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Article ; Online: Evaluation of a combination of Citrus aurantium var. Dulcis essential oil and albendazole for the treatment of sheep gastrointestinal nematodes.

Mesquita-Sousa, Dauana / Campos, Nagilla R C L / Pereira, Juliana R F / Gomes, Matheus N / Silva, Carolina R / Cutrim-Júnior, Jose A A / Brito, Danilo R B / Sampaio, Romildo M / Sargison, Neil D / Lifschitz, Adrian / Costa-Junior, Livio M

Veterinary parasitology

2023 Volume 318, Page(s) 109929

Abstract: Citrus fruits are consumed all over the world and their by-products are used for animal feed and essential oils production. This study aimed to evaluate the in vitro and in vivo activity of Citrus aurantium var. Dulcis essential oil (CaEO) combined with ... ...

Abstract	Citrus fruits are consumed all over the world and their by-products are used for animal feed and essential oils production. This study aimed to evaluate the in vitro and in vivo activity of Citrus aurantium var. Dulcis essential oil (CaEO) combined with ABZ against benzimidazole resistant Haemonchus contortus. In vitro egg hatching assays (EHA) were performed using CaEO and ABZ to estimate the effective concentration to achieve 50% egg death (EC
MeSH term(s)	Animals ; Sheep ; Albendazole/pharmacology ; Albendazole/therapeutic use ; Oils, Volatile/pharmacology ; Oils, Volatile/therapeutic use ; Citrus ; Nematoda ; Anthelmintics/pharmacology ; Anthelmintics/therapeutic use ; Haemonchus ; Benzimidazoles/pharmacology ; Feces/parasitology ; Sheep Diseases/drug therapy ; Sheep Diseases/parasitology ; Parasite Egg Count/veterinary ; Drug Resistance ; Haemonchiasis/drug therapy ; Haemonchiasis/veterinary ; Haemonchiasis/parasitology
Chemical Substances	Albendazole (F4216019LN) ; Oils, Volatile ; Anthelmintics ; Benzimidazoles
Language	English
Publishing date	2023-04-07
Publishing country	Netherlands
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vetpar.2023.109929
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Article ; Online: Evaluation of a combination of Citrus aurantium var. Dulcis essential oil and albendazole for the treatment of sheep gastrointestinal nematodes

Mesquita-Sousa, Dauana / Campos, Nagilla R.C.L. / Pereira, Juliana R.F. / Gomes, Matheus N. / Silva, Carolina R. / Cutrim-Júnior, Jose A.A. / Brito, Danilo R.B. / Sampaio, Romildo M. / Sargison, Neil D. / Lifschitz, Adrian / Costa-Junior, Livio M.

Veterinary Parasitology. 2023 June, v. 318 p.109929-

2023

Abstract	Citrus fruits are consumed all over the world and their by-products are used for animal feed and essential oils production. This study aimed to evaluate the in vitro and in vivo activity of Citrus aurantium var. Dulcis essential oil (CaEO) combined with ABZ against benzimidazole resistant Haemonchus contortus. In vitro egg hatching assays (EHA) were performed using CaEO and ABZ to estimate the effective concentration to achieve 50% egg death (EC₅₀) values and calculate the test essential oil and drug combinations using a simplex-centroid mixture design. These concentrations were used for a second round of EHAs. Sixteen sheep were randomly allocated into two groups and treated with ABZ and the combination of CaEO and ABZ, and faecal egg count reduction tests were performed. In the first round of EHA, CaEO and ABZ showed EC₅₀ values of 0.57 and 0.0048 mg mL⁻¹, respectively. The H. contortus strain used in the study was shown to be highly benzimidazole resistant, with only 1.5% of parasites having susceptible ß-tubulin SNP genotypes. The ABZ reduced the shedding of nematode eggs by 78%, however, its combination with CaEO reduced faecal egg counts by only 9%. The present study is important to highlight the interferences of natural products in anthelmintic metabolism and consequently in drug efficacy.
Keywords	Citrus aurantium ; Haemonchus contortus ; albendazole ; benzimidazole ; death ; eggs ; essential oils ; fecal egg count ; feeds ; gastrointestinal nematodes ; metabolism ; sheep ; veterinary parasitology ; Anthelmintic resistance ; Haemonchus control ; Plant oils ; Sheep diseases
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	196831-2
ISSN	1873-2550 ; 0304-4017
ISSN (online)	1873-2550
ISSN	0304-4017
DOI	10.1016/j.vetpar.2023.109929
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Article ; Online: Improving Intraoperative Communication in Trauma: The Educational Effect of the Joint DSTC™-DATC™ Courses.

Alexandrino, Henrique / Baptista, Sérgio / Vale, Luís / Júnior, José Hélio Zen / Espada, Paulo César / Junior, Danilo Stanzani / Vane, Luiz Antonio / Carvalho, Vanessa Henriques / Marcelo, Lara / Madeira, Filipa / Duarte, Ricardo / Ferreira, Luís / Pereira, Jorge / Pinheiro, Luís Filipe / Fraga, Gustavo Pereira / Mesquita, Carlos

World journal of surgery

2020 Volume 44, Issue 6, Page(s) 1856–1862

Abstract: Background: Operative management of severe trauma requires excellent communication among team members. The surgeon and anesthesiologist need to interact efficiently, exchanging vital information. The Definitive Surgical Trauma Care (DSTC) and Definitive ...

Abstract	Background: Operative management of severe trauma requires excellent communication among team members. The surgeon and anesthesiologist need to interact efficiently, exchanging vital information. The Definitive Surgical Trauma Care (DSTC) and Definitive Anesthesia Trauma Care (DATC) courses provide an excellent opportunity for teamwork training. Our goal was to study the impact of the joint DSTC-DATC courses in candidates' self-reported assessment in communication skills and techniques in a simulated intraoperative trauma scenario. Methods: Study population consists of 93 candidates (67 surgeons and 26 anesthesiologists) participating in four consecutive joint DSTC-DATC courses in May and June 2019 in Brazil (3) and in Portugal (1). Median age was 30 years; 53 (60%) of subjects were male (46 senior residents and 47 specialists). All participants attended joint lectures, case discussions and surgical skills session, emphasizing intraoperative communication. Post-course survey on several aspects of perioperative communication (responses on a Likert scale) was conducted with participants being asked which aspects of intraoperative communication they valued the most. Results: All participants responded to the survey. Results displayed an increase in the self-assessed importance of team briefing and intraoperative communication, particularly routine periodic communication, rather than only at critical moments. Postoperative team debriefing was also valued as highly relevant. Closed-loop and direct, by-name communication were highly rated. Self-reported communication skills improved significantly during the course. Conclusions: Joint training in the DSTC-DATC courses improved candidates' perception and skills on proficient intraoperative communication. Further studies should address both the durability of these changes and the potential impact on patient care.
MeSH term(s)	Adult ; Anesthesiologists/education ; Communication ; Female ; Humans ; Internship and Residency ; Intraoperative Period ; Male ; Middle Aged ; Patient Care Team/organization & administration ; Surgeons/education ; Wounds and Injuries/surgery
Language	English
Publishing date	2020-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-020-05421-5
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Article ; Online: The effects of freeze/thawing on the function and phenotype of CD4(+) lymphocyte subsets in normal individuals and patients with systemic lupus erythematosus.

Ferreira, Vanessa da Silva / Mesquita, Fernanda Vieira / Mesquita, Danilo Júnior / Andrade, Luís Eduardo Coelho

Cryobiology

2015 Volume 71, Issue 3, Page(s) 507–510

Abstract: Several studies report on lymphocyte phenotypic and functional abnormalities in Systemic Lupus Erythematosus (SLE). Freezing and thawing may alter functional and phenotypic properties of cells. We assessed the effect of the freezing/thawing process (F/T) ...

Abstract	Several studies report on lymphocyte phenotypic and functional abnormalities in Systemic Lupus Erythematosus (SLE). Freezing and thawing may alter functional and phenotypic properties of cells. We assessed the effect of the freezing/thawing process (F/T) on Th1 (CD3(+)CD4(+)CCR4(-)CXCR3(+)CCR5(+)), Th2 (CD3(+)CD4(+)CCR5(-)CXCR3(-)CCR4(+)), Th17 (CD3(+)CD4(+)CCR6(+)CD161(+)), and Treg (CD3(+)CD4(+)CD25(high)CD127(-)) cell cultures in healthy controls and SLE patients. F/T was associated with decreased frequency of Th2 and Th17 cells in cultures from SLE patients but not from controls. F/T was also associated with increased frequency of apoptotic cells, as measured by annexin V labeling, in all T cell subtypes analyzed, as well as increased cell proliferation, as measured by Ki-67 labeling, in all cells except Th1 from SLE patients. Thus, F/T can have differentiated effects on T lymphocyte subtypes from SLE patients and controls, and can have significant effects on cell death and proliferation. These findings should be carefully considered when designing and interpreting studies on functional and phenotypic aspects of T lymphocytes in SLE.
MeSH term(s)	Adult ; Cryopreservation ; Female ; Freezing/adverse effects ; Humans ; Lupus Erythematosus, Systemic/immunology ; Male ; Middle Aged ; Phenotype ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology
Language	English
Publishing date	2015-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80098-3
ISSN	1090-2392 ; 0011-2240
ISSN (online)	1090-2392
ISSN	0011-2240
DOI	10.1016/j.cryobiol.2015.10.149
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Article ; Online: Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women.

Cruvinel, Wilson de Melo / Mesquita Júnior, Danilo / Araújo, Júlio Antônio Pereira / Samazi, Karina Carvalho / Kállas, Esper Georges / Cendoroglo, Maysa Seabra / Andrade, Luis Eduardo Coelho

Revista da Associacao Medica Brasileira (1992)

2015 Volume 61, Issue 4, Page(s) 329–335

Abstract: Introduction: aging is associated with several immunologic changes. Regulatory (Treg) and effector T cells are involved in the pathogenesis of infectious, neoplastic, and autoimmune diseases. Little is known about the effects of aging on the frequency ... ...

Abstract	Introduction: aging is associated with several immunologic changes. Regulatory (Treg) and effector T cells are involved in the pathogenesis of infectious, neoplastic, and autoimmune diseases. Little is known about the effects of aging on the frequency and function of these T cell subpopulations. Methods: peripheral blood mononuclear cells (PBMC) were obtained from 26 young (under 44 years old) and 18 elderly (above 80 years old) healthy women. T cell subpopulations were analyzed by flow cytometry. Results: elderly individuals had lower frequency of several activated effector T cell phenotypes as compared with young individuals: CD3+CD4+CD25+ (3.82±1.93 versus 9.53±4.49; p<0.0001); CD3+CD4+CD25+CD127+(2.39±1.19 versus 7.26±3.84; p<0.0001); CD3+CD4+CD25+ (0.41±0.22 versus 1.86±0.85, p<0.0001); and CD3+CD4+CD25highCD127+(0.06±0.038 versus 0.94±0.64, p<0.0001). Treg (CD3+CD4+CD25+CD127øFoxp3+) presented lower frequency in elderly individuals as compared to young adults (0.34±0.18 versus 0.76±0.48; p=0.0004) and its frequency was inversely correlated with age in the whole group (r=-0.439; p=0.013). The elderly group showed higher frequency of two undefined CD25øFoxp3+ phenotypes: CD3+CD4+CD25øFoxp3+(15.05±7.34 versus 1.65±1.71; p<0.0001) and CD3+CD4+CD25øCD127øFoxp3+(13.0±5.52 versus 3.51±2.87; p<0.0001). Conclusions: the altered proportion of different T cell subsets herein documented in healthy elderly women may be relevant to the understanding of the immunologic behavior and disease susceptibility patterns observed in geriatric patients.
MeSH term(s)	Adult ; Age Factors ; Aged, 80 and over ; Aging/immunology ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/immunology ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; Young Adult
Language	English
Publishing date	2015-08
Publishing country	Brazil
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2027973-5
ISSN	1806-9282 ; 0104-4230
ISSN (online)	1806-9282
ISSN	0104-4230
DOI	10.1590/1806-9282.61.04.329
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Article ; Online: Diverse anthropogenic disturbances shift Amazon forests along a structural spectrum

Smith, Marielle N / Stark, Scott C / Taylor, Tyeen C / Schietti, Juliana / de Almeida, Danilo Roberti Alves / Aragón, Susan / Torralvo, Kelly / Lima, Albertina P. / de Oliveira, Gabriel / de Assis, Rafael Leandro / Leitold, Veronika / Pontes‐Lopes, Aline / Scoles, Ricardo / de Sousa Vieira, Luciana Cristina / Resende, Angelica Faria / Coppola, Alysha I / Brandão, Diego Oliveira / de Athaydes Silva Junior, João / Lobato, Laura F /

Freitas, Wagner / Almeida, Daniel / Souza, Mendell S / Minor, David M. / Villegas, Juan Camilo / Law, Darin J / Gonçalves, Nathan / da Rocha, Daniel Gomes / Guedes, Marcelino Carneiro / Tonini, Hélio / da Silva, Kátia Emídio / van Haren, Joost / Rosa, Diogo Martins / do Valle, Dalton Freitas / Cordeiro, Carlos Leandro / de Lima, Nicolas Zaslavsky / Shao, Gang / Menor, Imma Oliveras / Conti, Georgina / Florentino, Ana Paula / Montti, Lía / Aragão, Luiz EOC / McMahon, Sean M / Parker, Geoffrey G / Breshears, David D / Da Costa, Antonio Carlos Lola / Magnusson, William E. / Mesquita, Rita / Camargo, José Luís C / de Oliveira, Raimundo C / de Camargo, Plinio B / Saleska, Scott R / Nelson, Bruce Walker

Frontiers in Ecology and the Environment. 2023 Feb., v. 21, no. 1 p.24-32

2023

Abstract: Amazon forests are being degraded by myriad anthropogenic disturbances, altering ecosystem and climate function. We analyzed the effects of a range of land‐use and climate‐change disturbances on fine‐scale canopy structure using a large database of ... ...

Abstract	Amazon forests are being degraded by myriad anthropogenic disturbances, altering ecosystem and climate function. We analyzed the effects of a range of land‐use and climate‐change disturbances on fine‐scale canopy structure using a large database of profiling canopy lidar collected from disturbed and mature Amazon forest plots. At most of the disturbed sites, surveys were conducted 10–30 years after disturbance, with many exhibiting signs of recovery. Structural impacts differed in magnitude more than in character among disturbance types, producing a gradient of impacts. Structural changes were highly coordinated in a manner consistent across disturbance types, indicating commonalities in regeneration pathways. At the most severely affected site – burned igapó (seasonally flooded forest) – no signs of canopy regeneration were observed, indicating a sustained alteration of microclimates and consequently greater vulnerability to transitioning to a more open‐canopy, savanna‐like state. Notably, disturbances rarely shifted forests beyond the natural background of structural variation within mature plots, highlighting the similarities between anthropogenic and natural disturbance regimes, and indicating a degree of resilience among Amazon forests. Studying diverse disturbance types within an integrated analytical framework builds capacity to predict the risk of degradation‐driven forest transitions.
Keywords	canopy ; climate ; climate change ; databases ; ecosystems ; environment ; forests ; land use ; lidar ; risk
Language	English
Dates of publication	2023-02
Size	p. 24-32.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2110853-5
ISSN	1540-9309 ; 1540-9295
ISSN (online)	1540-9309
ISSN	1540-9295
DOI	10.1002/fee.2590
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Article: Rarity and beta diversity assessment as tools for guiding conservation strategies in marine tropical subtidal communities

Carlos‐Júnior, Lélis A / Spencer, Matthew / Neves, Danilo Mesquita / Moulton, Timothy Peter / Pires, Débora de Oliveira / e Castro, Clovis Barreira / Ventura, Carlos Renato Rezende / Ferreira, Carlos Eduardo Leite / Serejo, Cristiana Silveira / Oigman‐Pszczol, Simone / Casares, Fernanda Araújo / Mantelatto, Marcelo Checoli / Creed, Joel Christopher

Diversity & distributions. 2019 May, v. 25, no. 5

2019

Abstract: AIM: Our aim was to uncover patterns of distribution of marine subtidal rocky reef communities across six taxonomic groups and decompose the relative roles of species loss and turnover in total community variation. Additionally, we propose an easily ... ...

Abstract	AIM: Our aim was to uncover patterns of distribution of marine subtidal rocky reef communities across six taxonomic groups and decompose the relative roles of species loss and turnover in total community variation. Additionally, we propose an easily calculated index that can be used to highlight areas with unique species composition for conservation planning. We estimated the strengths of associations between environmental factors and species richness and rarity. LOCATION: Ilha Grande Bay, Brazil, covering about 150,000 ha harbouring different marine habitats. METHODS: We used the Marine Rapid Assessment Protocol at 42 sites to gather information on environmental variables and species in six subtidal marine groups. We determined “singular” sites as the regions harbouring higher numbers of rare species. Then, we estimated the roles of species loss and turnover on the observed total variation among sites. We used Generalized Linear Model to partition the relative importance of the selected environmental factors in driving variation in species richness and singularity. RESULTS: The singularity index and richness showed that the bay could be divided into three subregions for subtidal communities. Richness and rarity were structured at different spatial scales and associated with environmental variables related to water productivity and nutrients but varied among taxonomic groups. Community variation over space was largely associated with turnover of species. MAIN CONCLUSIONS: Higher singularity and richness on the western side of the bay and around the main island suggested that these regions should be conservation priorities, but high species turnover across the whole bay indicated that portions of the central channel should be included in conservation strategies. This draws attention to the importance of community variation rather than just species numbers in conservation and management planning. The high species turnover indicated that these rocky reefs have high beta diversity when compared to other studied biological systems.
Keywords	environmental factors ; habitats ; linear models ; nutrients ; planning ; protocols ; rapid methods ; rare species ; reefs ; species richness ; Brazil
Language	English
Dates of publication	2019-05
Size	p. 743-757.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2020139-4
ISSN	1472-4642 ; 1366-9516
ISSN (online)	1472-4642
ISSN	1366-9516
DOI	10.1111/ddi.12896
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Article ; Online: Characterization of Headache in COVID-19: a Retrospective Multicenter Study.

Dos Anjos de Paula, Rafael César / de Maria Frota Vasconcelos, Thaís / da Costa, Francisco Bruno Santana / de Brito, Lara Albuquerque / Torres, Danielle Mesquita / Moura, Alissa Elen Formiga / Oliveira, Danilo Nunes / de Lima Henn, Guilherme Alves / Rodrigues, Pedro Gustavo Barros / de Sousa Pereira, Isabelle / Braga, Ianna Lacerda Sampaio / Rocha, Felipe Araújo / Frota, Norberto Anízio Ferreira / Carvalho, Fernanda Martins Maia / Pitombeira, Milena Sales / Tavares-Junior, José Wagner Leonel / Montenegro, Raquel Carvalho / Braga-Neto, Pedro / Nóbrega, Paulo Ribeiro /

Sobreira-Neto, Manoel Alves

Molecular neurobiology

2021 Volume 58, Issue 9, Page(s) 4487–4494

Abstract: Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed ... ...

Abstract	Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed to analyze the clinical characteristics of COVID-19 associated headache in laboratory-confirmed cases. We conducted a retrospective evaluation of patients with COVID-19 and neurological symptoms. Patients who reported headache answered an interview about its clinical characteristics. Twenty-four patients with COVID-19 associated headache completed the interview. Mean age of patients was 53.8 (standard deviation-17.44), and 14 out of 24 (58.3%) were male. The majority (75%) had no previous history of headache. Fever was documented in 19 out of the 24 patients (79.1%). Headache was predominantly bifrontal or holocranial, in pressure, during hours, worsening with cough or physical activity. COVID-19 headache tends to appear in the first days of symptoms, be either frontal or holocranial and last for days. The quality of pain in pressure and the worsening with cough or physical activity were reported in most cases. We have not found any characteristic that could differentiate COVID-19 associated headache from other causes of headache, possibly because of its multifactorial mechanism.
MeSH term(s)	Adolescent ; Adult ; Antihypertensive Agents/therapeutic use ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Comorbidity ; Cytokines/physiology ; Endothelium, Vascular/physiopathology ; Endothelium, Vascular/virology ; Female ; Fever/etiology ; Headache/etiology ; Headache/physiopathology ; Humans ; Inflammation ; Male ; Models, Biological ; Neoplasms/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Symptom Assessment ; Trigeminal Nerve/virology ; Young Adult
Chemical Substances	Antihypertensive Agents ; Cytokines
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-021-02430-w
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Article ; Online: Dual emission tunable in the near-infrared (NIR) and visible (VIS) spectral range by mix-LnMOF.

de Jesus, Roberta Anjos / da Luz, Leonis Lourenço / Santos, Danilo Oliveira / Costa, José Arnaldo Santana / Navickiene, Sandro / Gatto, Claudia Cristina / Júnior, Severino Alves / de Mesquita, Maria Eliane

Dalton transactions (Cambridge, England : 2003)

2015 Volume 44, Issue 39, Page(s) 17318–17325

Abstract: In this study, we describe the synthetic approach, crystallographic structure, luminescent behavior and elucidation of the channels of the energy conversion in heteronuclear coordination polymers with emission in the visible (Eu(3+) and organic ligand) ... ...

Abstract	In this study, we describe the synthetic approach, crystallographic structure, luminescent behavior and elucidation of the channels of the energy conversion in heteronuclear coordination polymers with emission in the visible (Eu(3+) and organic ligand) and near-infrared (Nd(3+)) range. The [(Nd0.9Eu0.1)2(dipc)3(H2O)3]n·nH2O, [(Nd0.7Eu0.3)2(dipc)3(H2O)3]n·nH2O, [(Nd0.5Eu0.5)2(dipc)3(H2O)3]n·nH2O, [(Nd0.3Eu0.7)2(dipc)3(H2O)3]n·nH2O, [(Nd0.1Eu0.9)2(dipc)3(H2O)3]n·nH2O, [Eu2(dipc)3(H2O)3]n·nH2O and [Nd2(dipc)3(H2O)3]n·nH2O materials are obtained by hydrothermal conditions from pyridine-2,6-dicarboxylic acid (H2dipc) and Ln2O3 oxide (Ln = Eu and Nd). The fine structures in the emission spectrum and spectral profile are used to investigate the ion responsible for the emission characteristics of a material (6), based on coordination polyhedron. The heteronuclear systems show emission in the dual spectral range (NIR-VIS) tuned for blue or red. The tuning of emission on the red (Eu(3+)) or blue (organic ligand) range may be performed by controlling the stoichiometric ratio of the lanthanide ions and by controlling the excitation wavelength. Nd(3+) ions display self-absorption of emission to dipc ligand, resulting in interference on the emission band profile ranging from 400 to 600 nm. The energetic process of energy transfer is operated by a cascade of energy transfer, from dipc ligand mainly to Eu(3+) ions and finishing on the Nd(3+) ion. The efficient sensitization to Nd(3+) by Eu(3+) ions is due to the presence of many resonant energy levels and the short distance between these ions.
Language	English
Publishing date	2015-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c5dt01920f
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Article ; Online: RNA interference: a new alternative for rheumatic diseases therapy.

de França, Natália Regine / Mesquita Júnior, Danilo / Lima, Amanda Bandeira / Pucci, Fernando Vianna Cabral / Andrade, Luís Eduardo Coelho / Silva, Neusa Pereira

Revista brasileira de reumatologia

2010 Volume 50, Issue 6, Page(s) 695–702

Abstract: RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. This mechanism, recently described, is mediated by small double-stranded RNAs (dsRNAs) that can specifically recognize a target mRNA sequence and ... ...

Abstract	RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. This mechanism, recently described, is mediated by small double-stranded RNAs (dsRNAs) that can specifically recognize a target mRNA sequence and mediate its cleavage or translational repression. The use of RNAi as a tool for gene therapy has been extensively studied, especially in viral infections, cancer, inherited genetic disorders, cardiovascular and rheumatic diseases. Together with data from human genome, the knowledge of gene silencing mediated by RNAi could allow a functional determination of virtually any cell expressed gene and its involvement in cellular functioning and homeostasis. Several in vitro and in vivo therapeutic studies with autoimmune disease animal models have been carried out with promising results. The pathways of tolerance breakage and inflammation are potential targets for RNAi therapy in inflammatory autoimmune diseases. This review will present the basic principles of RNAi and discuss several aspects of RNAi-based therapeutic approaches, from in vitro tool design and target identification to in vivo pre-clinical drug delivery, and tests of autoimmune diseases in human cells and animal models. Finally, this review will present some recent clinical experience with RNAi-based therapy.
MeSH term(s)	Autoimmune Diseases/genetics ; Autoimmune Diseases/therapy ; Genetic Therapy/methods ; Humans ; RNA Interference ; Rheumatic Diseases/genetics ; Rheumatic Diseases/immunology ; Rheumatic Diseases/therapy
Language	Portuguese
Publishing date	2010-11
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2223192-4
ISSN	1809-4570 ; 0482-5004
ISSN (online)	1809-4570
ISSN	0482-5004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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