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Article ; Online: Sunny hours and variations in the prevalence of asthma in schoolchildren according to the International Study of Asthma and Allergies (ISAAC) Phase III in Spain.

Arnedo-Pena, Alberto / García-Marcos, Luis / Fernández-Espinar, Jorge Fuertes / Bercedo-Sanz, Alberto / Aguinaga-Ontoso, Ines / González-Díaz, Carlos / Carvajal-Urueña, Ignacio / Busquet-Monge, Rosa / Suárez-Varela, Maria Morales / de Andoin, Nagore García / Batlles-Garrido, Juan / Blanco-Quirós, Alfredo / Varela, Angel López-Silvarrey / García-Hernández, Gloria

International journal of biometeorology

2010 Volume 55, Issue 3, Page(s) 423–434

Abstract: ... of Asthma and Allergies (ISAAC) Phase III 2002-2003, and climate and socio-economic variables from official ... sources. Nine centres were studied and a further four centres, two of which are in ISAAC, to test ...

Abstract	The objective of this study was to estimate the relationship between the prevalence of asthma in schoolchildren aged 6-7 years and 13-14 years and the mean annual sunny hours (MASH) in Spain, and to explore predictive models for asthma prevalence. The prevalence of asthma was obtained from the International Study of Asthma and Allergies (ISAAC) Phase III 2002-2003, and climate and socio-economic variables from official sources. Nine centres were studied and a further four centres, two of which are in ISAAC, to test the predictive models. Logistic regression was used to estimate adjusted prevalence rates of asthma for each centre, and multiple regression models to study the effects of MASH and other meteorological and socio-economic variables. The adjusted prevalence rate of asthma decreased 0.6% [95% confidence interval (CI) 0.4-0.8%] for the 6-7 years group and 1.1% (95% CI 0.8-1.3%) for the 13-14 years group with an increase in the MASH of 100 h. Relative humidity was negatively associated with asthma in the older age group, and gross province product per capita (GPP) was positively associated with asthma in the younger age group. The predictive models, which included MASH, gender, relative humidity, and GPP, anticipated prevalence rates of asthma without significant differences between the levels observed and those expected in 9 of the 11 measurements carried out. The results indicate that sunny hours have a protective effect on the prevalence of asthma in schoolchildren.
MeSH term(s)	Adolescent ; Asthma/epidemiology ; Child ; Climate ; Female ; Global Health ; Humans ; Humidity ; Male ; Prevalence ; Rhinitis, Allergic, Seasonal/epidemiology ; Risk Factors ; Spain/epidemiology ; Sunlight ; Time Factors ; Vitamin D/metabolism
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2010-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280324-0
ISSN	1432-1254 ; 0020-7128
ISSN (online)	1432-1254
ISSN	0020-7128
DOI	10.1007/s00484-010-0353-x
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Article ; Online: Dual T cell receptor/chimeric antigen receptor engineered NK-92 cells targeting the HPV16 E6 oncoprotein and the tumor-associated antigen L1CAM exhibit enhanced cytotoxicity and specificity against tumor cells.

Quiros-Fernandez, Isaac / Libório-Ramos, Sofia / Leifert, Lena / Schönfelder, Bruno / Vlodavsky, Israel / Cid-Arregui, Angel

Journal of medical virology

2024 Volume 96, Issue 5, Page(s) e29630

Abstract: The human papillomavirus type 16 (HPV16) causes a large fraction of genital and oropharyngeal carcinomas. To maintain the transformed state, the tumor cells must continuously synthesize the E6 and E7 viral oncoproteins, which makes them tumor-specific ... ...

Abstract	The human papillomavirus type 16 (HPV16) causes a large fraction of genital and oropharyngeal carcinomas. To maintain the transformed state, the tumor cells must continuously synthesize the E6 and E7 viral oncoproteins, which makes them tumor-specific antigens. Indeed, specific T cell responses against them have been well documented and CD8
MeSH term(s)	Humans ; Oncogene Proteins, Viral/immunology ; Oncogene Proteins, Viral/genetics ; Receptors, Chimeric Antigen/immunology ; Receptors, Chimeric Antigen/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/genetics ; Repressor Proteins/immunology ; Repressor Proteins/genetics ; CD8-Positive T-Lymphocytes/immunology ; Killer Cells, Natural/immunology ; Human papillomavirus 16/immunology ; Human papillomavirus 16/genetics ; Cytotoxicity, Immunologic ; Cell Line, Tumor
Chemical Substances	Oncogene Proteins, Viral ; E6 protein, Human papillomavirus type 16 ; Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell ; Repressor Proteins
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29630
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Article ; Online: A costimulatory chimeric antigen receptor targeting TROP2 enhances the cytotoxicity of NK cells expressing a T cell receptor reactive to human papillomavirus type 16 E7.

Poorebrahim, Mansour / Quiros-Fernandez, Isaac / Marmé, Frederik / Burdach, Stefan Eg / Cid-Arregui, Angel

Cancer letters

2023 Volume 566, Page(s) 216242

Abstract: Immune cells modified to express a tumor-reactive T cell receptor (TCR) have shown limited efficacy as stand-alone therapy against solid tumors. Genital and oropharyngeal carcinomas induced by human papillomavirus (HPV) type 16 express constitutively its ...

Abstract	Immune cells modified to express a tumor-reactive T cell receptor (TCR) have shown limited efficacy as stand-alone therapy against solid tumors. Genital and oropharyngeal carcinomas induced by human papillomavirus (HPV) type 16 express constitutively its E6 and E7 oncoproteins, which makes them convenient targets for adoptive cell immunotherapy. However, viral antigen presentation by tumor cells is low and limits the anti-tumor efficacy of CD8
MeSH term(s)	Female ; Humans ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; CD8-Positive T-Lymphocytes ; Human papillomavirus 16/genetics ; Human papillomavirus 16/metabolism ; Human Papillomavirus Viruses ; Papillomavirus Infections/pathology ; Killer Cells, Natural ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Uterine Cervical Neoplasms/therapy ; Uterine Cervical Neoplasms/metabolism
Chemical Substances	Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-05-20
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2023.216242
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Article: Generation of CAR-T cells using lentiviral vectors.

Poorebrahim, Mansour / Quiros-Fernandez, Isaac / Fakhr, Elham / Cid-Arregui, Angel

Methods in cell biology

2021 Volume 167, Page(s) 39–69

Abstract: Cancer immunotherapy is nowadays largely focused on the development of therapeutic antibodies and chimeric antigen receptors (CARs). Two CARs targeting CD19 have been approved recently for the treatment of some hematological malignancies. This ... ...

Abstract	Cancer immunotherapy is nowadays largely focused on the development of therapeutic antibodies and chimeric antigen receptors (CARs). Two CARs targeting CD19 have been approved recently for the treatment of some hematological malignancies. This demonstrates the capability of engineered CAR T cells in generating effective tumor responses. Furthermore, several hundred ongoing clinical trials are exploring the feasibility of CAR-based approaches to target tumor-associated antigens in solid tumors. However, there still remain significant challenges and limitations in the design and production of CAR-modified T cells that need to be addressed, such as more effective transduction methods, expression and exhaustion issues, reliable in vitro and in vivo characterization methods, etc. Here we describe current techniques for generating CAR T cells using lentiviral vectors as well as detailed protocols for their functional characterization.
MeSH term(s)	Antigens, CD19/genetics ; Antigens, CD19/metabolism ; Genetic Vectors/genetics ; Immunotherapy, Adoptive/methods ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes/metabolism
Chemical Substances	Antigens, CD19 ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0091-679X
ISSN	0091-679X
DOI	10.1016/bs.mcb.2021.07.001
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Article ; Online: Immunogenic T cell epitopes of SARS-CoV-2 are recognized by circulating memory and naïve CD8 T cells of unexposed individuals.

Quiros-Fernandez, Isaac / Poorebrahim, Mansour / Fakhr, Elham / Cid-Arregui, Angel

EBioMedicine

2021 Volume 72, Page(s) 103610

Abstract: Background: Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected individuals, which has been attributed to cross-reactive CD4 memory T cells ... ...

Abstract	Background: Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected individuals, which has been attributed to cross-reactive CD4 memory T cells from previous exposure to seasonal coronaviruses. Less evidence of cross-reactive memory CD8 T cells has been documented to date. Methods: We used the NetCTLPan neural network of the Epitope Database and Analysis Resource to select a series of 27 HLA-A02:01 epitopes derived from the proteome of SARS-CoV-2. Their binding capacity was assessed by a HLA-A02:01 stabilization assay and by quantifying their binding to HLA-A02:01 monomers for the generation of tetramers. Their ability to stimulate and induce expansion of SARS-CoV-2 reactive CD8 T cells was measured by flow cytometry. The TCR repertoire of COVID convalescent and healthy unexposed donors was analysed using the MIRA database. Findings:* The HLA-A02:01 epitopes tested were able to stabilise HLA molecules and induce activation of CD8 T cells of healthy unexposed donors. Our results, based on specific tetramer binding, provide evidence supporting the presence of frequent cross-reactive CD8 T cells to SARS-CoV-2 antigens in non-exposed individuals. Interestingly, the reactive cells were distributed into naïve, memory and effector subsets. Interpretation:* Our data are consistent with a significant proportion of the reactive CD8 T clones belonging to the public shared repertoire, readily available in absence of previous contact with closely related coronaviruses. Furthermore, we demonstrate the immunogenic capacity of long peptides carrying T cell epitopes, which can serve to isolate virus-specific T cell receptors among the ample repertoire of healthy unexposed subjects and could have application in COVID-19 immunotherapy. Limitations of our study are that it concentrated on one MHC I allele (HLA-A02:01) and the low numbers of samples and epitopes tested. Funding:* See the Acknowledgements section.
MeSH term(s)	CD8-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; Computer Simulation ; Cross Reactions ; Epitopes, T-Lymphocyte/immunology ; Humans ; Immunotherapy ; Receptors, Antigen, T-Cell ; SARS-CoV-2/immunology
Chemical Substances	Epitopes, T-Lymphocyte ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2021-10-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2021.103610
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Article: Sunny hours and variations in the prevalence of asthma in schoolchildren according to the International Study of Asthma and Allergies (ISAAC) Phase III in Spain

International journal of biometeorology. 2011 May, v. 55, no. 3

2011

Abstract	The objective of this study was to estimate the relationship between the prevalence of asthma in schoolchildren aged 6-7 years and 13-14 years and the mean annual sunny hours (MASH) in Spain, and to explore predictive models for asthma prevalence. The prevalence of asthma was obtained from the International Study of Asthma and Allergies (ISAAC) Phase III 2002-2003, and climate and socio-economic variables from official sources. Nine centres were studied and a further four centres, two of which are in ISAAC, to test the predictive models. Logistic regression was used to estimate adjusted prevalence rates of asthma for each centre, and multiple regression models to study the effects of MASH and other meteorological and socio-economic variables. The adjusted prevalence rate of asthma decreased 0.6% [95% confidence interval (CI) 0.4-0.8%] for the 6-7 years group and 1.1% (95% CI 0.8-1.3%) for the 13-14 years group with an increase in the MASH of 100 h. Relative humidity was negatively associated with asthma in the older age group, and gross province product per capita (GPP) was positively associated with asthma in the younger age group. The predictive models, which included MASH, gender, relative humidity, and GPP, anticipated prevalence rates of asthma without significant differences between the levels observed and those expected in 9 of the11 measurements carried out. The results indicate that sunny hours have a protective effect on the prevalence of asthma in schoolchildren.
Keywords	asthma ; confidence interval ; hypersensitivity ; models ; protective effect ; regression analysis ; relative humidity ; socioeconomic factors ; Spain
Language	English
Dates of publication	2011-05
Size	p. 423-434.
Publisher	Springer-Verlag
Publishing place	Berlin/Heidelberg
Document type	Article
ZDB-ID	127361-9
ISSN	0067-8902 ; 0020-7128
ISSN	0067-8902 ; 0020-7128
DOI	10.1007/s00484-010-0353-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunogenic T cell epitopes of SARS-CoV-2 are recognized by circulating memory and naïve CD8 T cells of unexposed individuals

Isaac Quiros-Fernandez / Mansour Poorebrahim / Elham Fakhr / Angel Cid-Arregui

EBioMedicine, Vol 72, Iss , Pp 103610- (2021)

2021

Abstract	Background: Recent studies have provided evidence of T cell reactivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in significant numbers of non-infected individuals, which has been attributed to cross-reactive CD4 memory T cells from previous exposure to seasonal coronaviruses. Less evidence of cross-reactive memory CD8 T cells has been documented to date. Methods: We used the NetCTLPan neural network of the Epitope Database and Analysis Resource to select a series of 27 HLA-A02:01 epitopes derived from the proteome of SARS-CoV-2. Their binding capacity was assessed by a HLA-A02:01 stabilization assay and by quantifying their binding to HLA-A02:01 monomers for the generation of tetramers. Their ability to stimulate and induce expansion of SARS-CoV-2 reactive CD8 T cells was measured by flow cytometry. The TCR repertoire of COVID convalescent and healthy unexposed donors was analysed using the MIRA database. Findings: The HLA-A02:01 epitopes tested were able to stabilise HLA molecules and induce activation of CD8 T cells of healthy unexposed donors. Our results, based on specific tetramer binding, provide evidence supporting the presence of frequent cross-reactive CD8 T cells to SARS-CoV-2 antigens in non-exposed individuals. Interestingly, the reactive cells were distributed into naïve, memory and effector subsets. Interpretation: Our data are consistent with a significant proportion of the reactive CD8 T clones belonging to the public shared repertoire, readily available in absence of previous contact with closely related coronaviruses. Furthermore, we demonstrate the immunogenic capacity of long peptides carrying T cell epitopes, which can serve to isolate virus-specific T cell receptors among the ample repertoire of healthy unexposed subjects and could have application in COVID-19 immunotherapy. Limitations of our study are that it concentrated on one MHC I allele (HLA-A*02:01) and the low numbers of samples and epitopes tested. Funding: See the Acknowledgements section.
Keywords	SARS-CoV-2 ; COVID-19 ; T cell epitopes ; pre-existing cross-reactivity ; CD8 memory T cells ; immunotherapy ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	570
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells.

Quiros-Fernandez, Isaac / Figueroa-Protti, Lucía / Arias-Arias, Jorge L / Brenes-Cordero, Norman / Siles, Francisco / Mora, Javier / Mora-Rodríguez, Rodrigo Antonio

Metabolites

2021 Volume 11, Issue 9

Abstract: In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely used strategy against metastatic breast cancer, in spite of eliciting multiple adverse effects and having low responses with an average 5-year patient survival rate. ...

Abstract	In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely used strategy against metastatic breast cancer, in spite of eliciting multiple adverse effects and having low responses with an average 5-year patient survival rate. Among the new therapeutic targets that are currently in clinical trials, here, we addressed the association between the regulation of the metabolic process of autophagy and the exposure of damage-associated molecular patterns associated (DAMPs) to immunogenic cell death (ICD), which has not been previously studied. After validating an mCHR-GFP tandem LC3 sensor capacity to report dynamic changes of the autophagic metabolic flux in response to external stimuli and demonstrating that both basal autophagy levels and response to diverse autophagy regulators fluctuate among different cell lines, we explored the interaction between autophagy modulators and chemotherapeutic agents in regards of cytotoxicity and ICD using three different breast cancer cell lines. Since these interactions are very complex and variable throughout different cell lines, we designed a perturbation-based model in which we propose specific modes of action of chemotherapeutic agents on the autophagic flux and the corresponding strategies of modulation to enhance the response to chemotherapy. Our results point towards a promising therapeutic potential of the metabolic regulation of autophagy to overcome chemotherapy resistance by eliciting ICD.
Language	English
Publishing date	2021-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11090637
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Article ; Online: Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.

Dunlop, Charles R / Wallez, Yann / Johnson, Timothy Isaac / Bernaldo de Quirós Fernández, Sandra / Durant, Stephen T / Cadogan, Elaine B / Lau, Alan / Richards, Frances M / Jodrell, Duncan I

British journal of cancer

2020 Volume 123, Issue 9, Page(s) 1424–1436

Abstract: Background: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination ... ...

Abstract	Background: Personalised medicine strategies may improve outcomes in pancreatic ductal adenocarcinoma (PDAC), but validation of predictive biomarkers is required. Having developed a clinical trial to assess the ATR inhibitor, AZD6738, in combination with gemcitabine (ATRi/gem), we investigated ATM loss as a predictive biomarker of response to ATRi/gem in PDAC. Methods: Through kinase inhibition, siRNA depletion and CRISPR knockout of ATM, we assessed how ATM targeting affected the sensitivity of PDAC cells to ATRi/gem. Using flow cytometry, immunofluorescence and immunoblotting, we investigated how ATRi/gem synergise in ATM-proficient and ATM-deficient cells, before assessing the impact of ATM loss on ATRi/gem sensitivity in vivo. Results: Complete loss of ATM function (through pharmacological inhibition or CRISPR knockout), but not siRNA depletion, sensitised to ATRi/gem. In ATM-deficient cells, ATRi/gem-induced replication catastrophe was augmented, while phospho-Chk2-T68 and phospho-KAP1-S824 persisted via DNA-PK activity. ATRi/gem caused growth delay in ATM-WT xenografts in NSG mice and induced regression in ATM-KO xenografts. Conclusions: ATM loss augments replication catastrophe-mediated cell death induced by ATRi/gem and may predict clinical responsiveness to this combination. ATM status should be carefully assessed in tumours from patients with PDAC, since distinction between ATM-low and ATM-null could be critical in maximising the success of clinical trials using ATM expression as a predictive biomarker.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Ataxia Telangiectasia Mutated Proteins/antagonists & inhibitors ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/physiology ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Drug Synergism ; Female ; Gene Knockout Techniques ; Humans ; Indoles ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Morpholines ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacology ; Quinolines/administration & dosage ; Quinolines/pharmacology ; RNA, Small Interfering/pharmacology ; Sulfonamides ; Sulfoxides/administration & dosage ; Sulfoxides/pharmacology ; Xenograft Model Antitumor Assays ; Gemcitabine
Chemical Substances	Indoles ; Morpholines ; Pyridines ; Pyrimidines ; Quinolines ; RNA, Small Interfering ; Sulfonamides ; Sulfoxides ; Deoxycytidine (0W860991D6) ; ceralasertib (85RE35306Z) ; ATM protein, human (EC 2.7.11.1) ; ATR protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; AZD0156 (P5T0XWC07Z) ; Gemcitabine
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-020-1016-2
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Article ; Online: The ATR Inhibitor AZD6738 Synergizes with Gemcitabine

Wallez, Yann / Dunlop, Charles R / Johnson, Timothy Isaac / Koh, Siang-Boon / Fornari, Chiara / Yates, James W T / Bernaldo de Quirós Fernández, Sandra / Lau, Alan / Richards, Frances M / Jodrell, Duncan I

Molecular cancer therapeutics

2018 Volume 17, Issue 8, Page(s) 1670–1682

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, and overall survival rates have barely improved over the past five decades. The antimetabolite gemcitabine remains part of the standard of care but shows very limited antitumor ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, and overall survival rates have barely improved over the past five decades. The antimetabolite gemcitabine remains part of the standard of care but shows very limited antitumor efficacy. Ataxia telangiectasia and Rad3-related protein (ATR), the apical kinase of the intra-S-phase DNA damage response, plays a central role in safeguarding cells from replication stress and can therefore limit the efficacy of antimetabolite drug therapies. We investigated the ability of the ATR inhibitor, AZD6738, to prevent the gemcitabine-induced intra-S-phase checkpoint activation and evaluated the antitumor potential of this combination
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Animals ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/pathology ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Humans ; Indoles ; Mice ; Morpholines ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Sulfonamides ; Sulfoxides/pharmacology ; Sulfoxides/therapeutic use ; Gemcitabine
Chemical Substances	Antimetabolites, Antineoplastic ; Indoles ; Morpholines ; Pyrimidines ; Sulfonamides ; Sulfoxides ; Deoxycytidine (0W860991D6) ; ceralasertib (85RE35306Z) ; Gemcitabine
Language	English
Publishing date	2018-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-18-0010
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