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  1. Article ; Online: A Well-armed Approach Drives Relevant Non-HLA Antibody Targets Into the Open.

    Thomson, Angus W

    Transplantation

    2021  Volume 106, Issue 7, Page(s) 1310–1311

    MeSH term(s) Antibodies ; HLA Antigens
    Chemical Substances Antibodies ; HLA Antigens
    Language English
    Publishing date 2021-12-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  2. Article ; Online: Negative Vaccination Strategies for Promotion of Transplant Tolerance.

    Tunbridge, Matthew J / Luo, Xunrong / Thomson, Angus W

    Transplantation

    2024  

    Abstract: Organ transplantation requires the use of immunosuppressive medications that lack antigen specificity, have many adverse side effects, and fail to induce immunological tolerance to the graft. The safe induction of tolerance to allogeneic tissue without ... ...

    Abstract Organ transplantation requires the use of immunosuppressive medications that lack antigen specificity, have many adverse side effects, and fail to induce immunological tolerance to the graft. The safe induction of tolerance to allogeneic tissue without compromising host responses to infection or enhancing the risk of malignant disease is a major goal in transplantation. One promising approach to achieve this goal is based on the concept of "negative vaccination." Vaccination (or actively acquired immunity) involves the presentation of both a foreign antigen and immunostimulatory adjuvant to the immune system to induce antigen-specific immunity. By contrast, negative vaccination, in the context of transplantation, involves the delivery of donor antigen before or after transplantation, together with a "negative adjuvant" to selectively inhibit the alloimmune response. This review will explore established and emerging negative vaccination strategies for promotion of organ or pancreatic islet transplant tolerance. These include donor regulatory myeloid cell infusion, which has progressed to early-phase clinical trials, apoptotic donor cell infusion that has advanced to nonhuman primate models, and novel nanoparticle antigen-delivery systems.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Regulatory dendritic cell therapy in organ transplantation.

    Hadjiyannis, Yannis / Thomson, Angus W

    Current opinion in organ transplantation

    2023  Volume 29, Issue 2, Page(s) 121–130

    Abstract: Purpose of review: Regulatory dendritic cells (DCregs; also 'tolerogenic DCs'), innate immune cells that regulate the alloimmune response, are a novel cellular therapy for organ transplantation. Preliminary results from early-phase clinical trials in ... ...

    Abstract Purpose of review: Regulatory dendritic cells (DCregs; also 'tolerogenic DCs'), innate immune cells that regulate the alloimmune response, are a novel cellular therapy for organ transplantation. Preliminary results from early-phase clinical trials in live donor kidney and liver transplantation are promising. This follows many years of research elucidating mechanisms of action and utility of DCregs. Herein, we review early-phase clinical trial observations and recent advances in the production, modification, and future-trajectory of DCreg in organ transplantation.
    Recent findings: Preclinical work has demonstrated the ability of adoptively transferred DCreg to abrogate ischemia-reperfusion injury and promote long-term allograft survival. Good Manufacturing Practice-grade DCregs have been generated in adequate numbers for early-phase trials of autologous DCregs in kidney transplantation and donor-derived DCreg in liver transplantation. These trials have demonstrated feasibility and safety, with preliminary evidence of an influence on host immune reactivity. In both kidney and liver transplantation, reduced effector CD8 + T-cells have been noted, together with other changes that may be conducive to reduced dependence on immunosuppressive therapy.
    Summary: Substantial progress has been made in bringing DCreg to clinical testing in organ transplantation. Additional clinical and mechanistic studies are now needed to further explore and garner the full potential of DCreg in organ transplantation.
    MeSH term(s) Humans ; Organ Transplantation/adverse effects ; Kidney Transplantation ; Transplantation, Homologous ; T-Lymphocytes ; Dendritic Cells ; T-Lymphocytes, Regulatory
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000001127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Book: The cytokine handbook / 1

    Thomson, Angus W.

    2003  

    Author's details ed. by Angus W. Thomson
    Collection The cytokine handbook
    Keywords Cytokine
    Subject Zytokine
    Language English
    Size XXVII, 638 S., S. XXX - LXVII : Ill., graph. Darst.
    Edition 4. ed.
    Publisher Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT013733749
    ISBN 0-12-689663-1 ; 978-0-12-689663-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 A 2422 order for loan Magazin

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  5. Book: The cytokine handbook / 2

    Thomson, Angus W.

    2003  

    Author's details ed. by Angus W. Thomson
    Collection The cytokine handbook
    Keywords Cytokine
    Subject Zytokine
    Language English
    Size XXVII S., S. 644 - 1396, S. XXX - LXVII : Ill., graph. Darst.
    Edition 4. ed.
    Publisher Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT013733755
    ISBN 0-12-689663-1 ; 978-0-12-689663-3
    Database Catalogue ZB MED Medicine, Health

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  6. Book ; Collection: The cytokine handbook

    Thomson, Angus W.

    2003  

    Author's details ed. by Angus W. Thomson
    Keywords Cytokines / physiology ; Cytokines / therapeutic use ; Interleukins / physiology ; Tumor Necrosis Factor / physiology ; Colony-Stimulating Factors
    Language English
    Dates of publication 2003-9999
    Publisher Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Collection (display volumes)
    Note Bis 3. Aufl. als einbänd. Werk ersch.
    HBZ-ID HT013733700
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: A view of the future of regulatory immune cell therapy in organ transplantation.

    Thomson, Angus W

    Current opinion in organ transplantation

    2018  Volume 23, Issue 5, Page(s) 507–508

    Language English
    Publishing date 2018-08-06
    Publishing country United States
    Document type Introductory Journal Article ; Editorial
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Book: Therapeutic immunosuppression

    Thomson, Angus W.

    (Immunology and medicine ; 29)

    2001  

    Author's details ed. by Angus W. Thomson
    Series title Immunology and medicine ; 29
    Collection
    Keywords Immunosuppression ; Immunsuppression ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Immundepression ; Immunsystem
    Language English
    Size X, 512 S. : graph. Darst.
    Publisher Kluwer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT013101847
    ISBN 0-7923-6889-4 ; 978-0-7923-6889-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 3853 order for loan Magazin

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  9. Article ; Online: MyD88 Inhibitors and the Continuing Challenge of TLR Antagonism.

    Thomson, Angus W

    Transplantation

    2017  Volume 101, Issue 2, Page(s) 230–231

    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000001565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Book: The cytokine handbook

    Thomson, Angus W.

    1998  

    Author's details ed. by Angus W. Thomson
    Keywords Cytokine
    Subject Zytokine
    Language English
    Size XXII, 1017 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT009010228
    ISBN 0-12-689662-3 ; 978-0-12-689662-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1998 A 6441 order for loan Magazin

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