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  1. Article ; Online: Escalas de valoración cognitiva y conductual en español para la demencia severa.

    Salmerón Ríos, Sergio / Lozoya Moreno, Silvia / Soler Moratalla, Isabel / Salmerón Ríos, Raúl / Ramírez Relinque, Laura / Abizanda Soler, Pedro

    Revista espanola de salud publica

    2020  Volume 94

    Abstract: Background: There are different scales in Spanish for cognitive and behavioral assessment of patients with severe dementia. The objective of this study was to select those scales that are more accessible, useful and with better psychometric properties, ... ...

    Title translation Spanish tools of cognitive and behavior assessment of alzheimer´s disease in severe state.
    Abstract Background: There are different scales in Spanish for cognitive and behavioral assessment of patients with severe dementia. The objective of this study was to select those scales that are more accessible, useful and with better psychometric properties, both for clinical practice and for research.
    Methods: Literature review, by experts in the field, of scales of cognitive and behavioral assessment in dementia in the main scientific databases. Published in Spanish or English, excluding those not validated in Spanish.
    Results: 11 bibliographical references were selected. Cognitive scales: Severe Impairment Battery was the one with the most cognitive areas, its abbreviated version (SIB-s) had the best internal consistency (α=0.96), Baylor Profound Mental Status Examination had very good psychometric properties with 0.99 reliability and excellent concurrent validity with Mini-Mental State Examination (r=-0.91). Severe Cognitive Impairment Profile was the only one that allowed establishing subgroups of cognitive impairment. Behavioral scales: Neuropsychiatric Inventory was the gold standard in dementias, but there was only one specific scale for severe Alzheimer's disease, the Baylor Profound Mental Status Examination behavioral subscale.
    Conclusions: In Spanish severe dementia, Severe Cognitive Impairment Profile and the Neuropsychiatric Inventory are the gold standard tool for cognitive assessment for research studies, and the Baylor Profound Mental Status Examination is the most useful for daily clinical practice.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Cognition ; Cognition Disorders/diagnosis ; Female ; Humans ; Male ; Mental Status and Dementia Tests ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Psychometrics/methods ; Reproducibility of Results ; Severity of Illness Index ; Spain
    Language Spanish
    Publishing date 2020-09-21
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Eficacia de la ozonoterapia en el tratamiento de la hernia de disco

    Raúl Salmerón Ríos / Sergio Salmerón Ríos / Loreto Tárraga Marcos / Fátima Madrona Marcos / Pedro J. Tárraga López

    Jounal of Negative and No Positive Results, Pp 588-

    Revisión Sistemática

    2021  Volume 607

    Abstract: La hernia discal es el resultado de la degeneración del núcleo pulposo y del anillo fibroso del disco intervertebral, de modo que el primero sale por el anillo o incluso puede salir del espacio intervertebral, convirtiéndose en un fragmento libre en el ... ...

    Abstract La hernia discal es el resultado de la degeneración del núcleo pulposo y del anillo fibroso del disco intervertebral, de modo que el primero sale por el anillo o incluso puede salir del espacio intervertebral, convirtiéndose en un fragmento libre en el interior del canal raquídeo. Se suele asociar a espondilosis, sobreesfuerzo físico o traumatismos (menores de repetición o mayor único). Son más frecuentes en edades media de la vida, teniendo un pico de incidencia sobre la cuarta década. La clínica se caracteriza por un comienzo con dolor lumbar paravertebral y dolor a la percusión de las apófisis espinosas, acompañado de contractura muscular paravertebral. En las hernias lumbares el dolor se suele irradiar a la extremidad inferior debido a la compresión de la raíz nerviosa. Se ha realizado un estudio sobre el tratamiento de las hernias discales, concretamente sobre la ozonoterapia, debido a que: La ozonoterapia como indicación para la hernia discal es un tratamiento de reciente aparición, con resultados muy discutibles y sin criterios consensuados para determinar su indicación como tratamiento.
    Keywords hernia discal ; dolor ; ozonoterapia ; Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Asociación Para el Progreso de la Biomedicina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Eficacia de la enseñanza teórico-práctica en institutos de reanimación cardiopulmonar.

    Losa Ballesteros, Bernardo Javier / Rosell Pérez, Jorge / Salmerón Ríos, Sergio / Fernández Lozano, Juan Marcos

    Revista espanola de salud publica

    2020  Volume 94

    Abstract: Objective: Cardiovascular diseases is one of the most important health problems among population. Most preventable deaths which take place in a context different from the hospital are related to coronary heart diseases. Training the population in ... ...

    Title translation Effectiveness of practical theoretical teaching in high-school about cardiopulmonary resuscitation.
    Abstract Objective: Cardiovascular diseases is one of the most important health problems among population. Most preventable deaths which take place in a context different from the hospital are related to coronary heart diseases. Training the population in cardiopulmonary resuscitation (CPR) may well result in an increase in the survival rate before a cardiorespiratory arrest.
    Methods: An observational study -both prospective and analytical- was conducted through a sample of students in the fourth year of compulsory secondary education. They were divided in two groups: a first group was trained with a theoretical-practical course on CPR, the second group only a theoretical course on CPR. Three surveys on CPR knowledge were conducted, the first one prior to a CPR course, the second one after the course and the third carried out two months after completing it. The results were compared between the three surveys to examine the degree of acquisition and maintenance of knowledge.
    Results: 326 students, 213 theoretical-practical group and 113 theoretical group, whose average age was 15.6 years (DE=0.7, R 15-17) and 56% were girls. The average scores of the questionnaires were: 5.1 points (DE=1.8, R 0-10) on first exam, 8.2 points (DE=1.6, R 3-10) on second exam of the theoretical-practical group versus 7.7 points (DE=1.9, R 0-10) of the theoretical group, and 7.2 points (DE=3.8, R 1-10) on third exam. In the first exam, 5.2% of them knew the frequency of chest compressions and ventilations in CPR, improving to 68.1% in the second questionnaire of the theoretical-practical group, and a 79.6% of the theoretical group.
    Conclusions: Increased knowledge in cardiopulmonary resuscitation reflect in an increase of 3.1 points of average after the theoretical-practical sessions and in 2.1 points two months later. The theoretical-practical group obtain a better score in the post-course exam (8.2 points) compared to the theoretical group (7.7 points).
    MeSH term(s) Adolescent ; Cardiopulmonary Resuscitation/education ; Female ; Humans ; Learning ; Male ; Program Evaluation ; Prospective Studies ; Schools ; Spain ; Students ; Surveys and Questionnaires
    Language Spanish
    Publishing date 2020-08-13
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Unidad domiciliaria de atención integral: Reducción de recursos hospitalarios durante brotes de gripe.

    Salmerón Ríos, Sergio / Lozoya Moreno, Silvia / Solís García Del Pozo, Julián / Salmerón Ríos, Raúl / Plaza Carmona, Laura / Abizanda Soler, Pedro

    Revista espanola de salud publica

    2018  Volume 92

    Abstract: Objective: The Comprehensive Care Home Unit of the General Hospital of Villarrobledo is a unit formed by a geriatrician who sees people in nursing homes to improve their quality of care. The activity of the Unit has been analyzed, mainly with the ... ...

    Title translation Comprehensive Care Home Unit: reduction of hospital resources during influenza outbreaks.
    Abstract Objective: The Comprehensive Care Home Unit of the General Hospital of Villarrobledo is a unit formed by a geriatrician who sees people in nursing homes to improve their quality of care. The activity of the Unit has been analyzed, mainly with the objective of avoiding referral to the emergency room, avoiding hospital admissions, avoiding hospital readmissions and reducing the number of hospital admission days.
    Methods: We retrospectively described the clinical activity of the Unit during the influenza outbreak of 2017 and 2018. We selected sociodemographical variables, functional assessment scales (Katz index, Barthel index and the Functional Ambulation Classification), and the Global Deterioration Scale. We registered mortality, type of treatment, oncological patients and patients with supplementary tests. The population was divided into four subgroups: hospital admission avoided, hospital re-admission avoided, referral to the emergency department avoided and reduction of admission days. The demographic characteristics were described, including the mode or mean of the variables. An economic report was made, and an analysis of cost per process according to the subgroups, means of Related Groups for the Diagnosis and degree of dependency measured by the Barthel index.
    Results: We selected 112 patients, they had a mean age of 82.2 years, Katz G (34.8%), IB 28.8 (DE 34.9), FAC 0 (63.4%) and GDS 7 (22.3%). The most frequent disease seen was respiratory infection (63.2%), 71.4% received active treatment, 10.7% complementary tests were performed, 17.9% oncological and 17% mortality. Cost analysis: hospital readmission avoided (€ 4,128 per patient) and patients with total disability (BI 0-20, € 3,623 per patient) presented more economic saving. The economic savings were more than € 230,000.
    Conclusions: The contribution of the Unit during periods of influenza outbreak is cost saving because of reduced numbers of admissions, numbers of readmissions, days of admission and emergency room visits.
    MeSH term(s) Aged ; Aged, 80 and over ; Disease Outbreaks/economics ; Emergency Service, Hospital ; Female ; Geriatrics/economics ; Health Resources ; Hospitalization/economics ; Humans ; Influenza, Human/economics ; Influenza, Human/therapy ; Male ; Nursing Homes ; Patient Admission ; Patient Readmission ; Retrospective Studies ; Spain
    Language Spanish
    Publishing date 2018-11-02
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Riesgo de sarcopenia y desnutrición relacionado con COVID-19 en una población institucionalizada de Castilla-La Mancha: determinado por R-MAPP.

    Salmerón Ríos, Sergio / Plaza Carmona, Laura / Estrella Cazalla, Juan de Dios / Navarro Olivera, Javier / Gómez Díaz de la Rosa, Francisco / Alonso Lucas, María-Esther / Fernández Sánchez, Miguel / Martín Legorburo, María José / Arechederra Calderón, Juan José / García Alcaraz, Francisco

    Revista espanola de salud publica

    2022  Volume 96

    Abstract: Objective: Knowing the risk status of malnutrition and sarcopenia in institutionalized patients is essential to understand the current context after the impact of the coronavirus (COVID-19) pandemic.: Methods: This research used a retrospective, ... ...

    Title translation Risk of sarcopenia and malnutrition related to COVID-19 in an institutionalized population of Castilla-La Mancha (Spain): determined by R-MAPP.
    Abstract Objective: Knowing the risk status of malnutrition and sarcopenia in institutionalized patients is essential to understand the current context after the impact of the coronavirus (COVID-19) pandemic.
    Methods: This research used a retrospective, observational study. The results of the Remote Malnutrition APP test (R-MAPP) are described: risk factors for malnutrition (including COVID-19), the Malnutrition Universal Screening Tool (MUST) and the SARC-F, in a selected sample of 402 residents of Castilla-La Mancha (Spain) during 2021. An inferential analysis was performed to determine which factors were related to the MUST (≥2 points) and SARC-F (≥4 points) response measures. With the factors that obtained statistical significance, a multivariate regression model was performed, adjusting for each one. of those factors.
    Results: Mean age was 84.2 years, 70.1% women. Most frequent risk factor for malnutrition was aging (85.1%). The mean body mass index was 26.5 (SD 11.6). MUST≥2 points was obtained in 16.2%, and a SARC-F≥4 in 69.9%. COPD (Chronic obstructive pulmonary disease / OR 0.35; 95% CI 0.13-0.92; p 0.03) was a protective factor against the risk of malnutrition. The risk of sarcopenia was related to aging (OR 8.16; 95% CI 4.13-16.20; p 0.00), COVID-19 (OR 1.96; 95% CI 1.17-3.29; p 0.01) and COPD (OR 2.44; 95% CI 1.21-4.89; p 0.01).
    Conclusions: No relationship is found between COVID-19 and high risk of malnutrition. Aging, COVID-19 and COPD are risk factors for sarcopenia.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Female ; Geriatric Assessment/methods ; Humans ; Male ; Malnutrition/complications ; Malnutrition/epidemiology ; Pulmonary Disease, Chronic Obstructive ; Retrospective Studies ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Spain/epidemiology ; Surveys and Questionnaires
    Language Spanish
    Publishing date 2022-10-03
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 0034-8899 ; 1135-5727
    ISSN (online) 2173-9110
    ISSN 0034-8899 ; 1135-5727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immunogenicity after 6 months of BNT162b2 vaccination in frail or disabled nursing home residents: The COVID-A Study.

    Salmerón Ríos, Sergio / Cortés Zamora, Elisa Belén / Avendaño Céspedes, Almudena / Romero Rizos, Luis / Sánchez-Jurado, Pedro Manuel / Sánchez-Nievas, Ginés / Mas Romero, Marta / Tabernero Sahuquillo, María Teresa / Blas Señalada, José Joaquín / Murillo Romero, Antonio / García Nogueras, Inmaculada / Estrella Cazalla, Juan de Dios / Andrés-Pretel, Fernando / Lauschke, Volker Martin / Stebbing, Justin / Abizanda, Pedro

    Journal of the American Geriatrics Society

    2021  Volume 70, Issue 3, Page(s) 650–658

    Abstract: Background: There is incomplete information regarding evolution of antibody titers against SARS-CoV-2 after a two-dose strategy vaccination with BNT162b2 in older adults in long-term care facilities (LTCFs) with frailty, disability, or cognitive ... ...

    Abstract Background: There is incomplete information regarding evolution of antibody titers against SARS-CoV-2 after a two-dose strategy vaccination with BNT162b2 in older adults in long-term care facilities (LTCFs) with frailty, disability, or cognitive impairment. We aimed to determine IgG antibody titer loss in older adults in LTCFs.
    Methods: This is a multicenter longitudinal cohort study including 127 residents (90 females and 37 males) with a mean age of 82.7 years (range 65-99) with different frailty and disability profiles in two LTCFs in Albacete, Spain. Residents received two doses of BNT162b2 as per label, and antibody levels were determined 1 and 6 months after the second dose. Age, sex, previous history of coronavirus disease 2019 (COVID-19), comorbidity (Charlson Index), performance in activities of daily living (Barthel Index), frailty (FRAIL instrument), and cognitive status were assessed.
    Results: The mean antibody titers 1 and 6 months after the second vaccine dose were 32,145 AU/ml (SD 41,206) and 6182 AU/ml (SD 13,316), respectively. Across all participants, the median antibody titer loss measured 77.6% (interquartile range [IQR] 23.8%). Notably, the decline of titers in individuals with pre-vaccination COVID-19 infection was significantly lower than in those without a history of SARS-CoV-2 infection (72.2% vs. 85.3%; p < 0.001). The median titer decrease per follow-up day was 0.47% (IQR 0.14%) and only pre-vaccination COVID-19 was associated with lower rate of antibody decline at 6 months (hazard ratio 0.17; 95% confidence interval 0.07-0.41; p < 0.001). Frailty, disability, older age, cognitive impairment, or comorbidity were not associated with the extent of antibody loss.
    Conclusions: Older adults in LTCFs experience a rapid loss of antibodies over the first 6 months after the second dose of BNT162b2 vaccine. Only pre-vaccination COVID-19 is associated with a slower rate of antibody decrease. Our data support immunization with a third dose in this vulnerable, high-risk population.
    MeSH term(s) Aged ; Aged, 80 and over ; Antibody Formation ; BNT162 Vaccine/administration & dosage ; BNT162 Vaccine/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; Disabled Persons ; Female ; Frail Elderly ; Humans ; Longitudinal Studies ; Male ; Nursing Homes ; SARS-CoV-2 ; Spain
    Chemical Substances BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-12-17
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.17620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study.

    Salmerón Ríos, Sergio / Mas Romero, Marta / Cortés Zamora, Elisa Belén / Tabernero Sahuquillo, María Teresa / Romero Rizos, Luis / Sánchez-Jurado, Pedro Manuel / Sánchez-Nievas, Ginés / Señalada, José Joaquín Blas / García Nogueras, Inmaculada / Estrella Cazalla, Juan de Dios / Andrés-Pretel, Fernando / Murillo Romero, Antonio / Lauschke, Volker Martin / Stebbing, Justin / Abizanda, Pedro

    Journal of the American Geriatrics Society

    2021  Volume 69, Issue 6, Page(s) 1441–1447

    Abstract: Background/objectives: The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of ...

    Abstract Background/objectives: The safety and immunogenicity of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine in older adults with different frailty and disability profiles have not been well determined. Our objective was to analyze immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older adults across frailty and disability profiles.
    Design: Multicenter longitudinal cohort study.
    Setting and participants: A total of 134 residents aged ≥65 years with different frailty and disability profiles in five long-term care facilities (LTCFs) in Albacete, Spain.
    Intervention and measurements: Residents were administered two vaccine doses as per the label, and antibody levels were determined 21.9 days (SD 9.3) after both the first and second dose. Functional variables were assessed using activities of daily living (Barthel Index), and frailty status was determined with the FRAIL instrument. Cognitive status and comorbidity were also evaluated.
    Results: Mean age was 82.9 years (range 65-99), and 71.6% were female. The mean antibody titers in residents with and without previous COVID-19 infection were 49,878 AU/ml and 15,274 AU/ml, respectively (mean difference 34,604; 95% confidence interval [CI]: 27,699-41,509). No severe adverse reactions were observed, after either vaccine dose. Those with prevaccination COVID-19 had an increased antibody level after the vaccine (B = 31,337; 95% CI: 22,725-39,950; p < 0.001). Frailty, disability, older age, sex, cognitive impairment, or comorbidities were not associated with different antibody titers.
    Conclusions: The BNT162b2 mRNA COVID-19 vaccine in older adults is safe and produces immunogenicity, independently of the frailty and disability profiles. Older adults in LTCFs should receive a COVID-19 vaccine.
    MeSH term(s) Activities of Daily Living ; Aged ; Aged, 80 and over ; Antibody Formation ; COVID-19/prevention & control ; COVID-19 Serological Testing ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Comorbidity ; Disabled Persons ; Female ; Frail Elderly ; Health Status Indicators ; Humans ; Longitudinal Studies ; Male ; Nursing Homes ; SARS-CoV-2 ; Spain
    Chemical Substances COVID-19 Vaccines ; BNT162 vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.17153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors.

    Casado, Jorge / Iñigo-Chaves, Almudena / Jiménez-Ruiz, Sergio M / Ríos-Arrabal, Sandra / Carazo-Gallego, Ángel / González-Puga, Cristina / Núñez, María Isabel / Ruíz-Extremera, Ángeles / Salmerón, Javier / León, Josefa

    International journal of molecular sciences

    2017  Volume 18, Issue 6

    Abstract: The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures. p53 loss increases the pool of CSCs in colorectal cancer (CRC). Recent reports suggest that the oncostatic effects of melatonin could ... ...

    Abstract The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures. p53 loss increases the pool of CSCs in colorectal cancer (CRC). Recent reports suggest that the oncostatic effects of melatonin could be related to its ability to kill CSCs. Although there are no data linking the loss of p53 function and melatonin synthesis or signaling in cancer, melatonin does activate the p53 tumor-suppressor pathway in this disease. In this work, we analyze whether the expression of melatonin synthesis and signaling genes are related to the expression of CSC markers and the implication of p53 status in samples from patients with CRC. Arylalkylamine N-acetyltransferase (AA-NAT), MT1, and MT2 expression decreased in tumor samples versus normal mucosa samples in mutated p53 (mtp53) tumors versus those with wild-type p53 (wtp53). Further, AA-NAT and MT2 expression were lower in advanced stages of the disease in wtp53 tumors. On the contrary, CD44 and CD66c expression was higher in tumor versus normal mucosa in wtp53 tumors. Additionally, CD44 expression was higher in advanced stages of the disease regardless of the p53 status. Patients with CD44
    Language English
    Publishing date 2017-06-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms18061251
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  9. Article ; Online: Energetics of Aging and Frailty: The FRADEA Study.

    Abizanda, Pedro / Romero, Luis / Sánchez-Jurado, Pedro M / Ruano, Teresa Flores / Ríos, Sergio Salmerón / Sánchez, Miguel Fernández

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2016  Volume 71, Issue 6, Page(s) 787–796

    Abstract: Background: Resting metabolic rate (RMR) and total daily energy expenditure (TDEE) decrease with aging, but it is not known whether frailty modulates this association. We hypothesize that RMR and TDEE values are similar between younger and older ... ...

    Abstract Background: Resting metabolic rate (RMR) and total daily energy expenditure (TDEE) decrease with aging, but it is not known whether frailty modulates this association. We hypothesize that RMR and TDEE values are similar between younger and older nonfrail older adults, whereas they are lower in older prefrail and frail compared with younger adults.
    Methods: A cross-sectional analysis of the FRADEA study, Albacete (Spain), including 402 participants (213 women) older than 70 years (mean age 76 years; range 70-91), was conducted. Estimated RMR (eRMR), oxygen consumption (VO2), expired volume (Ve), and respiratory frequency (RF) were determined using indirect calorimetry; TDEE was determined with the Calcumed instrument; and fat-free mass was determined by bioimpedanciometry. General linear models were used for analysis.
    Results: Mean TDEE was 1,889 (SD 470) kcal and eRMR was 1,071 (SD 323) kcal. Both TDEE (B = -24 kcal/day; 95% confidence interval: -35.4 to -14.2; p < .001) and eRMR (B= -15.8 kcal/day; 95% confidence interval: -23.1 to -8.5; p < .001) diminished linearly with age, with lower values in frail and prefrail participants. There was a strong trend between frailty and lower eRMR (F = 2.9; p = .058), with a modifying effect between age and frailty (F = 3.6; p = .002). eRMR in prefrail and frail participants were on average 160 and 114 kcal/day less than that in the nonfrail participants, respectively, and taken together, 154 kcal/day less (F = 5.4; p = .020). Frail and prefrail participants also presented lower Ve and VO2 values that were partially compensated by an RF increase.
    Conclusion: Frailty status modulates the energy requirements of aging. Frail and prefrail older adults present lower eRMR than nonfrail adults.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging/metabolism ; Basal Metabolism ; Calorimetry, Indirect ; Cross-Sectional Studies ; Energy Metabolism ; Female ; Frail Elderly ; Geriatric Assessment ; Humans ; Male ; Oxygen Consumption ; Spain
    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glv182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer

    Jorge Casado / Almudena Iñigo-Chaves / Sergio M. Jiménez-Ruiz / Sandra Ríos-Arrabal / Ángel Carazo-Gallego / Cristina González-Puga / María Isabel Núñez / Ángeles Ruíz-Extremera / Javier Salmerón / Josefa León

    International Journal of Molecular Sciences, Vol 18, Iss 6, p

    Study of the Influence of Stage and p53 Status of Tumors

    2017  Volume 1251

    Abstract: The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures. p53 loss increases the pool of CSCs in colorectal cancer (CRC). Recent reports suggest that the oncostatic effects of melatonin could ... ...

    Abstract The characterization of colon cancer stem cells (CSCs) may help to develop novel diagnostic and therapeutic procedures. p53 loss increases the pool of CSCs in colorectal cancer (CRC). Recent reports suggest that the oncostatic effects of melatonin could be related to its ability to kill CSCs. Although there are no data linking the loss of p53 function and melatonin synthesis or signaling in cancer, melatonin does activate the p53 tumor-suppressor pathway in this disease. In this work, we analyze whether the expression of melatonin synthesis and signaling genes are related to the expression of CSC markers and the implication of p53 status in samples from patients with CRC. Arylalkylamine N-acetyltransferase (AA-NAT), MT1, and MT2 expression decreased in tumor samples versus normal mucosa samples in mutated p53 (mtp53) tumors versus those with wild-type p53 (wtp53). Further, AA-NAT and MT2 expression were lower in advanced stages of the disease in wtp53 tumors. On the contrary, CD44 and CD66c expression was higher in tumor versus normal mucosa in wtp53 tumors. Additionally, CD44 expression was higher in advanced stages of the disease regardless of the p53 status. Patients with CD44highCD66chigh and wtp53 tumors in advanced stages showed low expression of AA-NAT and MT2 in wtp53 tumors. These results could indicate a possible interaction of these pathways in CRC.
    Keywords colorectal cancer ; melatonin ; cancer stem cells ; p53 ; metastasis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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