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Article ; Online: The role of the glypican and syndecan families of heparan sulfate proteoglycans in cardiovascular function and disease.

Thota, Lakshmi Narasimha Rao / Chignalia, Andreia Zago

American journal of physiology. Cell physiology

2022 Volume 323, Issue 4, Page(s) C1052–C1060

Abstract: Heparan sulfate proteoglycans (HSPGs) are proteoglycans formed by a core protein to which one or multiple heparan sulfate chains are covalently bound. They are ubiquitously expressed in cellular surfaces and can be found in the extracellular matrix and ... ...

Abstract	Heparan sulfate proteoglycans (HSPGs) are proteoglycans formed by a core protein to which one or multiple heparan sulfate chains are covalently bound. They are ubiquitously expressed in cellular surfaces and can be found in the extracellular matrix and secretory vesicles. The cellular effects of HSPGs comprehend multiple functionalities that include
MeSH term(s)	Glypicans ; Heparan Sulfate Proteoglycans/metabolism ; Heparan Sulfate Proteoglycans/pharmacology ; Heparitin Sulfate/metabolism ; Membrane Proteins ; Peptide Hydrolases ; Receptors, Growth Factor ; Syndecan-1 ; Syndecans
Chemical Substances	Glypicans ; Heparan Sulfate Proteoglycans ; Membrane Proteins ; Receptors, Growth Factor ; Syndecan-1 ; Syndecans ; Heparitin Sulfate (9050-30-0) ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00018.2022
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Article ; Online: Expression analysis of pro-apoptotic

Raj S, Reshma / D N, Das / Mondal, S / Ashokan, M / Thota, Lakshmi Narasimha / Karuthadurai, T / J, Nikhil Kumar Tej / Ramesha, Kerekoppa P

Animal biotechnology

2022 Volume 34, Issue 4, Page(s) 1354–1361

Abstract: The study was designed with the objective of expression analysis of pro- ... ...

Abstract	The study was designed with the objective of expression analysis of pro-apoptotic
MeSH term(s)	Female ; Cattle/genetics ; Animals ; Genes, bcl-2/genetics ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; Lactation/genetics ; Milk/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/metabolism
Chemical Substances	bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger
Language	English
Publishing date	2022-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2043243-4
ISSN	1532-2378 ; 1049-5398
ISSN (online)	1532-2378
ISSN	1049-5398
DOI	10.1080/10495398.2021.2025066
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Article ; Online: Supplementation of sulfur and folic acid improves performance of broiler chicken fed suboptimal concentrations of dietary methionine.

Rao, Savaram Venkata Rama / Raju, Mantena Venkata Lakshmi Narasimha / Srilatha, Thota / Nagalakshmi, Devanaboyina / Rajkumar, Ullengala

Journal of the science of food and agriculture

2022 Volume 102, Issue 13, Page(s) 5720–5728

Abstract: Background: Supplementation of sulfur (S) and folic acid (FA) are known to spare the dietary requirement of methionine (Met) in chicken. An experiment was conducted to determine the effects of feeding graded concentrations of FA (0, 2, 4, 6, 8 mg kg: ... ...

Abstract	Background: Supplementation of sulfur (S) and folic acid (FA) are known to spare the dietary requirement of methionine (Met) in chicken. An experiment was conducted to determine the effects of feeding graded concentrations of FA (0, 2, 4, 6, 8 mg kg Results: Broilers fed the NC diet had lower body weight gain (BWG), high feed conversion ratio, lower ready-to-cook yield, higher lipid peroxidation and reduced concentrations of protein and albumin in serum. BWG improved with FA at day 21 and showed a trend of improvement at day 42. Similarly, BWG improved with S supplementation at day 42. The FA and S interaction indicated a significant reduction in lipid peroxidation with S supplementation at the majority of FA levels. Serum protein fractions increased with increased dietary FA content and increased further with S supplementation. Conclusion: Based on the results, it is concluded that the combination of FA (4 mg kg
MeSH term(s)	Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Animals ; Chickens/metabolism ; Diet/veterinary ; Dietary Supplements ; Folic Acid/metabolism ; Male ; Methionine/metabolism ; Sulfur/metabolism ; Weight Gain
Chemical Substances	Sulfur (70FD1KFU70) ; Folic Acid (935E97BOY8) ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.11920
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Article ; Online: Expression analysis of pro-apoptotic BAX and anti-apoptotic BCL-2 genes in relation to lactation performance in Deoni and Holstein Friesian crossbred cows

Raj S., Reshma / D. N., Das / Mondal, S. / Ashokan, M. / Thota, Lakshmi Narasimha / Karuthadurai, T. / J., Nikhil Kumar Tej / Ramesha, Kerekoppa P.

Animal Biotechnology. 2023 Aug. 1, v. 34, no. 4 p.1354-1361

2023

Abstract: The study was designed with the objective of expression analysis of pro-apoptotic BAX and anti-apoptotic BCL-2 genes on lactation performance in Bos indicus and HF crossbred cows during early lactation. BAX/BCL-2 mRNA expression ratio in HF crossbreds ... ...

Abstract	The study was designed with the objective of expression analysis of pro-apoptotic BAX and anti-apoptotic BCL-2 genes on lactation performance in Bos indicus and HF crossbred cows during early lactation. BAX/BCL-2 mRNA expression ratio in HF crossbreds showed a steady increase from 30th day to 90th day, but in Deoni cows the ratio exhibited a different pattern, which increased from day 30 to day 60, decreased on day 75, and then increased on day 90. BAX/BCL-2 expression ratio in Deoni and HF crossbreds were lowest on day 30 and highest on day 90. On contrary, the milk yield was highest on day 30 and lowest on day 90 suggesting BCL-2 gene favors milk production and BAX gene oppose milk production. In comparison to HF crossbreds, Deoni cows exhibited highest BAX/BCL-2 ratio at the end of early lactation, indicating Bos indicus cows were more sensitive to apoptosis than HF crossbreds. Comparison of daily milk yield with BAX/BCL-2 mRNA expression ratio revealed significant negative correlation with a correlation coefficient of −0.98 (P < 0.01) and −0.95 (P < 0.05) in Deoni and HF crossbred cows, respectively. Our study provides new insights into understanding the genetic control of mammary apoptosis between Bos indicus and HF crossbreds.
Keywords	Holstein ; apoptosis ; biotechnology ; crossbreds ; early lactation ; gene expression ; genes ; milk yield ; zebu ; Expression analysis ; BAX ; BCL-2 ; lactation
Language	English
Dates of publication	2023-0801
Size	p. 1354-1361.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2043243-4
ISSN	1532-2378 ; 1049-5398
ISSN (online)	1532-2378
ISSN	1049-5398
DOI	10.1080/10495398.2021.2025066
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Article ; Online: Long-Term Efficacy and Safety of Immunomodulatory Therapy for Atherosclerosis.

Thota, Lakshmi Narasimha / Ponnusamy, Thiruvelselvan / Lu, Xinjie / Mundkur, Lakshmi

Cardiovascular drugs and therapy

2019 Volume 33, Issue 4, Page(s) 385–398

Abstract: Background and aims: The long-term effect of immune tolerance has not been explored so far in atherosclerosis. In the present study, we assessed the effect of mucosal tolerance to a multi antigenic construct expressing three peptides from ApoB, HSP60, ... ...

Abstract	Background and aims: The long-term effect of immune tolerance has not been explored so far in atherosclerosis. In the present study, we assessed the effect of mucosal tolerance to a multi antigenic construct expressing three peptides from ApoB, HSP60, and outer membrane protein from Chlamydia pneumonia (AHC) for 30 weeks at every 6-week interval to understand the kinetics of immune modulation in disease progression. The safety profile of the molecule was also evaluated in mice. Methods: Apob Results: Treated animals showed an efficient reduction in plaque growth and lipid accumulation at 6 weeks (49%, p < 0.01) and 12 weeks (42.3%, p < 0.01) which decreased to 29% (p = 0.0001) at 18 weeks and at later time points. Macrophage accumulation was significantly lower at all time points (53% at 12 weeks to 27% at 30 weeks). Regulatory T cells increased in the spleen following treatment until 12 weeks (week 0 (2.57 ± 0.18 vs. 6.36 ± 0.03, p = 0.02), week 6 (4.52 ± 0.2 vs. 8.87 ± 0.32, p = 0.02), and week 12 (8.74 ± 0.37 vs. 15.4 ± 0.27, p = 0.02)) but showed a decline later. A similar trend was observed with tolerogenic dendritic cells. We observed an increase in antibody levels to low-density lipoprotein and oxidized LDL at later stages. AHC molecule was found to be safe in acute and repeated dose toxicity studies. Conclusions: Our results suggest that immune tolerance to AHC protein by oral administration is able to provide efficient atheroprotection up to 18 weeks and moderately at later stages. Apart from immune regulatory cells, protective antibodies may also have a role in controlling atherosclerosis.
MeSH term(s)	Animals ; Antigens, Bacterial/administration & dosage ; Antigens, Bacterial/immunology ; Apolipoprotein B-100/administration & dosage ; Apolipoprotein B-100/genetics ; Apolipoprotein B-100/immunology ; Atherosclerosis/blood ; Atherosclerosis/drug therapy ; Atherosclerosis/immunology ; Atherosclerosis/pathology ; Bacterial Outer Membrane Proteins/administration & dosage ; Bacterial Outer Membrane Proteins/immunology ; Biomarkers/blood ; Chaperonin 60/administration & dosage ; Chaperonin 60/immunology ; Chlamydophila pneumoniae/immunology ; Disease Models, Animal ; Female ; Immune Tolerance/drug effects ; Immunity, Mucosal/drug effects ; Immunologic Factors/administration & dosage ; Immunologic Factors/immunology ; Lipids/blood ; Lipids/immunology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Peptide Fragments/administration & dosage ; Peptide Fragments/immunology ; Plaque, Atherosclerotic ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Time Factors
Chemical Substances	Antigens, Bacterial ; Apob protein, mouse ; Apolipoprotein B-100 ; Bacterial Outer Membrane Proteins ; Biomarkers ; Chaperonin 60 ; Immunologic Factors ; Lipids ; Peptide Fragments ; Receptors, LDL
Language	English
Publishing date	2019-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-019-06890-0
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Article ; Online: Enhancement of performance and anti-oxidant variables in broiler chicken fed diets containing sub-optimal methionine level with graded concentrations of sulphur and folic acid

Venkata Rama Rao Savaram / Venkata Lakshmi Narasimha Raju Mantena / Shyam Sunder Paul / Nagalakshmi Devanaboyina / Srilatha Thota / Prakash Bhukya / Rajkumar Ullengala

Animal Bioscience, Vol 35, Iss 5, Pp 721-

2022 Volume 729

Abstract: Objective An experiment was conducted to determine the effects of supplementing graded concentrations of inorganic sulphur (S) without and with folic acid (FA) in maize-soybean meal diets on performance, slaughter and anti-oxidant variables, immune ... ...

Abstract	Objective An experiment was conducted to determine the effects of supplementing graded concentrations of inorganic sulphur (S) without and with folic acid (FA) in maize-soybean meal diets on performance, slaughter and anti-oxidant variables, immune responses and serum protein fractions in broiler chicken. Methods Inorganic S was supplemented at 0.05%, 0.10%, 0.15%, and 0.20% alone or in combination with FA (4 mg/kg) in basal diet (BD) containing no supplemental methionine (Met) and FA. A control group was fed with the recommended concentration of Met. Each diet was offered to 10 pens of 5 male broiler chicks (Cobb 400) and fed ad libitum from day 1 to 42. Results The broilers fed the BD had lower body weight gain (BWG), feed efficiency (FE), higher lipid peroxidation (LP), lower activity of glutathione peroxidase (GSHPx), lower lymphocyte proliferation ratio (LPR), and reduced concentrations of total protein, albumin, and globulin in serum. Supplementation of FA and S to the BD improved the BWG (all concentrations of S) and FE (0.20% S) similar to the control group. Similarly, the combination of S and FA significantly improved the concentrations of total protein, albumin, and globulin in serum, reduced the LP and increased the activity of GSHPx and LPR. However, responses in the above parameters were related to the concentration of S in the diet. The slaughter variables and antibody titres against the Newcastle disease were not affected with the treatments. Conclusion Based on the results, it is concluded that the combination of S (0.2%) and FA (4 mg/kg) improved the BWG and FE, similarly supplementation of these nutrients improved the concentration of protein fractions and reduced the stress (reduced LP and improved GSHPx) variables in serum and improved the cell mediated immune response (LPR) in broilers fed sub-optimal concentrations of Met in diet.
Keywords	broiler chicken ; methionine ; sulfur ; folic acid ; body weight ; anti-oxidant variables ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Asian-Australasian Association of Animal Production Societies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Supplementation of sulfur and folic acid improves performance of broiler chicken fed suboptimal concentrations of dietary methionine

Rao, Savaram Venkata Rama / Raju, Mantena Venkata Lakshmi Narasimha / Srilatha, Thota / Nagalakshmi, Devanaboyina / Rajkumar, Ullengala

Journal of the science of food and agriculture. 2022 Oct., v. 102, no. 13

2022

Abstract: BACKGROUND: Supplementation of sulfur (S) and folic acid (FA) are known to spare the dietary requirement of methionine (Met) in chicken. An experiment was conducted to determine the effects of feeding graded concentrations of FA (0, 2, 4, 6, 8 mg kg⁻¹) ... ...

Abstract	BACKGROUND: Supplementation of sulfur (S) and folic acid (FA) are known to spare the dietary requirement of methionine (Met) in chicken. An experiment was conducted to determine the effects of feeding graded concentrations of FA (0, 2, 4, 6, 8 mg kg⁻¹) and two concentrations of S (0 and 2 g kg⁻¹) in 5 × 2 factorial design. Diet without FA and S was considered as negative control (NC). Another diet with the recommended concentration of Met was considered as the positive control (PC). Each diet was offered ad libitum from day 1 to 42 to 10 pens of 20 male chicks each. RESULTS: Broilers fed the NC diet had lower body weight gain (BWG), high feed conversion ratio, lower ready‐to‐cook yield, higher lipid peroxidation and reduced concentrations of protein and albumin in serum. BWG improved with FA at day 21 and showed a trend of improvement at day 42. Similarly, BWG improved with S supplementation at day 42. The FA and S interaction indicated a significant reduction in lipid peroxidation with S supplementation at the majority of FA levels. Serum protein fractions increased with increased dietary FA content and increased further with S supplementation. CONCLUSION: Based on the results, it is concluded that the combination of FA (4 mg kg⁻¹) and S (2 g kg⁻¹) improved BWG. Similarly, the feed efficiency with 6 mg FA alone or with S was similar to the PC group. The improvement was probably due to the increase in protein accretion and reduction in lipid peroxidation with FA and S supplementation. © 2022 Society of Chemical Industry.
Keywords	agriculture ; albumins ; blood proteins ; blood serum ; body weight changes ; broiler chickens ; diet ; feed conversion ; folic acid ; lipid peroxidation ; males ; methionine ; nutrient requirements ; ready-to-cook foods ; sulfur
Language	English
Dates of publication	2022-10
Size	p. 5720-5728.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.11920
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Article ; Online: Author Correction: Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob

Thota, Lakshmi Narasimha / Ponnusamy, Thiruvelselvan / Philip, Sheena / Lu, Xinjie / Mundkur, Lakshmi

Scientific reports

2018 Volume 8, Issue 1, Page(s) 15974

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

Abstract	A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Language	English
Publishing date	2018-10-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-34060-z
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Article ; Online: Author Correction

Lakshmi Narasimha Thota / Thiruvelselvan Ponnusamy / Sheena Philip / Xinjie Lu / Lakshmi Mundkur

Scientific Reports, Vol 8, Iss 1, Pp 1-

Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apobtm2Sgy/Ldlrtm1Her/J mice

2018 Volume 1

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the ... ...

Abstract	A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Enhancement of performance and anti-oxidant variables in broiler chicken fed diets containing sub-optimal methionine level with graded concentrations of sulphur and folic acid.

Savaram, Venkata Rama Rao / Mantena, Venkata Lakshmi Narasimha Raju / Paul, Shyam Sunder / Devanaboyina, Nagalakshmi / Thota, Srilatha / Bhukya, Prakash / Ullengala, Rajkumar

Animal bioscience

2021 Volume 35, Issue 5, Page(s) 721–729

Abstract: Objective: An experiment was conducted to determine the effects of supplementing graded concentrations of inorganic sulphur (S) without and with folic acid (FA) in maize-soybean meal diets on performance, slaughter and anti-oxidant variables, immune ... ...

Abstract	Objective: An experiment was conducted to determine the effects of supplementing graded concentrations of inorganic sulphur (S) without and with folic acid (FA) in maize-soybean meal diets on performance, slaughter and anti-oxidant variables, immune responses and serum protein fractions in broiler chicken. Methods: Inorganic S was supplemented at 0.05%, 0.10%, 0.15%, and 0.20% alone or in combination with FA (4 mg/kg) in basal diet (BD) containing no supplemental methionine (Met) and FA. A control group was fed with the recommended concentration of Met. Each diet was offered to 10 pens of 5 male broiler chicks (Cobb 400) and fed ad libitum from day 1 to 42. Results: The broilers fed the BD had lower body weight gain (BWG), feed efficiency (FE), higher lipid peroxidation (LP), lower activity of glutathione peroxidase (GSHPx), lower lymphocyte proliferation ratio (LPR), and reduced concentrations of total protein, albumin, and globulin in serum. Supplementation of FA and S to the BD improved the BWG (all concentrations of S) and FE (0.20% S) similar to the control group. Similarly, the combination of S and FA significantly improved the concentrations of total protein, albumin, and globulin in serum, reduced the LP and increased the activity of GSHPx and LPR. However, responses in the above parameters were related to the concentration of S in the diet. The slaughter variables and antibody titres against the Newcastle disease were not affected with the treatments. Conclusion: Based on the results, it is concluded that the combination of S (0.2%) and FA (4 mg/kg) improved the BWG and FE, similarly supplementation of these nutrients improved the concentration of protein fractions and reduced the stress (reduced LP and improved GSHPx) variables in serum and improved the cell mediated immune response (LPR) in broilers fed sub-optimal concentrations of Met in diet.
Language	English
Publishing date	2021-08-25
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2765-0189
ISSN	2765-0189
DOI	10.5713/ab.21.0258
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