Article ; Online: Immune response in SARS-CoV-2 infection: the role of interferons type I and type III.
2020 Volume 24, Issue 5, Page(s) 428–433
Abstract: Background: There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases.: Objective: To review the available evidence on the role of interferons ... ...
| Abstract | Background: There is scarce information on the human immune response to the SARS-CoV-2 infection, and on the exacerbated inflammatory reaction observed in severe COVID-19 cases. Objective: To review the available evidence on the role of interferons type I and type III to SARS-CoV-2 infection. Methods: We reviewed the available published evidence on the role of immune response to SARS-CoV-2 infection as well as recent publications on characteristics and outcomes of COVID-19, and their relationship with interferons type I and type III. Results: The available data indicates that immune response plays an important role in controlling SARS-CoV-2 infection and the immune dysregulation can significantly modify the clinical outcomes of affected patients. In addition, the evidence suggests that IFN type I and III can play an important role in controlling viremia and modulating the immune response in COVID-19. Conclusions: Due to their central role in immune response against SARS-CoV-2 infection, IFN type I and III could be considered for treatment of COVID-19. |
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| MeSH term(s) | Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Interferon Type I ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 |
| Chemical Substances | Interferon Type I |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-08-26 |
| Publishing country | Brazil |
| Document type | Journal Article ; Review |
| ZDB-ID | 2041400-6 |
| ISSN | 1678-4391 ; 1413-8670 |
| ISSN (online) | 1678-4391 |
| ISSN | 1413-8670 |
| DOI | 10.1016/j.bjid.2020.07.011 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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