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  1. Article ; Online: IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration.

    Adamopoulos, Iannis E / Kuchroo, Vijay

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 9, Page(s) 535–536

    MeSH term(s) Humans ; Interleukin-17 ; Inflammation ; Cytokines ; Homeostasis ; Regeneration
    Chemical Substances Interleukin-17 ; Cytokines
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-01004-5
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    Zs.A 6338: Show issues Location:
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  2. Article ; Online: Innate immune memory in inflammatory arthritis.

    Jeljeli, Maxime M / Adamopoulos, Iannis E

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 10, Page(s) 627–639

    Abstract: The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was observed during the plague of Athens. Immunological memory has been linked with the adaptive features of T and B cells; however, in the ...

    Abstract The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was observed during the plague of Athens. Immunological memory has been linked with the adaptive features of T and B cells; however, in the past decade, evidence has demonstrated that innate immune cells can exhibit memory, a phenomenon called 'innate immune memory' or 'trained immunity'. Innate immune memory is currently being defined and is transforming our understanding of chronic inflammation and autoimmunity. In this Review, we provide an up-to-date overview of the memory-like features of innate immune cells in inflammatory arthritis and the crosstalk between chronic inflammatory milieu and cell reprogramming. Aberrant pro-inflammatory signalling, including cytokines, regulates the metabolic and epigenetic reprogramming of haematopoietic progenitors, leading to exacerbated inflammatory responses and osteoclast differentiation, in turn leading to bone destruction. Moreover, imprinted memory on mature cells including terminally differentiated osteoclasts alters responsiveness to therapies and modifies disease outcomes, commonly manifested by persistent inflammatory flares and relapse following medication withdrawal.
    MeSH term(s) Humans ; Trained Immunity ; Arthritis ; Inflammation ; Autoimmunity ; B-Lymphocytes
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-01009-0
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  3. Article ; Online: Interleukin-17A and Pathologic New Bone Formation: The Myth of Prometheus Revisited.

    Adamopoulos, Iannis E

    Arthritis & rheumatology (Hoboken, N.J.)

    2019  Volume 71, Issue 4, Page(s) 483–485

    MeSH term(s) Humans ; Inflammation ; Interleukin-17 ; Osteogenesis ; Spondylarthritis
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2019-02-18
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.40817
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  4. Article ; Online: Autophagy pathways in autoimmune diseases.

    Keller, Christian W / Adamopoulos, Iannis E / Lünemann, Jan D

    Journal of autoimmunity

    2023  Volume 136, Page(s) 103030

    Abstract: Autophagy comprises a growing range of cellular pathways, which occupy central roles in response to energy deprivation, organelle turnover and proteostasis. Over the years, autophagy has been increasingly linked to governing several aspects of immunity, ... ...

    Abstract Autophagy comprises a growing range of cellular pathways, which occupy central roles in response to energy deprivation, organelle turnover and proteostasis. Over the years, autophagy has been increasingly linked to governing several aspects of immunity, including host defence against various pathogens, unconventional secretion of cytokines and antigen presentation. While canonical autophagy-mediated antigen processing in thymic epithelial cells supports the generation of a self-tolerant CD4
    MeSH term(s) Animals ; Autoimmune Diseases/therapy ; Autophagy ; Lupus Erythematosus, Systemic/therapy ; Arthritis, Rheumatoid ; Histocompatibility Antigens Class II/metabolism ; Autoantigens
    Chemical Substances Histocompatibility Antigens Class II ; Autoantigens
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2023.103030
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  5. Article ; Online: IL-23 Inhibition in Ankylosing Spondylitis: Where Did It Go Wrong?

    Baeten, Dominique / Adamopoulos, Iannis E

    Frontiers in immunology

    2021  Volume 11, Page(s) 623874

    Abstract: Axial spondyloarthritis is a prevalent form of chronic arthritis which is related to psoriatic arthritis and skin psoriasis. TNF and IL-17A as well as IL-17F are key cytokines contributing to the pathobiology of this disease, as evidence by the ... ...

    Abstract Axial spondyloarthritis is a prevalent form of chronic arthritis which is related to psoriatic arthritis and skin psoriasis. TNF and IL-17A as well as IL-17F are key cytokines contributing to the pathobiology of this disease, as evidence by the therapeutic efficacy of inhibition of these factors. Despite the evidence that IL-23 acts as an upstream driver of Th17 cells, the T lymphocytes producing IL-17, and that IL-23 inhibition shows profound efficacy in psoriasis, blocking IL-23 failed to show any evidence of clinical efficacy in axial spondyloarthritis. In this viewpoint article, we revisit the reasons-to-believe in a role of IL-23 in the pathobiology of axial spondyloarthritis, discuss what we have learned on the pathobiology of this disease in general and on the function of the IL-23/IL-17 axis in particular, and share a handful of lessons learned that are of relevance for the translation of emerging biological insights into clinical therapeutics.
    MeSH term(s) Humans ; Interleukin-17/immunology ; Interleukin-23/antagonists & inhibitors ; Interleukin-23/immunology ; Spondylitis, Ankylosing/immunology ; Spondylitis, Ankylosing/pathology ; Spondylitis, Ankylosing/therapy ; Th17 Cells/immunology ; Th17 Cells/pathology
    Chemical Substances IL17A protein, human ; IL17F protein, human ; Interleukin-17 ; Interleukin-23
    Language English
    Publishing date 2021-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.623874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Axial spondyloarthritis: new advances in diagnosis and management.

    Ritchlin, Christopher / Adamopoulos, Iannis E

    BMJ (Clinical research ed.)

    2021  Volume 372, Page(s) m4447

    Abstract: Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton associated with significant pain and disability. Previously, the diagnosis of ankylosing spondylitis required advanced changes on plain radiographs of the sacroiliac joints. ...

    Abstract Axial spondyloarthritis (axSpA) is an inflammatory disease of the axial skeleton associated with significant pain and disability. Previously, the diagnosis of ankylosing spondylitis required advanced changes on plain radiographs of the sacroiliac joints. Classification criteria released in 2009, however, identified a subset of patients, under the age of 45, with back pain for more than three months in the absence of radiographic sacroiliitis who were classified as axSpA based on a positive magnetic resonance imaging or HLAB27 positivity and specific clinical features. This subgroup was labeled non-radiographic (nr)-axSpA. These patients, compared with those identified by the older New York criteria, contained a larger percentage of women and demonstrated less structural damage. However, their clinical manifestations and response to biologics were similar to radiographic axSpA. The discovery of the interleukin (IL) IL-23/IL-17 pathway revealed key molecules involved in the pathophysiology of axSpA. This discovery propelled the generation of antibodies directed toward IL-17A, which are highly effective and demonstrate treatment responses in axSpA that are similar to those observed with anti-TNF agents. The finding that agents that block IL-23 were not effective in axSpA came as a surprise and the potential underlying mechanisms underlying this lack of response are discussed. New agents with dual inhibition of the IL-17A and F isoforms and some oral small molecule agents that target the Jak-STAT pathway, have also shown efficacy in axSpA.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Exercise Therapy/methods ; HLA-B27 Antigen/blood ; Humans ; Interleukin-17 ; Interleukins ; Magnetic Resonance Imaging ; Spondylitis, Ankylosing/classification ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/physiopathology ; Spondylitis, Ankylosing/therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; HLA-B27 Antigen ; IL17A protein, human ; Interleukin-17 ; Interleukins ; MYDGF protein, human
    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m4447
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  7. Article ; Online: Inflammation in bone physiology and pathology.

    Adamopoulos, Iannis E

    Current opinion in rheumatology

    2017  Volume 30, Issue 1, Page(s) 59–64

    Abstract: Purpose of review: Bone is constantly being remodeled throughout adult life through constant anabolic and catabolic actions that maintain tissue homeostasis. A number of hormones, cytokines growth factors, and the proximity of various cells to bone ... ...

    Abstract Purpose of review: Bone is constantly being remodeled throughout adult life through constant anabolic and catabolic actions that maintain tissue homeostasis. A number of hormones, cytokines growth factors, and the proximity of various cells to bone surfaces influence this process. Inflammatory changes at the bone microenvironment result in alterations leading to both excessive bone loss and bone formation. Detailed understanding of the physiological and pathological mechanisms that dictate these changes will allow us to harness inflammatory signals in bone regeneration.
    Recent findings: Recent reports have suggested that inflammatory signals are able to stimulate transcription factors that regulate osteoblast differentiation from their precursors.
    Summary: In this review, we summarized current understanding of the roles of inflammation in bone resorption and bone formation, which give rise to different disorders and discuss the huge potential of harnessing these inflammatory signals to achieve bone regeneration.
    MeSH term(s) Animals ; Bone Remodeling/immunology ; Bone Resorption/immunology ; Bone and Bones/immunology ; Cell Differentiation/immunology ; Cytokines/immunology ; Humans ; Inflammation/immunology ; Osteoblasts/cytology ; Osteoblasts/immunology ; Osteoclasts/cytology ; Osteoclasts/immunology ; Osteogenesis/immunology ; Transcription Factors/metabolism
    Chemical Substances Cytokines ; Transcription Factors
    Language English
    Publishing date 2017-10-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000449
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    Zs.A 3028: Show issues Location:
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  8. Article ; Online: Go with the flow-hidden vascular passages in bone.

    Ritchlin, Christopher / Adamopoulos, Iannis E

    Nature metabolism

    2019  Volume 1, Issue 2, Page(s) 173–174

    Abstract: The circulatory system in long bones is incompletely understood. A new study published ... ...

    Abstract The circulatory system in long bones is incompletely understood. A new study published in
    Language English
    Publishing date 2019-01-21
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-018-0024-5
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  9. Article ; Online: Psoriatic arthritis under the influence of IFNγ.

    Dai, Hui / Adamopoulos, Iannis E

    Clinical immunology (Orlando, Fla.)

    2020  Volume 218, Page(s) 108513

    Abstract: Psoriasis is a common multifactorial autoimmune disease of the skin, and in a large percentage of patients, immune responses involve nail and joint pathology, which develop psoriatic arthritis (PsA). Historically, T helper 1 (Th1)-derived-IFN-γ was ... ...

    Abstract Psoriasis is a common multifactorial autoimmune disease of the skin, and in a large percentage of patients, immune responses involve nail and joint pathology, which develop psoriatic arthritis (PsA). Historically, T helper 1 (Th1)-derived-IFN-γ was abundantly detected in psoriatic skin and its correlation with development and severity of PsO, led to an early classification of psoriasis as a Th1-mediated disease. Investigations of the cellular and molecular mechanisms of PsO pathogenesis in recent years, together with impressive results of biologics against interleukin 17A (IL-17) have shifted focus on IL-17A. However, the contributions of IFN-γ in IL-17 induced pathology and its involvement in the development of PsA have been largely overshadowed. This review summarizes the current knowledge on IFN-γ and provides new insights on the contribution of IFN-γ to PsO and PsA disease pathogenesis and development.
    MeSH term(s) Animals ; Arthritis, Psoriatic/immunology ; Bone Resorption/immunology ; Humans ; Immunity, Innate ; Interferon-gamma/immunology ; Interleukin-17/immunology ; Synovitis/immunology
    Chemical Substances Interleukin-17 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108513
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    Zs.A 880: Show issues Location:
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  10. Article: Autoimmune or Autoiflammatory? Bad to the Bone.

    Adamopoulos, Iannis E

    International journal of clinical rheumatology

    2015  Volume 10, Issue 1, Page(s) 5–7

    Language English
    Publishing date 2015-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2596494-X
    ISSN 1758-4280 ; 1758-4272
    ISSN (online) 1758-4280
    ISSN 1758-4272
    DOI 10.2217/ijr.15.1
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