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Article ; Online: Régression complète d’une métastase choroïdienne d’un mélanome avec bithérapie ciblée.

Attia, R / Schmid, A / Chaneac, L / Aulanier, A / Natacha, N / David, T

2023

Title translation	Complete regression of a choroidal metastasis from melanoma with dual targeted therapy.
Language	French
Publishing date	2023-09-02
Publishing country	France
Document type	Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2023.07.008
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Article ; Online: Effect of high dose vitamin D supplementation on subsequent immune responses to administration of the live herpes zoster vaccine to long-term care residents.

Levin, Myron J / Ginde, Adit A / Schmid, D Scott / Lang, Nancy / Canniff, Jennifer / Schwartz, Robert S / Weinberg, Adriana

Vaccine

2024 Volume 42, Issue 9, Page(s) 2278–2281

Abstract: ... in which they were randomized to receive either oral daily standard dose (400-1000 IU/day) 25-hydroxy vitamin D ...

Abstract	Thirty-three long-term care residents (mean age 76.5 years), who were participating in a study in which they were randomized to receive either oral daily standard dose (400-1000 IU/day) 25-hydroxy vitamin D (vitamin D3) (SD) or high dose (3000-4000 IU/day) (HD) vitamin D3, were vaccinated with the live, attenuated herpes zoster vaccine. Blood was drawn at vaccination and three weeks later to determine varicella-zoster virus (VZV) antibody and T-cell mediated immune responses. ELISA and neutralizing antibodies increased significantly, but to the same extent, in both groups. The antibody avidity significantly increased from pre- to post-vaccination only in the HD group. VZV-CMI, as measured by FLUOROSPOT significantly increased post-vaccination in both groups, but the difference in interferon-γ spot-forming cells (SFC) and interleukin-2 SFC was lower in the HD than SD group. The increase in VZV-CMI correlated inversely with circulating regulatory T cells in the HD group. We conclude that pre-treatment with HD vitamin D3 does not appreciably enhance the antibody response to a live vaccine and that VZV-CMI responses were diminished in HD vitamin D3 recipients.
MeSH term(s)	Humans ; Aged ; Herpes Zoster Vaccine ; Long-Term Care ; Immunity, Cellular ; Herpesvirus 3, Human ; Herpes Zoster/prevention & control ; Antibodies, Viral ; Vitamin D ; Cholecalciferol ; Vaccines, Attenuated ; Dietary Supplements
Chemical Substances	Herpes Zoster Vaccine ; Antibodies, Viral ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Vaccines, Attenuated
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.055
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Article: Vitamin D ganzheitlich beschrieben

Schmid, Getraud

Naturheilpraxis

2021 Volume 74, Issue 7, Page(s) 24

Language	German
Document type	Article
ZDB-ID	2836713-3
ISSN	2366-4576
Database	Current Contents Medicine

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Article: Myiases d’ici et d’ailleurs : pseudo-furonculose et bactériémie à

Berthod, Delphine / Duss, François-Régis / Palazzuolo, Michele / Eyer, Myriam / Onya, Opota / Aellen, Steve / Bettschart, Vincent / Schmid, Timo / Greub, Gilbert / Troillet, Nicolas

Revue medicale suisse

2020 Volume 16, Issue 710, Page(s) 1932–1936

Abstract: Myiasis is an infestation by maggots. In humans, it predominates in regions with low socio-economic development. We report on two cases of myiasis acquired during a tropical travel and in Switzerland, respectively. The first one presented as a ... ...

Title translation	Myases from here and elsewhere : pseudo-furonculosis and Ignatzschineria larvae bacteremia.
Abstract	Myiasis is an infestation by maggots. In humans, it predominates in regions with low socio-economic development. We report on two cases of myiasis acquired during a tropical travel and in Switzerland, respectively. The first one presented as a furunculous-like disease due to the invasion of subcutaneous tissues by Cordylobia sp. larvae. The second corresponded to a chronic wound infestation that resulted in a rarely reported bacteremia due to Ignatzschineria larvae, a commensal bacteria of maggots' digestive tract. Surgery was necessary in both cases, mainly for psychological reasons in the first case. Both the entomologist and molecular biology were instrumental for treatment decisions.
MeSH term(s)	Animals ; Bacteremia/microbiology ; Diptera/microbiology ; Diptera/pathogenicity ; Gammaproteobacteria/pathogenicity ; Humans ; Larva/pathogenicity ; Myiasis/microbiology ; Myiasis/parasitology ; Switzerland
Language	French
Publishing date	2020-10-15
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Zs.A 5998: Show issues

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Article ; Online: Low Serum Vitamin D Status Is Associated with Incident Alzheimer's Dementia in the Oldest Old.

Melo van Lent, Debora / Egert, Sarah / Wolfsgruber, Steffen / Kleineidam, Luca / Weinhold, Leonie / Wagner-Thelen, Holger / Stoffel-Wagner, Birgit / Bickel, Horst / Wiese, Birgitt / Weyerer, Siegfried / Pentzek, Michael / Jessen, Frank / Schmid, Matthias / Maier, Wolfgang / Scherer, Martin / Riedel-Heller, Steffi G / Ramirez, Alfredo / Wagner, Michael

Nutrients

2022 Volume 15, Issue 1

Abstract: Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive ... A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated ... with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L ...

Abstract	Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.
MeSH term(s)	Aged, 80 and over ; Humans ; Aged ; Alzheimer Disease/epidemiology ; Alzheimer Disease/etiology ; Dementia/epidemiology ; Dementia/etiology ; beta Carotene ; Prospective Studies ; Vitamins ; Vitamin D ; Vitamin A ; Tocopherols ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology
Chemical Substances	beta Carotene (01YAE03M7J) ; Vitamins ; Vitamin D (1406-16-2) ; Vitamin A (11103-57-4) ; Tocopherols (R0ZB2556P8)
Language	English
Publishing date	2022-12-23
Publishing country	Switzerland
Document type	Multicenter Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15010061
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Article ; Online: Potent broadly neutralizing antibody VIR-3434 controls hepatitis B and D virus infection and reduces HBsAg in humanized mice.

Lempp, Florian A / Volz, Tassilo / Cameroni, Elisabetta / Benigni, Fabio / Zhou, Jiayi / Rosen, Laura E / Noack, Julia / Zatta, Fabrizia / Kaiser, Hannah / Bianchi, Siro / Lombardo, Gloria / Jaconi, Stefano / Vincenzetti, Lucia / Imam, Hasan / Soriaga, Leah B / Passini, Nadia / Belnap, David M / Schulze, Andreas / Lütgehetmann, Marc /

Telenti, Amalio / Cathcart, Andrea L / Snell, Gyorgy / Purcell, Lisa A / Hebner, Christy M / Urban, Stephan / Dandri, Maura / Corti, Davide / Schmid, Michael A

Journal of hepatology

2023 Volume 79, Issue 5, Page(s) 1129–1138

Abstract: ... targeting monoclonal antibody (mAb) with the potential to treat chronic hepatitis B and chronic hepatitis D ... hepatitis B or D.: Impact and implications: Chronic infection with hepatitis B virus and co-infection ... with hepatitis D virus place approximately 290 million individuals worldwide at risk of severe liver disease and ...

Abstract	Background & aims: Chronic hepatitis B is a global public health problem, and coinfection with hepatitis delta virus (HDV) worsens disease outcome. Here, we describe a hepatitis B virus (HBV) surface antigen (HBsAg)-targeting monoclonal antibody (mAb) with the potential to treat chronic hepatitis B and chronic hepatitis D. Methods: HBsAg-specific mAbs were isolated from memory B cells of HBV vaccinated individuals. In vitro neutralization was determined against HBV and HDV enveloped with HBsAg representing eight HBV genotypes. Human liver-chimeric mice were treated twice weekly with a candidate mAb starting 3 weeks post HBV inoculation (spreading phase) or during stable HBV or HBV/HDV coinfection (chronic phase). Results: From a panel of human anti-HBs mAbs, VIR-3434 was selected and engineered for pre-clinical development. VIR-3434 targets a conserved, conformational epitope within the antigenic loop of HBsAg and neutralized HBV and HDV infection with higher potency than hepatitis B immunoglobulins in vitro. Neutralization was pan-genotypic against strains representative of HBV genotypes A-H. In the spreading phase of HBV infection in human liver-chimeric mice, a parental mAb of VIR-3434 (HBC34) prevented HBV dissemination and the increase in intrahepatic HBV RNA and covalently closed circular DNA. In the chronic phase of HBV infection or co-infection with HDV, HBC34 treatment decreased circulating HBsAg by >1 log and HDV RNA by >2 logs. Conclusions: The potently neutralizing anti-HBs mAb VIR-3434 reduces circulating HBsAg and HBV/HDV viremia in human liver-chimeric mice. VIR-3434 is currently in clinical development for treatment of patients with chronic hepatitis B or D. Impact and implications: Chronic infection with hepatitis B virus and co-infection with hepatitis D virus place approximately 290 million individuals worldwide at risk of severe liver disease and cancer. Available treatments result in low rates of functional cure or require lifelong therapy that does not eliminate the risk of liver disease. We isolated and characterized a potent human antibody that neutralizes hepatitis B and D viruses and reduces infection in a mouse model. This antibody could provide a new treatment for patients with chronic hepatitis B and D.
Language	English
Publishing date	2023-07-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2023.07.003
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Book ; Online: Etude de l’importance des paramètres sol permettant d’évaluer l’aptitude agricole d’un site

Wendling, Marina / Schmid, Nathaniel / Charles, Raphael

2022

Abstract: ... ayant été décrite en 1997 (Brunner et al., 1997), il apparait important d’étudier si l’importance des facteurs ... utilisés pour définir l’aptitude agricole d’un site a évolué et si certains facteurs essentiels font défaut ... Quelle est l'importance des variables d'entrée de la méthode CA pour déterminer l'aptitude à l'utilisation agricole d ...

Abstract	La classe d'aptitude (CA) est une méthode de référence qui définit la qualité d'un sol pour l'utilisation agricole. Elle se base sur trois facteurs: le climat, le sol et la topographie La méthode ayant été décrite en 1997 (Brunner et al., 1997), il apparait important d’étudier si l’importance des facteurs utilisés pour définir l’aptitude agricole d’un site a évolué et si certains facteurs essentiels font défaut. Cette étude se concentre sur les facteurs sol mais donne également des indications sur un certain nombre de facteurs climatiques et de terrain. Elle a pour objectif de répondre aux questions suivantes: 1. Quelle est l'importance des variables d'entrée de la méthode CA pour déterminer l'aptitude à l'utilisation agricole d’un site selon les pratiques agricoles actuelles? 2. L'importance de ces variables d'entrée a-t-elle changé par rapport à la période précédente considérée dans la description de la CA? 3. Quels changements peut-on s'attendre à l'avenir en ce qui concerne l'importance des variables d'entrée? 4. Quels paramètres ne sont pas actuellement pris en compte dans la CA mais seraient également pertinentes pour une évaluation de l'aptitude des exploitations agricoles à l'avenir?
Keywords	Soil quality
Language	French
Publishing country	dk
Document type	Book ; Online
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Article ; Online: Dual-Use and Trustworthy? A Mixed Methods Analysis of AI Diffusion Between Civilian and Defense R&D.

Schmid, Stefka / Riebe, Thea / Reuter, Christian

Science and engineering ethics

2022 Volume 28, Issue 2, Page(s) 12

Abstract: ... research and development (R&D), we approach the diffusion of AI across both civilian and military spheres in the EU ... evaluations of R&D. ...

Abstract	Artificial Intelligence (AI) seems to be impacting all industry sectors, while becoming a motor for innovation. The diffusion of AI from the civilian sector to the defense sector, and AI's dual-use potential has drawn attention from security and ethics scholars. With the publication of the ethical guideline Trustworthy AI by the European Union (EU), normative questions on the application of AI have been further evaluated. In order to draw conclusions on Trustworthy AI as a point of reference for responsible research and development (R&D), we approach the diffusion of AI across both civilian and military spheres in the EU. We capture the extent of technological diffusion and derive European and German patent citation networks. Both networks indicate a low degree of diffusion of AI between civilian and defense sectors. A qualitative investigation of project descriptions of a research institute's work in both civilian and military fields shows that military AI applications stress accuracy or robustness, while civilian AI reflects a focus on human-centric values. Our work represents a first approach by linking processes of technology diffusion with normative evaluations of R&D.
MeSH term(s)	Artificial Intelligence ; Humans ; Research
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2136491-6
ISSN	1471-5546 ; 1353-3452
ISSN (online)	1471-5546
ISSN	1353-3452
DOI	10.1007/s11948-022-00364-7
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Book ; Online: Maîtriser le colchique d’automne

Schmid, Nathaniel

2018

Abstract: Certaines années, le colchique d’automne (Colchicum autumnale) se multiplie énormément ...

Abstract	Certaines années, le colchique d’automne (Colchicum autumnale) se multiplie énormément dans certaines prairies naturelles humides. On suppose que cela est provoqué par des hivers doux et l’extensification des prairies. La teneur en colchicine de ces plantes peut provoquer des intoxications du bétail.
Keywords	Health and welfare
Language	French
Publishing country	dk
Document type	Book ; Online
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Article: Cylindrospermopsin toxicity in mice following a 90-d oral exposure.

Chernoff, N / Hill, D J / Chorus, I / Diggs, D L / Huang, H / King, D / Lang, J R / Le, T-T / Schmid, J E / Travlos, G S / Whitley, E M / Wilson, R E / Wood, C R

Journal of toxicology and environmental health. Part A

2018 Volume 81, Issue 13, Page(s) 549–566

Abstract: ... subchronic oral exposure (90 d) of purified CYN from 75 to 300 µg/kg/d in mouse. At the end of the dosing ...

Abstract	Cylindrospermopsin (CYN) is a toxin associated with numerous species of freshwater cyanobacteria throughout the world. It is postulated to have caused an episode of serious illnesses in Australia through treated drinking water, as well as lethal effects in livestock exposed to water from farm ponds. Toxicity included effects indicative of both hepatic and renal dysfunction. In humans, symptoms progressed from initial hepatomegaly, vomiting, and malaise to acidosis and hypokalemia, bloody diarrhea, and hyperemia in mucous membranes. Laboratory animal studies predominantly involved the intraperitoneal (i.p.) route of administration and confirmed this pattern of toxicity with changes in liver enzyme activities and histopathology consistent with hepatic injury and adverse renal effects. The aim of this study was designed to assess subchronic oral exposure (90 d) of purified CYN from 75 to 300 µg/kg/d in mouse. At the end of the dosing period, examinations of animals noted (1) elevated organ to body weight ratios of liver and kidney at all dose levels, (2) treatment-related increases in serum alanine aminotransferase (ALT) activity, (3) decreased blood urea nitrogen (BUN) and cholesterol concentrations in males, and (4) elevated monocyte counts in both genders. Histopathological alterations included hepatocellular hypertrophy and cord disruption in the liver, as well as renal cellular hypertrophy, tubule dilation, and cortical tubule lesions that were more prominent in males. A series of genes were differentially expressed including Bax (apoptosis), Rpl6 (tissue regeneration), Fabp4 (fatty acid metabolism), and Proc (blood coagulation). Males were more sensitive to many renal end points suggestive of toxicity. At the end of exposure, toxicity was noted at all dose levels, and the 75 µg/kg group exhibited significant effects in liver and kidney/body weight ratios, reduced BUN, increased serum monocytes, and multiple signs of histopathology indicating that a no-observed-adverse-effect level could not be determined for any dose level.
MeSH term(s)	Administration, Oral ; Alkaloids ; Animals ; Bacterial Toxins/toxicity ; Blood Chemical Analysis ; Cyanobacteria Toxins ; Dose-Response Relationship, Drug ; Female ; Kidney/drug effects ; Kidney/growth & development ; Leukocyte Count ; Liver/drug effects ; Liver/growth & development ; Male ; Mice ; Monocytes/drug effects ; Organ Size/drug effects ; Sex Factors ; Toxicity Tests, Subchronic ; Uracil/analogs & derivatives ; Uracil/toxicity
Chemical Substances	Alkaloids ; Bacterial Toxins ; Cyanobacteria Toxins ; cylindrospermopsin (2JIZ556BA3) ; Uracil (56HH86ZVCT)
Language	English
Publishing date	2018-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1413345-3
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
DOI	10.1080/15287394.2018.1460787
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