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  1. Article ; Online: Electrocardiograms in Critical Care Cardiology.

    Chyu, Kuang-Yuh / Shah, Prediman K

    JACC. Case reports

    2022  Volume 4, Issue 23, Page(s) 101632

    Abstract: Patients with critical illness may present with electrocardiogram (ECG) findings with bizarre QRS morphology or abnormal amplitude. This article provides ECG examples from such clinical scenarios and discusses their clinical characteristics and ... ...

    Abstract Patients with critical illness may present with electrocardiogram (ECG) findings with bizarre QRS morphology or abnormal amplitude. This article provides ECG examples from such clinical scenarios and discusses their clinical characteristics and significance. (
    Language English
    Publishing date 2022-11-03
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.08.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ECGs in Critical Care Cardiology: Do Not Miss That Myocardial Infarction.

    Chyu, Kuang-Yuh / Shah, Prediman K

    JACC. Case reports

    2022  Volume 4, Issue 19, Page(s) 1297–1305

    Abstract: This paper provides clinical cases of acute myocardial infarction that do not show ST-segment elevation on 12-lead electrocardiogram, but should be clinically treated as ST-segment elevation myocardial infarction with early diagnostic coronary angiogram ... ...

    Abstract This paper provides clinical cases of acute myocardial infarction that do not show ST-segment elevation on 12-lead electrocardiogram, but should be clinically treated as ST-segment elevation myocardial infarction with early diagnostic coronary angiogram followed by appropriate strategy of revascularization. (
    Language English
    Publishing date 2022-10-05
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.07.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electrocardiograms in Critical Care Cardiology: Is it Acute Coronary Syndrome?

    Chyu, Kuang-Yuh / Shah, Prediman K

    JACC. Case reports

    2022  Volume 4, Issue 21, Page(s) 1394–1398

    Abstract: Patients with critical illness may present with electrocardiogram (ECG) findings difficult for physicians to distinguish them from acute coronary syndrome. This article provides three cases of such clinical scenarios. Examples of ECGs and their clinical ... ...

    Abstract Patients with critical illness may present with electrocardiogram (ECG) findings difficult for physicians to distinguish them from acute coronary syndrome. This article provides three cases of such clinical scenarios. Examples of ECGs and their clinical characteristics and significance are discussed. (
    Language English
    Publishing date 2022-11-02
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.06.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Pursuit of an Atherosclerosis Vaccine.

    Chyu, Kuang-Yuh / Shah, Prediman K

    Circulation research

    2018  Volume 123, Issue 10, Page(s) 1121–1123

    MeSH term(s) Animals ; Atherosclerosis/immunology ; Atherosclerosis/prevention & control ; Clinical Trials as Topic ; Humans ; Lipoproteins/immunology ; Vaccination/methods ; Vaccines/immunology
    Chemical Substances Lipoproteins ; Vaccines
    Language English
    Publishing date 2018-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.118.313842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.70: Show issues Location:
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  5. Article ; Online: Immunogenetics of Atherosclerosis-Link between Lipids, Immunity, and Genes.

    Chyu, Kuang-Yuh / Dimayuga, Paul C / Shah, Prediman K

    Current atherosclerosis reports

    2020  Volume 22, Issue 10, Page(s) 53

    Abstract: Purpose of review: Atherosclerosis is a complex disease process with lipid as a traditional modifiable risk factor and therapeutic target in treating atherosclerotic cardiovascular disease (ACVD). Recent evidence indicates that genetic influence and ... ...

    Abstract Purpose of review: Atherosclerosis is a complex disease process with lipid as a traditional modifiable risk factor and therapeutic target in treating atherosclerotic cardiovascular disease (ACVD). Recent evidence indicates that genetic influence and host immune response also are vital in this process. How these elements interact and modify each other and if immune response may emerge as a novel modifiable target remain poorly understood.
    Recent findings: Numerous preclinical studies have clearly demonstrated that hypercholesterolemia is essential for atherogenesis, but genetic variations and host immune-inflammatory responses can modulate the pro-atherogenic effect of elevated LDL-C. Clinical studies also suggest that a similar paradigm may also be operational in atherogenesis in humans. More importantly each element modifies the biological behavior of the other two elements, forming a triangular relationship among the three. Modulating any one of them will have downstream impact on atherosclerosis. This brief review summarizes the relationship among lipids, genes, and immunity in atherogenesis and presents evidence to show how these elements affect each other. Modulation of immune response, though in its infancy, has a potential to emerge as a novel clinical strategy in treating ACVD.
    MeSH term(s) Adaptive Immunity ; Animals ; Atherosclerosis/blood ; Atherosclerosis/etiology ; Atherosclerosis/genetics ; Atherosclerosis/immunology ; Cholesterol, LDL/blood ; Genotype ; Humans ; Hypercholesterolemia/complications ; Immunity, Innate
    Chemical Substances Cholesterol, LDL
    Language English
    Publishing date 2020-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-020-00874-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5534: Show issues Location:
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  6. Article ; Online: Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome.

    Chernomordik, Fernando / Cercek, Bojan / Zhou, Jianchang / Zhao, Xiaoning / Lio, Nicole Wai Man / Chyu, Kuang-Yuh / Shah, Prediman K / Dimayuga, Paul C

    Frontiers in immunology

    2023  Volume 14, Page(s) 1113904

    Abstract: Background: LL-37 is the only member of the cathelicidin family of antimicrobial peptides in humans and is an autoantigen in several autoimmune diseases and in acute coronary syndrome (ACS). In this report, we profiled the specific T cell response to ... ...

    Abstract Background: LL-37 is the only member of the cathelicidin family of antimicrobial peptides in humans and is an autoantigen in several autoimmune diseases and in acute coronary syndrome (ACS). In this report, we profiled the specific T cell response to the autoimmune self-antigen LL-37 and investigated the factors modulating the response in peripheral blood mononuclear cells (PBMCs) of healthy subjects and ACS patients.
    Methods and results: The activation induced marker (AIM) assay demonstrated differential T cell profiles characterized by the persistence of CD134 and CD137, markers that impair tolerance and promote immune effector and memory response, in ACS compared to Controls. Specifically, CD8+CD69+CD137+ T cells were significantly increased by LL-37 stimulation in ACS PBMCs. T effector cell response to LL-37 were either HLA dependent or independent as determined by blocking with monoclonal antibody to either Class-I HLA or Class-II HLA. Blocking of immune checkpoints PD-1 and CTLA-4 demonstrated the control of self-reactive T cell response to LL-37 was modulated predominantly by CTLA-4. Platelets from healthy controls down-modulated CD8+CD69+CD137+ T cell response to LL-37 in autologous PBMCs. CD8+CD69+CD137+ T cell AIM profile negatively correlated with platelet count in ACS patients.
    Conclusions: Our report demonstrates that the immune response to the autoantigen LL-37 in ACS patients is characterized specifically by CD8+CD69+CD137+ T cell AIM profile with persistent T cell activation and the generation of immunologic memory. The results provide potentially novel insight into mechanistic pathways of antigen-specific immune signaling in ACS.
    MeSH term(s) Humans ; Acute Coronary Syndrome/metabolism ; Autoantigens/metabolism ; CD8-Positive T-Lymphocytes ; CTLA-4 Antigen/metabolism ; Leukocytes, Mononuclear
    Chemical Substances Autoantigens ; CTLA-4 Antigen ; CAMP protein, human
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1113904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: HDL/ApoA-1 infusion and ApoA-1 gene therapy in atherosclerosis.

    Chyu, Kuang-Yuh / Shah, Prediman K

    Frontiers in pharmacology

    2015  Volume 6, Page(s) 187

    Abstract: The HDL hypothesis stating that simply raising HDL cholesterol (HDL-C) may produce cardiovascular benefits has been questioned recently based on several randomized clinical trials using CETP inhibitors or niacin to raise HDL-C levels. However, extensive ... ...

    Abstract The HDL hypothesis stating that simply raising HDL cholesterol (HDL-C) may produce cardiovascular benefits has been questioned recently based on several randomized clinical trials using CETP inhibitors or niacin to raise HDL-C levels. However, extensive pre-clinical data support the vascular protective effects of administration of exogenous ApoA-1 containing preβ-HDL like particles. Several small proof-of-concept clinical trials using such HDL/ApoA-1 infusion therapy have shown encouraging results but definitive proof of efficacy must await large scale clinical trials. In addition to HDL infusion therapy an alternative way to exploit beneficial cardiovascular effects of HDL/ApoA-1 is to use gene transfer. Preclinical studies have shown evidence of benefit using this approach; however clinical validation is yet lacking. This review summarizes our current knowledge of the aforementioned strategies.
    Language English
    Publishing date 2015-09-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2015.00187
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  8. Article: Vaccine against arteriosclerosis: an update.

    Chyu, Kuang-Yuh / Dimayuga, Paul C / Shah, Prediman K

    Therapeutic advances in vaccines

    2017  Volume 5, Issue 2, Page(s) 39–47

    Abstract: Substantial data from experimental and clinical investigation support the role of immune-mediated mechanisms in atherogenesis, with immune systems responding to many endogenous and exogenous antigens that play either proatherogenic or atheroprotective ... ...

    Abstract Substantial data from experimental and clinical investigation support the role of immune-mediated mechanisms in atherogenesis, with immune systems responding to many endogenous and exogenous antigens that play either proatherogenic or atheroprotective roles. An active immunization strategy against many of these antigens could potentially alter the natural history of atherosclerosis. This review mainly focuses on the important studies on the search for antigens that have been tested in vaccine formulations to reduce atherosclerosis in preclinical models. It will also address the opportunities and challenges associated with potential clinical application of this novel therapeutic paradigm.
    Language English
    Publishing date 2017-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2743628-7
    ISSN 2051-0144 ; 2051-0136
    ISSN (online) 2051-0144
    ISSN 2051-0136
    DOI 10.1177/2051013617693753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Differentiation between Descending Thoracic Aortic Diseases using Machine Learning and Plasma Proteomic Signatures.

    Momenzadeh, Amanda / Kreimer, Simion / Guo, Dongchuan / Ayres, Matthew / Berman, Daniel / Chyu, Kuang-Yuh / Shah, Prediman K / Milewicz, Dianna / Azizzadeh, Ali / Meyer, Jesse G / Parker, Sarah

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Background: Descending thoracic aortic aneurysms and dissections can go undetected until severe and catastrophic, and few clinical indices exist to screen for aneurysms or predict risk of dissection.: Methods: This study generated a plasma proteomic ... ...

    Abstract Background: Descending thoracic aortic aneurysms and dissections can go undetected until severe and catastrophic, and few clinical indices exist to screen for aneurysms or predict risk of dissection.
    Methods: This study generated a plasma proteomic dataset from 75 patients with descending type B dissection (Type B) and 62 patients with descending thoracic aortic aneurysm (DTAA). Standard statistical approaches were compared to supervised machine learning (ML) algorithms to distinguish Type B from DTAA cases. Quantitatively similar proteins were clustered based on linkage distance from hierarchical clustering and ML models were trained with uncorrelated protein lists across various linkage distances with hyperparameter optimization using 5-fold cross validation. Permutation importance (PI) was used for ranking the most important predictor proteins of ML classification between disease states and the proteins among the top 10 PI protein groups were submitted for pathway analysis.
    Results: Of the 1,549 peptides and 198 proteins used in this study, no peptides and only one protein, hemopexin (HPX), were significantly different at an adjusted p-value <0.01 between Type B and DTAA cases. The highest performing model on the training set (Support Vector Classifier) and its corresponding linkage distance (0.5) were used for evaluation of the test set, yielding a precision-recall area under the curve of 0.7 to classify between Type B from DTAA cases. The five proteins with the highest PI scores were immunoglobulin heavy variable 6-1 (IGHV6-1), lecithin-cholesterol acyltransferase (LCAT), coagulation factor 12 (F12), HPX, and immunoglobulin heavy variable 4-4 (IGHV4-4). All proteins from the top 10 most important correlated groups generated the following significantly enriched pathways in the plasma of Type B versus DTAA patients: complement activation, humoral immune response, and blood coagulation.
    Conclusions: We conclude that ML may be useful in differentiating the plasma proteome of highly similar disease states that would otherwise not be distinguishable using statistics, and, in such cases, ML may enable prioritizing important proteins for model prediction.
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.26.538468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Can we vaccinate against atherosclerosis?

    Chyu, Kuang-Yuh / Shah, Prediman K

    Journal of cardiovascular pharmacology and therapeutics

    2014  Volume 19, Issue 1, Page(s) 77–82

    Abstract: A large body of evidence implicates the immune system in the pathogenesis of atherosclerosis. Both active and passive immunizations have been tested as immunomodulation strategies to confer protective effect against atherogenesis. This review focuses on ... ...

    Abstract A large body of evidence implicates the immune system in the pathogenesis of atherosclerosis. Both active and passive immunizations have been tested as immunomodulation strategies to confer protective effect against atherogenesis. This review focuses on the current knowledge of the complex role and the potential for immune modulation therapy via active immunization for atherosclerosis.
    MeSH term(s) Animals ; Atherosclerosis/immunology ; Atherosclerosis/prevention & control ; Humans ; Immune System/immunology ; Immunization, Passive/methods ; Vaccination/methods ; Vaccines/administration & dosage ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2014-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1329372-2
    ISSN 1940-4034 ; 1074-2484
    ISSN (online) 1940-4034
    ISSN 1074-2484
    DOI 10.1177/1074248413498822
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    Zs.A 4895: Show issues Location:
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