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  1. Article: Treating our patients with compassion & respect: interview with Dr. Zhaolin Lu of the Department of Endocrinology of Peking Union Medical College Hospital.

    Liao, Lili / Zhang, Han

    Annals of translational medicine

    2017  Volume 5, Issue 21, Page(s) 437

    Language English
    Publishing date 2017-11-16
    Publishing country China
    Document type News
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2017.08.30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification and Thermostability Modification of the Mesophilic L-asparaginase from Limosilactobacillus secaliphilus.

    Zhang, Wenli / Dai, Quanyu / Huang, Zhaolin / Xu, Wei

    Applied biochemistry and biotechnology

    2023  

    Abstract: L-asparaginase (L-ASNase, E.C.3.5.1.1) could effectively inhibit the formation of acrylamide (AA) by hydrolyzing the AA precursor L-asparagine. However, most of the L-ASNases showed a relatively weak thermostability, posing a big threat on the ... ...

    Abstract L-asparaginase (L-ASNase, E.C.3.5.1.1) could effectively inhibit the formation of acrylamide (AA) by hydrolyzing the AA precursor L-asparagine. However, most of the L-ASNases showed a relatively weak thermostability, posing a big threat on the application of enzyme at high processing temperatures. Here, the recombinant L-ASNase from mesophilic bacteria Limosilactobacillus secaliphilus was identified for the first time. The recombinant enzyme exhibited its optimal activity at pH 8.0 and 60 ℃. Additionally, the thermostability of L. secaliphilus L-ASNase was enhanced by site-directed mutagenesis after multiple sequence alignment. Ten mutants were reasonably constructed, among which the single-point mutants L24Y, S55T, and V155S showed more than 1 ℃ elevated T
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04715-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3053: Show issues Location:
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  3. Article ; Online: Investigation on Air Ventilation within Idealised Urban Wind Corridors and the Influence of Structural Factors with Numerical Simulations

    Wen Xu / Lushuang Zhao / Yunwei Zhang / Zhaolin Gu

    Sustainability, Vol 15, Iss 13817, p

    2023  Volume 13817

    Abstract: Wind corridors are expected to be effective in alleviating the canopy urban heat island effect and air pollution. However, investigations on airflow characteristics within wind corridors, especially the influences of structural factors, are still limited. ...

    Abstract Wind corridors are expected to be effective in alleviating the canopy urban heat island effect and air pollution. However, investigations on airflow characteristics within wind corridors, especially the influences of structural factors, are still limited. This current work performed numerical simulations on a group of idealised wind corridor models with different aspect ratios (ARs) and varying heights and/or widths along the corridors. Simulations revealed that the AR value had a vital influence on the wind speed, and an AR value of 0.1 facilitated the best ventilation conditions within the wind corridor. Structural variations along the corridor have a critical influence on ventilation, where the width contraction (contraction structure) and high-rise buildings (protrusion structure) would considerably weaken the wind speed within the corridors. The results suggested that wider and step-up structural design along the corridor should be encouraged in urban wind corridor planning, which would be helpful in promoting ventilation efficiency; but contraction structures should be prevented for primary wind corridor design.
    Keywords wind corridor ; structural factor ; ventilation efficiency ; contraction structure ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 690
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Making Lemonade: Putting the Wisdom of the Genome to Work in Atopic Dermatitis.

    Zhang, Zhaolin / Elder, James T

    The Journal of investigative dermatology

    2021  Volume 141, Issue 11, Page(s) 2561–2564

    Abstract: Getting from a GWAS hit to an actionable gene remains a challenge in complex disease genetics. In a new article of the Journal of Investigative Dermatology, Sobczyk et al. (2021) use a wide variety of genomic data to generate a prioritization algorithm ... ...

    Abstract Getting from a GWAS hit to an actionable gene remains a challenge in complex disease genetics. In a new article of the Journal of Investigative Dermatology, Sobczyk et al. (2021) use a wide variety of genomic data to generate a prioritization algorithm to tackle this problem in atopic dermatitis, calling on the wisdom of the genome to generate promising results.
    MeSH term(s) Dermatitis, Atopic/genetics ; Eczema ; Genome-Wide Association Study ; Humans
    Language English
    Publishing date 2021-10-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.05.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
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  5. Article ; Online: The DFT and Machine Learning Method Accelerated the Discovery of DMSCs with High ORR and OER Catalytic Activities.

    Fang, Zhaolin / Li, Shuyuan / Zhang, Yunjiang / Wang, Yaxin / Meng, Kong / Huang, Chenyu / Sun, Shaorui

    The journal of physical chemistry letters

    2024  Volume 15, Issue 1, Page(s) 281–289

    Abstract: The oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) are crucial for the conversion of clean energy. Recently, dual-metal-site catalysts (DMSCs) have gained much attention due to their high atom utilization, stronger stability, and ...

    Abstract The oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) are crucial for the conversion of clean energy. Recently, dual-metal-site catalysts (DMSCs) have gained much attention due to their high atom utilization, stronger stability, and better catalytic performance. An advanced method that combines density functional theory (DFT) and machine learning (ML) has been employed in this study to investigate the adsorption free energies of adsorbates on hundreds of potential catalysts, with the aim of screening for catalysts that are highly active for the ORR and OER. The result of this study is that 30 DMSCs with ORR activity superior to Pt, 10 DMSCs with OER activity superior to RuO
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02938
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  6. Article ; Online: A 3D-FEA study on the impact of different preparation forms and materials on posterior occlusal veneers.

    Xu, Junchen / Ma, Junchi / Tan, Zhaolin / Zhang, Qi / Hu, Jian / Li, Jin

    Journal of the mechanical behavior of biomedical materials

    2024  Volume 152, Page(s) 106462

    Abstract: Objectives: To study the stress distribution and bonding performance in posterior occlusal veneers and tooth bodies under different preparation forms and materials.: Methods: An isolated lower right first molar was prepared with non-retention type ( ... ...

    Abstract Objectives: To study the stress distribution and bonding performance in posterior occlusal veneers and tooth bodies under different preparation forms and materials.
    Methods: An isolated lower right first molar was prepared with non-retention type (type A), cavity-retained type (type B), and encircling-retention type (type C) forms. MicroCT images of the tooth were obtained and digitally converted into three-dimensional solid models. Three-dimensional models of veneers for the three abutment teeth were designed, fabricated, and divided into nine models (A
    Results: The B
    Conclusions: The cavity-retained type better protected the veneers and dental tissues than the non-retention and encircling-retention types under lateral forces. E.max CAD material, with a high elastic modulus, reduced the stress transmitted to the remaining dental tissues. Lava Ultimate exhibited the best bonding performance.
    MeSH term(s) Molar ; Finite Element Analysis ; Computer Simulation ; Elastic Modulus
    Language English
    Publishing date 2024-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2024.106462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Role of sulfide on DNRA distribution and the microbial community structure in a sulfide-driven nitrate reduction process.

    Li, Xiaoling / Zhao, Jianqiang / Lu, Zhaolin / Zhou, Juncai / Zhang, Wenbo / Hu, Bo

    Environmental science and pollution research international

    2024  Volume 31, Issue 19, Page(s) 28803–28813

    Abstract: Microbial nitrate reduction processes involve two competing pathways: denitrification (DEN) and dissimilatory nitrate reduction to ammonium (DNRA). This study investigated the distribution of DNRA in a sole sulfur-driven nitrogen conversion process using ...

    Abstract Microbial nitrate reduction processes involve two competing pathways: denitrification (DEN) and dissimilatory nitrate reduction to ammonium (DNRA). This study investigated the distribution of DNRA in a sole sulfur-driven nitrogen conversion process using a laboratory-scale sequencing biofilm batch reactor (SBBR) through a series of batch tests with varying sulfide/nitrate (S/N) ratios. The results showed that DNRA became more dominant in the sulfide-oxidizing autotrophic denitrification (SOAD) process as the S/N ratio increased to 1.5:1, 1.7:1, and 2:1, reaching a peak of 35.3% at the S/N ratio of 1.5:1. Oxidation-reduction potential (ORP) patterns demonstrated distinct inflection points for nitrate and nitrite consumption under the SOAD-only conditions, whereas these points overlapped when DNRA coexisted with SOAD. Analysis of 16S ribosomal RNA identified Ignavibacterium, Hydrogenophaga, and Geobacter as the dominant genera responsible for DNRA during autotrophic nitrate reduction. The findings of the DNRA divergence investigation provided valuable insights into enhancing biological nitrogen removal processes, particularly when coupled with the anammox.
    MeSH term(s) Sulfides ; Nitrates/metabolism ; Denitrification ; Oxidation-Reduction ; Bioreactors ; Ammonium Compounds/metabolism ; RNA, Ribosomal, 16S ; Nitrogen
    Chemical Substances Sulfides ; Nitrates ; Ammonium Compounds ; RNA, Ribosomal, 16S ; Nitrogen (N762921K75)
    Language English
    Publishing date 2024-04-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32912-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  8. Article ; Online: A Joy-Stick Assistant Three-Dimensional Modified Technique of Minimally Invasive Surgery for Mild or Moderate Hallux Valgus.

    Geng, Xiang / Teng, Zhaolin / Chen, Li / Zhang, Chao / Huang, Jiazhang / Wang, Xu / Ma, Xin

    Orthopaedic surgery

    2024  

    Abstract: Background: Minimally invasive surgery (MIS) such as minimally invasive chevron osteotomy and Akin osteotomy (MICA) has become popular in the treatment of hallux valgus. However, how to correct three-dimensional deformities in hallux valgus effectively ... ...

    Abstract Background: Minimally invasive surgery (MIS) such as minimally invasive chevron osteotomy and Akin osteotomy (MICA) has become popular in the treatment of hallux valgus. However, how to correct three-dimensional deformities in hallux valgus effectively and simply in MICA is still difficult. Special equipment is required in MICA as has been reported before. It is meaningful and necessary to reduce the reliance on special equipment in MICA.
    Methods: From January 2021 to July 2022, patients with mild or moderate hallux valgus were treated with a joy-stick assistant three-dimensional modified technique (Joy-stick 3D technique) of MIS. VAS, AOFAS Hallux MTP-IP scores, hallux valgus angle (HVA), intermetatarsal angle (IMA), and distal metatarsal articular angle (DMAA) were measured pre- and postoperatively at the last follow-up of at least 6 months. Scores and radiologic angles were compared using paired sample t-test.
    Results: A total of 36 cases were included. HVA, IMA, and DMAA were (22.3 ± 6.1)°, (14.0 ± 3.2)°, and (8.9 ± 3.2)° preoperatively, and decreased to (7.0 ± 1.8)°, (3.7 ± 1.0)°, and (3.3 ± 1.1)° postoperatively. VAS decreased from 4.3 ± 1.7 to 0.7 ± 0.7. AOFAS Hallux MTP-IP scores improved from 68.6 ± 7.6 to 92.9 ± 6.1. Comparing mild and moderate cases, though HVA, IMA, and DMAA were significantly different preoperatively, the angles became statistically similar after surgery.
    Conclusions: A joy-stick assistant three-dimensional modified technique is proposed to control the three-dimensional position of the metatarsal head and to reduce dependence on special tools. Mild and moderate hallux valgus deformities are effectively corrected using Joy-stick 3D technique.
    Language English
    Publishing date 2024-04-14
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2503162-4
    ISSN 1757-7861 ; 1757-7853 ; 1757-7861
    ISSN (online) 1757-7861 ; 1757-7853
    ISSN 1757-7861
    DOI 10.1111/os.14056
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    Zs.A 6786: Show issues Location:
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  9. Article ; Online: MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma.

    Xiong, Jingfang / Wu, Yijun / Chen, Dongya / Zhang, Zhaolin / Liu, Yihui / Luo, Jiandong / Xu, Hong

    BMC gastroenterology

    2024  Volume 24, Issue 1, Page(s) 138

    Abstract: Objective: To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma.: Methods: A total of 1395 subjects ...

    Abstract Objective: To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma.
    Methods: A total of 1395 subjects were enrolled and divided into a colorectal adenoma group (593 subjects) and a control group (802 subjects) according to the inclusion and exclusion criteria. The characteristics of patients in the colorectal adenoma group and the control group were compared by the chi-square test. Univariate and multivariate logistic analyses were used to analyze independent risk factors and associations with different MAFLD subtypes. Colorectal adenoma characteristics and the proportion of patients with high-risk colorectal adenoma were also compared.
    Results: High-density lipoprotein (HDL-C) was significantly lower in patients in the colorectal adenoma group than in those in the control group (P < 0.001). Logistic regression analysis revealed that age, obesity status, central obesity status, hypertension status, diabetes status, fatty liver status, smoking history, BMI, waist circumference, triglyceride level, HDL-C level, fasting blood glucose level and degree of hepatic steatosis were all independent risk factors for colorectal adenoma. Notably, MAFLD was associated with a significantly increased risk of colorectal adenoma in patients with central obesity (P < 0.001). In addition, obesity, central obesity, diabetes, fatty liver and degree of hepatic steatosis were all shown to be independent risk factors for high-risk colorectal adenoma. In addition, a greater proportion of MAFLD patients with central obesity than those without central obesity had high-risk colorectal adenoma.
    Conclusion: MAFLD and central obesity are independently associated with the development of colorectal adenoma. MAFLD with central obesity is associated with an increased risk of colorectal adenoma and high-risk adenoma.
    MeSH term(s) Humans ; Male ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/epidemiology ; Female ; Adenoma/epidemiology ; Middle Aged ; Obesity, Abdominal/complications ; Obesity, Abdominal/epidemiology ; Risk Factors ; Aged ; Fatty Liver/complications ; Fatty Liver/epidemiology ; Adult ; Logistic Models ; Case-Control Studies ; Waist Circumference
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-024-03220-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Functional Analysis of the C-5 Sterol Desaturase PcErg3 in the Sterol Auxotrophic Oomycete Pathogen

    Wang, Weizhen / Cui, Tongshan / Zhang, Fan / Xue, Zhaolin / Zhang, Borui / Liu, Xili

    Frontiers in microbiology

    2022  Volume 13, Page(s) 811132

    Abstract: Although sterols play an important role in most eukaryotes, some oomycetes, ... ...

    Abstract Although sterols play an important role in most eukaryotes, some oomycetes, including
    Language English
    Publishing date 2022-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.811132
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