different ways of tea consumption, trace elements ...

Abstract	Tea is the most frequently consumed beverage worldwide and is obtained from the leaves Camellia sinensis. The traditional way of tea consumption through brewing is gradually being replaced by the consumption of bottled and hand-shaken tea. Despite the different ways of tea consumption, trace elements accumulation and contamination of tea leaves have caused concerns. However, limited studies have reported trace element concentrations in different types of tea in bottled or hand-shaken tea and their health risks. This study aimed to determine the level of trace elements (V, Cr, Co, As, Cd, Pb, Mn, and Zn) in green tea, black tea, and Oolong tea in two varieties of products (bottled and hand-shaken tea). The health risks associated with tea consumption in various age subgroups among Taiwan's general population were also estimated. A Monte Carlo simulation was applied to estimate the distribution of daily trace elements intake through bottled and hand-shaken tea consumption. As to the non-carcinogenic risks, the Monte Carlo simulation showed that hand-shaken green tea had a higher percentage of hazard index (HI) >1 (1.08%~6.05%) among all age groups. As to carcinogenic risks, the Monte Carlo simulation showed that the risks of As exposure from bottled Oolong tea and hand-shaken black, green, and Oolong teas in the 90th percentile in >18 to ≤65 and >65-year-old groups were higher than 10
MeSH term(s)	Humans ; Aged ; Trace Elements/analysis ; Taiwan ; Tea ; Camellia sinensis ; Beverages ; Risk Assessment
Chemical Substances	Trace Elements ; Tea
Language	English
Publishing date	2023-03-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-26130-1
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Book: Tao-te-king

Laozi / Pilone, Rosanna / Wu, Chin-hsing

(Bibliotheka Sinica; Nr. 4)

1956

Title variant	Daode jing [Transkriptionsvariante in Pinyin]
Institution	Istituto Culturale Italo-Cinese, Milano
Author's details	di Lao-Tse [Laozi]
Series title	Bibliotheka Sinica; Nr. 4
Language	Italian
Size	109 S
Edition	Orig.-Ausg
Publisher	Istituto Culturale Italo-Cinese
Publishing place	Mailand
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article: Versatile Effects of GABA Oolong Tea on Improvements in Diastolic Blood Pressure, Alpha Brain Waves, and Quality of Life.

Lin, Chih-Cheng / Hsieh, Chih-Yu / Chen, Li-Fen / Chen, Yen-Chun / Ho, Tien-Hwa / Chang, Shao-Chin / Chang, Jia-Feng

Foods (Basel, Switzerland)

2023 Volume 12, Issue 22

Abstract: ... aminobutyric acid (GABA)-fortified oolong (GO) tea could relieve human stress and exert versatile physiological ... benefits. The purpose of this human study was to investigate the therapeutic effects of daily GO tea ... that GO tea contained the most abundant amino acids and GABA, contributing to the relaxation activity ...

Abstract	Emerging evidence has demonstrated that using a new manufacturing technology to produce γ-aminobutyric acid (GABA)-fortified oolong (GO) tea could relieve human stress and exert versatile physiological benefits. The purpose of this human study was to investigate the therapeutic effects of daily GO tea consumption on improvements in blood pressure, relaxation-related brain waves, and quality of life (QOL) over a period of 28 consecutive days. Total polyphenols, major catechins, and free amino acids were analyzed via an HPLC assay. Changes in heart rate, blood pressure, α brain waves (index of relaxation), and the eight-item QOL score were investigated on days 0, 7, 14, 21, and 28. The chemical analysis results showed that GO tea contained the most abundant amino acids and GABA, contributing to the relaxation activity. Among all study participants, the daily consumption of GO tea could reduce systolic blood pressure on day 21 and diastolic blood pressure on day 28 (
Language	English
Publishing date	2023-11-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12224101
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Article ; Online: Molecular characterization of polyphenol oxidase between small and large leaf tea cultivars.

Chen, Chung-Tse / Yang, Chin-Ying / Tzen, Jason T C

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12870

Abstract: Tea is a widely consumed beverage prepared using the fresh leaves of Camellia sinensis L ... in tea manufacturing, catalyzes essential phenolic metabolites into different derivatives. To compare ... from four representative tea cultivars in Taiwan. Amino acid sequence alignment analyses indicated ...

Abstract	Tea is a widely consumed beverage prepared using the fresh leaves of Camellia sinensis L. Tea plants are classified into small- and large-leaf varieties. Polyphenol oxidase (PPO), a crucial enzyme in tea manufacturing, catalyzes essential phenolic metabolites into different derivatives. To compare the molecular characteristics of CsPPO between cultivars, we cloned the full-length sequence of CsPPO cDNA from four representative tea cultivars in Taiwan. Amino acid sequence alignment analyses indicated that CsPPO is highly conserved. PPO exhibited similar enzymatic activity in different tea cultivars. Quantitative real-time polymerase chain reaction revealed no significant differences in the CsPPO transcript level between the small- and large-leaf varieties. However, tea harvested in summer and from low-altitude areas had a higher CsPPO transcript level than that harvested in winter and from high-altitude areas. Regulation of CsPPO by temperature was more significant in the small-leaf variety than in the large-leaf variety. The content of flavonoids and the expression of chalcone synthase, anthocyanidin synthase, and anthocyanidin reductase genes involved in the tea flavonoid biosynthesis pathway were higher in the large-leaf than in the small-leaf varieties, suggesting that the large-leaf variety had a higher antioxidative capacity than did the small-leaf variety. Our study compared the molecular properties of CsPPO between two tea varieties and clarified the physiological role of PPO in tea.
MeSH term(s)	Camellia sinensis/metabolism ; Catechol Oxidase/genetics ; Catechol Oxidase/metabolism ; Gene Expression Regulation, Plant ; Plant Leaves/metabolism ; Plant Proteins/metabolism ; Tea/genetics ; Tea/metabolism
Chemical Substances	Plant Proteins ; Tea ; Catechol Oxidase (EC 1.10.3.1)
Language	English
Publishing date	2022-07-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-17184-1
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Article ; Online: Publisher Correction: Molecular characterization of polyphenol oxidase between small and large leaf tea cultivars.

Chen, Chung-Tse / Yang, Chin-Ying / Tzen, Jason T C

Scientific reports

2022 Volume 12, Issue 1, Page(s) 14026

Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-18490-4
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Article ; Online: Coffee, Black Tea, and Green Tea Consumption in Relation to Plasma Metabolites in an Asian Population.

Seow, Wei Jie / Low, Dorrain Yanwen / Pan, Wen-Chi / Gunther, Samuel H / Sim, Xueling / Torta, Federico / Herr, Deron R / Kovalik, Jean-Paul / Ching, Jianhong / Khoo, Chin Meng / Wenk, Markus R / Tai, E Shyong / van Dam, Rob M

Molecular nutrition & food research

2020 , Page(s) e2000527

Abstract: Scope: Coffee and tea are among the most popular beverages in the world. However, the association ... between habitual coffee, green tea, and black tea consumption with metabolomics profiles in Asian ... to obtain the estimates for the association between coffee and tea consumption with metabolite levels ...

Abstract	Scope: Coffee and tea are among the most popular beverages in the world. However, the association between habitual coffee, green tea, and black tea consumption with metabolomics profiles in Asian populations remain largely unknown. Methods and results: 158 metabolites (14 amino acids, 45 acylcarnitines, and 99 sphingolipids) in the blood plasma of participants are measured from the population-based Singapore Prospective Study Program cohort using mass spectrometry (MS). Linear regression models are used to obtain the estimates for the association between coffee and tea consumption with metabolite levels, adjusted for potential confounders and false discovery rate (FDR). Coffee consumption is significantly associated with higher levels of 63 sphingolipids (29 sphingomyelins, 32 ceramides, a sphingosine-1-phosphate, and a sphingosine) and lower levels of 13 acylcarnitines and alanine. Black tea consumption is significantly associated with higher levels of eight sphingolipids, and lower levels of an amino acid, whereas green tea is significantly inversely associated with four metabolites (C8:1-OH acylcarnitine, ganglioside GM3 d18:1/16:0, sphingomyelins d18:2/18:0 and d18:1/14:0). Conclusions: Coffee, black tea, and green tea consumption are associated with plasma levels of certain classes of sphingolipids and acylcarnitines in an Asian population, particularly sphingomyelins, which may mediate the health benefits of these beverages.
Language	English
Publishing date	2020-10-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.202000527
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