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Book ; Online: D4.3 - Set-up of Working Groups

Berchtold, Claudia / Wagner, Sebastian

2022

Abstract: ... Strategy but also civil protection policies. Over the course of the project’s lifetime, the five WGs ...

Abstract	Thematic Working Groups (WGs) are a central part of the Firelogue project. They offer a space for experts of the three Innovation Actions (IAs) and the wider (European) Wildfire Risk Management (WFRM) community to exchange ideas and debate issues in order to come up with holistic and effective policy recommendations. Furthermore, they serve to integrate the IA and FirEUrisk innovations and results into multi-stakeholder recommendations at EU level related for example with the EU Forestry Strategy, the Biodiversity Strategy but also civil protection policies. Over the course of the project’s lifetime, the five WGs will discuss a range of different topics within their field (Ecology/Economy, Societal, Insurance, Infrastructure and Civil Protection) during two Workshop Cycles, as well as in cross-WG meetings to discuss overarching issues in WFRM. The deliverable outlines both the basic criteria for the WG composition, as well as a detailed timeline for the next and most important steps for all Working Groups.
Keywords	FIRELOGUE ; Wildfire risk management
Subject code	710
Language	English
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: D7.4 Data management and IPR protection strategy

Wagner, Sebastian / Berchtold, Claudia

2022

Abstract: ... the initial of the two versions to be produced for the data management plan throughout the Firelogue project’s ...

Abstract	Deliverable, D7.4 provides an initial data management plan for Firelogue and details what will be done going forward. The plan will set out the consortium's strategy to improve and maximise access to and re‐use of research data generated or collected under the project, while ensuring data protection as well as the consortium's intellectual property rights (IPR). This document details the expected types of data to be collected by the consortium partners (Chapter 1), the storage of data and deliverables, the protection of data (Chapter 2), and states the role of the Data Protection Officer as the contact person for consortium members. The deliverable further focuses on the FAIR data requirements set out by the European Commission as well as data protection and data security measures that will be undertaken by the consortium. Chapter 3 deals with the questions of intellectual property and outlines the requirements as well as supportive measures. The concluding section (Chapter 4) provides a description of the future course of action in an effort to continuously adapt the plan, to expand it if necessary and to render it more precise. The data management plan is a living document in which information will be made available on a more detailed level as the implementation of the Firelogue project progresses and when significant changes occur. This document is the initial of the two versions to be produced for the data management plan throughout the Firelogue project’s duration with a second official version to be released at the end of the project.
Keywords	FIRELOGUE ; Wildfire risk management ; Data management plan
Subject code	710
Language	English
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties.

Borgo, Jimena / Wagner, Mariel S / Laurella, Laura C / Elso, Orlando G / Selener, Mariana G / Clavin, María / Bach, Hernán / Catalán, César A N / Bivona, Augusto E / Sepúlveda, Claudia S / Sülsen, Valeria P

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 4

Abstract: Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against ... ...

Abstract	Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared from six Asteraceae species, including
MeSH term(s)	Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Asteraceae/chemistry ; Methylene Chloride ; Phytochemicals/pharmacology ; Antiviral Agents/pharmacology ; Sesquiterpenes/chemistry
Chemical Substances	Plant Extracts ; Methylene Chloride (588X2YUY0A) ; Phytochemicals ; Antiviral Agents ; Sesquiterpenes
Language	English
Publishing date	2024-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29040814
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Article ; Online: Parallel CSF and serum temporal profile assessment of axonal injury biomarkers NF-L and pNF-H: Associations with patient outcome in moderate-severe traumatic brain injury.

Wang, Kevin K W / Barton, David J / McQuillan, Leah / Kobeissy, Firas / Cai, Guangzheng / Xu, Haiyan / Yang, Zhihui / Trifilio, Erin / Williamson, John B / Rubenstein, Richard / Robertson, Claudia S / Wagner, Amy K

Journal of neurotrauma

2024

Abstract: Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal profiles for ... ...

Abstract	Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal profiles for these proteins in blood, and interrelationships in the acute and chronic time periods post-TBI have not been established. Our objectives were 1) to characterize acute-to-chronic serum NF-L and pNF-H profiles after moderate-severe TBI, as well as acute cerebrospinal fluid (CSF) levels, 2) to evaluate CSF and serum NF-L and pNF-H associations with each other, and 3) to assess biomarker associations with global patient outcome using both the Glasgow Outcome Scale-Extended (GOS-E) and Disability Rating Scale (DRS). In this multi-cohort study, we measured serum and CSF NF-L and pNF-H levels in samples collected from two clinical cohorts (University of Pittsburgh [UPITT] and Baylor College of Medicine [BCM]) of individuals with moderate-to-severe TBI. The UPITT cohort includes 279 subjects from an observational cohort study; we obtained serum (n=277 unique subjects) and CSF (n=95 unique subjects) daily for one week, and serum every two weeks for six months. The BCM cohort included 103 subjects from a previous randomized clinical trial of erythropoietin and blood transfusion threshold after severe TBI, which showed no effect on neurological outcome between treatment arms; serum (n=99 unique subjects) and CSF (n=54 unique subjects) NF-L and pNF-H levels were measured at least daily during days (D) 0-10 post-injury. GOS-E and DRS were assessed at 6 months (both cohorts) and 12 months (UPITT cohort only). Results show serum NF-L and pNF-H gradually rise during the first 10 days and peak at D20-30 post-injury. In the UPITT cohort, acute (D0-6) NF-L and pNF-H levels correlate within CSF and serum (Spearman r=0.44-0.48; p<0.05). In the UPITT cohort, acute NF-L CSF and serum levels, as well as chronic (M2-6) serum NF-L levels, were higher among individuals with unfavorable GOS-E and worse DRS at 12 months (p<0.05, all comparisons). In the BCM cohort, higher acute serum NF-L levels were also associated with unfavorable GOS-E. Higher pNF-H serum concentrations (D0-6 and M2-6), but not CSF pNF-H, were associated with unfavorable GOS-E and worse DRS (p<0.05, all comparisons) in the UPITT cohort. Relationships between biomarker levels and favorable outcome persisted after controlling for age, sex, and GCS. This study shows for the first time that serum levels of NF-L and pNF-H peak at D20-30 post-TBI. Serum NF-L levels, and to a lesser extent pNF-H levels, are robustly associated with global patient outcomes and disability after moderate-to-severe TBI. Further studies on clinical utility as prognosis and treatment-response indicators are needed.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2023.0449
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Article ; Online: Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaks.

Gräf, Justus F / Mikicic, Ivan / Ping, Xiaofei / Scalera, Claudia / Mayr, Katharina / Stelzl, Lukas S / Beli, Petra / Wagner, Sebastian A

iScience

2022 Volume 25, Issue 9, Page(s) 104892

Abstract: ... regulation of transcription, and RNA processing. One-third of DSB-induced S/TQ phosphorylation sites are ...

Abstract	PPM1D is a p53-regulated protein phosphatase that modulates the DNA damage response (DDR) and is frequently altered in cancer. Here, we employed chemical inhibition of PPM1D and quantitative mass spectrometry-based phosphoproteomics to identify the substrates of PPM1D upon induction of DNA double-strand breaks (DSBs) by etoposide. We identified 73 putative PPM1D substrates that are involved in DNA repair, regulation of transcription, and RNA processing. One-third of DSB-induced S/TQ phosphorylation sites are dephosphorylated by PPM1D, demonstrating that PPM1D only partially counteracts ATM/ATR/DNA-PK signaling. PPM1D-targeted phosphorylation sites are found in a specific amino acid sequence motif that is characterized by glutamic acid residues, high intrinsic disorder, and poor evolutionary conservation. We identified a functionally uncharacterized protein Kanadaptin as ATM and PPM1D substrate upon DSB induction. We propose that PPM1D plays a role during the response to DSBs by regulating the phosphorylation of DNA- and RNA-binding proteins in intrinsically disordered regions.
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2022.104892
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Article ; Online: Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice.

Van Raamsdonk, Jeremy M / Al-Shekaili, Hilal H / Wagner, Laura / Bredy, Tim W / Chan, Laura / Pearson, Jacqueline / Schwab, Claudia / Murphy, Zoe / Devon, Rebecca S / Lu, Ge / Kobor, Michael S / Hayden, Michael R / Leavitt, Blair R

Aging and disease

2023 Volume 14, Issue 6, Page(s) 2249–2266

Abstract: Huntington disease (HD) is an adult-onset neurodegenerative disorder that is caused by a trinucleotide CAG repeat expansion in the HTT gene that codes for the protein huntingtin (HTT in humans or Htt in mice). HTT is a multi-functional, ubiquitously ... ...

Abstract	Huntington disease (HD) is an adult-onset neurodegenerative disorder that is caused by a trinucleotide CAG repeat expansion in the HTT gene that codes for the protein huntingtin (HTT in humans or Htt in mice). HTT is a multi-functional, ubiquitously expressed protein that is essential for embryonic survival, normal neurodevelopment, and adult brain function. The ability of wild-type HTT to protect neurons against various forms of death raises the possibility that loss of normal HTT function may worsen disease progression in HD. Huntingtin-lowering therapeutics are being evaluated in clinical trials for HD, but concerns have been raised that decreasing wild-type HTT levels may have adverse effects. Here we show that Htt levels modulate the occurrence of an idiopathic seizure disorder that spontaneously occurs in approximately 28% of FVB/N mice, which we have called FVB/N Seizure Disorder with SUDEP (FSDS). These abnormal FVB/N mice demonstrate the cardinal features of mouse models of epilepsy including spontaneous seizures, astrocytosis, neuronal hypertrophy, upregulation of brain-derived neurotrophic factor (BDNF), and sudden seizure-related death. Interestingly, mice heterozygous for the targeted inactivation of Htt (Htt+/- mice) exhibit an increased frequency of this disorder (71% FSDS phenotype), while over-expression of either full length wild-type HTT in YAC18 mice or full length mutant HTT in YAC128 mice completely prevents it (0% FSDS phenotype). Examination of the mechanism underlying huntingtin's ability to modulate the frequency of this seizure disorder indicated that over-expression of full length HTT can promote neuronal survival following seizures. Overall, our results demonstrate a protective role for huntingtin in this form of epilepsy and provide a plausible explanation for the observation of seizures in the juvenile form of HD, Lopes-Maciel-Rodan syndrome, and Wolf-Hirschhorn syndrome. Adverse effects caused by decreasing huntingtin levels have ramifications for huntingtin-lowering therapies that are being developed to treat HD.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2023.0423
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Article ; Online: Marketing authorisation and pricing of FDA-approved cancer drugs in Brazil: a retrospective analysis.

Ivama-Brummell, Adriana M / Marciniuk, Fernanda L / Wagner, Anita K / Osorio-de-Castro, Claudia G S / Vogler, Sabine / Mossialos, Elias / Tavares-de-Andrade, Carla L / Naci, Huseyin

Lancet regional health. Americas

2023 Volume 22, Page(s) 100506

Abstract: Background: Most cancer drugs enter the US market first. US Food and Drug Administration (FDA) approvals of new cancer drugs may influence regulatory decisions in other settings. The study examined whether characteristics of available evidence at FDA ... ...

Abstract	Background: Most cancer drugs enter the US market first. US Food and Drug Administration (FDA) approvals of new cancer drugs may influence regulatory decisions in other settings. The study examined whether characteristics of available evidence at FDA approval influenced time-to-marketing authorisation (MA) in Brazil, and price differences between the two countries. Methods: All new FDA-approved cancer drugs from 2010 to 2019 were matched to drugs with MA and prices approved in Brazil by December 2020. Characteristics of main studies, availability of randomised controlled trials (RCTs), overall survival (OS) benefit, added therapeutic benefit, and prices were compared. Findings: Fifty-six FDA-approved cancer drugs with matching indications received a MA at the Brazilian Health Regulatory Agency (Anvisa) after a median of 522 days following US approval (IQR: 351-932). Earlier authorisation in Brazil was associated with availability of RCT (median: 506 vs 760 days, p = 0.031) and evidence of OS benefit (390 vs 543 days, p = 0.019) at FDA approval. At Brazilian marketing authorisation, a greater proportion of cancer drugs had main RCTs (75% vs 60.7%) and OS benefit (42.9% vs 21.4%) than that in the US. Twenty-eight (50%) drugs did not demonstrate added therapeutic benefit over drugs for the same indication in Brazil. Median approved prices of new cancer drugs were 12.9% lower in Brazil compared to the US (adjusted by Purchasing Power Parity). However, for drugs with added therapeutic benefit median prices were 5.9% higher in Brazil compared to the US, while 17.9% lower for those without added benefit. Interpretation: High-quality clinical evidence accelerated the availability of cancer medicines in Brazil. The combination of marketing and pricing authorisation in Brazil may favour the approval of cancer drugs with better supporting evidence, and more meaningful clinical benefit albeit with variable degree of success in achieving lower prices compared to the US. Funding: None.
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2023.100506
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Article: Correction to: Risdiplam in Patients Previously Treated with Other Therapies for Spinal Muscular Atrophy: An Interim Analysis from the JEWELFISH Study.

Chiriboga, Claudia A / Bruno, Claudio / Duong, Tina / Fischer, Dirk / Mercuri, Eugenio / Kirschner, Janbernd / Kostera-Pruszczyk, Anna / Jaber, Birgit / Gorni, Ksenija / Kletzl, Heidemarie / Carruthers, Imogen / Martin, Carmen / Warren, Francis / Scalco, Renata S / Wagner, Kathryn R / Muntoni, Francesco

Neurology and therapy

2023 Volume 12, Issue 5, Page(s) 1799–1801

Language	English
Publishing date	2023-07-03
Publishing country	New Zealand
Document type	Published Erratum
ISSN	2193-8253
ISSN	2193-8253
DOI	10.1007/s40120-023-00503-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Phylogeny of Hawaiian

Paetzold, Claudia / Wood, Kenneth R / Eaton, Deren A R / Wagner, Warren L / Appelhans, Marc S

Frontiers in plant science

2019 Volume 10, Page(s) 1074

Abstract: ... ...

Abstract	Hawaiian
Language	English
Publishing date	2019-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2019.01074
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Article ; Online: Serial Measurements of Serum Glial Fibrillary Acidic Protein in Moderate-Severe Traumatic Brain Injury: Potential Utility in Providing Insights into Secondary Insults and Long-Term Outcome.

Robertson, Claudia S / Martinez, Felipe Salinas / McQuillan, Leah E / Williamson, John / Lamb, Damon G / Wang, Kevin K W / Rubenstein, Richard / Wagner, Amy K

Journal of neurotrauma

2023 Volume 41, Issue 1-2, Page(s) 73–90

Abstract: In patients with traumatic brain injury (TBI), serum biomarkers may have utility in assessing the evolution of secondary brain injury. A panel of nine brain-injury- associated biomarkers was measured in archived serum samples over 10 days post-injury ... ...

Abstract	In patients with traumatic brain injury (TBI), serum biomarkers may have utility in assessing the evolution of secondary brain injury. A panel of nine brain-injury- associated biomarkers was measured in archived serum samples over 10 days post-injury from 100 patients with moderate-severe TBI. Among the biomarkers evaluated, serum glial fibrillary acidic protein (GFAP) had the strongest associations with summary measures of acute pathophysiology, including intracranial pressure (ICP), cerebral perfusion pressure (CPP), and brain tissue pO
MeSH term(s)	Humans ; Glial Fibrillary Acidic Protein ; Brain Injuries, Traumatic ; Brain Injuries ; Biomarkers ; Intracranial Pressure/physiology
Chemical Substances	Glial Fibrillary Acidic Protein ; Biomarkers
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	645092-1
ISSN	1557-9042 ; 0897-7151
ISSN (online)	1557-9042
ISSN	0897-7151
DOI	10.1089/neu.2023.0111
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