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  1. Article ; Online: Introduction of the 2020 Clark P. Read Mentor Award Recipient, Professor Derek M. McKay.

    Buret, André G

    The Journal of parasitology

    2021  Volume 106, Issue 6, Page(s) 869–870

    MeSH term(s) Awards and Prizes ; Canada ; History, 20th Century ; History, 21st Century ; Mentors/history ; Northern Ireland ; Parasitology/history ; Societies, Scientific/history ; United States
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 300870-8
    ISSN 1937-2345 ; 0022-3395
    ISSN (online) 1937-2345
    ISSN 0022-3395
    DOI 10.1645/20-147
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  2. Article ; Online: The role of mucin

    Fekete, Elena / Buret, Andre G

    American journal of physiology. Gastrointestinal and liver physiology

    2023  Volume 324, Issue 6, Page(s) G452–G465

    Abstract: ... ...

    Abstract Mucin
    MeSH term(s) Humans ; Mucins/metabolism ; Intestinal Mucosa/metabolism ; Dysbiosis ; Microbiota ; Host-Pathogen Interactions ; Homeostasis ; Polysaccharides/chemistry ; Mucin-2/metabolism
    Chemical Substances Mucins ; Polysaccharides ; Mucin-2
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00261.2022
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  3. Article ; Online: Gut microbiota biofilms: From regulatory mechanisms to therapeutic targets.

    Buret, Andre G / Allain, Thibault

    The Journal of experimental medicine

    2023  Volume 220, Issue 3

    Abstract: Gut microbiota contain communities of viruses, bacteria, fungi, and Eukarya, and live as biofilms. In health, these biofilms adhere to the intestinal mucus surface without contacting the epithelium. Disruptions to the equilibrium between these biofilms ... ...

    Abstract Gut microbiota contain communities of viruses, bacteria, fungi, and Eukarya, and live as biofilms. In health, these biofilms adhere to the intestinal mucus surface without contacting the epithelium. Disruptions to the equilibrium between these biofilms and the host may create invasive pathobionts from these commensal communities and contribute to disease pathogenesis. Environmental factors appear to dominate over genetics in determining the shifts in microbiota populations and function, including when comparing microbiota between low-income and industrialized countries. The observations discussed herein carry enormous potential for the development of novel therapies targeting phenotype in microbiota dysbiosis.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Biofilms ; Microbiota ; Bacteria ; Symbiosis ; Dysbiosis/microbiology
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221743
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  4. Article ; Online: Acceptance of the 2019 Stoll-Stunkard Memorial Lectureship Award: The Study of Host-Parasite Interactions to Better Understand Fundamental Host Physiology: The Model of Giardiasis.

    Buret, André G

    The Journal of parasitology

    2020  Volume 105, Issue 6, Page(s) 955–960

    MeSH term(s) Animals ; Awards and Prizes ; Giardia/classification ; Giardia/genetics ; Giardia/physiology ; Giardia/ultrastructure ; Giardiasis/parasitology ; Host-Parasite Interactions/physiology ; Humans ; Microscopy, Electron, Scanning ; Parasitology ; Societies, Scientific ; United States
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Address ; Portrait ; Research Support, Non-U.S. Gov't
    ZDB-ID 300870-8
    ISSN 1937-2345 ; 0022-3395
    ISSN (online) 1937-2345
    ISSN 0022-3395
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  5. Article ; Online: Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions.

    DeMichele, Emily / Buret, Andre G / Taylor, Cormac T

    Pflugers Archiv : European journal of physiology

    2024  

    Abstract: Mammalian cells utilize glucose as a primary carbon source to produce energy for most cellular functions. However, the bioenergetic homeostasis of cells can be perturbed by environmental alterations, such as changes in oxygen levels which can be ... ...

    Abstract Mammalian cells utilize glucose as a primary carbon source to produce energy for most cellular functions. However, the bioenergetic homeostasis of cells can be perturbed by environmental alterations, such as changes in oxygen levels which can be associated with bacterial infection. Reduction in oxygen availability leads to a state of hypoxia, inducing numerous cellular responses that aim to combat this stress. Importantly, hypoxia strongly augments cellular glycolysis in most cell types to compensate for the loss of aerobic respiration. Understanding how this host cell metabolic adaptation to hypoxia impacts the course of bacterial infection will identify new anti-microbial targets. This review will highlight developments in our understanding of glycolytic substrate channeling and spatiotemporal enzymatic organization in response to hypoxia, shedding light on the integral role of the hypoxia-inducible factor (HIF) during host-pathogen interactions. Furthermore, the ability of intracellular and extracellular bacteria (pathogens and commensals alike) to modulate host cellular glucose metabolism will be discussed.
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-024-02953-w
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  6. Article: Regulatory Functions of Hypoxia in Host-Parasite Interactions: A Focus on Enteric, Tissue, and Blood Protozoa.

    DeMichele, Emily / Sosnowski, Olivia / Buret, Andre G / Allain, Thibault

    Microorganisms

    2023  Volume 11, Issue 6

    Abstract: Body tissues are subjected to various oxygenic gradients and fluctuations and hence can become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional regulator of the cellular hypoxic response and is capable of modulating ... ...

    Abstract Body tissues are subjected to various oxygenic gradients and fluctuations and hence can become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional regulator of the cellular hypoxic response and is capable of modulating cellular metabolism, immune responses, epithelial barrier integrity, and local microbiota. Recent reports have characterized the hypoxic response to various infections. However, little is known about the role of HIF activation in the context of protozoan parasitic infections. Growing evidence suggests that tissue and blood protozoa can activate HIF and subsequent HIF target genes in the host, helping or hindering their pathogenicity. In the gut, enteric protozoa are adapted to steep longitudinal and radial oxygen gradients to complete their life cycle, yet the role of HIF during these protozoan infections remains unclear. This review focuses on the hypoxic response to protozoa and its role in the pathophysiology of parasitic infections. We also discuss how hypoxia modulates host immune responses in the context of protozoan infections.
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11061598
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  7. Article ; Online: Regulatory Functions of Hypoxia in Host–Parasite Interactions

    Emily DeMichele / Olivia Sosnowski / Andre G. Buret / Thibault Allain

    Microorganisms, Vol 11, Iss 1598, p

    A Focus on Enteric, Tissue, and Blood Protozoa

    2023  Volume 1598

    Abstract: Body tissues are subjected to various oxygenic gradients and fluctuations and hence can become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional regulator of the cellular hypoxic response and is capable of modulating ... ...

    Abstract Body tissues are subjected to various oxygenic gradients and fluctuations and hence can become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional regulator of the cellular hypoxic response and is capable of modulating cellular metabolism, immune responses, epithelial barrier integrity, and local microbiota. Recent reports have characterized the hypoxic response to various infections. However, little is known about the role of HIF activation in the context of protozoan parasitic infections. Growing evidence suggests that tissue and blood protozoa can activate HIF and subsequent HIF target genes in the host, helping or hindering their pathogenicity. In the gut, enteric protozoa are adapted to steep longitudinal and radial oxygen gradients to complete their life cycle, yet the role of HIF during these protozoan infections remains unclear. This review focuses on the hypoxic response to protozoa and its role in the pathophysiology of parasitic infections. We also discuss how hypoxia modulates host immune responses in the context of protozoan infections.
    Keywords Giardia duodenalis ; protozoa ; hypoxia ; HIF ; Entamoeba ; Leishmania ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Pathogenesis and post-infectious complications in giardiasis.

    Allain, Thibault / Buret, André G

    Advances in parasitology

    2019  Volume 107, Page(s) 173–199

    Abstract: Giardia is an important cause of diarrhoea, and results in post-infectious and extra-intestinal complications. This chapter presents a state-of-the art of our understanding of how this parasite may cause such abnormalities, which appear to develop at ... ...

    Abstract Giardia is an important cause of diarrhoea, and results in post-infectious and extra-intestinal complications. This chapter presents a state-of-the art of our understanding of how this parasite may cause such abnormalities, which appear to develop at least in part in Assemblage-dependent manner. Findings from prospective longitudinal cohort studies indicate that Giardia is one of the four most prevalent enteropathogens in early life, and represents a risk factor for stunting at 2 years of age. This may occur independently of diarrheal disease, in strong support of the pathophysiological significance of the intestinal abnormalities induced by this parasite. These include epithelial malabsorption and maldigestion, increased transit, mucus depletion, and disruptions of the commensal microbiota. Giardia increases epithelial permeability and facilitates the invasion of gut bacteria. Loss of intestinal barrier function is at the core of the acute and post-infectious complications associated with this infection. Recent findings demonstrate that the majority of the pathophysiological responses triggered by this parasite can be recapitulated by the effects of its membrane-bound and secreted cysteine proteases.
    MeSH term(s) Giardia lamblia/physiology ; Giardiasis/complications ; Giardiasis/parasitology ; Giardiasis/pathology ; Humans ; Intestinal Diseases/etiology ; Intestinal Diseases/parasitology
    Language English
    Publishing date 2019-12-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 165-x
    ISSN 2163-6079 ; 0065-308X
    ISSN (online) 2163-6079
    ISSN 0065-308X
    DOI 10.1016/bs.apar.2019.12.001
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  9. Article ; Online: Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy.

    Buret, Andre G / Allain, Thibault / Motta, Jean-Paul / Wallace, John L

    Antioxidants & redox signaling

    2021  Volume 36, Issue 4-6, Page(s) 211–219

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Gastrointestinal Microbiome ; Gastrointestinal Tract ; Hydrogen Sulfide/pharmacology ; Microbiota ; Proteomics
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2021.0004
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  10. Article ; Online: Protoporphyrin IX derived from dual-species anaerobic biofilms of

    Lockhart, Joey S / Allain, Thibault / Hirota, Simon A / Buret, Andre G / Morck, Douglas W

    Biofilm

    2022  Volume 4, Page(s) 100095

    Abstract: Host immune cells and clinical interventions often fail to eradicate biofilm-mediated infections, resulting in chronic inflammation. The role of the biofilm three-dimensional structure in this tolerant phenotype has been studied extensively; however, the ...

    Abstract Host immune cells and clinical interventions often fail to eradicate biofilm-mediated infections, resulting in chronic inflammation. The role of the biofilm three-dimensional structure in this tolerant phenotype has been studied extensively; however, the impact of small molecules released from biofilm-bacteria in modulating host immune function is less well understood. A model of mixed-species biofilms composed of
    Language English
    Publishing date 2022-11-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-2075
    ISSN (online) 2590-2075
    DOI 10.1016/j.bioflm.2022.100095
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