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  1. Article ; Online: Tumor dissemination along biopsy trajectory in brain metastasis.

    Hatiboglu, Mustafa Aziz

    Japanese journal of clinical oncology

    2018  Volume 48, Issue 9, Page(s) 864–865

    Language English
    Publishing date 2018-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 190978-2
    ISSN 1465-3621 ; 0368-2811
    ISSN (online) 1465-3621
    ISSN 0368-2811
    DOI 10.1093/jjco/hyy103
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    Zs.A 1298: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Coronavirus pandemic: how is neurosurgical-oncology practice affected?

    Hatiboglu, Mustafa Aziz / Sinclair, Georges

    British journal of neurosurgery

    2020  Volume 35, Issue 6, Page(s) 805–807

    MeSH term(s) Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Medical Oncology ; Pandemics
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country England
    Document type Letter
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2020.1773398
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    Zs.A 2210: Show issues Location:
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  3. Article ; Online: Promising outcome of patients with recurrent glioblastoma after Gamma Knife-based hypofractionated radiotherapy.

    Hatiboglu, Mustafa Aziz / Akdur, Kerime / Sakarcan, Ayten / Seyithanoglu, Mehmet Hakan / Turk, Haci Mehmet / Sinclair, Georges / Oztanir, Mustafa Namik

    Neuro-Chirurgie

    2024  Volume 70, Issue 2, Page(s) 101532

    Abstract: Background: The role of Gamma Knife radiosurgery (GKRS) in recurrent glioblastoma remains unclear. The purpose of this study is to evaluate the effects of GKRS in a group of patients with recurrent glioblastoma, focusing on survival and safety.: ... ...

    Abstract Background: The role of Gamma Knife radiosurgery (GKRS) in recurrent glioblastoma remains unclear. The purpose of this study is to evaluate the effects of GKRS in a group of patients with recurrent glioblastoma, focusing on survival and safety.
    Methods: Patients undergoing GKRS for recurrent glioblastoma between September 2014 and April 2019 were included in this study. Relevant clinical and radiosurgical data, including GKRS-related complications, were recorded and analyzed. Overall survival (OS), local progression free survival (LPFS) and prognostic factors for outcome were thoroughly evaluated.
    Results: Fifty-three patients were analyzed (24 female, 29 male). The median age was 50 years (range, 19-78 years). The median GKRS treatment volume was 35.01 cm
    Conclusion: Our findings suggested that HRST would likely improve LPFS and OS in definite settings; the addition of Bevacizumab to GKRS was associated with increased rates of local control. No major complications were reported. Further prospective studies are warranted to confirm our findings.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Glioblastoma/radiotherapy ; Glioblastoma/surgery ; Bevacizumab ; Treatment Outcome ; Radiosurgery ; Progression-Free Survival ; Retrospective Studies ; Follow-Up Studies
    Chemical Substances Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2024-01-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 207146-0
    ISSN 1773-0619 ; 0028-3770 ; 0150-9586
    ISSN (online) 1773-0619
    ISSN 0028-3770 ; 0150-9586
    DOI 10.1016/j.neuchi.2024.101532
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    Uk I Zs.196: Show issues Location:
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  4. Article ; Online: Can COVID-19 induce glioma tumorogenesis through binding cell receptors?

    Khan, Imran / Hatiboglu, Mustafa Aziz

    Medical hypotheses

    2020  Volume 144, Page(s) 110009

    Abstract: The outbreak of Novel Coronavirus 2019 (COVID-19) represents a global threat to the public healthcare. The viral spike (S) glycoprotein is the key molecule for viral entry through interaction with angiotensin converting enzyme 2 (ACE2) receptor molecules ...

    Abstract The outbreak of Novel Coronavirus 2019 (COVID-19) represents a global threat to the public healthcare. The viral spike (S) glycoprotein is the key molecule for viral entry through interaction with angiotensin converting enzyme 2 (ACE2) receptor molecules present on the cell membranes. Moreover, it has been established that COVID-19 interacts and infects brain cells in humans via ACE2. Therefore in the light of these known facts we hypothesized that viral S protein molecule may bind to the other overexpressed receptor molecules in glioma cells and may play some role in glioma tumorogenesis. Thus we leverage docking analysis (HEX and Z-DOCK) between viral S protein and epidermal growth factor receptors (EGFR), vascular endothelial growth factor receptors (VEGFR) and hepatocyte growth factor receptors (HGFR/c-MET) to investigate the oncogenic potential of COVID-19. Our findings suggested higher affinity of Viral S protein towards EGFR and VEGFR. Although, the data presented is preliminary and need to be validated further via molecular dynamics studies, however it paves platform to instigate further investigations on this aspect considering the aftermath of COVID-19 pandemic in oncogenic perspective.
    MeSH term(s) Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Brain/virology ; Brain Neoplasms/etiology ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; COVID-19/complications ; Cell Transformation, Neoplastic ; ErbB Receptors/chemistry ; ErbB Receptors/metabolism ; Glioma/etiology ; Glioma/genetics ; Glioma/metabolism ; Humans ; Models, Molecular ; Molecular Docking Simulation ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Protein Binding ; Protein Conformation ; Proto-Oncogene Proteins c-met/chemistry ; Proto-Oncogene Proteins c-met/metabolism ; Receptors, Vascular Endothelial Growth Factor/chemistry ; Receptors, Vascular Endothelial Growth Factor/metabolism ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Spike Glycoprotein, Coronavirus/metabolism ; Up-Regulation ; Virus Internalization
    Chemical Substances Neoplasm Proteins ; Nerve Tissue Proteins ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; MET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110009
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    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Identification of Genetic Alterations in Rapid Progressive Glioblastoma by Use of Whole Exome Sequencing.

    Khan, Imran / Işık, Esra Büşra / Mahfooz, Sadaf / Khan, Asif M / Hatiboglu, Mustafa Aziz

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: Background: Glioblastoma poses an inevitable threat to patients despite aggressive therapy regimes. It displays a great level of molecular heterogeneity and numerous substitutions in several genes have been documented. Next-generation sequencing ... ...

    Abstract Background: Glioblastoma poses an inevitable threat to patients despite aggressive therapy regimes. It displays a great level of molecular heterogeneity and numerous substitutions in several genes have been documented. Next-generation sequencing techniques have identified various molecular signatures that have led to a better understanding of the molecular pathogenesis of glioblastoma. In this limited study, we sought to identify genetic variants in a small number of rare patients with aggressive glioblastoma.
    Methods: Five tumor tissue samples were isolated from four patients with rapidly growing glioblastoma. Genomic DNA was isolated and whole exome sequencing was used to study protein-coding regions. Generated FASTQ files were analyzed and variants were called for each sample. Variants were prioritized with different approaches and functional annotation was applied for the detrimental variants.
    Results: A total of 49,780 somatic variants were identified in the five glioblastoma samples studied, with the majority as missense substitutions. The top ten genes with the highest number of substitutions were
    Conclusion: The
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13061017
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  6. Article ; Online: Hypofractionated Radiation Therapy Suppresses Radioresistance in U87 Human Glioma Cells by Inhibiting Yap1 and Hsp90 Proteins.

    Khan, Imran / Mahfooz, Sadaf / Karacam, Busra / Elbasan, Elif Burce / Akdur, Kerime / Coban, Ganime / Hatiboglu, Mustafa Aziz

    Current radiopharmaceuticals

    2024  

    Abstract: Background: Radiotherapy plays a vital role in the management of high-grade gliomas. However, the radio resistance of glioma cells limits the effect of radiation and drives recurrence inside the irradiated tumor volume leading to poor outcomes for ... ...

    Abstract Background: Radiotherapy plays a vital role in the management of high-grade gliomas. However, the radio resistance of glioma cells limits the effect of radiation and drives recurrence inside the irradiated tumor volume leading to poor outcomes for patients.
    Methods: High-grade glioma cell radioresistance significantly contributes to radiotherapy failure, highlighting the importance of identifying predictive biomarkers for radioresistance. An increasing body of evidence complies with the Yes Associated Protein 1 (Yap-1) and heat shock protein 90 (Hsp90) as biomarkers for radioresistance in glioma cells. A number of studies suggest the potential of radioresistance-associated factors as biomarkers and/ or novel therapeutic targets in glioma cells. Thus, it is essential for glioblastoma patients to identify robust druggable targets involved in radioresistance, optimizing irradiation protocol, and understanding their underlying molecular mechanisms.
    Results: Therefore, in the present study, we hypothesized that hypofractionated Gamma Knife radiation therapy (HF-GKRT) could target Yap-1 and Hsp90 and downregulate the mechanism of radioresistance in high-grade glioma cells.
    Conclusion: For this purpose, expression levels of radioresistance markers Yap-1 and Hsp90 were evaluated after treatment with HF-GKRT, and this was compared with single fraction Gamma Knife radiation therapy (SF-GKRT) in U87MG primary human glioblastoma cell line model. This would help design a novel radiation therapy regimen for glioblastoma patients by reducing the risk of radioresistance.
    Language English
    Publishing date 2024-04-29
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1874-4729
    ISSN (online) 1874-4729
    DOI 10.2174/0118744710300495240409074900
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  8. Article ; Online: Can COVID-19 induce glioma tumorogenesis through binding cell receptors?

    Khan, Imran / Hatiboglu, Mustafa Aziz

    Medical Hypotheses

    2020  Volume 144, Page(s) 110009

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110009
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    Zs.A 1132: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Investigation of cellular effects of thymoquinone on glioma cell.

    Guler, Eray Metin / Sisman, Behice Hande / Kocyigit, Abdurrahim / Hatiboglu, Mustafa Aziz

    Toxicology reports

    2021  Volume 8, Page(s) 162–170

    Abstract: Glioblastoma, as an invasive tumor, is one of the most common primary malignant brain tumors. Despite maximum aggressive treatment, patients with glioblastoma have a dismal prognosis. Thymoquinone (TQ) has been found to show anti-cancer effects on ... ...

    Abstract Glioblastoma, as an invasive tumor, is one of the most common primary malignant brain tumors. Despite maximum aggressive treatment, patients with glioblastoma have a dismal prognosis. Thymoquinone (TQ) has been found to show anti-cancer effects on different types of cancer. There are a few
    Language English
    Publishing date 2021-01-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2020.12.026
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  10. Article ; Online: Identification of Genetic Alterations in Rapid Progressive Glioblastoma by Use of Whole Exome Sequencing

    Imran Khan / Esra Büşra Işık / Sadaf Mahfooz / Asif M. Khan / Mustafa Aziz Hatiboglu

    Diagnostics, Vol 13, Iss 1017, p

    2023  Volume 1017

    Abstract: Background: Glioblastoma poses an inevitable threat to patients despite aggressive therapy regimes. It displays a great level of molecular heterogeneity and numerous substitutions in several genes have been documented. Next-generation sequencing ... ...

    Abstract Background: Glioblastoma poses an inevitable threat to patients despite aggressive therapy regimes. It displays a great level of molecular heterogeneity and numerous substitutions in several genes have been documented. Next-generation sequencing techniques have identified various molecular signatures that have led to a better understanding of the molecular pathogenesis of glioblastoma. In this limited study, we sought to identify genetic variants in a small number of rare patients with aggressive glioblastoma. Methods: Five tumor tissue samples were isolated from four patients with rapidly growing glioblastoma. Genomic DNA was isolated and whole exome sequencing was used to study protein-coding regions. Generated FASTQ files were analyzed and variants were called for each sample. Variants were prioritized with different approaches and functional annotation was applied for the detrimental variants. Results: A total of 49,780 somatic variants were identified in the five glioblastoma samples studied, with the majority as missense substitutions. The top ten genes with the highest number of substitutions were MUC3A , MUC4 , MUC6 , OR4C5 , PDE4DIP , AHNAK2 , OR4C3 , ZNF806 , TTN , and RP1L1 . Notably, variant prioritization after annotation indicated that the MTCH2 (Chr11: 47647265 A>G) gene sequence change was putative deleterious in all of the aggressive tumor samples. Conclusion: The MTCH2 (Chr11: 47647265 A>G) gene substitution was identified as putative deleterious in highly aggressive glioblastomas, which merits further investigation. Moreover, a high tumor mutation burden was observed, with a signature of the highest substitutions in MUC3A , MUC4 , MUC6 , OR4C5 , PDE4DIP , AHNAK2 , OR4C3 , ZNF806 , TTN , and RP1L1 genes. The findings provide critical, initial data for the further rational design of genetic screening and diagnostic approaches against aggressive glioblastoma.
    Keywords whole exome sequencing ; glioblastoma ; cancer ; tumor mutation burden ; genetic screening ; genetic signature ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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