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Article: Immune-modifying and antimicrobial effects of Eucalyptus oil and simple inhalation devices.

Sadlon, Angela E / Lamson, Davis W

Alternative medicine review : a journal of clinical therapeutic

2010 Volume 15, Issue 1, Page(s) 33–47

Abstract: Eucalyptus oil (EO) and its major component, 1,8-cineole, have antimicrobial effects against many bacteria, including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA), viruses, and fungi (including Candida). Surprisingly ... ...

Abstract	Eucalyptus oil (EO) and its major component, 1,8-cineole, have antimicrobial effects against many bacteria, including Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA), viruses, and fungi (including Candida). Surprisingly for an antimicrobial substance, there are also immune-stimulatory, anti-inflammatory, antioxidant, analgesic, and spasmolytic effects. Of the white blood cells, monocytes and macrophages are most affected, especially with increased phagocytic activity. Application by either vapor inhalation or oral route provides benefit for both purulent and non-purulent respiratory problems, such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD). There is a long history of folk usage with a good safety record. More recently, the biochemical details behind these effects have been clarified. Although other plant oils may be more microbiologically active, the safety of moderate doses of EO and its broad-spectrum antimicrobial action make it an attractive alternative to pharmaceuticals. EO has also been shown to offset the myelotoxicity of one chemotherapy agent. Whether this is a general attribute that does not decrease the benefit of chemotherapy remains to be determined. This article also provides instruction on how to assemble inexpensive devices for vapor inhalation.
MeSH term(s)	Administration, Inhalation ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacology ; Asthma/drug therapy ; Bronchitis/drug therapy ; Eucalyptus ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Humans ; Immunity/drug effects ; Lymphocyte Activation/drug effects ; Monoterpenes/administration & dosage ; Monoterpenes/pharmacology ; Oils, Volatile/administration & dosage ; Oils, Volatile/pharmacology ; Pulmonary Disease, Chronic Obstructive/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Eucalyptus terpene oil ; Monoterpenes ; Oils, Volatile
Language	English
Publishing date	2010-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1465535-4
ISSN	1089-5159
ISSN	1089-5159
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Article: A case of MRSA controlled: predisposing factors and immune stimulation.

Lamson, Davis W / Sadlon, Angela E

Alternative medicine review : a journal of clinical therapeutic

2010 Volume 15, Issue 2, Page(s) 147–151

Abstract: Most treatments for methicillin-resistant Staphylococcus aureus (MRSA) focus on agents to eliminate the bacterium. Since MRSA infection is not universal, susceptibility factors are possible. Immune resistance could be lowered in such individuals; ... ...

Abstract	Most treatments for methicillin-resistant Staphylococcus aureus (MRSA) focus on agents to eliminate the bacterium. Since MRSA infection is not universal, susceptibility factors are possible. Immune resistance could be lowered in such individuals; therefore, locating immune-inhibiting or immune-enhancing factors might decrease susceptibility. Such seemed to be the case in a 48-year-old female who presented with recurring MRSA despite multiple rounds of a variety of antibiotics. When the patient encountered an intensely stressful situation an outbreak of MRSA occurred. The patient had additional underlying health issues that suppressed her immune system and made her more susceptible to stress. Gluten allergy and hypothyroidism were discovered and alleviated but did not end the MRSA outbreaks. Implementation of a popular treatment from the 1930s, intravenous dilute hydrochloric acid (for immune stimulation), prevented most MRSA outbreaks when administered frequently. This case provides anecdotal support for the proposition that immune enhancement is a viable approach to forestall or clear recurring MRSA.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Female ; Humans ; Hydrochloric Acid/administration & dosage ; Immunity/drug effects ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Middle Aged ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/physiopathology
Chemical Substances	Anti-Bacterial Agents ; Hydrochloric Acid (QTT17582CB)
Language	English
Publishing date	2010-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1465535-4
ISSN	1089-5159
ISSN	1089-5159
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Article ; Online: Effects of vitamin D, omega-3 and a simple strength exercise programme in cardiovascular disease prevention: The DO-HEALTH randomized controlled trial.

Gaengler, Stephanie / Sadlon, Angélique / De Godoi Rezende Costa Molino, Caroline / Willett, Walter C / Manson, JoAnn E / Vellas, Bruno / Steinhagen-Thiessen, Elisabeth / Von Eckardstein, Arnold / Ruschitzka, Frank / Rizzoli, René / da Silva, José A P / Kressig, Reto W / Kanis, John / Orav, E John / Egli, Andreas / Bischoff-Ferrari, Heike A

The journal of nutrition, health & aging

2024 Volume 28, Issue 2, Page(s) 100037

Abstract: Background: The effects of non-pharmaceutical interventions in the prevention of cardiovascular diseases (CVD) in older adults remains unclear. Therefore, the aim was to investigate the effect of 2000 IU/day of vitamin D: Methods: The risk of MACE ( ... ...

Abstract	Background: The effects of non-pharmaceutical interventions in the prevention of cardiovascular diseases (CVD) in older adults remains unclear. Therefore, the aim was to investigate the effect of 2000 IU/day of vitamin D Methods: The risk of MACE (coronary heart event or intervention, heart failure, stroke) was an exploratory endpoint of DO-HEALTH, incident hypertension and change in biomarkers were secondary endpoints. DO-HEALTH is a completed multicentre, randomised, placebo-controlled, 2 × 2 × 2 factorial design trial enrolling 2157 Europeans aged ≥70 years. Results: Participants' median age was 74 [72, 77] years, 61.7% were women, 82.5% were at least moderately physically active, and 40.7% had 25(OH)D < 20 ng/mL at baseline. Compared to their controls, omega-3 increased HDL-cholesterol (difference in change over 3 years: 0.08 mmol/L, 95% CI 0.05-0.10), decreased triglycerides (-0.08 mmol/L, (95%CI -0.12 to -0.03), but increased total- (0.15 mmol/L, 95%CI 0.09; 0.2), LDL- (0.11 mmol/L, 0.06; 0.16), and non-HDL-cholesterol (0.07 mmol/L, 95%CI 0.02; 0.12). However, neither omega-3 (adjustedHR 1.00, 95%CI 0.64-1.56), nor vitamin D Conclusion: Among generally healthy, active, and largely vitamin D replete, older adults, treatment with omega-3, vitamin D Gov identifier: NCT01745263.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Vitamin D ; Cardiovascular Diseases/prevention & control ; Vitamins/pharmacology ; Fatty Acids, Omega-3/therapeutic use ; Cholecalciferol/pharmacology ; Cholesterol ; Hypertension ; Exercise Therapy ; Biomarkers ; Dietary Supplements ; Double-Blind Method
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Fatty Acids, Omega-3 ; Cholecalciferol (1C6V77QF41) ; Cholesterol (97C5T2UQ7J) ; Biomarkers
Language	English
Publishing date	2024-01-09
Publishing country	France
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1016/j.jnha.2024.100037
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Article ; Online: Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.

Wieczorek, Maud / Schwarz, Franziska / Sadlon, Angélique / Abderhalden, Lauren A / de Godoi Rezende Costa Molino, Caroline / Spahn, Donat R / Schaer, Dominik J / Orav, E John / Egli, Andreas / Bischoff-Ferrari, Heike A

Aging clinical and experimental research

2021 Volume 34, Issue 3, Page(s) 515–525

Abstract: Background: The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults.: Aims: To assess whether iron deficiency at baseline and at any yearly follow-up ... ...

Abstract	Background: The longitudinal association between iron deficiency and inflammatory biomarkers levels has not been fully explored among relatively healthy older adults. Aims: To assess whether iron deficiency at baseline and at any yearly follow-up time point, with or without anemia, was associated with changes from baseline in high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels over 3 years. Methods: This is a post-hoc observational analysis of DO-HEALTH, a double-blind, randomized controlled trial including 2157 European community-dwelling adults age 70+. The outcomes were changes from baseline in hs-CRP and IL-6 levels, measured at 12, 24, and 36 months of follow-up. Iron deficiency was defined by soluble transferrin receptor levels > 28.1 nmol/L and baseline anemia by hemoglobin levels < 130 g/L for men and < 120 g/L for women. Results: In total, 2141 participants were included in the analyses (mean age: 74.9 years, 61.5% of women, 26.8% with iron deficiency). Baseline iron deficiency was associated with greater increase in IL-6 levels (mean difference in change: 0.52 ng/L, 95%CI 0.03-1.00, P = .04) over 3 years. Iron deficiency at any yearly time point was associated with higher increases in hs-CRP (mean difference in change: 1.62 mg/L, 95%CI 0.98-2.26, P < .001) and IL-6 levels (mean difference in change: 1.33 ng/L, 95%CI 0.87-1.79, P < .001) over 3 years. No significant interaction between iron deficiency and anemia was found, suggesting that the results are independent of the anemic status. Conclusions: These findings suggest that iron deficiency may play a role in low-grade chronic inflammation among relatively healthy older adults.
MeSH term(s)	Aged ; Anemia, Iron-Deficiency ; Biomarkers ; C-Reactive Protein/analysis ; Female ; Hemoglobins/analysis ; Humans ; Inflammation ; Iron Deficiencies ; Male
Chemical Substances	Biomarkers ; Hemoglobins ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-09-17
Publishing country	Germany
Document type	Journal Article ; Observational Study ; Randomized Controlled Trial
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-021-01955-3
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Article ; Online: Prevalence of polypharmacy in community-dwelling older adults from seven centres in five European countries: a cross-sectional study of DO-HEALTH.

de Godoi Rezende Costa Molino, Caroline / Chocano-Bedoya, Patricia O / Sadlon, Angélique / Theiler, Robert / Orav, John E / Vellas, Bruno / Rizzoli, Rene / Kressig, Reto W / Kanis, John A / Guyonnet, Sophie / Lang, Wei / Egli, Andreas / Bischoff-Ferrari, Heike A

BMJ open

2022 Volume 12, Issue 4, Page(s) e051881

Abstract: Objective: To investigate the prevalence of polypharmacy and characteristics associated with polypharmacy in older adults from seven European cities.: Design: Cross-sectional study of baseline data from DO-HEALTH.: Setting and participants: DO- ... ...

Abstract	Objective: To investigate the prevalence of polypharmacy and characteristics associated with polypharmacy in older adults from seven European cities. Design: Cross-sectional study of baseline data from DO-HEALTH. Setting and participants: DO-HEALTH enrolled 2157 community-dwelling adults age 70 and older from seven centres in Europe. Participants were excluded if they had major health problems or Mini-Mental State Examination Score <24 at baseline. Primary outcome measures: Extensive information on prescription and over-the-counter medications were recorded. Polypharmacy was defined as the concomitant use of five or more medications, excluding vitamins or dietary supplements. Bivariate and multivariable logistic regression was used to test the association of sociodemographic factors (age, sex, years of education, living situation and city) and health-related indicators (number of comorbidities, cognitive function, frailty status, body mass index (BMI), prior fall, self-rated health and smoking status) with polypharmacy. Results: 27.2% of participants reported polypharmacy ranging from 16.4% in Geneva to 60.8% in Coimbra. In the multivariable logistic regression analyses, older age (OR 1.07; 95% CI 1.04 to 1.10), greater BMI (OR 1.09; 95% CI 1.06 to 1.12) and increased number of comorbidities (OR 2.13; 95% CI 1.92 to 2.36) were associated with polypharmacy. Women were less likely to report polypharmacy than men (OR 0.65; 95% CI 0.51 to 0.84). In comparison to participants from Zurich, participants from Coimbra were more likely to report polypharmacy (OR 2.36; 95% CI 1.56 to 3.55), while participants from Geneva or Toulouse were less likely to report polypharmacy ((OR 0.36; 95% CI 0.22 to 0.59 and OR 0.64; 95% CI 0.42 to 0.96), respectively). Living situation, smoking status, years of education, prior fall, cognitive function, self-rated health and frailty status were not significantly associated with polypharmacy. Conclusion: Polypharmacy is common among relatively healthy older adults, with moderate variability across seven European cities. Independent of several confounders, being a woman, older age, greater BMI and greater number of comorbidities were associated with increased odds for polypharmacy. Trial registration number: NCT01745263.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Europe/epidemiology ; Female ; Frailty/epidemiology ; Humans ; Independent Living ; Male ; Polypharmacy ; Prevalence
Language	English
Publishing date	2022-04-29
Publishing country	England
Document type	Clinical Study ; Journal Article ; Multicenter Study
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-051881
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increased brain age in adults with Prader-Willi syndrome.

Azor, Adriana M / Cole, James H / Holland, Anthony J / Dumba, Maureen / Patel, Maneesh C / Sadlon, Angelique / Goldstone, Anthony P / Manning, Katherine E

NeuroImage. Clinical

2019 Volume 21, Page(s) 101664

Abstract: Prader-Willi syndrome (PWS) is the most common genetic obesity syndrome, with associated learning difficulties, neuroendocrine deficits, and behavioural and psychiatric problems. As the life expectancy of individuals with PWS increases, there is concern ... ...

Abstract	Prader-Willi syndrome (PWS) is the most common genetic obesity syndrome, with associated learning difficulties, neuroendocrine deficits, and behavioural and psychiatric problems. As the life expectancy of individuals with PWS increases, there is concern that alterations in brain structure associated with the syndrome, as a direct result of absent expression of PWS genes, and its metabolic complications and hormonal deficits, might cause early onset of physiological and brain aging. In this study, a machine learning approach was used to predict brain age based on grey matter (GM) and white matter (WM) maps derived from structural neuroimaging data using T1-weighted magnetic resonance imaging (MRI) scans. Brain-predicted age difference (brain-PAD) scores, calculated as the difference between chronological age and brain-predicted age, are designed to reflect deviations from healthy brain aging, with higher brain-PAD scores indicating premature aging. Two separate adult cohorts underwent brain-predicted age calculation. The main cohort consisted of adults with PWS (n = 20; age mean 23.1 years, range 19.8-27.7; 70.0% male; body mass index (BMI) mean 30.1 kg/m
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Body Mass Index ; Brain/pathology ; Female ; Gray Matter/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neuroimaging/methods ; Obesity/complications ; Obesity/genetics ; Prader-Willi Syndrome/complications ; Prader-Willi Syndrome/diagnosis ; Prader-Willi Syndrome/pathology ; Uniparental Disomy/pathology ; Young Adult
Language	English
Publishing date	2019-01-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701571-3
ISSN	2213-1582 ; 2213-1582
ISSN (online)	2213-1582
ISSN	2213-1582
DOI	10.1016/j.nicl.2019.101664
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prevalence of polypharmacy in community-dwelling older adults from seven centres in five European countries

Andreas Egli / Rene Rizzoli / Robert Theiler / Bruno Vellas / John A Kanis / Patricia O Chocano-Bedoya / Reto W Kressig / Caroline de Godoi Rezende Costa Molino / Angélique Sadlon / John E Orav / Sophie Guyonnet / Wei Lang / Heike A. Bischoff-Ferrari

BMJ Open, Vol 12, Iss

a cross-sectional study of DO-HEALTH

2022 Volume 4

Keywords	Medicine ; R
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The vitamin C:vitamin K3 system - enhancers and inhibitors of the anticancer effect.

Lamson, Davis W / Gu, Yu-Huan / Plaza, Steven M / Brignall, Matthew S / Brinton, Cathy A / Sadlon, Angela E

Alternative medicine review : a journal of clinical therapeutic

2010 Volume 15, Issue 4, Page(s) 345–351

Abstract: The oxidizing anticancer system of vitamin C and vitamin K₃ (VC:VK₃, producing hydrogen peroxide via superoxide) was combined individually with melatonin, curcumin, quercetin, or cholecalciferol (VD₃) to determine interactions. Substrates were LNCaP and ... ...

Abstract	The oxidizing anticancer system of vitamin C and vitamin K₃ (VC:VK₃, producing hydrogen peroxide via superoxide) was combined individually with melatonin, curcumin, quercetin, or cholecalciferol (VD₃) to determine interactions. Substrates were LNCaP and PC-3 prostate cancer cell lines. Three of the tested antioxidants displayed differences in cell line cytotoxicity. Melatonin combined with VC:VK₃ quenched the oxidizing effect, while VC:VK₃ applied 24 hours after melatonin showed no quenching. With increasing curcumin concentrations, an apparent combined effect of VC:VK₃ and curcumin occurred in LNCaP cells, but not PC-3 cells. Quercetin alone was cytotoxic on both cell lines, but demonstrated an additional 50-percent cytotoxicity on PC-3 cells when combined with VC:VK₃. VD₃ was effective against both cell lines, with more effect on PC-3. This effect was negated on LNCaP cells with the addition of VC:VK₃. In conclusion, a natural antioxidant can enhance or decrease the cytotoxicity of an oxidizing anticancer system in vitro, but generalizations about antioxidants cannot be made.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Cell Cycle/drug effects ; Cholecalciferol/pharmacology ; Curcumin/pharmacology ; Cytotoxins/pharmacology ; Drug Interactions ; Drug Therapy, Combination ; Humans ; Male ; Melatonin/pharmacology ; Oxidative Stress/drug effects ; Prostatic Neoplasms/drug therapy ; Quercetin/pharmacology ; Tumor Cells, Cultured ; Vitamin K 3/pharmacology
Chemical Substances	Antineoplastic Agents ; Antioxidants ; Cytotoxins ; Cholecalciferol (1C6V77QF41) ; Vitamin K 3 (723JX6CXY5) ; Quercetin (9IKM0I5T1E) ; Curcumin (IT942ZTH98) ; Melatonin (JL5DK93RCL) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2010-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1465535-4
ISSN	1089-5159
ISSN	1089-5159
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Article ; Online: Increased brain age in adults with Prader-Willi syndrome

Adriana M. Azor / James H. Cole / Anthony J. Holland / Maureen Dumba / Maneesh C. Patel / Angelique Sadlon / Anthony P. Goldstone / Katherine E. Manning

NeuroImage: Clinical, Vol 21, Iss , Pp - (2019)

2019

Abstract	Prader-Willi syndrome (PWS) is the most common genetic obesity syndrome, with associated learning difficulties, neuroendocrine deficits, and behavioural and psychiatric problems. As the life expectancy of individuals with PWS increases, there is concern that alterations in brain structure associated with the syndrome, as a direct result of absent expression of PWS genes, and its metabolic complications and hormonal deficits, might cause early onset of physiological and brain aging.In this study, a machine learning approach was used to predict brain age based on grey matter (GM) and white matter (WM) maps derived from structural neuroimaging data using T1-weighted magnetic resonance imaging (MRI) scans. Brain-predicted age difference (brain-PAD) scores, calculated as the difference between chronological age and brain-predicted age, are designed to reflect deviations from healthy brain aging, with higher brain-PAD scores indicating premature aging.Two separate adult cohorts underwent brain-predicted age calculation. The main cohort consisted of adults with PWS (n = 20; age mean 23.1 years, range 19.8–27.7; 70.0% male; body mass index (BMI) mean 30.1 kg/m2, 21.5–47.7; n = 19 paternal chromosome 15q11–13 deletion) and age- and sex-matched controls (n = 40; age 22.9 years, 19.6–29.0; 65.0% male; BMI 24.1 kg/m2, 19.2–34.2) adults (BMI PWS vs. control P = .002). Brain-PAD was significantly greater in PWS than controls (effect size mean ± SEM +7.24 ± 2.20 years [95% CI 2.83, 11.63], P = .002). Brain-PAD remained significantly greater in PWS than controls when restricting analysis to a sub-cohort matched for BMI consisting of n = 15 with PWS with BMI range 21.5–33.7 kg/m2, and n = 29 controls with BMI 21.7–34.2 kg/m2 (effect size +5.51 ± 2.56 years [95% CI 3.44, 10.38], P = .037). In the PWS group, brain-PAD scores were not associated with intelligence quotient (IQ), use of hormonal and psychotropic medications, nor severity of repetitive or disruptive behaviours. A 24.5 year old man (BMI 36.9 kg/m2) with PWS from a ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	616
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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