LIVIVO - Search results -

Search results

Result 1 - 10 of total 85

Search options

Article ; Online: A specific module of ESCRT regulates STING activity termination by controlling STING degradation.

Zhao, Yuan / Zhou, Chenxuan / Tian, Wenmin / Chen, Yang / Zhao, Chongchong / Li, Yan / Wang, Shixuan / Rong, Yueguang

2024 Volume 69, Issue 8, Page(s) 1000–1005

MeSH term(s)	Signal Transduction ; Membrane Proteins/metabolism ; Endosomal Sorting Complexes Required for Transport/genetics
Chemical Substances	Membrane Proteins ; Endosomal Sorting Complexes Required for Transport
Language	English
Publishing date	2024-01-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2816140-3
ISSN	2095-9281 ; 2095-9273
ISSN (online)	2095-9281
ISSN	2095-9273
DOI	10.1016/j.scib.2024.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Mapping tree species diversity of temperate forests using multi-temporal Sentinel-1 and -2 imagery

Yanbiao Xi / Wenmin Zhang / Martin Brandt / Qingjiu Tian / Rasmus Fensholt

Science of Remote Sensing, Vol 8, Iss , Pp 100094- (2023)

2023

Abstract: Accurate information on tree species diversity is critical for forest biodiversity, conservation and management, but mapping forest diversity over large and mixed forest areas using satellite remote sensing data remains a challenge because of scale- and ... ...

Abstract	Accurate information on tree species diversity is critical for forest biodiversity, conservation and management, but mapping forest diversity over large and mixed forest areas using satellite remote sensing data remains a challenge because of scale- and ecosystem-dependent relationships between spectral heterogeneity and tree species diversity. In this study, three different diversity indices (Simpson (λ), Shannon (H’), and Pielou (J’)), were tested to characterize forest tree species diversity using individual monthly and multi-temporal Sentinel-1 and -2 images during 2021. The performance of three different machine learning models, Random Forest (RF), Extreme Gradient Boosting (XGB), and Deep Neural Network (DNN) were tested. A collection of 1,020 plot measurements (comprising 47 tree species and 28,122 trees), randomly collected in a mixed broadleaf-conifer forest area in northeast China, was used to train (n = 816) and validate (n = 204) the models. The models dependent on multi-temporal Sentinel-1/2 imagery were found to outperform the models based on individual monthly data, in predicting forest tree species diversity, with average accuracies of 78% for H’, 77% for λ and 77% for J’. The use of DNN performed marginally better than the XGB and RF models, with accuracies of 81% for H’, 80% for λ and 79% for J’, respectively. Finally, a boosted regression model, involving environmental variable predictors and the DNN-based estimated tree species diversity, showed that on average 63 ± 4% of the spatial variations of tree species diversity was explained by environmental variables, including annual temperature (29.30%), followed by soil fertility (27.03%), snow cover (13.63%) and a digital elevation model (12.33%). Our results highlight that an empirical approach based on machine learning and multi-temporal Sentinel-1/2 data can accurately predict forest tree species diversity and we further show the important roles of air temperature and soil fertility in governing the spatial variability of tree species ...
Keywords	Forest diversity ; Sentinel-1&2 ; Deep neural network ; Mixed broadleaf-conifer forest ; Physical geography ; GB3-5030 ; Science ; Q
Subject code	333 ; 580
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Proteomics of Serum Samples for the Exploration of the Pathological Mechanism of Obstetric Antiphospholipid Syndrome.

Zhang, Yinmei / Jin, Shangjia / Tian, Wenmin / Shi, Dongxue / Chen, Yang / Cui, Liyan / Zheng, Jiajia

Journal of proteome research

2023 Volume 23, Issue 1, Page(s) 289–300

Abstract: Obstetric antiphospholipid syndrome (OAPS) is a multisystem disorder characterized by thrombosis or recurrent fetal loss. In this study, we aim to explore the pathological mechanism of OAPS. Herein, we carried out data-independent acquisition (DIA) mass ... ...

Abstract	Obstetric antiphospholipid syndrome (OAPS) is a multisystem disorder characterized by thrombosis or recurrent fetal loss. In this study, we aim to explore the pathological mechanism of OAPS. Herein, we carried out data-independent acquisition (DIA) mass spectrometry quantitative proteomic analysis of serum samples from OAPS patients and healthy controls. A set of 93 differentially expressed proteins was identified, including 75 upregulated and 18 downregulated proteins compared with the levels in controls. Those proteins are enriched in KEGG pathways related to autoimmune diseases, allergic diseases, and pathogen infection. Interestingly, metabolic pathways such as fatty acid degradation and type I diabetes were enriched, indicating that OAPS is metabolic disease related. The significantly increased triglyceride also supported this idea. The differentially expressed proteins insulin-like growth factor-binding protein-1 (IGFBP-1), C-reactive protein (CRP), and ferritin light chain (FTL) were validated by ELISA. Our study presented a deep serum proteomics of OAPS and advanced our understanding of OAPS pathogenesis.
MeSH term(s)	Pregnancy ; Female ; Humans ; Antiphospholipid Syndrome ; Antibodies, Antiphospholipid ; Proteomics ; Pregnancy Complications ; Thrombosis
Chemical Substances	Antibodies, Antiphospholipid
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00554
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6189: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The reduced mortality of malignant melanoma at the population level is mainly attributable to treatment advances for the past decade.

Li, Si / Tang, Tian / Han, Jianglong / Liu, Wenmin / Chen, Ruyan / Deng, Haiyu / Jian, Tingting / Fu, Zhenming

Cancer epidemiology

2024 Volume 88, Page(s) 102515

Abstract: Background: Cutaneous malignant melanoma (CMM) causes most skin cancer deaths in the United States (US). The mortality has been decreasing in the US population. We hypothesize that this population-level reduction is mainly attributable to the treatment ... ...

Abstract	Background: Cutaneous malignant melanoma (CMM) causes most skin cancer deaths in the United States (US). The mortality has been decreasing in the US population. We hypothesize that this population-level reduction is mainly attributable to the treatment advances, rather than the successful primary and secondary prevention. Methods: Using data from the Surveillance, Epidemiology, and End Results (SEER) databases, we collected the incidence, incidence-based mortality (IBM), and 5-year survival (5-YS) rates of CMM from 1994 to 2019. Trends by stage and sex were examined by joinpoint regression analyses and age-period-cohort analyses. Results: The overall incidence of CMM rose by 1.6% yearly from 1994 to 2006 (95% confidence interval [CI]: 0.9% to 2.2%) and then increased with a numerical trend. And we projected the incidence will continue to increase until 2029. In contrast, the IBM for all CMM has decreased yearly by 2.8% (95% CI: -3.9% to -1.8%) since 2010 after continuously increasing by 3.8% annually (95% CI: 3.2% to 4.4%) from 1996 to 2010. For early-stage (localized and regional) CMM, we found the incidence since 2005 plateaued without further increase, while the incidence for CMM at distant stage continuously increased by 1.4% per year (95% CI: 0.9% to 2.0%). Improvements in 5-YS were observed over the study period for all CMM and were most obvious in distant stage. And significant period effects were noted around the year 2010. Conclusion: This study demonstrated improved survival and reduced mortality of CMM at the US population level since 2010, which were consistent with the introduction of novel therapies. Encouraging effects of primary prevention among adolescents in the most recent cohorts were found. However, the plateaued overall incidence and early diagnosis rates indicated that advances in primary and secondary prevention are very much needed to further control the burden of CMM.
MeSH term(s)	Adolescent ; Humans ; United States/epidemiology ; Melanoma/epidemiology ; Melanoma/therapy ; Melanoma/diagnosis ; Skin Neoplasms/epidemiology ; Skin Neoplasms/therapy ; Skin Neoplasms/diagnosis ; Incidence ; Forecasting ; Regression Analysis
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2508729-0
ISSN	1877-783X ; 1877-7821
ISSN (online)	1877-783X
ISSN	1877-7821
DOI	10.1016/j.canep.2023.102515
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1427: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Umbelliferone and scopoletin target tyrosine kinases on fibroblast-like synoviocytes to block NF-κB signaling to combat rheumatoid arthritis.

Chen, Qilei / Zhou, Wenmin / Huang, Yueming / Tian, Yuanyang / Wong, Sum Yi / Lam, Wing Ki / Ying, Ka Yee / Zhang, Jianye / Chen, Hubiao

Frontiers in pharmacology

2022 Volume 13, Page(s) 946210

Abstract: Rheumatoid arthritis (RA) is a complex autoimmune condition primarily affecting synovial joints, which targeted synthetic drugs have damaging safety issues. ...

Abstract	Rheumatoid arthritis (RA) is a complex autoimmune condition primarily affecting synovial joints, which targeted synthetic drugs have damaging safety issues.
Language	English
Publishing date	2022-07-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.946210
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.

Tian, Wenmin / Shi, Dongxue / Zhang, Yinmei / Wang, Hongli / Tang, Haohao / Han, Zhongyu / Wong, Catherine C L / Cui, Liyan / Zheng, Jiajia / Chen, Yang

Communications biology

2024 Volume 7, Issue 1, Page(s) 99

Abstract: Proteins in the plasma/serum mirror an individual's physiology. Circulating extracellular vesicles (EVs) proteins constitute a large portion of the plasma/serum proteome. Thus, deep and unbiased proteomic analysis of circulating plasma/serum ... ...

Abstract	Proteins in the plasma/serum mirror an individual's physiology. Circulating extracellular vesicles (EVs) proteins constitute a large portion of the plasma/serum proteome. Thus, deep and unbiased proteomic analysis of circulating plasma/serum extracellular vesicles holds promise for discovering disease biomarkers as well as revealing disease mechanisms. We established a workflow for simple, deep, and reproducible proteome analysis of both serum large and small EVs enriched fractions by ultracentrifugation plus 4D-data-independent acquisition mass spectrometry (4D-DIA-MS). In our cohort study of obstetric antiphospholipid syndrome (OAPS), 4270 and 3328 proteins were identified from large and small EVs enriched fractions respectively. Both of them revealed known or new pathways related to OAPS. Increased levels of von Willebrand factor (VWF) and insulin receptor (INSR) were identified as candidate biomarkers, which shed light on hypercoagulability and abnormal insulin signaling in disease progression. Our workflow will significantly promote our understanding of plasma/serum-based disease mechanisms and generate new biomarkers.
MeSH term(s)	Pregnancy ; Female ; Humans ; Proteome/metabolism ; Proteomics/methods ; Antiphospholipid Syndrome/metabolism ; Cohort Studies ; Biomarkers ; Extracellular Vesicles/metabolism
Chemical Substances	Proteome ; Biomarkers
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05789-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Hazards and Improvement Measures of Microplastic Pollution

Gan Quan / Tian Jinxiao / Li Zhixin / Mi Shiyu / Wang Wenmin

E3S Web of Conferences, Vol 257, p

A Review

2021 Volume 03006

Abstract: Microplastics is one category of plastics with relatively small diameter and is considered as the common ingredient of waste accumulation zone in oceans. However, since countless plastic products are emitted into oceans annually as waste all around the ... ...

Abstract	Microplastics is one category of plastics with relatively small diameter and is considered as the common ingredient of waste accumulation zone in oceans. However, since countless plastic products are emitted into oceans annually as waste all around the world, pollution caused by them is severe and the resulting problems have attracted attention globally, while current policies and cooperation around the globe for tackling microplastics pollution still need to be improved. To deal with microplatics-related problems in the ocean, our review first discussed the toxicity of microplastics based on previous research related to marine microplastics, which was caused by the plastics themselves and their leaching substances with impacts on marine creatures and human body along the food chain. After summarizing some measures that have been already performed, we suggested that the authority should take more actions to mitigate those problems resulted from microplastics, pay more attention on researching, and encourage citizens to offer their proposals. By finally analyzing the advantages and disadvantages of different handling methods, as well as physical, chemical, and biological treatment technologies on oceanic microplastic issues, our work provided experience on disposing microplastics waste under various actual situations with an example for more holistic waste treatment.
Keywords	Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Remarkable contamination characteristics, potential hazards and source apportionment of heavy metals in surface dust of kindergartens in a northern megacity of China.

Wang, Peng / Han, Guilin / Hu, Jian / Zhang, Qian / Tian, Liyan / Wang, Lingqing / Liu, Tingyi / Ma, Wenmin / Li, Jun / Zheng, Houyi

Journal of hazardous materials

2023 Volume 465, Page(s) 133295

Abstract: It is essential to understand the impact of heavy metals (HMs) present in the surface dust (SD) of kindergartens on children, who are highly sensitive to contaminated dust in cities in their growth stage. A study was conducted on 11 types of HMs present ... ...

Abstract	It is essential to understand the impact of heavy metals (HMs) present in the surface dust (SD) of kindergartens on children, who are highly sensitive to contaminated dust in cities in their growth stage. A study was conducted on 11 types of HMs present in the SD of 73 kindergartens in Beijing. This study aims to assess the pollution levels and sources of eleven HMs in Beijing's kindergartens surface dust (KSD), and estimate the potential health risks in different populations and sources. The results indicate that Cd has the highest contamination in the KSD, followed by Pb, Zn, Ni, Ba, Cr, and Cu. The sources of these pollutants are identified as industrial sources (23.7%), natural sources (22.1%), traffic sources (30.4%), and construction sources (23.9%). Cancer risk is higher in children (4.02E-06) than in adults (8.93E-06). Notably, Cr is the priority pollutant in the KSD, and industrial and construction activities are the main sources of pollution that need to be controlled. The pollution in the central and surrounding areas is primarily caused by historical legacy industrial sites, transportation, urban development, and climate conditions. This work provides guidance to manage the pollution caused by HMs in the KSD of Beijing. ENVIRONMENTAL IMPLICATION: Children within urban populations are particularly sensitive to pollutants present in SD. Prolonged exposure to contaminated SD significantly heightens the likelihood of childhood illnesses. The pollution status and potential health risks of HMs within SD from urban kindergartens are comprehensively investigated. Additionally, the contributions from four primary sources are identified and quantified. Furthermore, a pollution-source-oriented assessment is adopted to clearly distinguish the diverse impacts of different sources on health risks, and the priority pollutants and sources are determined. This work holds pivotal importance for risk management, decision-making, and environmental control concerning HMs in KSD.
MeSH term(s)	Adult ; Child ; Humans ; Dust/analysis ; Environmental Monitoring ; Risk Assessment ; Metals, Heavy/analysis ; Environmental Pollutants/analysis ; Cities ; China ; Soil Pollutants/analysis
Chemical Substances	Dust ; Metals, Heavy ; Environmental Pollutants ; Soil Pollutants
Language	English
Publishing date	2023-12-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.133295
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Proteogenomics Integrating Novel Junction Peptide Identification Strategy Discovers Three Novel Protein Isoforms of Human NHSL1 and EEF1B2.

He, Cuitong / Guo, Jiangtao / Tian, Wenmin / Wong, Catherine C L

Journal of proteome research

2021 Volume 20, Issue 12, Page(s) 5294–5303

Abstract: In eukaryotes, alternative pre-mRNA splicing allows a single gene to encode different protein isoforms that function in many biological processes, and they are used as biomarkers or therapeutic targets for diseases. Although protein isoforms in the human ...

Abstract	In eukaryotes, alternative pre-mRNA splicing allows a single gene to encode different protein isoforms that function in many biological processes, and they are used as biomarkers or therapeutic targets for diseases. Although protein isoforms in the human genome are well annotated, we speculate that some low-abundance protein isoforms may still be under-annotated because most genes have a primary coding product and alternative protein isoforms tend to be under-expressed. A peptide coencoded by a novel exon and an annotated exon separated by an intron is known as a novel junction peptide. In the absence of known transcripts and homologous proteins, traditional whole-genome six-frame translation-based proteogenomics cannot identify novel junction peptides, and it cannot capture novel alternative splice sites. In this article, we first propose a strategy and tool for identifying novel junction peptides, called CJunction, which we then integrate into a proteogenomics process specifically designed for novel protein isoform discovery and apply to the analysis of a deep-coverage HeLa mass spectrometry data set with identifier PXD004452 in ProteomeXchange. We succeeded in identifying and validating three novel protein isoforms of two functionally important genes, NHSL1 (causative gene of Nance-Horan syndrome) and EEF1B2 (translation elongation factor), which validate our hypothesis. These novel protein isoforms have significant sequence differences from the annotated gene-coding products introduced by the novel N-terminal, suggesting that they may play importantly different functions.
MeSH term(s)	Alternative Splicing ; Genome, Human ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Humans ; Mass Spectrometry ; Peptide Elongation Factor 1/genetics ; Peptide Elongation Factor 1/metabolism ; Peptides/chemistry ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Proteins/genetics ; Proteins/metabolism ; Proteogenomics/methods
Chemical Substances	Guanine Nucleotide Exchange Factors ; NHSL1 protein, human ; Peptide Elongation Factor 1 ; Peptides ; Protein Isoforms ; Proteins ; eEF1B-beta protein, human
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.1c00373
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6189: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Quantifying understory vegetation density using multi-temporal Sentinel-2 and GEDI LiDAR data

Xi, Yanbiao / Tian, Qingjiu / Zhang, Wenmin / Zhang, Zhichao / Tong, Xiaoye / Brandt, Martin / Fensholt, Rasmus

GIScience & Remote Sensing. 2022 Dec. 31, v. 59, no. 1 p.2068-2083

2022

Abstract: Understory vegetation contributes considerably to biodiversity and total aboveground biomass of forest ecosystems. Whereas field inventories and LiDAR data are generally used to estimate understory vegetation density, methods for large-scale and ... ...

Abstract	Understory vegetation contributes considerably to biodiversity and total aboveground biomass of forest ecosystems. Whereas field inventories and LiDAR data are generally used to estimate understory vegetation density, methods for large-scale and spatially continuous estimation of understory vegetation density are still lacking. For an evergreen coniferous forest area in southern China, we developed and tested an effective and practical remote sensing-driven approach for mapping understory vegetation, based on phenological differences between over and understory vegetation. Specifically, we used plant area volume density (PAVD) calculations based on GEDI data to train a support vector regression model and subsequently estimated the understory vegetation density from Sentinel-2 derived metrics. We produced maps of PAVD for the growing and non-growing season respectively, both performing well compared against independent GEDI samples (R² = 0.89 and 0.93, p < 0.01). Understory vegetation density was derived from the differences in PAVD between the growing and non-growing season. The understory vegetation density map was validated against field samples from 86 plots showing an overall R² of 0.52 (p < 0.01), rRMSE = 21%. Our study developed a tangible approach to map spatially continuous understory vegetation density with the combination of GEDI LiDAR data and Sentinel-2 imagery, showing the potential to improve the estimation of terrestrial carbon storage and better understand forest ecosystem processes across larger areas.
Keywords	aboveground biomass ; biodiversity ; carbon sequestration ; coniferous forests ; forest ecosystems ; lidar ; phenology ; regression analysis ; understory ; China ; Understory vegetation ; GEDI LiDAR data ; plant area volume density ; support vector regression
Language	English
Dates of publication	2022-1231
Size	p. 2068-2083.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2209042-3
ISSN	1943-7226 ; 1548-1603
ISSN (online)	1943-7226
ISSN	1548-1603
DOI	10.1080/15481603.2022.2148338
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito