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  1. Article ; Online: An extraordinary story of discovery: an interview with Doctor Max D Cooper.

    Ioachimescu, Octavian C / Cooper, Max D

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2022  

    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type Editorial
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1136/jim-2022-002505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 307: Show issues Location:
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  2. Article: Intracellular ionic concentration by calibration from fluorescence indicator emission spectra, its relationship to the K(d), F(min), F(max) formula, and use with Na-Green for presynaptic sodium.

    Winslow, James L / Cooper, Robin L / Atwood, Harold L

    Journal of neuroscience methods

    2002  Volume 118, Issue 2, Page(s) 163–175

    Abstract: The emission spectra calibration curves for a fluorescence indicator and the F(min), F(max), and K ... d) formula were shown to be related. Using the known calibrated fluorescence emitted by Sodium Green ...

    Abstract The emission spectra calibration curves for a fluorescence indicator and the F(min), F(max), and K(d) formula were shown to be related. Using the known calibrated fluorescence emitted by Sodium Green (Na-Green) and photo-multiplier-tube quantum efficiency, we calculated the detection signal over a range of sodium concentrations. The calculated calibration curves were compared for optical filters passing a narrow band, medium band or full spectrum. We found that a method based on the full emission spectrum was the most appropriate. Given a known resting concentration of intracellular sodium, calibrated readings can be converted to concentration values. This method is applicable to any fluorescence indicator when curves for emission spectra over a range of concentrations are available. We measured sodium concentration changes during trains of action potentials (APs) at a crayfish motor axon's presynaptic terminals injected with Na-Green. During low frequency AP trains, net sodium increases asymptotically with frequency. Average net Na-flux per AP decreases for increasing terminal size. The terminals of crayfish motor axon have surface area to volume ratio which is 7700 times larger than for squid. Thus, in comparison to squid, crayfish terminals exhibit a larger change in [Na(+)](i) during equivalent AP activity.
    MeSH term(s) Action Potentials/physiology ; Animals ; Astacoidea ; Calibration ; Cells, Cultured ; Fluorescent Dyes ; Intracellular Fluid/metabolism ; Microscopy, Fluorescence/methods ; Motor Neurons/physiology ; Neuromuscular Junction/metabolism ; Neuromuscular Junction/physiology ; Organic Chemicals ; Osmolar Concentration ; Presynaptic Terminals/physiology ; Sodium/metabolism ; Spectrometry, Fluorescence/methods
    Chemical Substances Fluorescent Dyes ; Organic Chemicals ; sodium green ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2002-10-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/s0165-0270(02)00100-0
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    Zs.A 1486: Show issues Location:
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  3. Book: Inhibition of immune cell function

    Cooper, Max D.

    (Immunological reviews ; 224)

    2008  

    Author's details Max D. Cooper, guest ed
    Series title Immunological reviews ; 224
    Collection
    Language English
    Size 296 S. : Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015655697
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 160 -224- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Unraveling the Arthus Mystery: Fc Receptors and the Holy Grail of Inflammation.

    Nimmerjahn, Falk / Cooper, Max D

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 208, Issue 7, Page(s) 1517–1518

    MeSH term(s) Arthus Reaction ; Humans ; Inflammation ; Receptors, Fc
    Chemical Substances Receptors, Fc
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200086
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  5. Book: The interface between innate and acquired immunity

    Cooper, Max D.

    with 3 tables

    (Current topics in microbiology and immunology ; 266)

    2002  

    Author's details ed. by M. D. Cooper
    Series title Current topics in microbiology and immunology ; 266
    Collection
    Keywords Immunität
    Language English
    Size IX, 116 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013316690
    ISBN 3-540-42894-1 ; 978-3-540-42894-7
    Database Catalogue ZB MED Medicine, Health

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    Ud II Zs 24 -266- verfügbar in Königswinter Königswinter

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  6. Book ; Conference proceedings: Activating and inhibitory immunoglobulin-like receptors

    Cooper, Max D.

    2001  

    Institution Core Research for Evolutional Science and Technology
    Event/congress CREST International Symposium on Immunoglobulin-Like Receptors (2000, Sendai)
    Author's details M. D. Cooper ... (eds.). [CREST International Symposium on Immunoglobulin-like Receptors ... september 18-19, 2000, ... in Sendai City]
    Keywords Receptors / immunology ; Receptors / physiology ; Immunoglobulins / Physiology ; Immune System / physiology ; Immunglobuline ; Rezeptor ; FC-Rezeptor
    Subject FCR ; Gamma-Globuline ; Ig ; Immunoglobuline ; Immunglobulin vom Menschen ; Beriglotin
    Language English
    Size X, 246 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Tokyo u.a.
    Publishing country Japan
    Document type Book ; Conference proceedings
    HBZ-ID HT013289540
    ISBN 4-431-70297-0 ; 978-4-431-70297-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 A 1942 order for loan Magazin

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  7. Article ; Online: Cytokine Receptor Diversity in the Lamprey Predicts the Minimal Essential Cytokine Networks of Vertebrates.

    Boulay, Jean-Louis / Du Pasquier, Louis / Cooper, Max D

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 5, Page(s) 1013–1020

    Abstract: The vertebrate adaptive immune systems (Agnatha and Gnathostomata) use sets of T and B lymphocyte lineages that somatically generate highly diverse repertoires of Ag-specific receptors and Abs. In Gnathostomata, cytokine networks regulate the activation ... ...

    Abstract The vertebrate adaptive immune systems (Agnatha and Gnathostomata) use sets of T and B lymphocyte lineages that somatically generate highly diverse repertoires of Ag-specific receptors and Abs. In Gnathostomata, cytokine networks regulate the activation of lymphoid and myeloid cells, whereas little is known about these components in Agnathans. Most gnathostome cytokines are four-helix bundle cytokines with poorly conserved primary sequences. In contrast, sequence conservation across bilaterians has been observed for cognate cytokine receptor chains, allowing their structural classification into two classes, and for downstream JAK/STAT signaling mediators. With conserved numbers among Gnathostomata, human cytokine receptor chains (comprising 34 class I and 12 class II) are able to interact with 28 class I helical cytokines (including most ILs) and 16 class II cytokines (including all IFNs), respectively. Hypothesizing that the arsenal of cytokine receptors and transducers may reflect homologous cytokine networks, we analyzed the lamprey genome and transcriptome to identify genes and transcripts for 23 class I and five class II cytokine receptors alongside one JAK signal mediator and four STAT transcription factors. On the basis of deduction of their respective orthologs, we predict that these receptors may interact with 16 class I and 3 class II helical cytokines (including IL-4, IL-6, IL-7, IL-12, IL-10, IFN-γ, and thymic stromal lymphoprotein homologs). On the basis of their respective activities in mammals, this analysis suggests the existence of lamprey cytokine networks that may regulate myeloid and lymphoid cell differentiation, including potential Th1/Th2 polarization. The predicted networks thus appear remarkably homologous to those of Gnathostomata, albeit reduced to essential functions.
    MeSH term(s) Animals ; Cytokines/metabolism ; Humans ; Interleukin-10 ; Interleukin-12 ; Interleukin-4 ; Interleukin-6 ; Interleukin-7 ; Lampreys ; Mammals/metabolism ; Receptors, Cytokine/genetics ; STAT Transcription Factors ; Vertebrates/metabolism
    Chemical Substances Cytokines ; Interleukin-6 ; Interleukin-7 ; Receptors, Cytokine ; STAT Transcription Factors ; Interleukin-10 (130068-27-8) ; Interleukin-12 (187348-17-0) ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2200274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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  8. Article ; Online: Urgent call to prevent late stage presentation of head and neck cancer.

    Mackinnon, Euan D / Sornalingam, Sangeetha / Cooper, Max

    BMJ (Clinical research ed.)

    2021  Volume 373, Page(s) n1194

    MeSH term(s) COVID-19 ; Head and Neck Neoplasms ; Humans ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n1194
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  9. Article ; Online: The early history of B cells.

    Cooper, Max D

    Nature reviews. Immunology

    2015  Volume 15, Issue 3, Page(s) 191–197

    Abstract: The separate development of functionally intertwined lineages of lymphocytes known as B cells and T cells is now recognized as a fundamental organizing principle of the adaptive immune system in all vertebrates. Immunologists strive to define the ... ...

    Abstract The separate development of functionally intertwined lineages of lymphocytes known as B cells and T cells is now recognized as a fundamental organizing principle of the adaptive immune system in all vertebrates. Immunologists strive to define the different sublineages of the clonally diverse B cells and T cells, how they interact with each other and how they interact with innate lymphoid cells and other elements of the innate immune system to counter infections, cancer and the development of autoimmune and inflammatory diseases. On the 50th anniversary of the recognition of B cells as a discrete cell lineage, this Timeline article recounts some of the milestones marking the development of the concept that B cells are a functionally and developmentally distinct arm of the adaptive immune system.
    MeSH term(s) Allergy and Immunology/history ; Animals ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Cell Lineage/immunology ; History, 20th Century ; History, 21st Century ; Humans ; Immunity, Cellular/immunology ; Immunity, Humoral/immunology ; Lymphocytes/immunology ; T-Lymphocytes/immunology
    Language English
    Publishing date 2015-02-06
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri3801
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    Zs.A 5565: Show issues Location:
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  10. Book ; Conference proceedings: Lymphopoiesis 1993

    Cooper, Max D. / Grossi, Carlo E.

    a Scientific Symposium to Honor Max Cooper ; on August 30 and 31, 1993 ... at the Lymphopoiesis '93 Meeting held in Birmingham, Alabama

    1993  

    Event/congress Scientific Symposium to Honor Max Cooper (1993, BirminghamAla.) ; Lymphopoiesis Meeting (1993, BirminghamAla.)
    Author's details Carlo E. Grossi ... eds
    Keywords B-Lymphocytes / immunology / congresses ; Hematopoiesis / congresses
    Language English
    Publishing country Italy
    Document type Book ; Conference proceedings
    Note In: Fundamental and clinical immunology. - ISSN 1120-3765. - 1 (1993),4, S. [167] - 200
    HBZ-ID HT006637174
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 4144 -1- verfügbar in Königswinter Königswinter

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