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  1. Article ; Online: Not All Parenchymal Changes on Computed Tomography Are Interstitial Lung Disease.

    Vijayakumar, Bavithra / Shah, Pallav L

    Annals of the American Thoracic Society

    2021  Volume 18, Issue 9, Page(s) 1597

    MeSH term(s) Humans ; Lung Diseases, Interstitial/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202101-084LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
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  2. Article ; Online: Is Fibrosis Really Fibrosis?

    Vijayakumar, Bavithra / Shah, Pallav L

    American journal of respiratory and critical care medicine

    2020  Volume 203, Issue 11, Page(s) 1440–1442

    MeSH term(s) Fibrosis ; Humans
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202102-0334LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A novel 2-week wait lung cancer pathway starting with a telephone consultation, with patient satisfaction survey results.

    Vijayakumar, Bavithra / Shahidi, Mitra / Thakkar, Raj / Prasad, Anjani

    Future healthcare journal

    2020  Volume 7, Issue Suppl 1, Page(s) s15

    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.7.1.s15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Procedural skills training for medical registrars - is it needed?

    Vijayakumar, Bavithra / Kitt, Jamie / Hynes, Gareth / Millette, Sarah / Fitzpatrick, Michael

    Future healthcare journal

    2020  Volume 7, Issue Suppl 1, Page(s) s110–s111

    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.7.1.s110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An effective procedure skills training programme for GIM registrars.

    Vijayakumar, Bavithra / Hynes, Gareth / Kitt, Jamie / Millette, Sarah / FitzPatrick, Michael

    Future healthcare journal

    2021  Volume 8, Issue 1, Page(s) e117–e122

    Abstract: Background: The Royal College of Physicians' : Methods: An online survey was sent to general internal medicine (GIM) trainees within the Thames Valley Deanery in January 2019. This identified a need for procedure skills training. Ninety per cent of ... ...

    Abstract Background: The Royal College of Physicians'
    Methods: An online survey was sent to general internal medicine (GIM) trainees within the Thames Valley Deanery in January 2019. This identified a need for procedure skills training. Ninety per cent of trainees felt simulation training would improve their confidence in the outlined procedures.
    We trialled a simulation programme for GIM registrars between September 2019 and October 2019. Sessions lasted 3-3.5 hours and trainees rotated through four stations. Feedback was obtained from trainees and trainers during each pilot session.
    Results: Thirty-two trainees attended across both sites. Excellent feedback was obtained and trainee confidence improved by visual analogue scale scoring post-training for all procedures. Almost 90% of trainees felt the sessions would improve safety on GIM on calls.
    Conclusion: Simulation training is an effective way to improve trainee confidence in procedural skills and this pilot shows such training is desired and necessitated in higher specialty training. Further work will assess its impact on maintaining trainee skillsets and impact on patient safety.
    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.2020-0090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of COVID-19 on people with asthma

    Jennifer K Quint / Andrew Cumella / Nicholas S Hopkinson / Sara Buttery / Keir Elmslie James Philip / Sebastian L Johnston / Parris Williams / Bavithra Vijayakumar / James Tonkin / Lottie Renwick / Lizzie Ogden

    BMJ Open Respiratory Research, Vol 9, Iss

    a mixed methods analysis from a UK wide survey

    2022  Volume 1

    Keywords Medicine ; R ; Diseases of the respiratory system ; RC705-779
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The Use of Benralizumab in the Treatment of Near-Fatal Asthma: A New Approach.

    Ramakrishnan, Sanjay / Camp, James R / Vijayakumar, Bavithra / Hardinge, Frances M / Downs, Matilda L / Russell, Richard E K / Pavord, Ian D / Bafadhel, Mona

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 11, Page(s) 1441–1443

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Humans ; Male ; Middle Aged ; Severity of Illness Index
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202001-0093LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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  8. Article ; Online: CT Lung Abnormalities after COVID-19 at 3 Months and 1 Year after Hospital Discharge.

    Vijayakumar, Bavithra / Tonkin, James / Devaraj, Anand / Philip, Keir E J / Orton, Christopher M / Desai, Sujal R / Shah, Pallav L

    Radiology

    2021  Volume 303, Issue 2, Page(s) 444–454

    Abstract: Background Data on the long-term pulmonary sequelae in COVID-19 are lacking. Purpose To assess symptoms, functional impairment, and residual pulmonary abnormalities on serial chest CT scans in COVID-19 survivors discharged from hospital at up to 1-year ... ...

    Abstract Background Data on the long-term pulmonary sequelae in COVID-19 are lacking. Purpose To assess symptoms, functional impairment, and residual pulmonary abnormalities on serial chest CT scans in COVID-19 survivors discharged from hospital at up to 1-year follow-up. Materials and Methods Adult patients with COVID-19 discharged between March 2020 and June 2020 were prospectively evaluated at 3 months and 1 year through systematic assessment of symptoms, functional impairment, and thoracic CT scans as part of the PHENOTYPE study, an observational cohort study in COVID-19 survivors. Lung function testing was limited to participants with CT abnormalities and/or persistent breathlessness. Bonferroni correction was used. Results Eighty participants (mean age, 59 years ± 13 [SD]; 53 men) were assessed. At outpatient review, persistent breathlessness was reported in 37 of the 80 participants (46%) and cough was reported in 17 (21%). CT scans in 73 participants after discharge (median, 105 days; IQR, 95-141 days) revealed persistent abnormalities in 41 participants (56%), with ground-glass opacification (35 of 73 participants [48%]) and bands (27 of 73 participants [37%]) predominating. Unequivocal signs indicative of established fibrosis (ie, volume loss and/or traction bronchiectasis) were present in nine of 73 participants (12%). Higher admission serum C-reactive protein (in milligrams per liter), fibrinogen (in grams per deciliter), urea (millimoles per liter), and creatinine (micromoles per liter) levels; longer hospital stay (in days); older age (in years); and requirement for invasive ventilation were associated with CT abnormalities at 3-month follow-up. Thirty-two of 41 participants (78%) with abnormal findings at 3-month follow-up CT underwent repeat imaging at a median of 364 days (range, 360-366 days), with 26 (81%) showing further radiologic improvement (median, 18%; IQR, 10%-40%). Conclusion CT abnormalities were common at 3 months after COVID-19 but with signs of fibrosis in a minority. More severe acute disease was linked with CT abnormalities at 3 months. However, radiologic improvement was seen in the majority at 1-year follow-up. ClinicalTrials.gov identifier: NCT04459351. © RSNA, 2022
    MeSH term(s) COVID-19/diagnostic imaging ; Dyspnea ; Fibrosis ; Hospitals ; Humans ; Lung/diagnostic imaging ; Patient Discharge ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-10-05
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2021211746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.106: Show issues Location:
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  9. Article ; Online: Impact of COVID-19 on people with asthma: a mixed methods analysis from a UK wide survey.

    Philip, Keir Elmslie James / Buttery, Sara / Williams, Parris / Vijayakumar, Bavithra / Tonkin, James / Cumella, Andrew / Renwick, Lottie / Ogden, Lizzie / Quint, Jennifer K / Johnston, Sebastian L / Polkey, Michael I / Hopkinson, Nicholas S

    BMJ open respiratory research

    2022  Volume 9, Issue 1

    Abstract: Introduction: The impact of acute COVID-19 on people with asthma appears complex, being moderated by multiple interacting disease-specific, demographic and environmental factors. Research regarding longer-term effects in this group is limited. We aimed ... ...

    Abstract Introduction: The impact of acute COVID-19 on people with asthma appears complex, being moderated by multiple interacting disease-specific, demographic and environmental factors. Research regarding longer-term effects in this group is limited. We aimed to assess impacts of COVID-19 and predictors of persistent symptoms, in people with asthma.
    Methods: Using data from an online UK-wide survey of 4500 people with asthma (median age 50-59 years, 81% female), conducted in October 2020, we undertook a mixed methods analysis of the characteristics and experience of those reporting having had COVID-19.
    Results: The COVID-19 group (n=471, 10.5%) reported increased inhaler use and worse asthma management, compared with those not reporting COVID-19, but did not differ by gender, ethnicity or household income. Among the COVID-19 group, 56.1% reported having long COVID, 20.2% were 'unsure'. Those with long COVID were more likely than those without long COVID to describe: their breathing as worse or much worse after their initial illness (73.7% vs 34.8%, p<0.001), increased inhaler use (67.8% vs 34.8%, p<0.001) and worse or much worse asthma management (59.6% vs 25.6%, p<0.001). Having long COVID was not associated with age, gender, ethnicity, UK nation or household income.Analysis of free text survey responses identified three key themes: (1) variable COVID-19 severity, duration and recovery; (2) symptom overlap and interaction between COVID-19 and asthma; (3) barriers to accessing healthcare.
    Conclusions: Persisting symptoms are common in people with asthma following COVID-19. Measures are needed to ensure appropriate healthcare access including clinical evaluation and investigation, to distinguish between COVID-19 symptoms and asthma.
    MeSH term(s) Asthma/drug therapy ; Asthma/epidemiology ; COVID-19/complications ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2021-001056
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  10. Article ; Online: Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.

    Vijayakumar, Bavithra / Boustani, Karim / Ogger, Patricia P / Papadaki, Artemis / Tonkin, James / Orton, Christopher M / Ghai, Poonam / Suveizdyte, Kornelija / Hewitt, Richard J / Desai, Sujal R / Devaraj, Anand / Snelgrove, Robert J / Molyneaux, Philip L / Garner, Justin L / Peters, James E / Shah, Pallav L / Lloyd, Clare M / Harker, James A

    Immunity

    2022  Volume 55, Issue 3, Page(s) 542–556.e5

    Abstract: Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airways and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after ... ...

    Abstract Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airways and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with an elevated concentration of proteins associated with apoptosis, tissue repair, and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. A one-year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to the ongoing activation of cytotoxic T cells.
    MeSH term(s) Adult ; Aged ; B-Lymphocytes/immunology ; COVID-19/complications ; COVID-19/immunology ; Female ; Follow-Up Studies ; Humans ; Immunity, Cellular ; Immunoproteins ; Male ; Middle Aged ; Monocytes/immunology ; Proteome ; Respiration Disorders/etiology ; Respiration Disorders/immunology ; Respiratory System/immunology ; Respiratory System/pathology ; SARS-CoV-2/physiology ; T-Lymphocytes, Cytotoxic/immunology
    Chemical Substances Immunoproteins ; Proteome
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.01.017
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    Zs.MG 69: Show issues

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