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  1. Article ; Online: Nano-Nutraceuticals Dietary Supplements for Athletes: An Eminent Approach for Managing Traumatic Brain Injuries.

    Javed, Noushad / Pottoo, Faheem Hyder / Barreto, George E

    Current molecular pharmacology

    2022  Volume 15, Issue 1, Page(s) 1–2

    MeSH term(s) Athletes ; Brain Injuries, Traumatic/drug therapy ; Dietary Supplements ; Humans
    Language English
    Publishing date 2022-03-11
    Publishing country United Arab Emirates
    Document type Editorial
    ISSN 1874-4702
    ISSN (online) 1874-4702
    DOI 10.2174/1874467215666220104212247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nanogels as Drug Delivery Carrier: A Narrative Review on Formulation Techniques, Characterization, Applications, and Patents.

    Kumari, Alpana / Bhardwaj, Kamini / Mishra, Supriya / Singh, Lubhan / Pottoo, Faheem Hyder / Yasir, Mohd

    Current pharmaceutical biotechnology

    2024  

    Abstract: Under the umbrella of targeted drug delivery systems, several techniques are unleashed in the market that allow a drug or other pharmacologically active material to be delivered to the target cell to treat a condition or health problem. The improvement ... ...

    Abstract Under the umbrella of targeted drug delivery systems, several techniques are unleashed in the market that allow a drug or other pharmacologically active material to be delivered to the target cell to treat a condition or health problem. The improvement of the pharmaceutical delivery systems' effectiveness, safety, and stability is accomplished through the Formulation of the nano-gel-based delivery system. Nanogels are aqueous dispersions of submicronsized, three-dimensional, strongly cross-linked networks of hydrophilic polymers that are inflated by water. Through a variety of delivery routes, such as oral, pulmonary, nasal, parenteral, and intraocular, an active pharmaceutical agent or therapeutic agent with a high or low molecular weight can be easily encapsulated into nanogels. Nanogels have been researched as drug delivery systems due to their beneficial qualities, such as biocompatibility, high stability, flexible particle size, drug loading capacity, and potential surface modification for active targeting by attaching ligands that recognize cognate receptors on target cells or tissues. By responding to internal or external stimuli, including pH, temperature, light, and redox, nano gels can be made to be stimulus-responsive, allowing for regulated drug release. Thus, in the fact of said characteristics' of nano gels, this review manuscript aims to provide an overview of characterization, evaluation, formulation technique, recent applications, and patents of nano gels.
    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010281504240403053144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: WITHDRAWN: Cannabis Sativa In Phytotherapy : Reappraisal Of Therapeutic Potential And Regulatory Aspects

    Gupta, Priya / Singh, Archu / Shafi, Sadat / Ralli, Tanya / Pottoo, Faheem Hyder / Kohli, Kanchan

    Current pharmaceutical biotechnology

    2022  

    Language English
    Publishing date 2022-10-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201024666221021141626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: WITHDRAWN: Pharmaceutical Nanoemulsion System: A Strategy to Enhance the Bioavailability of Drugs

    Kumar, Shobhit / Waliyan, Parul / Pahwa, Rakesh / Ali, Javed / Baboota, Sanjula / Sharma, Shrestha / Hyder Pottoo, Faheem

    Current drug metabolism

    2022  

    Language English
    Publishing date 2022-06-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064815-7
    ISSN 1875-5453 ; 1389-2002
    ISSN (online) 1875-5453
    ISSN 1389-2002
    DOI 10.2174/1389200223666220630161615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recent Advancements in CNS Acting Drugs: A Step Towards End of Illness.

    Javed, Md Noushad / Pottoo, Faheem Hyder / Naim, Mohd Javed / Chawla, Pooja A

    CNS & neurological disorders drug targets

    2022  Volume 21, Issue 10, Page(s) 882–883

    Abstract: Progressive degeneration in the morphology and functions of neuronal cells leads to multifactorial pathogenesis conditions of oxidative stress, mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity, and neuro-inflammation to mediate ... ...

    Abstract Progressive degeneration in the morphology and functions of neuronal cells leads to multifactorial pathogenesis conditions of oxidative stress, mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity, and neuro-inflammation to mediate heterogeneous types of neurodegenerative diseases, such as Epilepsy, Alzheimer's (AD) and Parkinson's (PD), more prominently among aging populations. In this editorial, complex mechanisms, challenges, and advancements made in the discovery of new neurotherapeutics, as well as designing approaches being adopted to fabricate brain-targeted delivery systems, are discussed.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Brain/pathology ; Central Nervous System Agents/pharmacology ; Central Nervous System Agents/therapeutic use ; Humans ; Neurons/pathology ; Oxidative Stress/physiology
    Chemical Substances Central Nervous System Agents
    Language English
    Publishing date 2022-09-05
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/187152732110220722112205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Convenient Synthesis of

    El Rayes, Samir Mohamed / El-Enany, Gaber / Gomaa, Mohamed Sayed / Ali, Ibrahim A I / Fathalla, Walid / Pottoo, Faheem Hyder / Khan, Firdos Alam

    ACS omega

    2022  Volume 7, Issue 38, Page(s) 34166–34176

    Abstract: A series of 27 new quinoxaline derivatives ( ...

    Abstract A series of 27 new quinoxaline derivatives (
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c03522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sulfadiazine Exerts Potential Anticancer Effect in HepG2 and MCF7 Cells by Inhibiting TNFα, IL1b, COX-1, COX-2, 5-LOX Gene Expression: Evidence from In Vitro and Computational Studies.

    Gomaa, Mohamed / Gad, Wael / Hussein, Dania / Pottoo, Faheem Hyder / Tawfeeq, Nada / Alturki, Mansour / Alfahad, Dhay / Alanazi, Razan / Salama, Ismail / Aziz, Mostafa / Zahra, Aboelnasr / Hanafy, Abeer

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 2

    Abstract: Drug repurposing is a promising approach that has the potential to revolutionize the drug discovery and development process. By leveraging existing drugs, we can bring new treatments to patients more quickly and affordably. Anti-inflammatory drugs have ... ...

    Abstract Drug repurposing is a promising approach that has the potential to revolutionize the drug discovery and development process. By leveraging existing drugs, we can bring new treatments to patients more quickly and affordably. Anti-inflammatory drugs have been shown to target multiple pathways involved in cancer development and progression. This suggests that they may be more effective in treating cancer than drugs that target a single pathway. Cell viability was measured using the MTT assay. The expression of genes related to inflammation (TNFa, IL1b, COX-1, COX-2, and 5-LOX) was measured in HepG2, MCF7, and THLE-2 cells using qPCR. The levels of TNFα, IL1b, COX-1, COX-2, and 5-LOX were also measured in these cells using an ELISA kit. An enzyme binding assay revealed that sulfadiazine expressed weaker inhibitory activity against COX-2 (IC
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17020189
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  8. Article ; Online: Cannabis Sativa in Phytotherapy: Reappraisal of Therapeutic Potential and Regulatory Aspects.

    Gupta, Priya / Singh, Archu / Shafi, Sadat / Ralli, Tanya / Pottoo, Faheem Hyder / Sultana, Yasmin / Kohli, Kanchan

    Current pharmaceutical biotechnology

    2023  

    Abstract: Cannabis sativa is widely used as a folk medicine in many parts of the globe and has been reported to be a treasure trove of phytoconstituents, including cannabinoids, terpenoids, and flavonoids. Accumulating evidence from various pre-clinical and ... ...

    Abstract Cannabis sativa is widely used as a folk medicine in many parts of the globe and has been reported to be a treasure trove of phytoconstituents, including cannabinoids, terpenoids, and flavonoids. Accumulating evidence from various pre-clinical and clinical studies revealed the therapeutic potential of these constituents in various pathological conditions, including chronic pain, inflammation, neurological disorders, and cancer. However, the psychoactive effect and addiction potential associated with cannabis use limited its clinical application. In the past two decades, extensive research on cannabis has led to a resurgence of interest in the clinical application of its constituents, particularly cannabinoids. This review summarizes the therapeutic effect and molecular mechanism of various phytoconstituents of cannabis. Furthermore, recently developed nanoformulations of cannabis constituents have also been reviewed. Since cannabis is often associated with illicit use, regulatory aspects are of vital importance and this review therefore also documented the regulatory aspects of cannabis use along with clinical data and commercial products of cannabis.
    Language English
    Publishing date 2023-05-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201024666230508142114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Retraction Note to: A novel self-nanoemulsifying drug delivery system for curcumin used in the treatment of wound healing and inflammation.

    Ahmad, Niyaz / Ahmad, Rizwan / Al-Qudaihi, Ali / Alaseel, Salman Edrees / Fita, Ibrahim Zuhair / Khalid, Mohammed Saifuddin / Pottoo, Faheem Hyder / Bolla, Srinivasa Rao

    3 Biotech

    2022  Volume 12, Issue 4, Page(s) 94

    Abstract: This retracts the article DOI: 10.1007/s13205-019-1885-3.]. ...

    Abstract [This retracts the article DOI: 10.1007/s13205-019-1885-3.].
    Language English
    Publishing date 2022-03-16
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-022-03161-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nanotechnological Approaches for the Treatment of Triple-Negative Breast Cancer: A Comprehensive Review.

    Guha, Lahanya / Bhat, Ishfaq Ahmad / Bashir, Aasiya / Rahman, Jawad Ur / Pottoo, Faheem Hyder

    Current drug metabolism

    2022  

    Abstract: Breast cancer is the most prevalent cancer in women around the world, having a sudden spread nowadays because of the poor sedentary lifestyle of people. Comprising of several subtypes, one of the most dangerous and aggressive ones is triple-negative ... ...

    Abstract Breast cancer is the most prevalent cancer in women around the world, having a sudden spread nowadays because of the poor sedentary lifestyle of people. Comprising of several subtypes, one of the most dangerous and aggressive ones is triple-negative breast cancer or TNBC. Even though conventional surgical approaches like single and double mastectomy and preventive chemotherapeutic approaches are there, but they are not selective to cancer cells and are only for symptomatic treatment. A new branch called nanotechnology has emerged in the last few decades that offer various novel characteristics such as size in nanometric scale, enhanced adherence to multiple targeting moieties, active and passive targeting, controlled release, and site-specific targeting. Among various nanotherapeutic approaches like dendrimers, lipid-structured nanocarriers, carbon nanotubes, etc. nanoparticle targeted therapeutics can be termed the best among all for their specific cytotoxicity to cancer cells and increased bioavailability to a target site. This review focuses on the types and molecular pathways involving TNBC, existing treatment strategies, various nanotechnological approaches like exosomes, carbon nanotubes, dendrimers, lipid, and carbon-based nanocarriers, and especially various nanoparticles (NPs) like polymeric, photodynamic, peptide conjugated, antibody-conjugated, metallic, inorganic, natural product capped and CRISPR based nanoparticles already approved for treatment or are under clinical and pre-clinical trials for TNBC.
    Language English
    Publishing date 2022-06-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064815-7
    ISSN 1875-5453 ; 1389-2002
    ISSN (online) 1875-5453
    ISSN 1389-2002
    DOI 10.2174/1389200223666220608144551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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