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Article ; Online: Immune suppression in head and neck cancers: a review.

Duray, Anaëlle / Demoulin, Stéphanie / Hubert, Pascale / Delvenne, Philippe / Saussez, Sven

2011 Volume 2010, Page(s) 701657

Abstract: Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained ... ...

Abstract	Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis.
MeSH term(s)	Animals ; Apoptosis ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/immunology ; Carcinoma, Squamous Cell/physiopathology ; HLA Antigens/genetics ; HLA Antigens/metabolism ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/immunology ; Head and Neck Neoplasms/physiopathology ; Humans ; Immunosuppression ; Macrophages/immunology ; Neovascularization, Pathologic ; T-Lymphocytes/immunology ; Tumor Escape ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	HLA Antigens ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2011-03-10
Publishing country	Egypt
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2119646-1
ISSN	1740-2530 ; 1740-2522
ISSN (online)	1740-2530
ISSN	1740-2522
DOI	10.1155/2010/701657
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Article ; Online: Immune Suppression in Head and Neck Cancers

Anaëlle Duray / Stéphanie Demoulin / Pascale Hubert / Philippe Delvenne / Sven Saussez

Clinical and Developmental Immunology, Vol

A Review

2010 Volume 2010

Abstract	Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis.
Keywords	Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Immunologic diseases. Allergy ; RC581-607
Subject code	610
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article: Cervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion.

Demoulin, Stéphanie A / Somja, Joan / Duray, Anaëlle / Guénin, Samuel / Roncarati, Patrick / Delvenne, Philippe O / Herfs, Michael F / Hubert, Pascale M

Oncoimmunology

2015 Volume 4, Issue 6, Page(s) e1008334

Abstract: The progression of genital human papillomavirus (HPV) infections into preneoplastic lesions suggests that infected/malignant cells are not adequately recognized by the immune system. In this study, we demonstrated that cervical/vulvar cancer cells ... ...

Abstract	The progression of genital human papillomavirus (HPV) infections into preneoplastic lesions suggests that infected/malignant cells are not adequately recognized by the immune system. In this study, we demonstrated that cervical/vulvar cancer cells secrete factor(s) that affect both the maturation and function of dendritic cells (DC) leading to a tolerogenic profile. Indeed, DC cocultured with cancer cell lines display both a partially mature phenotype after lipopolysaccharide (LPS) maturation and an altered secretory profile (IL-10
Language	English
Publishing date	2015-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-4011
ISSN (online)	2162-402X
ISSN	2162-4011
DOI	10.1080/2162402X.2015.1008334
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Article ; Online: The importance of the tumor microenvironment in the therapeutic management of cancer.

Pottier, Charles / Wheatherspoon, Alodie / Roncarati, Patrick / Longuespée, Rémi / Herfs, Michael / Duray, Anaelle / Delvenne, Philippe / Quatresooz, Pascale

Expert review of anticancer therapy

2015 Volume 15, Issue 8, Page(s) 943–954

Abstract: Tumor prognosis is generally defined by various tumor parameters. However, it is well known that paracrine, endocrine and cell-cell interactions between the tumor and its microenvironment contribute to its growth. The tumor microenvironment (TME) can ... ...

Abstract	Tumor prognosis is generally defined by various tumor parameters. However, it is well known that paracrine, endocrine and cell-cell interactions between the tumor and its microenvironment contribute to its growth. The tumor microenvironment (TME) can also influence disease prognosis and is likely to be considered as an important prognostic factor. In addition, conventional therapies can influence the microenvironment and antitumor immunity. Similarly, the TME will influence the effectiveness of therapy. The purpose of this review is to demonstrate how TME is important in therapeutic management. Key interactions between TME and different cancer therapies as well as their current clinical consequences have been described. More research is needed to establish the important network between tumor cells and their environment to highlight their relationships with conventional therapies and develop global therapeutic strategies.
MeSH term(s)	Animals ; Humans ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Prognosis ; Tumor Microenvironment/immunology ; Tumor Microenvironment/physiology
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1586/14737140.2015.1059279
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Article ; Online: Detection and quantification of human papillomavirus in benign and malignant parotid lesions.

Descamps, Géraldine / Duray, Anaëlle / Rodriguez, Alexandra / Chantrain, Gilbert / Depuydt, Christophe E / Delvenne, Philippe / Saussez, Sven

Anticancer research

2012 Volume 32, Issue 9, Page(s) 3929–3932

Abstract: Background/aim: Human papillomavirus (HPV) is implicated in head and neck squamous cell carcinomas. However, the causal role of HPV in carcinomas of the parotid gland remains uncertain and less documented. This study aimed to determine the potential ... ...

Abstract	Background/aim: Human papillomavirus (HPV) is implicated in head and neck squamous cell carcinomas. However, the causal role of HPV in carcinomas of the parotid gland remains uncertain and less documented. This study aimed to determine the potential implication of HPV in the development of benign and malignant lesions of the parotid gland. Materials and methods: Paraffin-embedded biopsies were obtained from 40 patients with benign parotid gland tumors and from 39 patients with parotid gland carcinomas. The 79 samples were evaluated for the presence of HPV DNA using both GP5+/GP6+ consensus Polymerase Chain Reaction (PCR) and type-specific E6/E7 PCR to detect 18 HPV types. Results: Our results showed a low prevalence of HPV, with only three HPV-positive cases among the 40 benign tumors and one infected carcinoma in the malignant population. Conclusion: No association between the presence of HPV DNA and the development of parotid gland tumors was found in our study.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cyclin-Dependent Kinase Inhibitor p16 ; DNA, Viral/analysis ; DNA, Viral/genetics ; DNA-Binding Proteins/genetics ; Female ; Human papillomavirus 16/genetics ; Human papillomavirus 16/isolation & purification ; Human papillomavirus 18/genetics ; Human papillomavirus 18/isolation & purification ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Oncogene Proteins, Viral/genetics ; Papillomavirus Infections/metabolism ; Papillomavirus Infections/pathology ; Papillomavirus Infections/virology ; Parotid Neoplasms/metabolism ; Parotid Neoplasms/pathology ; Parotid Neoplasms/virology ; Young Adult
Chemical Substances	CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; DNA, Viral ; DNA-Binding Proteins ; E6 protein, Human papillomavirus type 18 ; E7 protein, Human papillomavirus type 18 ; Neoplasm Proteins ; Oncogene Proteins, Viral
Language	English
Publishing date	2012-09-17
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Article ; Online: Galectin fingerprinting in naso-sinusal diseases.

Duray, Anaëlle / De Maesschalck, Thibault / Decaestecker, Christine / Remmelink, Myriam / Chantrain, Gilbert / Neiveyans, Jennifer / Horoi, Mihaela / Leroy, Xavier / Gabius, Hans-Joachim / Saussez, Sven

Oncology reports

2014 Volume 32, Issue 1, Page(s) 23–32

Abstract: Galectins, a family of endogenous lectins, are multifunctional effectors that act at various sites and can be used in immunohistochemical localization studies of diseased states. Since they form a potentially cooperative and antagonistic network, we ... ...

Abstract	Galectins, a family of endogenous lectins, are multifunctional effectors that act at various sites and can be used in immunohistochemical localization studies of diseased states. Since they form a potentially cooperative and antagonistic network, we tested the hypothesis that histopathological fingerprinting of galectins could refine the molecular understanding of naso-sinusal pathologies. Using non-cross-reactive antibodies against galectin-1, -3, -4, -7, -8 and -9, we characterized the galectin profiles in chronic rhinosinusitis, nasal polyposis, inverted papillomas and squamous cell carcinomas. The expression, signal location and quantitative parameters describing the percentage of positive cells and labeling intensity were assessed for various cases. We discovered that inverted papillomas showed a distinct galectin immunohistochemical profile. Indeed, epithelial overexpression of galectin-3 (p=0.0002), galectin-4 (p<10-6), galectin-7 (p<10-6) and galectin-9 (p<10-6) was observed in inverted papillomas compared to non-malignant diseases. Regarding carcinomas, we observed increased expression of galectin-9 (p<10-6) in epithelial cells compared to non-tumor pathologies. Our results suggest that galectin-3, -4, -7 and -9 could be involved in the biology of inverted papillomas. In addition, we observed that the expression of galectin in naso-sinusal diseases seems to be affected by tumor progression and not inflammatory or allergic phenomena.
MeSH term(s)	Adolescent ; Adult ; Aged ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Child ; Female ; Galectins/metabolism ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Nasal Polyps/metabolism ; Nasal Polyps/pathology ; Papilloma, Inverted/metabolism ; Papilloma, Inverted/pathology ; Paranasal Sinus Neoplasms/metabolism ; Paranasal Sinus Neoplasms/pathology ; Retrospective Studies ; Rhinitis/metabolism ; Rhinitis/pathology ; Sinusitis/metabolism ; Sinusitis/pathology ; Young Adult
Chemical Substances	Biomarkers, Tumor ; Galectins
Language	English
Publishing date	2014-05-23
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2014.3213
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Article: Considering temozolomide as a novel potential treatment for esophageal cancer.

Bruyère, Céline / Lonez, Caroline / Duray, Anaelle / Cludts, Stéphanie / Ruysschaert, Jean-Marie / Saussez, Sven / Yeaton, Paul / Kiss, Robert / Mijatovic, Tatjana

Cancer

2011 Volume 117, Issue 9, Page(s) 2004–2016

Abstract: Background: C-X-C ligand (CXCL) chemokines exert major roles in the biologic aggressiveness of esophageal cancer. In the current study, the authors investigated temozolomide (TMZ)-induced effects on activity of the CXCL chemokine network in human ... ...

Abstract	Background: C-X-C ligand (CXCL) chemokines exert major roles in the biologic aggressiveness of esophageal cancer. In the current study, the authors investigated temozolomide (TMZ)-induced effects on activity of the CXCL chemokine network in human esophageal cancer cells. To the authors' knowledge, TMZ has not been investigated previously in experimental or clinical esophageal cancers. Methods: A complete mapping of CXCL chemokines and their receptor messenger RNA was performed in 2 established human esophageal cancer cell lines (OE21 and OE33) and in 4 surgical samples from patients with esophageal carcinoma. The analyses pointed out the potential importance of CXCL2, and monitoring CXCL2 with quantitative videomicroscopy indicated that its biologic activity was silenced in OE21 esophageal cancer cells. TMZ-mediated antitumor activity was determined in vivo in an OE21 metastatic nude mice xenograft model. Results: The messenger RNA levels of CXC chemokines and their receptors were similar in both cell lines and in the 4 surgical specimens. CXCL2 depletion by small interfering RNA (siRNA) displayed marked effects on the proliferation of transfected OE21 cells. Chronic in vitro TMZ treatment of OE21 and OE33 cells markedly decreased CXCL2 and CXCL3 secretion. In vivo, TMZ induced significant delays in OE21 xenograft tumor development and improved the survival of OE21 xenograft-bearing mice, whereas cisplatin did not. Analyses performed on tissue samples from in vivo experiments revealed that TMZ also impaired tumor angiogenesis. Conclusions: The current study emphasized the role of proangiogenic chemokines in esophageal cancer biology and indicated the possibility of using TMZ as a clinically compatible drug to impair the actions of the CXCL chemokine network in esophageal cancers.
MeSH term(s)	Animals ; Antineoplastic Agents, Alkylating/therapeutic use ; Cell Line, Tumor ; Chemokine CXCL12/genetics ; Chemokine CXCL12/metabolism ; Dacarbazine/analogs & derivatives ; Dacarbazine/therapeutic use ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/metabolism ; Female ; Gene Knockdown Techniques ; Humans ; Mice ; Mice, Nude ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents, Alkylating ; Chemokine CXCL12 ; Cxcl12 protein, mouse ; Dacarbazine (7GR28W0FJI) ; temozolomide (YF1K15M17Y)
Language	English
Publishing date	2011-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.25687
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Article ; Online: ΔNp63 isoform-mediated β-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma.

Suarez-Carmona, Meggy / Hubert, Pascale / Gonzalez, Arnaud / Duray, Anaelle / Roncarati, Patrick / Erpicum, Charlotte / Boniver, Jacques / Castronovo, Vincent / Noel, Agnès / Saussez, Sven / Peulen, Olivier / Delvenne, Philippe / Herfs, Michael

Oncotarget

2014 Volume 5, Issue 7, Page(s) 1856–1868

Abstract: Beside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype in tumorigenesis is still confusing. ... ...

Abstract	Beside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype in tumorigenesis is still confusing. Constitutively produced or induced in inflammatory conditions, human beta-defensins (HβDs) are cationic peptides involved in host defenses against bacteria, viruses and fungi. Here, we investigated both the role of p63 proteins in the regulation of HβDs and the implication of these antimicrobial peptides in tumor (lymph)angiogenesis. Thus, in contrast to TAp63 isotypes, we observed that ΔNp63 proteins (α, β, γ) induce HβD1, 2 and 4 expression. Similar results were observed in cancer tissues and cell lines. We next demonstrated that ΔNp63-overexpressing SCC are associated with both a poor prognosis and a high tumor vascularisation and lymphangiogenesis. Moreover, we showed that HβDs exert a chemotactic activity for (lymphatic) endothelial cells in a CCR6-dependent manner. The ability of HβDs to enhance (lymph)angiogenesis in vivo was also evaluated. We observed that HβDs increase the vessel number and induce a significant increase in relative vascular area compared to negative control. Taken together, the results of this study suggest that ΔNp63-regulated HβD could promote tumor (lymph)angiogenesis in SCC microenvironment.
MeSH term(s)	Adult ; Aged ; Carcinoma, Squamous Cell/blood supply ; Carcinoma, Squamous Cell/chemistry ; Carcinoma, Squamous Cell/genetics ; Cell Line, Tumor ; Chemotaxis ; Endothelial Cells ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Head and Neck Neoplasms/blood supply ; Head and Neck Neoplasms/chemistry ; Head and Neck Neoplasms/genetics ; Humans ; Keratinocytes ; Lymphangiogenesis ; Male ; Middle Aged ; Neovascularization, Pathologic/metabolism ; Prognosis ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; Receptors, CCR6/metabolism ; Survival Rate ; Transcription Factors/analysis ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transfection ; Tumor Microenvironment ; Tumor Suppressor Proteins/analysis ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Up-Regulation ; Uterine Cervical Neoplasms/blood supply ; Uterine Cervical Neoplasms/chemistry ; Uterine Cervical Neoplasms/genetics ; beta-Defensins/analysis ; beta-Defensins/genetics ; beta-Defensins/metabolism
Chemical Substances	CCR6 protein, human ; RNA, Messenger ; RNA, Small Interfering ; Receptors, CCR6 ; TP63 protein, human ; Transcription Factors ; Tumor Suppressor Proteins ; beta-Defensins
Language	English
Publishing date	2014-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.1819
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Article ; Online: Human papillomavirus predicts the outcome following concomitant chemoradiotherapy in patients with head and neck squamous cell carcinomas.

Duray, Anaëlle / Descamps, Géraldine / Decaestecker, Christine / Sirtaine, Nicolas / Gilles, André / Khalifé, Mohamad / Chantrain, Gilbert / Depuydt, Christophe E / Delvenne, Philippe / Saussez, Sven

Oncology reports

2013 Volume 30, Issue 1, Page(s) 371–376

Abstract: We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers ... ...

Abstract	We investigated the prevalence of human papillomavirus (HPV) in a clinical series of 72 patients with head and neck squamous cell carcinoma (HNSCC) using a retrospective and prospective study design. The majority of patients were smokers and/or drinkers and were treated with concomitant chemoradiotherapy (CCR). Furthermore, we assessed the impact of HPV positivity on the response to CCR. Paraffin-embedded samples from HNSCC patients (n=72) were evaluated for the presence of HPV DNA using both GP5+/GP6+ consensus PCR and type-specific E6/E7 PCR to detect HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67 and 68. The type-specific E6/E7 PCR demonstrated that 20 out of 69 HNSCC patients (29%) presented with high-risk (HR) HPV types and that 5 of the 69 HNSCC patients (7%) presented with low-risk (LR) HPV types. Using the GP5+/GP6+ PCR, we observed that the rate of response was statistically lower in the HPV+ group (P=0.02). Concerning patient outcomes in terms of recurrence and survival, we observed that the prognosis was poorer for HPV+ patients. We showed for the first time that patients with HPV+ HNSCC present with a worse prognosis after CCR. This observation highlights the need for prospective studies with large numbers of patients and a detailed history of tobacco and alcohol consumption before validating HPV as a marker of prognosis following CCR.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/therapeutic use ; Carboplatin/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/virology ; Cetuximab ; Chemoradiotherapy ; Cisplatin/therapeutic use ; DNA, Viral/analysis ; Female ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/virology ; Humans ; Male ; Middle Aged ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/virology ; Prospective Studies ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck ; Survival Rate ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; DNA, Viral ; Carboplatin (BG3F62OND5) ; Cetuximab (PQX0D8J21J) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2013-04-22
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2013.2415
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Article: Combined analysis of HPV DNA, p16, p21 and p53 to predict prognosis in patients with stage IV hypopharyngeal carcinoma

Ernoux-Neufcoeur, Perle / Arafa, Mohammad / Decaestecker, Christine / Duray, Anaëlle / Remmelink, Myriam / Leroy, Xavier / Herfs, Michael / Somja, Joan / Depuydt, Christophe E / Delvenne, Philippe / Saussez, Sven

Journal of cancer research and clinical oncology. 2011 Jan., v. 137, no. 1

2011

Abstract: Purpose We examined p16, p21 and p53 expression in combination with the presence of human papillomavirus (HPV) DNA as molecular markers to predict survival in patients with stage IV hypopharyngeal squamous cell carcinoma (HSCC). Methods Paraffin-embedded ...

Abstract	Purpose We examined p16, p21 and p53 expression in combination with the presence of human papillomavirus (HPV) DNA as molecular markers to predict survival in patients with stage IV hypopharyngeal squamous cell carcinoma (HSCC). Methods Paraffin-embedded tumours from HSCC patients (n = 75) were evaluated for p16, p21 and p53 expression by immunohistochemistry. HPV DNA was detected by GP5+/6+ consensus PCR and subsequent genotyping by E6/E7 type-specific PCR for HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68. Results Among the 61 specimens that tested positive for the β-globin, HPV typing identified 50 patients with high-risk (hr) HPV types. HPV 16E7 DNA was detected in 74% (37 cases) of these specimens. Twelve patients were found to be infected with multiple HPV types. However, the presence of hrHPV DNA was not found to correlate with the proportion of disease-free patients. The 5-year disease-free survival rate was 73% in p53− tumours versus 48% in p53+ tumours (P = 0.008). Conclusion In our series of patients with stage IV HSCC, the hrHPV+ subgroup had a similar prognosis (in terms of recurrence risk) as the HPV− subgroup. p53 overexpression was associated with a worse prognosis.
Keywords	carcinoma
Language	English
Dates of publication	2011-01
Size	p. 173-181.
Publisher	Springer-Verlag
Publishing place	Berlin/Heidelberg
Document type	Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-010-0871-2
Database	NAL-Catalogue (AGRICOLA)

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