LIVIVO - Search results -

Search results

Result 1 - 10 of total 23

Search options

Article ; Online: Not lost in host translation: The new roles of long noncoding RNAs in infectious diseases.

Reisacher, Caroline / Arbibe, Laurence

2019 Volume 21, Issue 11, Page(s) e13119

Abstract: Long non-coding RNAs (lncRNAs) play a central role in the regulation of gene expression. Although they were initially described as mRNA-like transcripts not encoding proteins, global approaches such as ribosome profiling have shown that they frequently ... ...

Abstract	Long non-coding RNAs (lncRNAs) play a central role in the regulation of gene expression. Although they were initially described as mRNA-like transcripts not encoding proteins, global approaches such as ribosome profiling have shown that they frequently associate with ribosomes, opening the possibility that lncRNAs are a source of cryptic translation events with functional roles. Recent studies have shed more light on small ORFs borne by lncRNAs and encoding short peptides potentially involved in infectious immunity. This review outlines the main strategies used to determine the coding potential of lncRNAs and discusses our emerging understanding of the implication of the encoded peptides in infectious diseases.
MeSH term(s)	Animals ; Communicable Diseases/genetics ; Communicable Diseases/immunology ; Communicable Diseases/metabolism ; Gene Expression Profiling ; Humans ; Open Reading Frames/genetics ; Peptides/immunology ; Peptides/metabolism ; Protein Biosynthesis/genetics ; Protein Biosynthesis/immunology ; Proteomics ; RNA, Long Noncoding/chemistry ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/immunology ; RNA, Long Noncoding/metabolism ; Ribosomes/metabolism
Chemical Substances	Peptides ; RNA, Long Noncoding
Language	English
Publishing date	2019-10-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1468320-9
ISSN	1462-5822 ; 1462-5814
ISSN (online)	1462-5822
ISSN	1462-5814
DOI	10.1111/cmi.13119
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5288: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: HP1γ Prevents Activation of the cGAS/STING Pathway by Preserving Nuclear Envelope and Genomic Integrity in Colon Adenocarcinoma Cells.

Mata-Garrido, Jorge / Frizzi, Laura / Nguyen, Thien / He, Xiangyan / Chang-Marchand, Yunhua / Xiang, Yao / Reisacher, Caroline / Casafont, Iñigo / Arbibe, Laurence

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Chronic inflammatory processes in the intestine result in serious conditions such as inflammatory bowel disease (IBD) and cancer. An increased detection of cytoplasmic DNA sensors has been reported in the IBD colon mucosa, suggesting their contribution ... ...

Abstract	Chronic inflammatory processes in the intestine result in serious conditions such as inflammatory bowel disease (IBD) and cancer. An increased detection of cytoplasmic DNA sensors has been reported in the IBD colon mucosa, suggesting their contribution in mucosal inflammation. Yet, the mechanisms altering DNA homeostasis and triggering the activation of DNA sensors remain poorly understood. In this study, we show that the epigenetic regulator HP1γ plays a role in preserving nuclear envelope and genomic integrity in enterocytic cells, thereby protecting against the presence of cytoplasmic DNA. Accordingly, HP1 loss of function led to the increased detection of cGAS/STING, a cytoplasmic DNA sensor that triggers inflammation. Thus, in addition to its role as a transcriptional silencer, HP1γ may also exert anti-inflammatory properties by preventing the activation of the endogenous cytoplasmic DNA response in the gut epithelium.
MeSH term(s)	Humans ; Nuclear Envelope/metabolism ; Signal Transduction ; Adenocarcinoma/genetics ; Colonic Neoplasms/genetics ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Inflammation/pathology ; DNA ; Inflammatory Bowel Diseases ; Genomics
Chemical Substances	Nucleotidyltransferases (EC 2.7.7.-) ; DNA (9007-49-2)
Language	English
Publishing date	2023-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087347
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Customizing Host Chromatin: a Bacterial Tale.

Connor, Michael / Arbibe, Laurence / Hamon, Mélanie

Microbiology spectrum

2019 Volume 7, Issue 2

Abstract: Successful bacterial colonizers and pathogens have evolved with their hosts and have acquired mechanisms to customize essential processes that benefit their lifestyle. In large part, bacterial survival hinges on shaping the transcriptional signature of ... ...

Abstract	Successful bacterial colonizers and pathogens have evolved with their hosts and have acquired mechanisms to customize essential processes that benefit their lifestyle. In large part, bacterial survival hinges on shaping the transcriptional signature of the host, a process regulated at the chromatin level. Modifications of chromatin, either on histone proteins or on DNA itself, are common targets during bacterium-host cross talk and are the focus of this article.
MeSH term(s)	Bacteria/growth & development ; Bacteria/metabolism ; Bacteria/pathogenicity ; Bacterial Infections/immunology ; Bacterial Infections/metabolism ; Bacterial Infections/microbiology ; Cell Nucleus/metabolism ; Chromatin/metabolism ; DNA/metabolism ; DNA Methylation ; Histones/metabolism ; Host-Pathogen Interactions/immunology ; Host-Pathogen Interactions/physiology ; Humans
Chemical Substances	Chromatin ; Histones ; DNA (9007-49-2)
Language	English
Publishing date	2019-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2165-0497
ISSN (online)	2165-0497
DOI	10.1128/microbiolspec.BAI-0015-2019
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Immune subversion by chromatin manipulation: a 'new face' of host-bacterial pathogen interaction.

Arbibe, Laurence

Cellular microbiology

2008 Volume 10, Issue 8, Page(s) 1582–1590

Abstract: Bacterial pathogens have evolved various strategies to avoid immune surveillance, depending of their in vivo'lifestyle'. The identification of few bacterial effectors capable to enter the nucleus and modifying chromatin structure in host raises the ... ...

Abstract	Bacterial pathogens have evolved various strategies to avoid immune surveillance, depending of their in vivo'lifestyle'. The identification of few bacterial effectors capable to enter the nucleus and modifying chromatin structure in host raises the fascinating questions of how pathogens modulate chromatin structure and why. Chromatin is a dynamic structure that maintains the stability and accessibility of the host DNA genome to the transcription machinery. This review describes the various strategies used by pathogens to interface with host chromatin. In some cases, chromatin injury can be a strategy to take control of major cellular functions, such as the cell cycle. In other cases, manipulation of chromatin structure at specific genomic locations by modulating epigenetic information provides a way for the pathogen to impose its own transcriptional signature onto host cells. This emerging field should strongly influence our understanding of chromatin regulation at interphase nucleus and may provide invaluable openings to the control of immune gene expression in inflammatory and infectious diseases.
MeSH term(s)	Animals ; Bacteria/immunology ; Bacterial Infections/microbiology ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Host-Pathogen Interactions ; Humans ; Plant Diseases/microbiology ; Plants/microbiology ; Transcription, Genetic
Chemical Substances	Chromatin
Language	English
Publishing date	2008-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1468320-9
ISSN	1462-5822 ; 1462-5814
ISSN (online)	1462-5822
ISSN	1462-5814
DOI	10.1111/j.1462-5822.2008.01170.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5288: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the

Ramond, Elodie / Jamet, Anne / Ding, Xiongqi / Euphrasie, Daniel / Bouvier, Clémence / Lallemant, Louison / He, Xiangyan / Arbibe, Laurence / Coureuil, Mathieu / Charbit, Alain

mBio

2021 Volume 12, Issue 3, Page(s) e0027621

Abstract: Antibiotic-resistant Staphylococcus aureus strains constitute a major public health concern worldwide and are responsible for both health care- and community-associated infections. Here, we establish a robust and easy-to-implement model of oral S. aureus ...

Abstract	Antibiotic-resistant Staphylococcus aureus strains constitute a major public health concern worldwide and are responsible for both health care- and community-associated infections. Here, we establish a robust and easy-to-implement model of oral S. aureus infection using Drosophila melanogaster larvae that allowed us to follow the fate of S. aureus at the whole-organism level as well as the host immune responses. Our study demonstrates that S. aureus infection triggers H
MeSH term(s)	Animals ; Disease Models, Animal ; Drosophila melanogaster/immunology ; Drosophila melanogaster/microbiology ; Gene Expression Regulation, Bacterial ; Host-Pathogen Interactions/immunology ; Immunity, Innate ; Larva/immunology ; Larva/microbiology ; Methicillin-Resistant Staphylococcus aureus/immunology ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Pore Forming Cytotoxic Proteins/genetics ; Pore Forming Cytotoxic Proteins/immunology ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Staphylococcal Infections/immunology ; Staphylococcal Infections/microbiology ; Virulence
Chemical Substances	Pore Forming Cytotoxic Proteins ; Reactive Oxygen Species
Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.00276-21
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Les calpaïnes : un rôle décisif dans la vie et la mort de la niche épithéliale infectée par l'entéropathogène Shigella flexneri.

Bergounioux, Jean / Arbibe, Laurence

Medecine sciences : M/S

2012 Volume 28, Issue 12, Page(s) 1029–1031

Title translation	Calpain activation by Shigella flexneri regulates key steps in the life and death of bacterium's epithelial niche.
MeSH term(s)	Animals ; Calpain/metabolism ; Calpain/physiology ; Dysentery, Bacillary/metabolism ; Dysentery, Bacillary/microbiology ; Dysentery, Bacillary/pathology ; Enzyme Activation/physiology ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Microbial Viability ; Models, Biological ; Shigella flexneri/growth & development ; Shigella flexneri/physiology ; Signal Transduction
Chemical Substances	Calpain (EC 3.4.22.-)
Language	French
Publishing date	2012-12
Publishing country	France
Document type	News
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/20122812002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Immune subversion by chromatin manipulation: a 'new face' of host-bacterial pathogen interaction

Arbibe, Laurence

Cellular microbiology. 2008 Aug., v. 10, no. 8

2008

Abstract	Bacterial pathogens have evolved various strategies to avoid immune surveillance, depending of their in vivo'lifestyle'. The identification of few bacterial effectors capable to enter the nucleus and modifying chromatin structure in host raises the fascinating questions of how pathogens modulate chromatin structure and why. Chromatin is a dynamic structure that maintains the stability and accessibility of the host DNA genome to the transcription machinery. This review describes the various strategies used by pathogens to interface with host chromatin. In some cases, chromatin injury can be a strategy to take control of major cellular functions, such as the cell cycle. In other cases, manipulation of chromatin structure at specific genomic locations by modulating epigenetic information provides a way for the pathogen to impose its own transcriptional signature onto host cells. This emerging field should strongly influence our understanding of chromatin regulation at interphase nucleus and may provide invaluable openings to the control of immune gene expression in inflammatory and infectious diseases.
Language	English
Dates of publication	2008-08
Size	p. 1582-1590.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	1468320-9
ISSN	1462-5822 ; 1462-5814
ISSN (online)	1462-5822
ISSN	1462-5814
DOI	10.1111/j.1462-5822.2008.01170.x
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 5288: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis.

Mata-Garrido, Jorge / Xiang, Yao / Chang-Marchand, Yunhua / Reisacher, Caroline / Ageron, Elisabeth / Guerrera, Ida Chiara / Casafont, Iñigo / Bruneau, Aurelia / Cherbuy, Claire / Treton, Xavier / Dumay, Anne / Ogier-Denis, Eric / Batsché, Eric / Costallat, Mickael / Revêchon, Gwladys / Eriksson, Maria / Muchardt, Christian / Arbibe, Laurence

Nature communications

2022 Volume 13, Issue 1, Page(s) 6834

Abstract: Defects in RNA splicing have been linked to human disorders, but remain poorly explored in inflammatory bowel disease (IBD). Here, we report that expression of the chromatin and alternative splicing regulator HP1γ is reduced in ulcerative colitis (UC). ... ...

Abstract	Defects in RNA splicing have been linked to human disorders, but remain poorly explored in inflammatory bowel disease (IBD). Here, we report that expression of the chromatin and alternative splicing regulator HP1γ is reduced in ulcerative colitis (UC). Accordingly, HP1γ gene inactivation in the mouse gut epithelium triggers IBD-like traits, including inflammation and dysbiosis. In parallel, we find that its loss of function broadly increases splicing noise, favoring the usage of cryptic splice sites at numerous genes with functions in gut biology. This results in the production of progerin, a toxic splice variant of prelamin A mRNA, responsible for the Hutchinson-Gilford Progeria Syndrome of premature aging. Splicing noise is also extensively detected in UC patients in association with inflammation, with progerin transcripts accumulating in the colon mucosa. We propose that monitoring HP1γ activity and RNA splicing precision can help in the management of IBD and, more generally, of accelerated aging.
MeSH term(s)	Humans ; Mice ; Animals ; Chromobox Protein Homolog 5 ; Colitis, Ulcerative/genetics ; RNA Splicing/genetics ; Progeria/genetics ; Progeria/metabolism ; Inflammation
Chemical Substances	Chromobox Protein Homolog 5 (107283-02-3)
Language	English
Publishing date	2022-11-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-34556-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Targeting of chromatin readers: a novel strategy used by the

Harouz, Habiba / Rachez, Christophe / Meijer, Benoit / Muchardt, Christian / Arbibe, Laurence

Microbial cell (Graz, Austria)

2014 Volume 2, Issue 1, Page(s) 26–28

Abstract: ... Shigella ... ...

Abstract	Shigella flexneri
Language	English
Publishing date	2014-12-28
Publishing country	Austria
Document type	Journal Article ; Comment
ZDB-ID	2814756-X
ISSN	2311-2638
ISSN	2311-2638
DOI	10.15698/mic2015.01.183
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy.

Arbibe, Laurence / Sansonetti, Philippe J

Cell host & microbe

2007 Volume 1, Issue 4, Page(s) 244–246

Abstract: Tolerance to lipopolysaccharide (LPS) is part of the host's strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit ... ...

Abstract	Tolerance to lipopolysaccharide (LPS) is part of the host's strategy to avoid harmful excessive inflammation in the presence of Gram-negative commensals and pathogens. Macrophages are the major cells endowed with this property, allowing them to limit expression of proinflammatory genes while maintaining efficient antimicrobial functions. In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation.
MeSH term(s)	Cytokines/physiology ; Drug Design ; Drug Tolerance ; Gene Expression Regulation ; Humans ; Inflammation/prevention & control ; Lipopolysaccharides/toxicity ; Toll-Like Receptor 4/physiology ; Toll-Like Receptors/physiology
Chemical Substances	Cytokines ; Lipopolysaccharides ; TLR4 protein, human ; Toll-Like Receptor 4 ; Toll-Like Receptors
Language	English
Publishing date	2007-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2007.05.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6578: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito