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Book ; Online: Chapter 4 PREDICTING RESPONSES OF GEO-ECOLOGICALCARBONATE REEF SYSTEMS TO CLIMATE CHANGE:A CONCEPTUAL MODEL AND REVIEW

BROWNE, NICOLA K. / CUTTLER, MICHAEL / MOON, KATIE / MORGAN, KYLE / ROSS, CLAIRE L. / CASTRO-SANGUINO, CAROLINA / KENNEDY, EMMA / HARRIS, DAN / BARNES, PETER / BAUMAN, ANDREW / BEETHAM, EDDIE / BONESSO, JOSHUA / BOZEC, YVES-MARIE / CORNWALL, CHRISTOPHER / DEE, SHANNON / DECARLO, THOMAS / D'OLIVO, JUAN P. / DOROPOULOS, CHRISTOPHER / EVANS, RICHARD D. /

EYRE, BRADLEY / GATENBY, PETER / GONZALEZ, MANUEL / HAMYLTON, SARAH / HANSEN, JEFF / LOWE, RYAN

2021

Keywords	bic Book Industry Communication ; oceanography, climate change, reefs, marine science, marine conservation, marine research
Size	1 electronic resource (143 pages)
Publisher	Taylor and Francis
Document type	Book ; Online
Note	English[eng] ; Open Access
HBZ-ID	HT021291011
ISBN	9780367685225 ; 0367685221
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Anticytokine autoantibody-associated immunodeficiency.

Browne, Sarah K

Annual review of immunology

2014 Volume 32, Page(s) 635–657

Abstract: Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy adults. Patients with these syndromes demonstrate a unique infectious phenotype associated with neutralizing autoantibodies that target a specific cytokine. Examples ... ...

Abstract	Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy adults. Patients with these syndromes demonstrate a unique infectious phenotype associated with neutralizing autoantibodies that target a specific cytokine. Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma. Other anticytokine autoantibodies may contribute to an infectious phenotype such as anti-granulocyte colony stimulating factor and anti-IFN-α autoantibodies, although the strength of the association is less clear. Their identification not only affects disease management but also may uncover key mechanisms of host defense against specific organisms. Furthermore, it raises the possibility that currently idiopathic diseases will someday be explained by a yet unidentified anticytokine autoantibody. This review focuses on the current understanding, both clinical and mechanistic, of anticytokine autoantibody-associated immunodeficiency.
MeSH term(s)	Animals ; Autoantibodies/immunology ; Candidiasis/diagnosis ; Candidiasis/immunology ; Candidiasis/therapy ; Cytokines/immunology ; Humans ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/therapy ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/therapy ; Thymoma/diagnosis ; Thymoma/immunology ; Thymoma/therapy
Chemical Substances	Autoantibodies ; Cytokines
Language	English
Publishing date	2014
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	604953-9
ISSN	1545-3278 ; 0732-0582
ISSN (online)	1545-3278
ISSN	0732-0582
DOI	10.1146/annurev-immunol-032713-120222
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Article: Foliar Endophytic Fungi from the Endangered Eastern Mountain Avens (

Adams, Sarah J / Robicheau, Brent M / LaRue, Diane / Browne, Robin D / Walker, Allison K

Plants (Basel, Switzerland)

2021 Volume 10, Issue 5

Abstract: Eastern Mountain Avens ( ...

Abstract	Eastern Mountain Avens (
Language	English
Publishing date	2021-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10051026
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Article ; Online: Reference Values for Fetal Cardiac Dimensions, Volumes, Ventricular Function and Left Ventricular Longitudinal Strain Using Doppler Ultrasound Gated Cardiac Magnetic Resonance Imaging in Healthy Third Trimester Fetuses.

Minocha, Prashant K / Englund, Erin K / Friesen, Richard M / Fujiwara, Takashi / Smith, Sarah A / Meyers, Mariana L / Browne, Lorna P / Barker, Alex J

Journal of magnetic resonance imaging : JMRI

2023

Abstract: Background: Recent advances in hardware and software permit the use of cardiac MRI of late gestation fetuses, however there is a paucity of MRI-based reference values.: Purpose: To provide initial data on fetal cardiac MRI-derived cardiac dimensions, ...

Abstract	Background: Recent advances in hardware and software permit the use of cardiac MRI of late gestation fetuses, however there is a paucity of MRI-based reference values. Purpose: To provide initial data on fetal cardiac MRI-derived cardiac dimensions, volumes, ventricular function, and left ventricular longitudinal strain in healthy developing fetuses >30 weeks gestational age. Study type: Prospective. Population: Twenty-five third trimester (34 ± 1 weeks, range of 32-37 weeks gestation) women with healthy developing fetuses. Field strength/sequence: Studies were performed at 1.5 T and 3 T. Cardiac synchronization was achieved with a Doppler ultrasound device. The protocol included T2 single shot turbo spin echo stacks for fetal weight and ultrasound probe positioning, and multiplanar multi-slice cine balanced steady state free precession gradient echo sequences. Assessment: Primary analyses were performed by a single observer. Weight indexed right ventricular (RV) and left ventricular (LV) volumes and function were calculated from short axis (SAX) stacks. Cardiac dimensions were calculated from the four-chamber and SAX stacks. Single plane LV longitudinal strain was calculated from the four-chamber stack. Interobserver variability was assessed in 10 participants. Cardiac MRI values were compared against available published normative fetal echocardiogram data using z-scores. Statistical tests: Mean and SDs were calculated for baseline maternal/fetal demographics, cardiac dimensions, volumes, ventricular function, and left ventricular longitudinal strain. Bland-Altman and intraclass correlation coefficient analysis was performed to test interobserver variability. Results: The mean gestational age was 34 ± 1.4 weeks. The mean RV and LV end diastolic volumes were 3.1 ± 0.6 mL/kg and 2.4 ± 0.5 mL/kg respectively. The mean RV cardiac output was 198 ± 49 mL/min/kg while the mean LV cardiac output was 173 ± 43 mL/min/kg. Data conclusion: This paper reports initial reference values obtained by cardiac MRI in healthy developing third trimester fetuses. MRI generally resulted in slightly larger indexed values (by z-score) compared to reports in literature using fetal echocardiography. Evidence level: 1 TECHNICAL EFFICACY: Stage 2.
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.29077
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Article ; Online: The Southern Health system's Community Health Council: establishment and processes to engage with communities, whānau and patients.

Derrett, Sarah / Adank, Charlotte / Browne, Karen / Takurua, Kelly

The New Zealand medical journal

2022 Volume 135, Issue 1554, Page(s) 63–72

Abstract: Aims: This paper aims to: describe steps to establish the Southern Health system's Community Health Council (CHC) and its associated advisors; discuss support for the CHC, advisors and staff; and reflect on engagement activities, what has worked well, ... ...

Abstract	Aims: This paper aims to: describe steps to establish the Southern Health system's Community Health Council (CHC) and its associated advisors; discuss support for the CHC, advisors and staff; and reflect on engagement activities, what has worked well, and opportunities for development. Method: Prompts for establishing the CHC came from the Health Quality & Safety Commission and previous commissioners of the Southern District Health Board (SDHB). Following support from the Iwi Governance Committee and SDHB and WellSouth Primary Health Organisation (PHO) chief executives and their leadership teams, advertisements called for people interested in joining the CHC. After group interviews, the CHC was established in 2017. Results: It became evident that an 11 member CHC could not support all requests for engagement throughout the Southern Health system. Consequently, the CHC developed a framework for engagement, a large team of CHC advisors, and a Roadmap to support engagement activities. Conclusions: The CHC has supported over 120 CHC members and advisors working on over 95 engagement projects throughout the Southern Health system. It is hoped that the processes described will be useful to the establishment of robust community, whānau and patient forums intended to sit at the centre of Aotearoa New Zealand's restructured health system.
MeSH term(s)	Humans ; Leadership ; New Zealand ; Public Health
Language	English
Publishing date	2022-05-06
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	390590-1
ISSN	1175-8716 ; 0028-8446 ; 0110-7704
ISSN (online)	1175-8716
ISSN	0028-8446 ; 0110-7704
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Article ; Online: Summary of the Vaccines and Related Biological Products Advisory Committee meeting held to consider evaluation of vaccine candidates for the prevention of respiratory syncytial virus disease in RSV-naïve infants.

Browne, Sarah K / Beeler, Judy A / Roberts, Jeffrey N

Vaccine

2019 Volume 38, Issue 2, Page(s) 101–106

Abstract: Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed ... ...

Abstract	Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed preventive vaccine. Clinical trials conducted in the 1960s evaluating a formalin-inactivated RSV vaccine (FI-RSV) in RSV-naïve infants resulted in observations of enhanced respiratory disease (ERD) following subsequent natural RSV infection in vaccinees. In these studies, infants immunized with FI-RSV had higher rates of severe RSV disease compared with controls. This outcome redirected focus on identifying the immunologic mechanisms that precipitated ERD as a prerequisite to further vaccine development. Improved understanding of the immunopathogenesis of ERD derived from animal models has stimulated development of new candidate vaccines and engendered discussions among RSV experts about the safety data needed to advance these products into the clinic, and ultimately, into the target population of RSV-naïve infants. The recognition that multiple products would soon be ready for testing in infants and children prompted the FDA to hold a Vaccines and Related Biological Products Advisory Committee (VRBPAC) meeting to seek perspectives and advice of experts regarding the types and extent of preclinical and clinical data that might be needed to support testing in RSV-naïve infants for specific types of candidate RSV vaccines. Committee members agreed that, if certain conditions are met in preclinical and early clinical studies, it would be reasonable to move forward from studies in adults and older children and into clinical trials evaluating vaccine safety and efficacy in RSV-naïve infants. Herein, we review and summarize perspectives on the discussion regarding recommendations for RSV vaccine development in this population.
MeSH term(s)	Advisory Committees ; Animals ; Biological Products/administration & dosage ; Child, Preschool ; Disease Models, Animal ; Humans ; Immunization ; Infant ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines/administration & dosage ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus, Human/immunology ; Severity of Illness Index
Chemical Substances	Biological Products ; Respiratory Syncytial Virus Vaccines
Language	English
Publishing date	2019-11-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2019.10.048
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Article: Good syndrome, bad problem.

Martinez, Bianca / Browne, Sarah K

Frontiers in oncology

2014 Volume 4, Page(s) 307

Language	English
Publishing date	2014-11-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2014.00307
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Article ; Online: Exploring the interagency collaboration between a pediatric oncology health care setting and community schools.

Rooney, Evan / Johnson, Ayanna A / Klein, Sarah / Jurbergs, Niki / Duvall, Anne / Heidelberg, R Elyse / Potter, Brian S / Harman, Jennifer / Browne, Emily K / Jones, Anna M / Webster, Rachel T

School psychology (Washington, D.C.)

2023

Abstract: Globally, approximately 400,000 youth are diagnosed with pediatric cancer each year. Treatment-related side effects, psychosocial challenges, and frequent school absences may adversely impact learning and the education experience among these youth. ... ...

Abstract	Globally, approximately 400,000 youth are diagnosed with pediatric cancer each year. Treatment-related side effects, psychosocial challenges, and frequent school absences may adversely impact learning and the education experience among these youth. Efforts to enhance interagency collaboration between health care settings and community schools are imperative to facilitate school reintegration. The
Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Journal Article
ISSN	2578-4226
ISSN (online)	2578-4226
DOI	10.1037/spq0000566
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Article: Severe Facial Herpes Vegetans and Viremia in

Parsons, Karyn / Cipriano, Sarah D / Rosen, Lindsey B / Browne, Sarah K / Walter, Jolan E / Stone, Bryan L / Keeshin, Susana / Chen, Karin

Frontiers in pediatrics

2019 Volume 7, Page(s) 61

Abstract: With the accessibility of next-generation sequencing modalities, an increasing number of primary immunodeficiency disorders (PIDDs) such as common variable immunodeficiency (CVID) have gained improved understanding of molecular pathogenesis and disease ... ...

Abstract	With the accessibility of next-generation sequencing modalities, an increasing number of primary immunodeficiency disorders (PIDDs) such as common variable immunodeficiency (CVID) have gained improved understanding of molecular pathogenesis and disease phenotype with the identification of a genetic etiology. We report a patient with early-onset CVID due to an autosomal dominant loss-of-function mutation in
Language	English
Publishing date	2019-03-19
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2019.00061
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Article: Summary of the Vaccines and Related Biological Products Advisory Committee meeting held to consider evaluation of vaccine candidates for the prevention of respiratory syncytial virus disease in RSV-naïve infants

Browne, Sarah K / Beeler, Judy A / Roberts, Jeffrey N

Vaccine. 2020 Jan. 10, v. 38, no. 2

2020

Abstract	Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed preventive vaccine. Clinical trials conducted in the 1960s evaluating a formalin-inactivated RSV vaccine (FI-RSV) in RSV-naïve infants resulted in observations of enhanced respiratory disease (ERD) following subsequent natural RSV infection in vaccinees. In these studies, infants immunized with FI-RSV had higher rates of severe RSV disease compared with controls. This outcome redirected focus on identifying the immunologic mechanisms that precipitated ERD as a prerequisite to further vaccine development. Improved understanding of the immunopathogenesis of ERD derived from animal models has stimulated development of new candidate vaccines and engendered discussions among RSV experts about the safety data needed to advance these products into the clinic, and ultimately, into the target population of RSV-naïve infants. The recognition that multiple products would soon be ready for testing in infants and children prompted the FDA to hold a Vaccines and Related Biological Products Advisory Committee (VRBPAC) meeting to seek perspectives and advice of experts regarding the types and extent of preclinical and clinical data that might be needed to support testing in RSV-naïve infants for specific types of candidate RSV vaccines. Committee members agreed that, if certain conditions are met in preclinical and early clinical studies, it would be reasonable to move forward from studies in adults and older children and into clinical trials evaluating vaccine safety and efficacy in RSV-naïve infants. Herein, we review and summarize perspectives on the discussion regarding recommendations for RSV vaccine development in this population.
Keywords	adults ; animal models ; children ; clinical trials ; experts ; infants ; morbidity ; mortality ; Respiratory syncytial virus ; respiratory tract diseases ; vaccine development ; vaccines
Language	English
Dates of publication	2020-0110
Size	p. 101-106.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2019.10.048
Database	NAL-Catalogue (AGRICOLA)

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