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  1. Book ; Online ; E-Book: 2024 Nelson's Pediatric Antimicrobial Therapy

    Bradley, John S. / Nelson, John D. / Elizabeth, Barnett / Cantey, Joseph B. / Kimberlin, David W. / Palumbo, Paul E. / Sauberan, Jason / Smart, J. Howard / Steinbach, William J.

    2024  

    Abstract: Completely updated and revised, the 30th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select ... ...

    Abstract Completely updated and revised, the 30th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select the best of all antimicrobial choices. Drug descriptions cover all antimicrobial agents available today and include complete information about dosing regimens. Free updates available at aap.org/Nelsons.
    Language English
    Size 1 online resource (403 pages)
    Edition 30th ed.
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-61002-697-7 ; 9781610026963 ; 978-1-61002-697-0 ; 1610026969
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online: Nelson's Neonatal Antimicrobial Therapy

    Cantey, Joseph B. / Sauberan, Jason / Nelson, John D. / Elizabeth, Barnett / Bradley, John S. / Kimberlin, David W. / Palumbo, Paul E. / Smart, J. Howard / Steinbach, William J.

    2024  

    Abstract: Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial ... ...

    Abstract Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial therapy, this resource aims to help clinicians select the right drug, dose, and duration for the treatment of bacterial, viral, fungal, and parasitic infections in neonates.
    Subject code 618.9201
    Language English
    Size 1 online resource (103 pages)
    Edition 2nd ed.
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village
    Document type Book ; Online
    ISBN 9781610026994 ; 9781610026987 ; 1610026993 ; 1610026985
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: G. E. Moore and J. M. Keynes

    Bateman, Bradley W

    The American economic review 78 ,5, S. 1098-1106

    a missing chapter in the history of the expected utility model

    1988  

    Author's details by Bradley W. Bateman
    Keywords Ökonomische Ideengeschichte ; Theorie
    Language English
    Publisher American Economic Assoc
    Publishing place Nashville, Tenn
    Document type Article
    ZDB-ID 203590x ; 2009979-4
    ISSN 0002-8282
    ISSN 0002-8282
    Database ECONomics Information System

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  4. Book ; Online ; E-Book: Nelson's neonatal antimicrobial therapy

    Cantey, Joseph B. / Nelson, John D. / Elizabeth, Barnett / Bradley, John S. / Kimberlin, David W. / Palumbo, Paul E. / Smart, J. Howard / Steinbach, William J. / Sauberan, Jason

    2024  

    Abstract: Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial ... ...

    Title variant Neonatal antimicrobial therapy
    Institution American Academy of Pediatrics
    Author's details Joseph B. Cantey, MD, MPH, Jason Sauberan, PharmD Editors in Chief, John D. Nelson, Emeritus
    Abstract Completely updated and revised, Nelson's Neonatal Antimicrobial Therapy, 2nd Edition, provides the most current, practical, and evidence-based recommendations for health care professionals treating neonates. Developed by leading experts in antimicrobial therapy, this resource aims to help clinicians select the right drug, dose, and duration for the treatment of bacterial, viral, fungal, and parasitic infections in neonates.

    Front Matter -- 1. Choosing an Antibiotic for the Neonate -- 2. Antimicrobial Drug Therapy for Neonates -- 3. Bacterial Infections in Neonates -- 4. Viral Infections in Neonates -- 5. Fungal Infections in Neonates -- 6. Parasitic Infections in Neonates -- 7. Antimicrobial Stewardship in the Nursery -- Index.
    Subject code 618.9201
    Language English
    Size 1 Online-Ressource (x, 92 Seiten)
    Edition Second edition
    Publisher American Academy of Pediatrics
    Publishing place Elk Grove Village
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030696544
    ISBN 978-1-61002-699-4 ; 9781610026987 ; 1-61002-699-3 ; 1610026985
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  5. Article ; Online: Interpreting diagnostic accuracy studies based on retrospective routinely collected data.

    Bradley, Stephen H / Shinkins, Bethany / Abel, Gary / Callister, Matthew E J

    Journal of clinical epidemiology

    2024  , Page(s) 111359

    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2024.111359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.206: Show issues Location:
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  6. Article ; Online: Identification of Induced Copy Number Variation from Low Coverage Sequence Data.

    Till, Bradley J

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2787, Page(s) 141–152

    Abstract: ... ionizing radiation. This has been shown to create a variety of different DNA lesions including large (e.g., >=10,000 ...

    Abstract Induced mutations have been an important tool for plant breeding and functional genomics for more than 80 years. Novel mutations can be induced by treating seed or other plant cells with chemical mutagens or ionizing radiation. The majority of released mutant crop varieties were developed using ionizing radiation. This has been shown to create a variety of different DNA lesions including large (e.g., >=10,000 bps) copy number variations (CNV). Detection of induced DNA lesions from whole genome sequence data is useful for choosing a mutagen dosage prior to committing resources to develop a large mutant population for forward or reverse-genetic screening. Here I provide a method for detecting large induced CNV from mutant plants that utilizes a new tool to streamline the process of obtaining read coverage directly from BAM files, comparing non-mutagenized controls and mutagenized samples, and plotting the results for visual evaluation. Example data is provided from low coverage sequence data from gamma-irradiated vegetatively propagated triploid banana.
    MeSH term(s) DNA Copy Number Variations ; Genome, Plant ; Musa/genetics ; Mutation ; High-Throughput Nucleotide Sequencing/methods ; Mutagens ; Plant Breeding/methods ; Sequence Analysis, DNA/methods
    Chemical Substances Mutagens
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3778-4_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Implementation science for cancer control: One center's experience addressing context, adaptation, equity, and sustainment.

    Glasgow, Russell E / Ford, Bryan S / Bradley, Cathy J

    Translational behavioral medicine

    2023  Volume 14, Issue 4, Page(s) 215–224

    Abstract: Implementation science (IS) has great potential to enhance the frequency, speed, and quality of the translation of evidence-based programs, policies, products, and guidelines into practice. Progress has been made, but with some notable exceptions, this ... ...

    Abstract Implementation science (IS) has great potential to enhance the frequency, speed, and quality of the translation of evidence-based programs, policies, products, and guidelines into practice. Progress has been made, but with some notable exceptions, this promise has not been achieved for cancer prevention and control. We discuss five interrelated but conceptually distinct, crosscutting issues important to accelerate IS for cancer prevention and control and how our Colorado Implementation Science Center in Cancer Control (COISC3) addressed these issues. These needs and opportunities include more fully addressing changing, multi-level context; guiding rapid, iterative adaptations; evaluating innovative approaches to engagement and health equity; greater attention to costs and economic issues; and sustainability. We summarize conceptual issues; evaluation needs and capacity building activities and then provide examples of how our IS center addressed these five needs for cancer prevention and control. We discuss changes made to address priorities of (i) guiding adaptations of implementation strategies to address changing context and (ii) working on issues identified and prioritized by our primary care partners rather than the research team. We conclude with discussion of lessons learned, limitations, and directions for future research and practice in IS to enhance cancer prevention and control as well as translational behavioral medicine more generally.
    MeSH term(s) Humans ; Implementation Science ; Delivery of Health Care ; Policy ; Neoplasms/prevention & control ; Needs Assessment
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2586893-7
    ISSN 1613-9860 ; 1869-6716
    ISSN (online) 1613-9860
    ISSN 1869-6716
    DOI 10.1093/tbm/ibad078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Clusterin as a Potential Biomarker of Obesity-Related Alzheimer's Disease Risk.

    Bradley, David

    Biomarker insights

    2020  Volume 15, Page(s) 1177271920964108

    Abstract: ... status, and Apolipoprotein E (ApoE) genotype. Among patients over the age of 65 with dementia, 37% have ... Clusterin, also known as apolipoprotein J (ApoJ), is a multifunctional glycoprotein that acts ...

    Abstract Over 35% of the adult US population is obese. In turn, excess adiposity increases the risk of multiple complications including type 2 diabetes (T2D), insulin resistance, and cardiovascular disease; yet, obesity also independently heightens risk of Alzheimer's Disease (AD), even after adjusting for other important confounding risk factors including blood pressure, sociodemographics, cholesterol levels, smoking status, and Apolipoprotein E (ApoE) genotype. Among patients over the age of 65 with dementia, 37% have coexisting diabetes, and an estimated 7.3% of cases of AD are directly attributable to midlife obesity. Clusterin, also known as apolipoprotein J (ApoJ), is a multifunctional glycoprotein that acts as a molecular chaperone, assisting folding of secreted proteins. Clusterin has been implicated in several physiological and pathological states, including AD, metabolic disease, and cardiovascular disease. Despite long-standing interest in elucidating clusterin's relationship with amyloid beta (Aβ) aggregation/clearance and toxicity, significant knowledge gaps still exist. Altered clusterin expression and protein levels have been linked with cognitive and memory function, disrupted central nervous system lipid flux, as well as pathogenic brain structure; and its role in cardiometabolic disease suggests that it may be a link between insulin resistance, dyslipidemia, and AD. Here, we briefly highlight clusterin's relevance to AD by presenting existing evidence linking clusterin to AD and cardiometabolic disease, and discussing its potential utility as a biomarker for AD in the presence of obesity-related metabolic disease.
    Language English
    Publishing date 2020-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1177-2719
    ISSN 1177-2719
    DOI 10.1177/1177271920964108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Bitter-Sweet Story: Unraveling the Genes Involved in Quinolizidine Alkaloid Synthesis in

    Osorio, Claudia E / Till, Bradley J

    Frontiers in plant science

    2022  Volume 12, Page(s) 795091

    Abstract: Alkaloids are part of a structurally diverse group of over 21,000 cyclic nitrogen-containing secondary metabolites that are found in over 20% of plant species. ...

    Abstract Alkaloids are part of a structurally diverse group of over 21,000 cyclic nitrogen-containing secondary metabolites that are found in over 20% of plant species.
    Language English
    Publishing date 2022-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.795091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase.

    Mullins, Elwood A / Salay, Lauren E / Durie, Clarissa L / Bradley, Noah P / Jackman, Jane E / Ohi, Melanie D / Chazin, Walter J / Eichman, Brandt F

    Nature structural & molecular biology

    2024  

    Abstract: The mechanism by which polymerase α-primase (polα-primase) synthesizes chimeric RNA-DNA primers of defined length and composition, necessary for replication fidelity and genome stability, is unknown. Here, we report cryo-EM structures of Xenopus laevis ... ...

    Abstract The mechanism by which polymerase α-primase (polα-primase) synthesizes chimeric RNA-DNA primers of defined length and composition, necessary for replication fidelity and genome stability, is unknown. Here, we report cryo-EM structures of Xenopus laevis polα-primase in complex with primed templates representing various stages of DNA synthesis. Our data show how interaction of the primase regulatory subunit with the primer 5' end facilitates handoff of the primer to polα and increases polα processivity, thereby regulating both RNA and DNA composition. The structures detail how flexibility within the heterotetramer enables synthesis across two active sites and provide evidence that termination of DNA synthesis is facilitated by reduction of polα and primase affinities for the varied conformations along the chimeric primer-template duplex. Together, these findings elucidate a critical catalytic step in replication initiation and provide a comprehensive model for primer synthesis by polα-primase.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/s41594-024-01227-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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