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  1. Article ; Online: Alternative splicing in cardiomyopathy insights.

    Schiano, Concetta / Napoli, Claudio

    Pharmacological research

    2024  Volume 201, Page(s) 107106

    MeSH term(s) Alternative Splicing ; Cardiomyopathies/genetics ; Humans
    Language English
    Publishing date 2024-02-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2024.107106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Unexplored horizons on sex bias and progression of heart failure with preserved ejection fraction.

    Benincasa, Giuditta / Napoli, Claudio

    European heart journal. Cardiovascular pharmacotherapy

    2023  Volume 9, Issue 6, Page(s) 502–504

    MeSH term(s) Humans ; Stroke Volume ; Sexism ; Heart Failure/diagnosis ; Hospitalization
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvad050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transgenerational Epigenetic Inheritance of Cardiovascular Diseases: A Network Medicine Perspective.

    Benincasa, Giuditta / Napoli, Claudio / DeMeo, Dawn L

    Maternal and child health journal

    2024  Volume 28, Issue 4, Page(s) 617–630

    Abstract: Introduction: The ability to identify early epigenetic signatures underlying the inheritance of cardiovascular risk, including trans- and intergenerational effects, may help to stratify people before cardiac symptoms occur.: Methods: Prospective and ... ...

    Abstract Introduction: The ability to identify early epigenetic signatures underlying the inheritance of cardiovascular risk, including trans- and intergenerational effects, may help to stratify people before cardiac symptoms occur.
    Methods: Prospective and retrospective cohorts and case-control studies focusing on DNA methylation and maternal/paternal effects were searched in Pubmed from 1997 to 2023 by using the following keywords: DNA methylation, genomic imprinting, and network analysis in combination with transgenerational/intergenerational effects.
    Results: Maternal and paternal exposures to traditional cardiovascular risk factors during critical temporal windows, including the preconceptional period or early pregnancy, may perturb the plasticity of the epigenome (mainly DNA methylation) of the developing fetus especially at imprinted loci, such as the insulin-like growth factor type 2 (IGF2) gene. Thus, the epigenome is akin to a "molecular archive" able to memorize parental environmental insults and predispose an individual to cardiovascular diseases onset in later life. Direct evidence for human transgenerational epigenetic inheritance (at least three generations) of cardiovascular risk is lacking but it is supported by epidemiological studies. Several blood-based association studies showed potential intergenerational epigenetic effects (single-generation studies) which may mediate the transmittance of cardiovascular risk from parents to offspring.
    Discussion: In this narrative review, we discuss some relevant examples of trans- and intergenerational epigenetic associations with cardiovascular risk. In our perspective, we propose three network-oriented approaches which may help to clarify the unsolved issues regarding transgenerational epigenetic inheritance of cardiovascular risk and provide potential early biomarkers for primary prevention.
    MeSH term(s) Male ; Pregnancy ; Female ; Humans ; Epigenesis, Genetic ; Cardiovascular Diseases/genetics ; Retrospective Studies ; Prospective Studies ; DNA Methylation
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1339905-6
    ISSN 1573-6628 ; 1092-7875
    ISSN (online) 1573-6628
    ISSN 1092-7875
    DOI 10.1007/s10995-023-03886-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6170: Show issues Location:
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  4. Article ; Online: Carotid Computed Tomography Crescent Sign.

    Zedde, Marialuisa / Napoli, Manuela / Moratti, Claudio / Pascarella, Rosario

    Stroke

    2023  Volume 54, Issue 6, Page(s) e235–e236

    MeSH term(s) Humans ; Tomography, X-Ray Computed/methods ; Magnetic Resonance Angiography ; Carotid Stenosis ; Carotid Artery, Internal
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.123.042916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 448: Show issues Location:
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  5. Article ; Online: A vertebral artery "donut sign".

    Zedde, Marialuisa / Moratti, Claudio / Napoli, Manuela / Valzania, Franco / Pascarella, Rosario

    Acta neurologica Belgica

    2023  

    Language English
    Publishing date 2023-10-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-023-02386-9
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  6. Article ; Online: Mediator complex in neurological disease.

    Schiano, Concetta / Luongo, Livio / Maione, Sabatino / Napoli, Claudio

    Life sciences

    2023  Volume 329, Page(s) 121986

    Abstract: Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a ... ...

    Abstract Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a large, evolutionarily conserved multiprotein that facilities the interaction between transcription factors and RNA Polymerase II in eukaryotes. Some MED subunits have been found altered in the brain, although their specific functions in neurodegenerative diseases are not fully understood. Mutations in MED subunits were associated with a wide range of genetic diseases for MED12, MED13, MED13L, MED20, MED23, MED25, and CDK8 genes. In addition, MED12 and MED23 were deregulated in the Alzheimer's Disease. Interestingly, most of the genomic mutations have been found in the subunits of the kinase module. To date, there is only one evidence on MED1 involvement in post-stroke cognitive deficits. Although the underlying neurodegenerative disorders may be different, we are confident that the signal cascades of the biological-cognitive mechanisms of brain adaptation, which begin after brain deterioration, may also differ. Here, we analysed relevant studies in English published up to June 2023. They were identified through a search of electronic databases including PubMed, Medline, EMBASE and Scopus, including search terms such as "Mediator complex", "neurological disease", "brains". Thematic content analysis was conducted to collect and summarize all studies demonstrating MED alteration to understand the role of this central transcriptional regulatory complex in the brain. Improved and deeper knowledge of the regulatory mechanisms in neurological diseases can increase the ability of physicians to predict onset and progression, thereby improving diagnostic care and providing appropriate treatment decisions.
    MeSH term(s) Humans ; Cyclin-Dependent Kinase 8/genetics ; Cyclin-Dependent Kinase 8/metabolism ; Transcription Factors/metabolism ; Mutation ; Mediator Complex/genetics
    Chemical Substances Cyclin-Dependent Kinase 8 (EC 2.7.11.22) ; Transcription Factors ; MED25 protein, human ; Mediator Complex
    Language English
    Publishing date 2023-07-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.121986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.368: Show issues Location:
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  7. Article ; Online: Unsolved Issues on Beneficial Effects of Combination Therapy With Sotatercept in Pulmonary Arterial Hypertension.

    Benincasa, Giuditta / Strozziero, Maria Grazia / Trama, Ugo / Napoli, Claudio

    Heart, lung & circulation

    2023  Volume 33, Issue 1, Page(s) 12–13

    MeSH term(s) Humans ; Pulmonary Arterial Hypertension/drug therapy ; Recombinant Fusion Proteins ; Familial Primary Pulmonary Hypertension
    Chemical Substances ACE-011 ; Recombinant Fusion Proteins
    Language English
    Publishing date 2023-11-30
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4988: Show issues Location:
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  8. Article ; Online: Epigenetic challenges on the horizon of chimeric antigen receptor-T.

    Benincasa, Giuditta / Strozziero, Maria Grazia / Di Pastena, Maria Assunta / Criscuolo, Clelia / Cetani, Giusy / Trama, Ugo / Napoli, Claudio

    Cytotherapy

    2024  

    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2024.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5601: Show issues Location:
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  9. Article ; Online: Basic Pathogenic Mechanisms and Epigenetic Players Promoted by Extracellular Vesicles in Vascular Damage.

    Schiano, Concetta / Balbi, Carolina / de Nigris, Filomena / Napoli, Claudio

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Both progression from the early pathogenic events to clinically manifest cardiovascular diseases (CVD) and cancer impact the integrity of the vascular system. Pathological vascular modifications are affected by interplay between endothelial cells and ... ...

    Abstract Both progression from the early pathogenic events to clinically manifest cardiovascular diseases (CVD) and cancer impact the integrity of the vascular system. Pathological vascular modifications are affected by interplay between endothelial cells and their microenvironment. Soluble factors, extracellular matrix molecules and extracellular vesicles (EVs) are emerging determinants of this network that trigger specific signals in target cells. EVs have gained attention as package of molecules with epigenetic reversible activity causing functional vascular changes, but their mechanisms are not well understood. Valuable insights have been provided by recent clinical studies, including the investigation of EVs as potential biomarkers of these diseases. In this paper, we review the role and the mechanism of exosomal epigenetic molecules during the vascular remodeling in coronary heart disease as well as in cancer-associated neoangiogenesis.
    MeSH term(s) Humans ; Endothelial Cells/pathology ; Extracellular Vesicles/genetics ; Extracellular Vesicles/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Cardiovascular Diseases/pathology ; Epigenesis, Genetic ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases.

    Benincasa, Giuditta / Suades, Rosa / Padró, Teresa / Badimon, Lina / Napoli, Claudio

    European heart journal. Cardiovascular pharmacotherapy

    2023  Volume 9, Issue 8, Page(s) 758–769

    Abstract: Although bioinformatic methods gained a lot of attention in the latest years, their use in real-world studies for primary and secondary prevention of atherosclerotic cardiovascular diseases (ASCVD) is still lacking. Bioinformatic resources have been ... ...

    Abstract Although bioinformatic methods gained a lot of attention in the latest years, their use in real-world studies for primary and secondary prevention of atherosclerotic cardiovascular diseases (ASCVD) is still lacking. Bioinformatic resources have been applied to thousands of individuals from the Framingham Heart Study as well as health care-associated biobanks such as the UK Biobank, the Million Veteran Program, and the CARDIoGRAMplusC4D Consortium and randomized controlled trials (i.e. ODYSSEY, FOURIER, ASPREE, and PREDIMED). These studies contributed to the development of polygenic risk scores (PRS), which emerged as novel potent genetic-oriented tools, able to calculate the individual risk of ASCVD and to predict the individual response to therapies such as statins and proprotein convertase subtilisin/kexin type 9 inhibitor. ASCVD are the first cause of death around the world including coronary heart disease (CHD), peripheral artery disease, and stroke. To achieve the goal of precision medicine and personalized therapy, advanced bioinformatic platforms are set to link clinically useful indices to heterogeneous molecular data, mainly epigenomics, transcriptomics, metabolomics, and proteomics. The DIANA study found that differential methylation of ABCA1, TCF7, PDGFA, and PRKCZ significantly discriminated patients with acute coronary syndrome from healthy subjects and their expression levels positively associated with CK-MB serum concentrations. The ARIC Study revealed several plasma proteins, acting or not in lipid metabolism, with a potential role in determining the different pleiotropic effects of statins in each subject. The implementation of molecular high-throughput studies and bioinformatic techniques into traditional cardiovascular risk prediction scores is emerging as a more accurate practice to stratify patients earlier in life and to favour timely and tailored risk reduction strategies. Of note, radiogenomics aims to combine imaging features extracted for instance by coronary computed tomography angiography and molecular biomarkers to create CHD diagnostic algorithms useful to characterize atherosclerotic lesions and myocardial abnormalities. The current view is that such platforms could be of clinical value for prevention, risk stratification, and treatment of ASCVD.
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Atherosclerosis/diagnosis ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Coronary Disease/drug therapy ; Computational Biology
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvad059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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