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  1. Article ; Online: Soliciting international perspectives on an American national research agenda for inherited bleeding disorders.

    Witkop, Michelle L / Robinson, Fiona / DiMichele, Donna

    Expert review of hematology

    2023  Volume 16, Issue sup1, Page(s) 13–17

    MeSH term(s) Humans ; United States ; Surveys and Questionnaires ; Internationality
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2023.2178411
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  2. Article ; Online: The National Hemophilia Foundation State of the Science Research Summit initiative: executive summary.

    Valentino, Leonard A / Witkop, Michelle L / Santaella, Maria E / DiMichele, Donna / Recht, Michael

    Expert review of hematology

    2023  Volume 16, Issue sup1, Page(s) 129–134

    Abstract: Introduction: The National Hemophilia Foundation State of the Science Research Summit initiative sought to unify research efforts in the US inherited bleeding disorders (BDs) community around key topics of importance to people living with inherited BDs, ...

    Abstract Introduction: The National Hemophilia Foundation State of the Science Research Summit initiative sought to unify research efforts in the US inherited bleeding disorders (BDs) community around key topics of importance to people living with inherited BDs, the lived experience experts.
    Areas covered: This community-led and -informed project focused on six broad areas - hemophilia A or B; von Willebrand Disease (VWD), platelet dysfunctions and other mucocutaneous inherited BDs; ultra-rare inherited BDs; the unique challenges of people with the potential to menstruate with inherited BDs; diversity, equity and inclusion, health services research, and implementation science; and facilitating research in the inherited BD community through designing an optimizied research infrastructure, enabling resources and funding, and furthering workforce capabilities required to execute the research priorities.
    Expert opinion: The work summarized here, and in the accompanying supplement manuscripts , has implications not only for the US population but for people globally who have inherited BDs. The information is equally relevant to people living with hemophilia, VWD, the spectrum of inherited platelet disorders, ultra-rare factor deficiencies, and all other inherited BDs as it is to the health care providers and researchers focused on the care and treatment of inherited BDs in the US and globally.
    MeSH term(s) Humans ; Hemophilia A/diagnosis ; Hemophilia A/genetics ; Hemophilia A/therapy ; von Willebrand Diseases/complications ; Blood Platelet Disorders/complications ; Health Personnel
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2023.2181782
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  3. Article ; Online: The National Hemophilia Foundation's State of the Science Research Summit: the foundation of a national research blueprint for inherited bleeding disorders.

    Valentino, Leonard A / Witkop, Michelle L / Santaella, Maria E / DiMichele, Donna / Recht, Michael

    Expert review of hematology

    2023  Volume 16, Issue sup1, Page(s) 1–5

    MeSH term(s) Humans ; Hemophilia A/diagnosis ; Hemophilia A/genetics ; Hemophilia A/therapy ; Medicine
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2023.2178412
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  4. Article ; Conference proceedings: Influence of Superficial Digital Flexor Tendon Grafts as a Method to Augment the Primary Core Suture Repair of Canine Gastrocnemius Tendons

    DiMichele, J. / Duffy, D. / Chang, Y. / Moore, G.

    Veterinary and Comparative Orthopaedics and Traumatology

    2022  Volume 35, Issue 05

    Event/congress Abstracts of the 6th World Veterinary Orthopedic Congress, Snowmass, Colorado, United States, 2022-02-05
    Language English
    Publishing date 2022-07-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 286750-3
    ISSN 2567-6911 ; 0932-0814
    ISSN (online) 2567-6911
    ISSN 0932-0814
    DOI 10.1055/s-0042-1758269
    Database Thieme publisher's database

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  5. Article ; Online: The North American Immune Tolerance Registry: contributions to the thirty-year experience with immune tolerance therapy.

    Dimichele, D

    Haemophilia : the official journal of the World Federation of Hemophilia

    2009  Volume 15, Issue 1, Page(s) 320–328

    Abstract: The North American Immune Tolerance Registry (NAITR) began in 1992 as a project of the ISTH Factor VIII/IX Subcommittee with the goal of further determining immune tolerance induction (ITI) practices in Canada and the United States. This retrospective ... ...

    Abstract The North American Immune Tolerance Registry (NAITR) began in 1992 as a project of the ISTH Factor VIII/IX Subcommittee with the goal of further determining immune tolerance induction (ITI) practices in Canada and the United States. This retrospective registry study, published in 2002, was limited in its capacity to provide definitive answers to many unresolved ITI practice issues. Nonetheless, it played a role in developing guidelines for current ITI practice and in generating hypotheses that must now be examined through rigorous prospective data collection efforts. For haemophilia A, the logical next step has been the initiation of international prospective randomized studies of ITI outcome relative to factor VIII (FVIII) dose and purity for subjects with high titre inhibitors. Both trials will additionally provide platforms for translational study of the immunology of tolerance, a prelude to the next generation of safe and effective tolerizing strategies. For the less common problem of FIX inhibitor eradication, prospective randomized studies will not be a feasible way to confirm the NAITR observations. Coordinated international efforts will still be required to prospectively collect data on ITI outcome to document new potentially effective therapeutic strategies for inhibitor eradication. These registries will hopefully also serve to identify potential subjects for scientific studies of immunology of haemophilia B-related allergic phenomena, a devastating complication of FIX antibody development.
    MeSH term(s) Factor IX/immunology ; Factor VIII/immunology ; Hemophilia A/drug therapy ; Hemophilia A/immunology ; Hemophilia B/drug therapy ; Hemophilia B/immunology ; Humans ; Immune Tolerance/drug effects ; Isoantibodies/blood ; Male ; North America ; Prognosis ; Registries ; Treatment Outcome
    Chemical Substances Isoantibodies ; Factor VIII (9001-27-8) ; Factor IX (9001-28-9)
    Language English
    Publishing date 2009-01
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/j.1365-2516.2008.01880.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Building the blueprint: Formulating a community-generated national plan for future research in inherited bleeding disorders.

    Valentino, Leonard A / Witkop, Michelle L / Santaella, Maria E / DiMichele, Donna / Recht, Michael

    Haemophilia : the official journal of the World Federation of Hemophilia

    2022  Volume 28, Issue 5, Page(s) 760–768

    Abstract: Introduction: Decades of inherited bleeding disorders (BD) research transformed severe haemophilia from a childhood killer to a disorder managed across a full lifespan for many in economically developed countries. Health equity, a life unimpaired by ... ...

    Abstract Introduction: Decades of inherited bleeding disorders (BD) research transformed severe haemophilia from a childhood killer to a disorder managed across a full lifespan for many in economically developed countries. Health equity, a life unimpaired by disease complications, however, remains unimaginable for most people with an inherited BD (PWIBD).
    Aim: The National Hemophilia Foundation (NHF) and American Thrombosis and Hemostasis Network (ATHN) undertook the development of a community-driven United States (US) National Blueprint for Inherited Bleeding Disorders Research to transform the experience of all PWIBD and those who care for them.
    Methods: Extensive community consultations were conducted to identify the issues most important to PWIBD and those who love and care for them. Expert multidisciplinary teams distilled these key areas of need into prioritised research questions, and identified the resources and infrastructure required to pursue them. A summit was held to gather feedback and inform the detailed blueprint.
    Results: Community-prioritised research areas fell into three broad categories: issues common across inherited BDs, those specific to individual disorders, and issues of infrastructure and capacity. NHF State of the Science Research Summit discussions of the research questions derived from the community priorities by six working groups provided important input for the drafting of the research blueprint for the coming decades.
    Conclusion: The inherited BD community came together to develop the US National Blueprint for Inherited Bleeding Disorders Research dedicated to transforming the lives of all PWIBD including innovating solutions for the rarest disorders and under-represented populations.
    MeSH term(s) Child ; Hemophilia A ; Hemostasis ; Humans ; United States
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14588
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  7. Article ; Conference proceedings: Evaluation of Variability in Performance by Dogs Completing Dog Walk Obstacles in Agility Competition

    DiMichele, J.D. / Markley, A. Pechette / Shoben, A. / Kieves, N.R.

    Veterinary and Comparative Orthopaedics and Traumatology

    2023  Volume 36, Issue 05

    Event/congress Abstracts of the 50th Annual Conference of the Veterinary Orthopedic Society, Big Sky, Montana, United States, 2023-03-11
    Language English
    Publishing date 2023-09-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 286750-3
    ISSN 2567-6911 ; 0932-0814
    ISSN (online) 2567-6911
    ISSN 0932-0814
    DOI 10.1055/s-0043-1775633
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  8. Article: Immune tolerance therapy for factor VIII inhibitors: moving from empiricism to an evidence-based approach.

    Dimichele, D

    Journal of thrombosis and haemostasis : JTH

    2007  Volume 5 Suppl 1, Page(s) 143–150

    Abstract: Currently, the only proven strategy for achieving antigen-specific tolerance to factor VIII (FVIII) is immune tolerance induction (ITI) therapy. This paper discusses our current knowledge of the host and treatment factors, as well as supportive care ... ...

    Abstract Currently, the only proven strategy for achieving antigen-specific tolerance to factor VIII (FVIII) is immune tolerance induction (ITI) therapy. This paper discusses our current knowledge of the host and treatment factors, as well as supportive care initiatives, known or suspected to influence the outcome of ITI in the treatment of inhibitors arising in patients with severe hemophilia A. Among these, questions surrounding the choice of therapeutic product and/or dosing regimen generate the most controversy, given the lack of a definitive evidence-based approach to either. Furthermore, the potential for central venous access device (CVAD) and intercurrent bleeding complications to impact the ultimate success of ITI remains unclear. The ongoing clinical trials designed to further clarify several of these polarizing issues are reviewed. This paper also explores the current and future role of immune modulation in possible salvage, ancillary or primary alternative tolerance induction strategies. The special cases of low titer/ responding inhibitors and inhibitors developing in mild hemophilia A patients are considered. Finally, this paper summarizes the currently recommended approach to ITI and makes the case for a move from empiric therapeutics to a risk-stratified evidence-based approach to FVIII inhibitor eradication.
    MeSH term(s) Empirical Research ; Factor VIII/antagonists & inhibitors ; Humans ; Immune Tolerance ; Serine Proteinase Inhibitors/pharmacology
    Chemical Substances Serine Proteinase Inhibitors ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2007-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/j.1538-7836.2007.02474.x
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  9. Article ; Online: Paleoclimate and the origin of two 1000 km Lower Mississippian facies tracts in southeastern Laurentia (USA): Cool-humid Famennian and Kinderhookian – warm-arid Osagean

    Cecil, C. B. / DiMichele, William A. / Rahl, Jeffrey M. / Dulong, Frank T. / Michel, Lauren / Elrick, Scott D.

    Palaeogeography, Palaeoclimatology, Palaeoecology. 2023 May, v. 618 p.111521-

    2023  

    Abstract: Two lithologically distinctive Mississippian facies tracts (MFTs) are described from Lower and Middle Mississippian strata (Kinderhookian and Osagean North American Stages) in southeast Laurentia (SEL). The MFTs extend from the central Appalachian Basin ... ...

    Abstract Two lithologically distinctive Mississippian facies tracts (MFTs) are described from Lower and Middle Mississippian strata (Kinderhookian and Osagean North American Stages) in southeast Laurentia (SEL). The MFTs extend from the central Appalachian Basin westward across the Cincinnati Arch, through the Eastern (Illinois) Basin, onto the Burlington shelf in central Missouri and into the Western Interior (Forest City) Basin, USA. The MFTs developed under radically different climatic regimes. Kinderhookian climate cycles ranged from 3rd order humid to 4th and 5th order humid-subhumid alternation. These climate fluctuations controlled Kinderhookian sediment flux, evidenced by fluvial-deltaic sandstones, coal beds, and pro-deltaic terrestrial-organic-matter-enriched marine black shales. A dramatic climate shift coincided with the Kinderhook-Osage boundary, from 3rd order cool-humid to 3rd order warm-arid conditions, causing cessation of deltaic sedimentation and the onset of eolian sedimentation at that boundary. This abrupt climate reorganization is reflected in 3rd, 4th, and 5th order continental and eolo-marine loessites that replaced fluvial-deltaic facies. Eolianites, evaporites, and calcareous protosols indicate Osagean aridity. Consequently, we reject the deltaic depositional paradigm for Osagean siliciclastic facies. Osagean eolian sediment consisted mainly of quartz silt with significant pristine (unaltered) feldspar silt (∼ ≤ 10%). Pristine feldspars are consistent with an arid sedimentary source that lacked significant chemical weathering under an arid paleoclimate. Dissolution of the chemically reactive disordered lattice of eolian-abraded quartz in subarkosic loess served as the predominant source of silica for massive amounts of biotic and abiotic chert in Osagean eolo-marine sediments. The ≤20 μm fraction of quartz dust is particularly susceptible to dissolution and re-precipitation as microcrystalline quartz (chert). We conclude that tectonic, eustatic, and climatic (allocyclic) processes all exerted some control on deposition; tectonics and eustasy controlled accommodation space, whereas paleoclimate changes (cycles), driven predominantly by orbital forcing, were the principal control on sediment supply and lithostratigraphy.
    Keywords Middle Mississippian epoch ; basins ; climate ; coal ; dry environmental conditions ; dust ; feldspar ; forests ; loess ; palaeogeography ; paleoclimatology ; paleoecology ; quartz ; silt ; tectonics ; Illinois ; Missouri ; Chert ; Eolo-marine
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 417718-6
    ISSN 0031-0182
    ISSN 0031-0182
    DOI 10.1016/j.palaeo.2023.111521
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: In praise of long-term prospective data collection: questions and perspectives.

    Dimichele, D

    Journal of thrombosis and haemostasis : JTH

    2003  Volume 2, Issue 7, Page(s) 1044–1046

    MeSH term(s) Cause of Death ; Data Collection/standards ; Data Collection/trends ; Databases as Topic ; Factor IX/immunology ; Factor VIII/immunology ; Hemophilia A/epidemiology ; Hemophilia A/immunology ; Hemophilia A/mortality ; Hemophilia B/epidemiology ; Hemophilia B/immunology ; Hemophilia B/mortality ; Humans ; Isoantibodies/blood ; Prospective Studies ; Time
    Chemical Substances Isoantibodies ; Factor VIII (9001-27-8) ; Factor IX (9001-28-9)
    Language English
    Publishing date 2003-07-14
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/j.1538-7836.2004.00831.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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