LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 287

Search options

  1. Article ; Online: Advancing our understanding of monocyte HLA-DR, S100A9, and the potential for individualized therapies in sepsis.

    Monneret, Guillaume

    Military Medical Research

    2023  Volume 10, Issue 1, Page(s) 28

    MeSH term(s) Humans ; Monocytes/immunology ; HLA-DR Antigens ; Sepsis ; Gene Expression Profiling
    Chemical Substances HLA-DR Antigens
    Language English
    Publishing date 2023-06-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2768940-2
    ISSN 2054-9369 ; 2054-9369
    ISSN (online) 2054-9369
    ISSN 2054-9369
    DOI 10.1186/s40779-023-00465-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Advancing our understanding of monocyte HLA-DR, S100A9, and the potential for individualized therapies in sepsis

    Guillaume Monneret

    Military Medical Research, Vol 10, Iss 1, Pp 1-

    2023  Volume 3

    Keywords Sepsis ; Monocyte ; HLA-DR ; S100A9 ; Immunosuppression ; Medicine (General) ; R5-920 ; Military Science ; U
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Immunostimulation in critically ill patients: do not forget to consider the timing, stratification, and monitoring.

    Monneret, Guillaume / Payen, Didier

    Annals of intensive care

    2024  Volume 14, Issue 1, Page(s) 75

    Language English
    Publishing date 2024-05-17
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-024-01302-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The double sides of NLRP3 inflammasome activation in sepsis.

    Vigneron, Clara / Py, Bénédicte F / Monneret, Guillaume / Venet, Fabienne

    Clinical science (London, England : 1979)

    2023  Volume 137, Issue 5, Page(s) 333–351

    Abstract: Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic. It is schematically described as an early dysregulated systemic inflammatory ... ...

    Abstract Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic. It is schematically described as an early dysregulated systemic inflammatory response leading to organ failures and early deaths, followed by the development of persistent immune alterations affecting both the innate and adaptive immune responses associated with increased risk of secondary infections, viral reactivations, and late mortality. In this review, we will focus on the role of NACHT, leucin-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome in the pathophysiology of sepsis. NLRP3 inflammasome is a multiproteic intracellular complex activated by infectious pathogens through a two-step process resulting in the release of the pro-inflammatory cytokines IL-1β and IL-18 and the formation of membrane pores by gasdermin D, inducing a pro-inflammatory form of cell death called pyroptosis. The role of NLRP3 inflammasome in the pathophysiology of sepsis can be ambivalent. Indeed, although it might protect against sepsis when moderately activated after initial infection, excessive NLRP3 inflammasome activation can induce dysregulated inflammation leading to multiple organ failure and death during the acute phase of the disease. Moreover, this activation might become exhausted and contribute to post-septic immunosuppression, driving impaired functions of innate and adaptive immune cells. Targeting the NLRP3 inflammasome could thus be an attractive option in sepsis either through IL-1β and IL-18 antagonists or through inhibition of NLRP3 inflammasome pathway downstream components. Available treatments and results of first clinical trials will be discussed.
    MeSH term(s) Humans ; Inflammasomes ; Interleukin-18 ; NLR Family, Pyrin Domain-Containing 3 Protein ; Sepsis ; Cell Death
    Chemical Substances Inflammasomes ; Interleukin-18 ; NLR Family, Pyrin Domain-Containing 3 Protein
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220556
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Immature neutrophils and myeloid-derived suppressor cells in sepsis: differences in occurrence kinetics.

    Coudereau, Rémy / Haem Rahimi, Muzhda / Lukaszewicz, Anne-Claire / Cour, Martin / Bidar, Frank / Argaud, Laurent / Venet, Fabienne / Monneret, Guillaume

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 7

    MeSH term(s) Humans ; Neutrophils ; Myeloid-Derived Suppressor Cells ; Sepsis
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04781-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Immune checkpoint inhibitors for the treatment of sepsis:insights from preclinical and clinical development.

    Rienzo, Mario / Skirecki, Tomasz / Monneret, Guillaume / Timsit, Jean-François

    Expert opinion on investigational drugs

    2022  Volume 31, Issue 9, Page(s) 885–894

    Abstract: Introduction: It is now well established that sepsis induces a state of acquired immunosuppression, with an increased risk of secondary infections that contributes to patients' worsening. Thus, tackling sepsis-induced immunosuppression represents a ... ...

    Abstract Introduction: It is now well established that sepsis induces a state of acquired immunosuppression, with an increased risk of secondary infections that contributes to patients' worsening. Thus, tackling sepsis-induced immunosuppression represents a promising perspective.
    Areas covered: Of mechanisms responsible for sepsis-induced immunosuppression, the increased expression of co-inhibitory receptors such as PD-1, CTLA4, TIM-3, LAG-3, or BTLA and their ligands recently received considerable interest since their inhibition, thanks to the so-called checkpoint inhibitors (CPI), provided astonishing results in cancer by rebooting immune functions. This review reports on the first landmarks of these molecules in sepsis.
    Expert opinion: Preclinical results are positive and the first human early phase clinical trials showed a beneficial effect on immunological functions and/or markers and suggested that tolerance of CPIs side effects, mainly auto-immune disorders, is acceptable in sepsis. Elsewhere, in some specific severe ICU infections such as fungal infections, preliminary convincing case reports have been published. Overall, the first results regarding CPIs in sepsis appear encouraging. However, further efforts are warranted, especially in defining the right patients to be treated (i.e. in an individualized approach) and establishing the optimal time to start an immune restoration. Larger trials are now mandatory to confirm CPIs' potential in sepsis.
    MeSH term(s) Biomarkers ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Neoplasms/drug therapy ; Sepsis/drug therapy
    Chemical Substances Biomarkers ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2022.2102477
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Dysregulated expression of amino-acid and glucose transporters on circulating plasma cells in septic shock patients: a preliminary study.

    Lepage, Margot / Gossez, Morgane / Lukaszewicz, Anne-Claire / Monneret, Guillaume / Venet, Fabienne

    Intensive care medicine experimental

    2022  Volume 10, Issue 1, Page(s) 44

    Language English
    Publishing date 2022-10-31
    Publishing country Germany
    Document type Letter
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-022-00472-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Monocyte HLA-DR expression as an enrollment biomarker in sepsis clinical trials: Evaluation of two sampling tubes and definition of respective clinical thresholds.

    Haem Rahimi, Muzhda / Conti, Filippo / Llitjos, Jean-Francois / Fleurie, Aurore / Cerro, Valérie / Venet, Fabienne / Lukaszewicz, Anne-Claire / Monneret, Guillaume

    Cytometry. Part B, Clinical cytometry

    2023  Volume 104, Issue 6, Page(s) 468–470

    MeSH term(s) Humans ; Monocytes/metabolism ; Flow Cytometry ; HLA-DR Antigens ; Sepsis/diagnosis ; Biomarkers/metabolism
    Chemical Substances HLA-DR Antigens ; Biomarkers
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.22133
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1688: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Monocyte HLA-DR Expression to Monitor Immune Response and Potential Infection Risks Following Vaso-Occlusive Crises in Patients with Sickle Cell Anemia.

    Fort, Romain / Monneret, Guillaume / Nader, Elie / Cannas, Giovanna / Connes, Philippe / Venet, Fabienne / Hot, Arnaud

    Mediterranean journal of hematology and infectious diseases

    2022  Volume 14, Issue 1, Page(s) e2022078

    Language English
    Publishing date 2022-11-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2022.078
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Lack of SARS-CoV-2-specific cellular response in critically ill COVID-19 patients despite apparent effective vaccination.

    Bidar, Frank / Monneret, Guillaume / Berthier, Franck / Lukaszewicz, Anne-Claire / Venet, Fabienne

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 170

    MeSH term(s) COVID-19 ; Critical Illness/therapy ; Humans ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-06-08
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-04038-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top