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Article ; Online: [Immune Regulation by TNF Receptor-associated Factor 5].

So, Takanori

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2024 Volume 144, Issue 5, Page(s) 489–496

Abstract: The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular adaptors that regulate cellular signaling through members of the TNFR and Toll-like receptor superfamily. Mammals have seven TRAF molecules numbered ... ...

Abstract	The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular adaptors that regulate cellular signaling through members of the TNFR and Toll-like receptor superfamily. Mammals have seven TRAF molecules numbered sequentially from TRAF1 to TRAF7. Although TRAF5 was identified as a potential regulator of TNFR superfamily members, the in vivo function of TRAF5 has not yet been fully elucidated. We identified an unconventional role of TRAF5 in interleukin-6 (IL-6) receptor signaling involving CD4
MeSH term(s)	Humans ; Animals ; TNF Receptor-Associated Factor 5/genetics ; TNF Receptor-Associated Factor 5/metabolism ; TNF Receptor-Associated Factor 5/physiology ; Signal Transduction ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/etiology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Cytokine Receptor gp130/physiology ; Cytokine Receptor gp130/metabolism ; Th17 Cells/immunology ; Interleukin-6/metabolism ; Interleukin-6/physiology ; Cell Differentiation ; Receptors, Interleukin-6/physiology ; Receptors, Interleukin-6/metabolism ; Janus Kinases/metabolism ; Janus Kinases/physiology ; STAT Transcription Factors/physiology ; STAT Transcription Factors/metabolism ; Mice
Chemical Substances	TNF Receptor-Associated Factor 5 ; Cytokine Receptor gp130 (133483-10-0) ; Interleukin-6 ; Receptors, Interleukin-6 ; Janus Kinases (EC 2.7.10.2) ; STAT Transcription Factors
Language	Japanese
Publishing date	2024-05-02
Publishing country	Japan
Document type	Journal Article ; Review ; English Abstract
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.23-00154-3
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Article ; Online: The immunological significance of tumor necrosis factor receptor-associated factors (TRAFs).

So, Takanori

International immunology

2021 Volume 34, Issue 1, Page(s) 7–20

Abstract: The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular signaling adaptors and control diverse signaling pathways mediated not only by the TNFR superfamily and the Toll-like receptor/IL-1 receptor ... ...

Abstract	The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular signaling adaptors and control diverse signaling pathways mediated not only by the TNFR superfamily and the Toll-like receptor/IL-1 receptor superfamily but also by unconventional cytokine receptors such as IL-6 and IL-17 receptors. There are seven family members, TRAF1 to TRAF7, in mammals. Exaggerated immune responses induced through TRAF signaling downstream of these receptors often lead to inflammatory and autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, psoriasis and autoinflammatory syndromes, and thus those signals are major targets for therapeutic intervention. For this reason, it has been very important to understand signaling mechanisms regulated by TRAFs that greatly impact on life/death decisions and the activation, differentiation and survival of cells of the innate and adaptive immune systems. Accumulating evidence suggests that dysregulated cellular expression and/or signaling of TRAFs causes overproduction of pro-inflammatory cytokines, which facilitates aberrant activation of immune cells. In this review, I will explain the structural and functional aspects that are responsible for the cellular activity and disease outcomes of TRAFs, and summarize the findings of recent studies on TRAFs in terms of how individual TRAF family molecules regulate biological and disease processes in the body in both positive and negative ways. This review also discusses how TRAF mutations contribute to human disease.
MeSH term(s)	Animals ; Autoimmunity/immunology ; Humans ; Infections/immunology ; Neoplasms/immunology ; Signal Transduction/immunology ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/immunology
Chemical Substances	Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Language	English
Publishing date	2021-08-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxab058
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Exploring the Potential of Lateral Wedge Insoles in Alleviating Bone Marrow Lesions in End-Stage Knee Osteoarthritis: A Preliminary Case Report.

Tanaka, So / Taniguchi, Takanori / Tokunaga, Masami / Yoshimoto, Takaaki / Nishigami, Tomohiko

Cureus

2024 Volume 16, Issue 1, Page(s) e52473

Abstract: The efficacy of lateral wedge insoles (LWIs) in patients with end-stage knee osteoarthritis (OA) is unclear. A 43-year-old male underwent two anterior cruciate ligament reconstructions in his right knee and was later diagnosed with end-stage knee OA. An ... ...

Abstract	The efficacy of lateral wedge insoles (LWIs) in patients with end-stage knee osteoarthritis (OA) is unclear. A 43-year-old male underwent two anterior cruciate ligament reconstructions in his right knee and was later diagnosed with end-stage knee OA. An LWI combining arch support with a lateral heel wedge was fabricated for this patient and used over 12 months. As a result, after 12 months, the bone marrow lesion (BML), as measured by the magnetic resonance imaging Osteoarthritis Knee Score (MOAKS), was downgraded from grade 2 to grade 1. The use of LWI in a patient with end-stage knee OA showed lower co-contraction ratios in knee muscles even after 12 months. The results provide preliminary evidence suggesting the use of LWI in patients with end-stage knee OA has potential benefits for reducing BML.
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52473
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Article ; Online: Hydrodeoxygenative Coupling and Transformation of Aldehydes at a N

So, Yat-Ming / To, Ching Tat / Guru, Murali Mohan / Shima, Takanori / Hou, Zhaomin

Journal of the American Chemical Society

2023 Volume 145, Issue 30, Page(s) 16906–16912

Abstract: Carbon-carbon bond formation via coupling of two organic components is among the most important chemical transformations in organic synthesis. Herein, we report an unprecedented hydrodeoxygenative coupling of aromatic aldehydes to form bibenzyls by a ... ...

Abstract	Carbon-carbon bond formation via coupling of two organic components is among the most important chemical transformations in organic synthesis. Herein, we report an unprecedented hydrodeoxygenative coupling of aromatic aldehydes to form bibenzyls by a N
Language	English
Publishing date	2023-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c05525
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Article ; Online: Transmembrane helix 6 of ABCD4 is indispensable for cobalamin transport.

Imai, Momoka / Kawaguchi, Kosuke / Morita, Masashi / Imanaka, Tsuneo / So, Takanori

Journal of inherited metabolic disease

2023 Volume 47, Issue 2, Page(s) 366–373

Abstract: ABCD4, which belongs to the ABC protein subfamily D, plays a role in the transport of cobalamin from lysosomes to the cytosol by cooperating with ATP-binding and ATP-hydrolysis. Pathogenic variants in the ABCD4 gene lead to an inherited metabolic ... ...

Abstract	ABCD4, which belongs to the ABC protein subfamily D, plays a role in the transport of cobalamin from lysosomes to the cytosol by cooperating with ATP-binding and ATP-hydrolysis. Pathogenic variants in the ABCD4 gene lead to an inherited metabolic disorder characterized by cobalamin deficiency. However, the structural requirements for cobalamin transport in ABCD4 remain unclear. In this study, six proteoliposomes were prepared, each containing a different chimeric ABCD4 protein, wherein each of the six transmembrane (TM) helices was replaced with the corresponding ABCD1. We analyzed the cobalamin transport activities of the ABCD mutants. In the proteoliposome with chimeric ABCD4 replacing TM helix 6, the cobalamin transport activity disappeared without a reduction in ATPase activity, indicating that TM helix 6 contributes to substrate recognition. Furthermore, the substitution of aspartic acid at position 329 or threonine at position 332 in TM helix 6 with the basic amino acid lysine led to a decrease in cobalamin-transport activity without causing a reduction in ATPase activity. The amino acids in TM helix 6 may be critically involved in substrate recognition; the charged state in the C-terminal half of TM helix 6 of ABCD4 is responsible for cobalamin transport activity.
MeSH term(s)	Humans ; Biological Transport/genetics ; Vitamin B 12/genetics ; Vitamin B 12/metabolism ; Vitamin B 12 Deficiency/metabolism ; Adenosine Triphosphatases/metabolism ; Adenosine Triphosphate/metabolism ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism
Chemical Substances	Vitamin B 12 (P6YC3EG204) ; Adenosine Triphosphatases (EC 3.6.1.-) ; Adenosine Triphosphate (8L70Q75FXE) ; ABCD4 protein, human ; ATP-Binding Cassette Transporters
Language	English
Publishing date	2023-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	438341-2
ISSN	1573-2665 ; 0141-8955
ISSN (online)	1573-2665
ISSN	0141-8955
DOI	10.1002/jimd.12694
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Zs.A 1508: Show issues

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Article: The TNF-TNFR Family of Co-signal Molecules.

So, Takanori / Ishii, Naoto

Advances in experimental medicine and biology

2019 Volume 1189, Page(s) 53–84

Abstract: Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF) ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion, differentiation, and survival of antigen-primed ... ...

Abstract	Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF) ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion, differentiation, and survival of antigen-primed CD4
MeSH term(s)	Humans ; Immunotherapy ; Lymphocyte Activation ; Neoplasms ; Receptors, Tumor Necrosis Factor/metabolism ; Signal Transduction ; T-Lymphocytes/cytology ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2019-11-22
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-32-9717-3_3
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Article ; Online: Increased neurotoxicity of high-density lipoprotein secreted from murine reactive astrocytes deficient in a peroxisomal very-long-chain fatty acid transporter Abcd1.

Fujitani, Naoki / Akashi, Tomoya / Saito, Masayoshi / Morita, Masashi / So, Takanori / Oka, Kozo

Journal of inherited metabolic disease

2023 Volume 47, Issue 2, Page(s) 289–301

Abstract: X-linked adrenoleukodystrophy (X-ALD) is a genetic neurodegenerative disorder caused by pathogenic variants in ABCD1, resulting in the accumulation of very-long-chain fatty acids (VLCFAs) in tissues. The etiology of X-ALD is unclear. Activated astrocytes ...

Abstract	X-linked adrenoleukodystrophy (X-ALD) is a genetic neurodegenerative disorder caused by pathogenic variants in ABCD1, resulting in the accumulation of very-long-chain fatty acids (VLCFAs) in tissues. The etiology of X-ALD is unclear. Activated astrocytes play a pathological role in X-ALD. Recently, reactive astrocytes have been shown to induce neuronal cell death via saturated lipids in high-density lipoprotein (HDL), although how HDL from reactive astrocytes exhibits neurotoxic effects has yet to be determined. In this study, we obtained astrocytes from wild-type and Abcd1-deficient mice. HDL was purified from the culture supernatant of astrocytes, and the effect of HDL on neurons was evaluated in vitro. To our knowledge, this study shows for the first time that HDL obtained from Abcd1-deficient reactive astrocytes induces a significantly higher level of lactate dehydrogenase (LDH) release, a marker of cell damage, from mouse primary cortical neurons as compared to HDL from wild-type reactive astrocytes. Notably, HDL from Abcd1-deficient astrocytes contained significantly high amounts of VLCFA-containing phosphatidylcholine (PC) and LysoPC. Activation of Abcd1-deficient astrocytes led to the production of HDL containing decreased amounts of PC with arachidonic acid in sn-2 acyl moieties and increased amounts of LysoPC, presumably through cytosolic phospholipase A
MeSH term(s)	Mice ; Animals ; Adrenoleukodystrophy/metabolism ; ATP-Binding Cassette Transporters/genetics ; Astrocytes/metabolism ; Fatty Acids/metabolism ; Fatty Acids, Nonesterified/metabolism ; Central Nervous System/metabolism ; ATP Binding Cassette Transporter, Subfamily D, Member 1/genetics
Chemical Substances	ATP-Binding Cassette Transporters ; Fatty Acids ; Fatty Acids, Nonesterified ; Abcd1 protein, mouse ; ATP Binding Cassette Transporter, Subfamily D, Member 1
Language	English
Publishing date	2023-12-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	438341-2
ISSN	1573-2665 ; 0141-8955
ISSN (online)	1573-2665
ISSN	0141-8955
DOI	10.1002/jimd.12703
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Article: [Regulation of T-lymphocyte signaling by TNF superfamily members: an evolutionary perspective].

So, Takanori

Seikagaku. The Journal of Japanese Biochemical Society

2012 Volume 84, Issue 2, Page(s) 102–106

MeSH term(s)	Animals ; Evolution, Molecular ; Humans ; Multigene Family ; Receptors, Tumor Necrosis Factor/physiology ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/physiology ; Tumor Necrosis Factor-alpha/physiology
Chemical Substances	Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha
Language	Japanese
Publishing date	2012-02
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	282319-6
ISSN	0037-1017
ISSN	0037-1017
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Zs.B 592: Show issues

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Article ; Online: Detection of Characteristic Phosphatidylcholine Containing Very Long Chain Fatty Acids in Cerebrospinal Fluid from Patients with X-Linked Adrenoleukodystrophy.

Fujitani, Naoki / Saito, Masayoshi / Akashi, Tomoya / Morita, Masashi / So, Takanori / Oka, Kozo

Biological & pharmaceutical bulletin

2022 Volume 45, Issue 11, Page(s) 1725–1727

Abstract: X-linked Adrenoleukodystrophy (X-ALD) is a rare genetic neurological disorder caused by a mutation of the ABCD1 gene that encodes a peroxisomal ABC protein ABCD1. ABCD1 has a role in transporting very long chain fatty acid (VLCFA)-CoA into the peroxisome ...

Abstract	X-linked Adrenoleukodystrophy (X-ALD) is a rare genetic neurological disorder caused by a mutation of the ABCD1 gene that encodes a peroxisomal ABC protein ABCD1. ABCD1 has a role in transporting very long chain fatty acid (VLCFA)-CoA into the peroxisome for β-oxidation. ABCD1 dysfunction leads to reduced VLCFA β-oxidation and in turn increased VLCFA levels in the plasma and the cells of all tissues; these increased plasma levels have been used to diagnose X-ALD. It has been reported that plasma VLCFA is not correlated with the severity and disease phenotype of X-ALD. Therefore, we cannot predict the disease progression by the plasma VLCFA level. Cerebrospinal fluid (CSF) is constantly produced by brain, and thus levels of lipids containing VLCFA in CSF might be informative in terms of assessing X-ALD pathology. LC-MS/MS-based analysis showed that phosphatidylcholine (PC) containing VLCFA signals, such as PC 40 : 0(24 : 0/16 : 0), PC 42 : 0(26 : 0/16 : 0), PC 44 : 4(24 : 0/20 : 4) and PC 46 : 4(26 : 0/20 : 4) were characteristically detected only in the CSF from patients with X- ALD. In the present study, we analyzed limited number of patient's CSF samples (2 patients with X-ALD) due to the limitations of the availability for CSF samples from this rare disease. However, our finding would offer helpful information for studying the disease progression biomarkers in X-ALD. To our knowledge, this is the first report of analyzing lipids containing VLCFA in CSF from patients with X-ALD.
MeSH term(s)	Humans ; Adrenoleukodystrophy/diagnosis ; Adrenoleukodystrophy/metabolism ; Chromatography, Liquid ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Fatty Acids/metabolism ; Tandem Mass Spectrometry ; Fatty Acids, Nonesterified ; Lecithins ; Disease Progression
Chemical Substances	ATP-Binding Cassette Transporters ; Fatty Acids ; Fatty Acids, Nonesterified ; Lecithins
Language	English
Publishing date	2022-11-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b22-00506
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Zs.A 1474: Show issues

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Article ; Online: The lysosomal protein ABCD4 can transport vitamin B

Kitai, Katsuki / Kawaguchi, Kosuke / Tomohiro, Takenori / Morita, Masashi / So, Takanori / Imanaka, Tsuneo

The Journal of biological chemistry

2021 Volume 296, Page(s) 100654

Abstract: ... Vitamin ... ...

Abstract	Vitamin B
MeSH term(s)	ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Adenosine Triphosphatases/metabolism ; Biological Transport ; Humans ; Intracellular Membranes/metabolism ; Liposomes/metabolism ; Mutation ; Nucleocytoplasmic Transport Proteins/genetics ; Nucleocytoplasmic Transport Proteins/metabolism ; Saccharomycetales/genetics ; Saccharomycetales/growth & development ; Saccharomycetales/metabolism ; Vitamin B 12/metabolism
Chemical Substances	ABCD4 protein, human ; ATP-Binding Cassette Transporters ; LMBRD1 protein, human ; Liposomes ; Nucleocytoplasmic Transport Proteins ; Adenosine Triphosphatases (EC 3.6.1.-) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100654
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