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  1. Article ; Online: Vaccination in patients with kidney failure: lessons from COVID-19.

    Babel, Nina / Hugo, Christian / Westhoff, Timm H

    Nature reviews. Nephrology

    2022  Volume 18, Issue 11, Page(s) 708–723

    Abstract: Infection is the second leading cause of death in patients with chronic kidney disease (CKD). Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize pathogen entry and promote pathogen clearance to enable infection ... ...

    Abstract Infection is the second leading cause of death in patients with chronic kidney disease (CKD). Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize pathogen entry and promote pathogen clearance to enable infection control. Vaccination can generate cellular and humoral immunity against specific pathogens and is used to prevent many life-threatening infectious diseases. However, vaccination efficacy is diminished in patients with CKD. Premature ageing of the immune system and chronic systemic low-grade inflammation are the main causes of immune alteration in these patients. In the case of SARS-CoV-2 infection, COVID-19 can have considerable detrimental effects in patients with CKD, especially in those with kidney failure. COVID-19 prevention through successful vaccination is therefore paramount in this vulnerable population. Although patients receiving dialysis have seroconversion rates comparable to those of patients with normal kidney function, most kidney transplant recipients could not generate humoral immunity after two doses of the COVID-19 vaccine. Importantly, some patients who were not able to produce antibodies still had a detectable vaccine-specific T cell response, which might be sufficient to prevent severe COVID-19. Correlates of protection against SARS-CoV-2 have not been established for patients with kidney failure, but they are urgently needed to enable personalized vaccination regimens.
    MeSH term(s) Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines ; Renal Dialysis ; Vaccination ; Immunity, Humoral ; Vaccines ; Renal Insufficiency ; Renal Insufficiency, Chronic/complications
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-08-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00617-5
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  2. Article: Case report: SARS-CoV-2 specific T-cells are associated with myocarditis after COVID-19 vaccination with mRNA-1273.

    Stervbo, Ulrik / Van Bracht, Marc / Philippou, Stathis / Babel, Nina / Westhoff, Timm H

    Frontiers in medicine

    2023  Volume 10, Page(s) 1088764

    Abstract: Vaccination of SARS-CoV-2 with BNT162b2 or mRNA-1273 both have a low incidence of induction of myocarditis. Here we report on utilizing adaptive immune receptor repertoire sequencing (AIRR-Seq) as a way to assess the specificity of tissue infiltrating ... ...

    Abstract Vaccination of SARS-CoV-2 with BNT162b2 or mRNA-1273 both have a low incidence of induction of myocarditis. Here we report on utilizing adaptive immune receptor repertoire sequencing (AIRR-Seq) as a way to assess the specificity of tissue infiltrating immune cells.
    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1088764
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  3. Article ; Online: Predictors of blood pressure response to continuous positive airway pressure treatment in patients with sleep apnea.

    Seidel, Maximilian / Kiziler, Muhammed F / Matiakis, Marios / Bertram, Sebastian / Wang, Simon / Seibert, Felix S / Babel, Nina / Westhoff, Timm H

    Journal of hypertension

    2024  Volume 42, Issue 5, Page(s) 777–782

    Abstract: Background: Sleep apnea is associated with hypertension. Metaanalyses indicate that treatment of sleep apnea by continuous positive airway pressure (CPAP) reduces blood pressure (BP) by a mean of 3 mmHg. To date, predictors of BP response to CPAP remain ...

    Abstract Background: Sleep apnea is associated with hypertension. Metaanalyses indicate that treatment of sleep apnea by continuous positive airway pressure (CPAP) reduces blood pressure (BP) by a mean of 3 mmHg. To date, predictors of BP response to CPAP remain incompletely understood. We hypothesized that the magnitude of CPAP-induced BP reduction depends on baseline apnea-hypopnea index (AHI) and the extent of daytime sleepiness.
    Methods: We performed a retrospective study on the association of BP response to CPAP with polysomnographic readings, intensity of sleepiness (measured by Epworth Sleepiness Scale, ESS), and epidemiologic parameters in 2461 patients with obstructive sleep apnea. BP response was defined as the difference between office BP at polysomonography examinations before and after initiation of CPAP.
    Results: Five hundred and fifty-five patients fulfilled all inclusion and exclusion criteria and were included in the analysis. Median monthly CPAP usage was 143.7 h (85.4-204.1 h). BP was significantly higher at baseline than at follow-up (129.9 ± 15.5 vs. 128.3 ± 15.2, P  = 0.021) resulting in mean reduction of BP of -1.5 ± 19.2 mmHg. patients with a higher than median baseline AHI (median 21) showed a more pronounced reduction of BP than those with lower AHI (AHI ≥21: 130.5 ± 15.3 vs. 128.6 ± 14.6, P  = 0.06; AHI <21: 129.5 ± 15.8 vs. 127.9 ± 15.8, P  = 0.18). CPAP therapy led to a significant reduction in sleepiness (8.3 ± 4.8 vs. 6.6 ± 4.5, P  < 0.0001). Those subjects with higher than median sleepiness score (ESS ≥8), however, did not show a significant difference in BP response compared with those with a lower sleepiness score. Receiver-operating characteristic (ROC) curve analyses investigating the accuracy of AHI and ESS to predict a BP reduction at least 5 mmHg revealed an AUC of 0.51 and 0.52, respectively.
    Conclusion: The study confirms that CPAP therapy for sleep apnea has a mild BP lowering effect. Although this effect is slightly higher in patients with above-average AHI, neither AHI nor ESS can be used to define threshold values predicting a BP decrease at least 5 mmHg.
    MeSH term(s) Humans ; Blood Pressure/physiology ; Continuous Positive Airway Pressure ; Retrospective Studies ; Sleepiness ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003694
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  4. Article: Empagliflozin Reduces Interleukin-6 Levels in Patients with Heart Failure.

    Gotzmann, Michael / Henk, Pauline / Stervbo, Ulrik / Blázquez-Navarro, Arturo / Mügge, Andreas / Babel, Nina / Westhoff, Timm H

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134458
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  5. Article ; Online: Case report

    Ulrik Stervbo / Marc Van Bracht / Stathis Philippou / Nina Babel / Timm H. Westhoff

    Frontiers in Medicine, Vol

    SARS-CoV-2 specific T-cells are associated with myocarditis after COVID-19 vaccination with mRNA-1273

    2023  Volume 10

    Abstract: Vaccination of SARS-CoV-2 with BNT162b2 or mRNA-1273 both have a low incidence of induction of myocarditis. Here we report on utilizing adaptive immune receptor repertoire sequencing (AIRR-Seq) as a way to assess the specificity of tissue infiltrating ... ...

    Abstract Vaccination of SARS-CoV-2 with BNT162b2 or mRNA-1273 both have a low incidence of induction of myocarditis. Here we report on utilizing adaptive immune receptor repertoire sequencing (AIRR-Seq) as a way to assess the specificity of tissue infiltrating immune cells.
    Keywords COVID-19 ; SARS-CoV-2 ; vaccination ; mRNA-1273 ; myocarditis ; AIRR-Seq ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls.

    Pellegrino, Antonio / Fabig, Sophie-Charlotte / Kersebaum, Dilara / Hüllemann, Philipp / Baron, Ralf / Roch, Toralf / Babel, Nina / Seitz, Harald

    Biomedicines

    2023  Volume 11, Issue 3

    Abstract: Polyneuropathies (PNP) are the most common type of disorder of the peripheral nervous system in adults. However, information on microRNA expression in PNP is lacking. Following microRNA sequencing, we compared the expression of microRNAs in the serum of ... ...

    Abstract Polyneuropathies (PNP) are the most common type of disorder of the peripheral nervous system in adults. However, information on microRNA expression in PNP is lacking. Following microRNA sequencing, we compared the expression of microRNAs in the serum of patients experiencing chronic painful PNP with healthy age-matched controls. We have been able to identify four microRNAs (
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11030764
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  7. Article: Association of plasma propionate concentration with coronary artery disease in a large cross-sectional study.

    Pagonas, Nikolaos / Seibert, Felix S / Liebisch, Gerhard / Seidel, Maximillian / Giannakopoulos, Theodoros / Sasko, Benjamin / Ritter, Oliver / Babel, Nina / Westhoff, Timm H

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1063296

    Abstract: Background: Microbiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association of short-chain fatty acids (SCFA) with CAD are lacking. This study aimed to evaluate the role of propionate, ...

    Abstract Background: Microbiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association of short-chain fatty acids (SCFA) with CAD are lacking. This study aimed to evaluate the role of propionate, the most important SCFA in patients with CAD.
    Methods: We performed a cross-sectional study enrolling patients admitted for invasive coronary angiography in two university hospitals in Germany. Patients with known or suspected CAD and risk factors for cardiovascular disease were prospectively recruited. Blood sampling was performed after overnight fasting and before invasive procedures. Measurement of propionate was performed by liquid chromatography.
    Results: The study included 1,253 patients (median [IQR], 67 [58-76] years; 799 men [64%]). A total of 739 had invasively confirmed CAD with at least one coronary artery stenosis ≥50% and 514 had exclusion of CAD. CAD patients had significant lower levels of propionate (median 5.75 μM, IQR, 4.1-7.6) compared to the non-CAD groups 6.53 μM (4.6-8.6,
    Conclusion: The study provides large-scale
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1063296
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  8. Article ; Online: Immunogenicity of Bivalent Omicron BA.4/5-Adapted Vaccine in Hemodialysis Patients.

    Anft, Moritz / Skrzypczyk, Sarah / Frahnert, Michael / Fricke, Lutz / Zapka, Jan / Kühn, Daniel / Koos, Björn / Adamzik, Michael / Pfaender, Stephanie / Stervbo, Ulrik / Westhoff, Timm H / Babel, Nina

    Kidney international reports

    2023  Volume 8, Issue 4, Page(s) 939–941

    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.01.020
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  9. Article ; Online: Acute interstitial nephritis after vaccination with BNT162b2.

    Rieckmann, Sonja / Seibert, Felix S / Hogeweg, Maximilian / Bertram, Sebastian / Doevelaar, Adrian A N / Amann, Kerstin / Babel, Nina / Westhoff, Timm H

    Journal of nephrology

    2022  Volume 35, Issue 3, Page(s) 779–782

    MeSH term(s) BNT162 Vaccine ; Humans ; Nephritis, Interstitial/chemically induced ; Nephritis, Interstitial/diagnosis ; Vaccination/adverse effects
    Chemical Substances BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-03-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01275-3
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  10. Article ; Online: Intravenous immunoglobulins in the treatment of post-COVID: A case-control study.

    Hogeweg, Maximilian / Doevelaar, Adrian / Rieckmann, Sonja / Seibert, Felix / Scholten, David / Segelmacher, Monika / Stervbo, Ulrik / Babel, Nina / Westhoff, Timm H

    Journal of internal medicine

    2022  Volume 293, Issue 5, Page(s) 656–658

    MeSH term(s) Humans ; Immunoglobulins, Intravenous/therapeutic use ; Case-Control Studies ; COVID-19 ; Immunoglobulins
    Chemical Substances Immunoglobulins, Intravenous ; Immunoglobulins
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13592
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