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  1. Book ; Online ; E-Book: Health informatics

    Brown, Gordon D. / Pasupathy, Kalyan S. / Patrick, Timothy B.

    a systems perspective

    2019  

    Author's details Gordon D. Brown, Kalyan S. Pasupathy, Timothy B. Patrick
    Subject code 610.285
    Language English
    Size 1 Online-Ressource (xix, 417 Seiten), Diagramme
    Edition Second edition
    Publisher Health Administration Press (HAP) ; Association of University Programs in Health Administration (AUPHA)
    Publishing place Chicago, Illinois ; Washington, DC
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019858375
    ISBN 978-1-64055-006-3 ; 9781640550056 ; 9781640550070 ; 9781640550087 ; 9781640550094 ; 1-64055-006-2 ; 1640550054 ; 1640550070 ; 1640550089 ; 1640550097
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: Immunity to fungi: Editorial overview.

    Willment, Janet A / Brown, Gordon D

    Seminars in immunology

    2023  Volume 66, Page(s) 101734

    MeSH term(s) Humans ; Fungi ; Immunity, Innate
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101734
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  3. Article ; Online: Incomparability and Incommensurability in Choice: No Common Currency of Value?

    Walasek, Lukasz / Brown, Gordon D A

    Perspectives on psychological science : a journal of the Association for Psychological Science

    2023  , Page(s) 17456916231192828

    Abstract: Models of decision-making typically assume the existence of some common currency of value, such as utility, happiness, or inclusive fitness. This common currency is taken to allow comparison of options and to underpin everyday choice. Here we suggest ... ...

    Abstract Models of decision-making typically assume the existence of some common currency of value, such as utility, happiness, or inclusive fitness. This common currency is taken to allow comparison of options and to underpin everyday choice. Here we suggest instead that there is no universal value scale, that incommensurable values pervade everyday choice, and hence that most existing models of decision-making in both economics and psychology are fundamentally limited. We propose that choice objects can be compared only with reference to specific but nonuniversal "covering values." These covering values may reflect decision-makers' goals, motivations, or current states. A complete model of choice must accommodate the range of possible covering values. We show that abandoning the common-currency assumption in models of judgment and decision-making necessitates rank-based and "simple heuristics" models that contrast radically with conventional utility-based approaches. We note that if there is no universal value scale, then Arrow's impossibility theorem places severe bounds on the rationality of individual decision-making and hence that there is a deep link between the incommensurability of value, inconsistencies in human decision-making, and rank-based coding of value. More generally, incommensurability raises the question of whether it will ever be possible to develop single-quantity-maximizing models of decision-making.
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2224911-4
    ISSN 1745-6924 ; 1745-6916
    ISSN (online) 1745-6924
    ISSN 1745-6916
    DOI 10.1177/17456916231192828
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  4. Article ; Online: Cross-presentation is getting DNGRous.

    Hatinguais, Remi / Brown, Gordon D

    Nature immunology

    2021  Volume 22, Issue 2, Page(s) 108–110

    MeSH term(s) Cross-Priming
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-00831-y
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  5. Article ; Online: Managing the mycobiota with IgA.

    Dambuza, Ivy M / Brown, Gordon D

    Nature microbiology

    2021  Volume 6, Issue 12, Page(s) 1471–1472

    MeSH term(s) Fungi ; Gastrointestinal Microbiome ; Immunoglobulin A
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2021-11-22
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-021-01006-7
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  6. Article ; Online: Myeloid C-type lectin receptors in innate immune recognition.

    Reis E Sousa, Caetano / Yamasaki, Sho / Brown, Gordon D

    Immunity

    2024  Volume 57, Issue 4, Page(s) 700–717

    Abstract: C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from ... ...

    Abstract C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and markers of altered self. These receptors, classified into distinct subgroups, play pivotal roles in immune recognition and modulation of immune responses. Their intricate signaling pathways orchestrate a spectrum of cellular responses, influencing processes such as phagocytosis, cytokine production, and antigen presentation. Beyond their contributions to host defense in viral, bacterial, fungal, and parasitic infections, myeloid CLRs have been implicated in non-infectious diseases such as cancer, allergies, and autoimmunity. A nuanced understanding of myeloid CLR interactions with endogenous and microbial triggers is starting to uncover the context-dependent nature of their roles in innate immunity, with implications for therapeutic intervention.
    MeSH term(s) Humans ; Lectins, C-Type/metabolism ; Immunity, Innate ; Myeloid Cells/metabolism ; Signal Transduction ; Neoplasms/metabolism ; Receptors, Pattern Recognition/metabolism
    Chemical Substances Lectins, C-Type ; Receptors, Pattern Recognition
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.03.005
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    Zs.MG 69: Show issues

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  7. Article: The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in

    Brown, Nora C / Gordon, Benjamin / McDonough-Goldstein, Caitlin E / Misra, Snigdha / Findlay, Geoffrey D / Clark, Andrew G / Wolfner, Mariana F

    bioRxiv : the preprint server for biology

    2023  

    Abstract: ... ...

    Abstract In
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.03.526941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Promoting good mental health over the menopause transition.

    Brown, Lydia / Hunter, Myra S / Chen, Rong / Crandall, Carolyn J / Gordon, Jennifer L / Mishra, Gita D / Rother, Viktoria / Joffe, Hadine / Hickey, Martha

    Lancet (London, England)

    2024  Volume 403, Issue 10430, Page(s) 969–983

    Abstract: The potential risk for mental health conditions over the menopause transition shapes women's expectations and informs putative physiological mechanisms regulating women's mental health. We review evidence from prospective studies reporting on ... ...

    Abstract The potential risk for mental health conditions over the menopause transition shapes women's expectations and informs putative physiological mechanisms regulating women's mental health. We review evidence from prospective studies reporting on associations between mental health conditions and the menopause transition. Major depressive disorder and the more prevalent subthreshold depressive symptoms are the most common conditions studied. We reviewed 12 prospective studies reporting depressive symptoms, major depressive disorder, or both over the menopause transition and found no compelling evidence for a universal increased risk for either condition. However, specific subgroups of participants, primarily defined by menopause-related risk factors (ie, vasomotor symptoms that are severe or disturb sleep, a long duration of the transition, or reproductive hormone dynamics) and psychosocial risk factors (eg, stressful life events), were vulnerable to depressive symptoms. The increased risk of major depressive disorder over the menopause transition appears predominantly in individuals with previous major depressive disorder. Greater focus on recognising risk factors in primary care is warranted. On the basis of scarce data, we found no compelling evidence that risk of anxiety, bipolar disorder, or psychosis is universally elevated over the menopause transition. Potential misattribution of psychological distress and psychiatric disorders to menopause could harm women by delaying accurate diagnosis and the initiation of effective psychotropic treatments, and by creating negative expectations for people approaching menopause. A paradigm shift is needed. We conclude with recommendations for the detection and treatment of depressive symptoms or major depressive disorder and strategies to promote good mental health over the menopause transition, while responsibly preparing and supporting those at risk.
    MeSH term(s) Female ; Humans ; Mental Health ; Depressive Disorder, Major/epidemiology ; Prospective Studies ; Menopause/psychology ; Women's Health ; Depression/epidemiology ; Depression/psychology
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02801-5
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  9. Article ; Online: The role of episodic memory sampling in evaluation.

    Mason, Alice / Brown, Gordon D A / Ward, Geoff / Farrell, Simon

    Psychonomic bulletin & review

    2023  

    Abstract: Many models of choice assume that people retrieve memories of past experiences and use them to guide evaluation and choice. In this paper, we examine whether samples of recalled past experiences do indeed underpin our evaluations of options. We showed ... ...

    Abstract Many models of choice assume that people retrieve memories of past experiences and use them to guide evaluation and choice. In this paper, we examine whether samples of recalled past experiences do indeed underpin our evaluations of options. We showed participants sequences of numerical values and asked them to recall as many of those values as possible and also to state how much they would be willing to pay for another draw from the sequence. Using Bayesian mixed effects modeling, we predicted participants' evaluation of the sequences at the group level from either the average of the values they recalled or the average of the values they saw. Contrary to the predictions of recall-based models, people's evaluations appear to be sensitive to information beyond what was actually recalled. Moreover, we did not find consistent evidence that memory for specific items is sufficient to predict evaluation of sequences. We discuss the implications for sampling models of memory and decision-making and alternative explanations.
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2031311-1
    ISSN 1531-5320 ; 1069-9384
    ISSN (online) 1531-5320
    ISSN 1069-9384
    DOI 10.3758/s13423-023-02413-z
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  10. Article ; Online: The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in

    Brown, Nora C / Gordon, Benjamin / McDonough-Goldstein, Caitlin E / Misra, Snigdha / Findlay, Geoffrey D / Clark, Andrew G / Wolfner, Mariana Federica

    eLife

    2023  Volume 12

    Abstract: ... ...

    Abstract In
    MeSH term(s) Male ; Female ; Animals ; Drosophila melanogaster/physiology ; Odorants ; Drosophila Proteins/metabolism ; Seeds ; Fertility/genetics ; Spermatozoa/physiology ; Sexual Behavior, Animal
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.86409
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