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  1. Article ; Online: Field evaluation the effect of two transgenic Bt maize events on predatory arthropods in the Huang-Huai-Hai summer maize-growing region of China.

    Huang, Jianrong / Li, Guoping / Liu, Bing / Gao, Yu / Wu, Kongming / Feng, Hongqiang

    Environmental entomology

    2024  

    Abstract: ... in the Huang-Huai-Hai summer maize-growing region in China, the abundance of 7 common predator taxa (Geocoris ... the predator community in the Huang-Huai-Hai summer maize-growing region of China. ...

    Abstract To illustrate the impact of genetically modified (GM) Bt maize on the natural enemy communities in the Huang-Huai-Hai summer maize-growing region in China, the abundance of 7 common predator taxa (Geocoris pallidipennis Costa, Harmonia axyridis (Pallas), lacewings, Orius sauteri (Poppius), Propylea japonica (Thunberg), spiders, and Staphylinidae) was quantitatively evaluated by comparing Bt-Cry1Ab DBN9936 and Bt-Cry1Ab/Cry2Aj Ruifeng 125 events to their near non-Bt isolines during the growing season from 2016 to 2019. A total of 10,302, 19,793, 13,536, and 5,672 individuals were observed during 4 years, and the abundance of each taxa on Bt maize varied between sample dates among those arthropod taxa. Shannon-Wiener diversity index of predator communities from 7 taxa showed very similar temporal dynamics and principal response curve analyses to examine community-level effects showed no significant differences in predator abundance in Bt maize compared with non-Bt maize. We conclude that the 2 Bt maize hybrids did not adversely affect the predator community in the Huang-Huai-Hai summer maize-growing region of China.
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 120799-4
    ISSN 1938-2936 ; 0046-2268 ; 0046-225X
    ISSN (online) 1938-2936
    ISSN 0046-2268 ; 0046-225X
    DOI 10.1093/ee/nvae021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Study on the accessibility and affordability of 50 drugs in Wuhan based on the WHO/HAI standardization method.

    Dong, Zuojun / Zhang, Shaoya / Wu, Shuaijun / Xie, Xintong / Sun, Guojun / Yu, Xuanyao

    Frontiers in public health

    2023  Volume 11, Page(s) 1108007

    Abstract: ... by the WHO and Health Action International (HAI), a sample of 50 essential drugs was selected to investigate and ...

    Abstract Objective: To understand the availability and affordability of essential drugs in Wuhan since the implementation of the national essential medicine system, and to provide a basis for the subsequent formulation and improvement of related policies.
    Methods: Using the standard survey method jointly developed by the WHO and Health Action International (HAI), a sample of 50 essential drugs was selected to investigate and evaluate their availability and affordability in public medical and health institutions and social retail pharmacies in Wuhan, using six diseases with high clinical morbidity as the targets.
    Results: The availability of the original drug and the lowest-priced generic drug in public hospitals is 26.4 and 42.47% respectively, and that in retail pharmacies is 26.8 and 54.4% respectively. The median price ratio of the original drug and the lowest-priced generic drug is 28.71 and 2.23 respectively in public hospitals, and 29.24 and 3.59 respectively in retail pharmacies; In addition to individual drugs, such as omeprazole, others are affordable. The availability of essential drugs in public hospitals in Wuhan is lower than that in social retail pharmacies, and the availability of the lowest-priced generic drugs is much higher than that of original drugs.
    Conclusion: The availability of essential drugs in public hospitals in Wuhan is lower than that in social retail pharmacies, and the availability of the lowest-priced generic drugs is much higher than that of original drugs. The price of the original drug is much higher than the international reference price; The price of medicines in public hospitals is lower than that in retail pharmacies;the overall condition of affordability is good, but there is a big gap between the affordability levels of original drugs and generic drugs, and the affordability of original drugs is relatively poor. It is recommended to adjust the relevant policies according to the actual situation of Wuhan city itself, moderately ensure the supply of original drugs, improve the price transparency of retail pharmacies, and ensure that the basic drug needs of the public are met.
    MeSH term(s) Drugs, Generic ; Drugs, Essential ; Health Services Accessibility ; Costs and Cost Analysis ; Reference Standards ; World Health Organization
    Chemical Substances Drugs, Generic ; Drugs, Essential
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1108007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enhancing daily streamflow simulation using the coupled SWAT-BiLSTM approach for climate change impact assessment in Hai-River Basin.

    Zhang, Xianqi / Qi, Yu / Liu, Fang / Li, Haiyang / Sun, Shifeng

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15169

    Abstract: ... severity of flood disasters have been increasing. In recent years, influenced by climate change, the Hai ...

    Abstract Against the backdrop of accelerated global climate change and urbanization, the frequency and severity of flood disasters have been increasing. In recent years, influenced by climate change, the Hai-River Basin (HRB) has experienced multiple large-scale flood disasters. During the widespread extraordinary flood event from July 28th to August 1st, 2023, eight rivers witnessed their largest floods on record. These events caused significant damage and impact on economic and social development. The development of hydrological models with better performance can help researchers understand the impacts of climate change, provide risk information on different disaster events within watersheds, support decision-makers in formulating adaptive measures, urban planning, and improve flood defense mechanisms to address the ever-changing climate environment. This study examines the potential for enhancing streamflow simulation accuracy in the HRB located in Northeast China by combining the physically-based hydrological model with the data-driven model. Three hybrid models, SWAT-D-BiLSTM, SWAT-C-BiLSTM and SWAT-C-BiLSTM with SinoLC-1, were constructed in this study, in which SWAT was used as a transfer function to simulate the base flow and quick flow generation process based on weather data and spatial features, and BiLSTM was used to directly predict the streamflow according to the base flow and quick flow. In the SWAT-C-BiLSTM model, SWAT parameters with P values less than 0.4 in each hydrological station-controlled watershed were calibrated, while the SWAT-D-BiLSTM model did not undergo calibration. Additionally, this study utilizes both 30 m resolution land use and land cover (LULC) map and the first 1 m resolution LULC map SinoLC-1 as input data for the models to explore the impact on streamflow simulation performance. Among five models, the NSE of SWAT-C-BiLSTM with SinoLC-1 reached 0.93 and the R
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42512-4
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  4. Article ; Online: A novel composite drought index combining precipitation, temperature and evapotranspiration used for drought monitoring in the Huang-Huai-Hai Plain

    Jiale Li / Yu Li / Lei Yin / Quanhua Zhao

    Agricultural Water Management, Vol 291, Iss , Pp 108626- (2024)

    2024  

    Abstract: ... in the Huang-Huai-Hai Plain, it is compared with the PCI, TCI, ETCI and PCACDI (Principal Component Analysis ...

    Abstract Single drought index such as Precipitation Condition Index (PCI), Temperature Condition Index (TCI), Evapotranspiration Condition Index (ETCI) and so on, has a limited capability to indicate drought state. It has been proved that the composite drought index proposed by integrating multiple single drought indices can indicate and predict drought state more efficiently and accurately. This paper presents the Precipitation Temperature Evapotranspiration Drought Index (PTEDI) combining the PCI, TCI and ETCI. The three-dimensional Euclidean PCI-TCI-ETCI space is built, and the PTEDI is defined as the magnitude of the vector in the PCI-TCI-ETCI space. To verify the rationality and effectiveness of the PTEDI as a desired drought index in the Huang-Huai-Hai Plain, it is compared with the PCI, TCI, ETCI and PCACDI (Principal Component Analysis Combined Drought Index), and is evaluated with the Drought Affected/Disaster Area (DAA/DDA) and Net Primary Productivity (NPP). The results indicate that the PTEDI outperforms the PCI, TCI, ETCI and PCACDI, and is highly correlated with the Standardized Precipitation Index (SPI-1) (R = 0.61), Soil Moisture Condition Index (SMCI) (R= 0.56), and NPP (R = 0.56). The time series of the PTEDI and four indices (SPI-1, SMCI, Crop Water Stress Index (CWSI) and Temperature Vegetation Drought Index (TVDI)) exhibits good spatial consistency. The PTEDI has a negative correlation with the DAA/DDA (R < −0.6). Furthermore, to illustrate the applicability of the PTEDI, the drought spatiotemporal variation is analyzed by taking it as a drought index. At the monthly scale, moderate drought occurs most frequently in March and July. At the annual scale, the PTEDI fluctuates between 0.34 and 0.60 without obvious periodicity, and the study area is mainly characterized by mild drought. Moreover, the drought evolution is analyzed by using the timing analysis methods. In conclusion, the PTEDI can be applied to monitor drought effectively.
    Keywords Remote sensing ; Composite drought index ; Spatiotemporal variation ; Irrigation optimization ; Agriculture (General) ; S1-972 ; Agricultural industries ; HD9000-9495
    Subject code 910
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells.

    Barndt, Robert B / Lee, Mon-Juan / Huang, Nanxi / Lu, Dajun D / Lee, See-Chi / Du, Po-Wen / Chang, Chun-Chia / Tsai, Ping-Feng B / Huang, Yu-Siou K / Chang, Hao-Ming / Wang, Jehng-Kang / Lai, Chih-Hsin / Johnson, Michael D / Lin, Chen-Yong

    Human molecular genetics

    2021  Volume 30, Issue 19, Page(s) 1833–1850

    Abstract: Mutations of SPINT2, the gene encoding the integral membrane, Kunitz-type serine inhibitor HAI-2 ... primarily affect the intestine, while sparing many other HAI-2-expressing tissues, causing sodium loss ... previously identified as a HAI-2 target protease in intestinal tissues but not in the skin. In both tissues ...

    Abstract Mutations of SPINT2, the gene encoding the integral membrane, Kunitz-type serine inhibitor HAI-2, primarily affect the intestine, while sparing many other HAI-2-expressing tissues, causing sodium loss in patients with syndromic congenital sodium diarrhea. The membrane-bound serine protease prostasin was previously identified as a HAI-2 target protease in intestinal tissues but not in the skin. In both tissues, the highly related inhibitor HAI-1 is, however, the default inhibitor for prostasin and the type 2 transmembrane serine protease matriptase. This cell-type selective functional linkage may contribute to the organ-selective damage associated with SPINT 2 mutations. To this end, the impact of HAI-2 deletion on matriptase and prostasin proteolysis was, here, compared using Caco-2 human colorectal adenocarcinoma cells and HaCaT human keratinocytes. Greatly enhanced prostasin proteolytic activity with a prolonged half-life and significant depletion of HAI-1 monomer were observed with HAI-2 loss in Caco-2 cells but not HaCaT cells. The constitutive, high level prostasin zymogen activation observed in Caco-2 cells, but not in HaCaT cells, also contributes to the excessive prostasin proteolytic activity caused by HAI-2 loss. HAI-2 deletion also caused increased matriptase zymogen activation, likely as an indirect result of increased prostasin proteolysis. This increase in activated matriptase, however, only had a negligible role in depletion of HAI-1 monomer. Our study suggests that the constitutive, high level of prostasin zymogen activation and the cell-type selective functional relationship between HAI-2 and prostasin renders Caco-2 cells more susceptible than HaCaT cells to the loss of HAI-2, causing a severe imbalance favoring prostasin proteolysis.
    MeSH term(s) Caco-2 Cells ; Epithelial Cells/metabolism ; Humans ; Intestines ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Proteinase Inhibitory Proteins, Secretory/genetics ; Proteinase Inhibitory Proteins, Secretory/metabolism ; Proteolysis ; Serine Endopeptidases
    Chemical Substances Membrane Glycoproteins ; Proteinase Inhibitory Proteins, Secretory ; SPINT2 protein, human ; Serine Endopeptidases (EC 3.4.21.-) ; prostasin (EC 3.4.21.-)
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddab150
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  6. Article ; Online: Utility of self-report antiretroviral adherence for predicting HIV viral load among persons who inject drugs in Hai Phong Vietnam: assessing differences by methamphetamine use.

    Feelemyer, Jonathan / Des Jarlais, Don C / Nagot, Nicolas / Huong, Duong Thi / Oanh, Khuat Thi Hai / Khue, Pham Minh / Thi Giang, Hoang / Tuyet Thanh, Nham Thi / Cleland, Charles M / Arasteh, Kamyar / Caniglia, Ellen / Chen, Yu / Bart, Gavin / Moles, Jean Pierre / Vinh, Vu Hai / Vallo, Roselyne / Quillet, Catherine / Rapoud, Delphine / Le, Sao M /
    Michel, Laurent / Laureillard, Didier / Khan, Maria R

    AIDS care

    2023  Volume 36, Issue 4, Page(s) 553–560

    Abstract: ... ...

    Abstract ABSTRACT
    MeSH term(s) Humans ; Methamphetamine/therapeutic use ; Self Report ; Substance Abuse, Intravenous/epidemiology ; Substance Abuse, Intravenous/drug therapy ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Vietnam/epidemiology ; Viral Load ; Drug Users ; Cross-Sectional Studies ; Anti-Retroviral Agents/therapeutic use ; Medication Adherence
    Chemical Substances Methamphetamine (44RAL3456C) ; Anti-Retroviral Agents
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2023.2275041
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  7. Article: Grain-filling characteristics and yield formation of wheat in two different soil fertility fields in the Huang-Huai-Hai Plain.

    Zheng, Xuejiao / Yu, Zhenwen / Yu, Fengxin / Shi, Yu

    Frontiers in plant science

    2022  Volume 13, Page(s) 932821

    Abstract: ... for smallholder farming systems in the Huang-Huai-Hai Plain (3HP), which characterized by a large variation ...

    Abstract Clarifying factors that underpinning the variation in wheat yield components between high and middle soil fertility fields is critical to increase grain production and narrow yield gap for smallholder farming systems in the Huang-Huai-Hai Plain (3HP), which characterized by a large variation in soil fertility. Two-year field experiments were conducted to investigate wheat tillering, leaf photosynthesis, and grain filling characteristics in different soil fertility fields: high soil fertility field (HF) and middle soil fertility field (MF). Results showed that the spike formation rate in HF was 12.7%-13.0% higher than that in MF, leading to an 18.0%-19.8% increase in spike number. In addition, HF improved canopy light interception and leaf photosynthesis characteristics after anthesis and delayed leaf senescence, contributing to the increase in both the active grain filling period and grain filling rate. This resulted in a higher 1,000 grain weight in HF, which was 8.2%-8.3% higher than that in MF. Compared to MF, HF obtained higher yields at 9,840 kg ha
    Language English
    Publishing date 2022-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.932821
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  8. Article ; Online: Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity

    Yi-Lin Chiu / Yi-Ying Wu / Robert B. Barndt / Yu-Wen Lin / Hou-Ping Sytwo / Amy Cheng / Kacy Yang / Khee-Siang Chan / Jehng-Kang Wang / Michael D. Johnson / Chen-Yong Lin

    Genes and Diseases, Vol 9, Iss 4, Pp 1049-

    2022  Volume 1061

    Abstract: The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2, can suppress ... in some neoplastic B-cells with high levels of endogenous HAI-2, indicating that HAI-2 may be an ineffective ... in the HAI Teton Daudi Burkitt lymphoma cells, which naturally express matriptase with very low levels of HAI ...

    Abstract The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2, can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase proteolytic activity have, however, been observed in some neoplastic B-cells with high levels of endogenous HAI-2, indicating that HAI-2 may be an ineffective matriptase inhibitor at the cellular level. The different effectiveness of the HAIs in the control of extracellular matriptase proteolytic activity is examined here. Upon inducing matriptase zymogen activation in the HAI Teton Daudi Burkitt lymphoma cells, which naturally express matriptase with very low levels of HAI-2 and no HAI-1, nascent active matriptase was rapidly inhibited or shed as an enzymatically active enzyme. With increasing HAI-1 expression, cellular matriptase-HAI-1 complex increased, and extracellular active matriptase decreased proportionally. Increasing HAI-2 expression, however, resulted in cellular matriptase-HAI-2 complex levels reaching a plateau, while extracellular active matriptase remained high. In contrast to this differential effect, both HAI-1 and HAI-2, even at very low levels, were shown to promote the expression and cell-surface translocation of endogenous matriptase. The difference in the suppression of extracellular active matriptase by the two closely related serine protease inhibitors could result from the primarily cell surface expression of HAI-1 compared to the mainly intracellular localization of HAI-2. The HAIs, therefore, resemble one another with respect to promoting matriptase expression and surface translocation but differ in their effectiveness in the control of extracellular matriptase enzymatic activity.
    Keywords HAI-1 ; HAI-2 ; Matriptase ; Neoplastic B-cells ; Proteolytic activity ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 690
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity.

    Chiu, Yi-Lin / Wu, Yi-Ying / Barndt, Robert B / Lin, Yu-Wen / Sytwo, Hou-Ping / Cheng, Amy / Yang, Kacy / Chan, Khee-Siang / Wang, Jehng-Kang / Johnson, Michael D / Lin, Chen-Yong

    Genes & diseases

    2020  Volume 9, Issue 4, Page(s) 1049–1061

    Abstract: The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2, can suppress ... in some neoplastic B-cells with high levels of endogenous HAI-2, indicating that HAI-2 may be an ineffective ... in the HAI Teton Daudi Burkitt lymphoma cells, which naturally express matriptase with very low levels of HAI ...

    Abstract The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2, can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase proteolytic activity have, however, been observed in some neoplastic B-cells with high levels of endogenous HAI-2, indicating that HAI-2 may be an ineffective matriptase inhibitor at the cellular level. The different effectiveness of the HAIs in the control of extracellular matriptase proteolytic activity is examined here. Upon inducing matriptase zymogen activation in the HAI Teton Daudi Burkitt lymphoma cells, which naturally express matriptase with very low levels of HAI-2 and no HAI-1, nascent active matriptase was rapidly inhibited or shed as an enzymatically active enzyme. With increasing HAI-1 expression, cellular matriptase-HAI-1 complex increased, and extracellular active matriptase decreased proportionally. Increasing HAI-2 expression, however, resulted in cellular matriptase-HAI-2 complex levels reaching a plateau, while extracellular active matriptase remained high. In contrast to this differential effect, both HAI-1 and HAI-2, even at very low levels, were shown to promote the expression and cell-surface translocation of endogenous matriptase. The difference in the suppression of extracellular active matriptase by the two closely related serine protease inhibitors could result from the primarily cell surface expression of HAI-1 compared to the mainly intracellular localization of HAI-2. The HAIs, therefore, resemble one another with respect to promoting matriptase expression and surface translocation but differ in their effectiveness in the control of extracellular matriptase enzymatic activity.
    Language English
    Publishing date 2020-12-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2020.12.001
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  10. Article ; Online: Association between recent methamphetamine use, antiretroviral therapy and HIV viral load; a mediation analysis from a cohort of HIV positive persons who inject drugs in Hai Phong, Vietnam.

    Feelemyer, Jonathan / Des Jarlais, Don / Nagot, Nicolas / Duong Thi, Huong / Thi Hai, Oanh Khuat / Pham Minh, Khuê / Hoang Thi, Giang / Nham Thi Tuyet, Thanh / Cleland, Charles M / Arasteh, Kamyar / Caniglia, Ellen / Chen, Yu / Bart, Gavin / Moles, Jean Pierre / Vu Hai, Vinh / Vallo, Roselyne / Quillet, Catherine / Rapoud, Delphine / Sao, Mai Le /
    Michel, Laurent / Laureillard, Didier / Khan, Maria R

    International journal of STD & AIDS

    2023  Volume 34, Issue 4, Page(s) 236–244

    Abstract: ... among people who inject drugs (PWID) in Hai Phong, Vietnam.: Methods: We recruited PWID from October 2016 ...

    Abstract Background: There has been a significant increase in methamphetamine use among persons who use drugs in Vietnam in the last 5-10 years. We examined the degree to which adherence to antiretroviral therapy (ART) mediates the relationship between recent methamphetamine use and unsuppressed HIV viral load among people who inject drugs (PWID) in Hai Phong, Vietnam.
    Methods: We recruited PWID from October 2016-October 2018 and enrolled HIV positive PWID into a cohort, with up to three years of total follow-up. We assessed relationships among recent methamphetamine use frequency, ART adherence and unsuppressed HIV viral load. Mediation analysis was used to estimate the total and natural direct effects of recent methamphetamine use on unsuppressed HIV viral load and the indirect effect proportion.
    Results: We enrolled 792 HIV seropositive PWID into the cohort; approximately 75.9% reported high/perfect ART adherence at baseline and 81.3% were virally suppressed. In mediation analysis, the total effect for the association between methamphetamine use and unsuppressed HIV viral load (1000 copies/mL) was 3.94 (95% CI: 1.95, 7.96); the natural direct effect was 2.14 (95% CI: 1.29, 3.55); the proportion mediated by self-reported ART adherence was 0.444. Similar results were found when examining lower unsuppressed HIV viral load cutpoints of 250 copies/mL and 500 copies/mL.
    Conclusions: Methamphetamine use is associated with unsuppressed HIV viral load among PWID despite high levels of ART adherence. Further research is needed to better understand these relationships, with emphasis on potential biological pathways that may interact with ART.
    MeSH term(s) Humans ; Methamphetamine ; Drug Users ; Substance Abuse, Intravenous/complications ; Vietnam ; Viral Load ; Mediation Analysis ; HIV Infections/drug therapy ; HIV Seropositivity/complications
    Chemical Substances Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624221142366
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