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  1. Article ; Online: Immunogenomic phases of COVID-19 and appropriate clinical management.

    Haznedaroglu, Ibrahim C

    The Lancet. Microbe

    2020  Volume 1, Issue 7, Page(s) e278

    MeSH term(s) Autopsy ; COVID-19 ; Cohort Studies ; Humans ; Prospective Studies ; SARS-CoV-2/genetics
    Language English
    Publishing date 2020-11-04
    Publishing country England
    Document type Letter ; Comment
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(20)30165-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nilotinib-Associated Multiple Silent Arterial Stenoses in a Patient with Chronic Myeloid Leukemia

    Tokatlı, Mert / Ismayilov, Rashad / Erkin Çınar, Olgu / Haznedaroğlu, İbrahim C.

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2023  Volume 41, Issue 1, Page(s) 59–60

    MeSH term(s) Humans ; Constriction, Pathologic/complications ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications ; Pyrimidines/adverse effects ; Leukemia, Myeloid/complications ; Protein Kinase Inhibitors/adverse effects ; Antineoplastic Agents/adverse effects ; Leukemia, Myeloid, Chronic-Phase/complications
    Chemical Substances Pyrimidines ; Protein Kinase Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2023-12-28
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2023.2023.0288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19, Renin-Angiotensin System, and Hematopoiesis

    Çiftçiler, Rafiye / Haznedaroğlu, İbrahim C.

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2020  Volume 37, Issue 3, Page(s) 207–208

    MeSH term(s) Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Disease Susceptibility ; Hematopoiesis ; Host-Pathogen Interactions ; Humans ; Pandemics ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Renin-Angiotensin System ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country Turkey
    Document type Letter
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2020.2020.0174
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  4. Article ; Online: Immunogenomic phases of COVID-19 and appropriate clinical management

    Haznedaroglu, Ibrahim C

    The Lancet Microbe

    2020  Volume 1, Issue 7, Page(s) e278

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2666-5247
    DOI 10.1016/s2666-5247(20)30165-8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Immunogenomic phases of COVID-19 and appropriate clinical management

    Ibrahim C Haznedaroglu

    The Lancet Microbe, Vol 1, Iss 7, Pp e278- (2020)

    2020  

    Keywords Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  6. Article ; Online: COVID-19, Renin-Angiotensin System, and Hematopoiesis

    Rafiye Çiftçiler / İbrahim C. Haznedaroğlu

    Turkish Journal of Hematology, Vol 37, Iss 3, Pp 207-

    2020  Volume 208

    Keywords covid-19 ; renin-angiotensin system ; hematopoiesis ; sars-cov-2 ; Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Protein Kinases in Hematological Disorders.

    Okay, Mufide / Haznedaroglu, Ibrahim C

    Advances in experimental medicine and biology

    2021  Volume 1275, Page(s) 383–393

    Abstract: Cell signaling is an important part of the complex system of molecular communication that governs basic cellular activities and coordinates cell cycle machinery. Pathological alterations in the cellular information processing may be responsible for the ... ...

    Abstract Cell signaling is an important part of the complex system of molecular communication that governs basic cellular activities and coordinates cell cycle machinery. Pathological alterations in the cellular information processing may be responsible for the diseases such as cancer. Numerous diseases may be treated effectively via the pharmacological management of cellular signaling. Protein kinases (PK) have significantly important roles in the cell signal transduction process. Protein kinases phosphorylate serine, threonine, tyrosine and histidine amino acids in a wide variety of molecular networks. Two main PK groups are distinguished; serine/threonine kinase and tyrosine kinases. MAPK (mitogen-activated protein kinases), ERK, EGFR (epidermal growth factor receptor), src, abl, FAK (focal adesion kinase), and JAK (janus family kinase) are considered as the main PK molecular networks. Protein kinases are closely related to the pathobiology of hematologic neoplastic disorders. For instance; JAKV617F point mutation-causing polycythemia vera and essential thrombocytosis occur at the position 617 in the JH2 domain of the JAK2 gene. The protein kinase inhibitor drugs targeting specific kinase molecules have already been developed and widely used in the field of Clinical Hematology. The existence of a local renin-angiotensin system (RAS) specific to the hematopoietic bone marrow (BM) microenvironment had been proposed two decades ago. Local BM RAS is important in hematopoietic stem cell biology and microenvironment. There are interactions among the local BM RAS and PK. For example, ACE2-ang(1-7)-Mas axis inhibits p38 MAPK/NF-КB signaling pathway. The Local BM RAS may have a role in the effect on PK in this biological spectrum. The aim of this review is to outline the functions of PKs in the pathobiology of hematologic neoplastic disorders.
    MeSH term(s) Hematopoietic Stem Cells/metabolism ; Janus Kinases/metabolism ; Phosphorylation ; Renin-Angiotensin System ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances Janus Kinases (EC 2.7.10.2) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-49844-3_15
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  8. Article ; Online: On Being a “Physician Patient” with His Own Experimental Therapeutic Drug

    Çiftçiler, Rafiye / Haznedaroğlu, İbrahim C.

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2018  Volume 35, Issue 4, Page(s) 302–303

    Title translation Deneysel Tedavi Edici İlaç ile “Doktor Hasta” Birlikteliği Üzerine
    MeSH term(s) Burns/drug therapy ; Humans ; Male ; Physicians ; Plant Extracts/therapeutic use
    Chemical Substances Plant Extracts ; ankaferd blood stopper
    Language English
    Publishing date 2018-07-24
    Publishing country Turkey
    Document type Case Reports ; Letter
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.2018.0254
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    Zs.A 6534: Show issues Location:
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  9. Article: Current management of chronic myeloid leukemia with tyrosine kinase inhibitors.

    Haznedaroğlu, Ibrahim C

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2013  Volume 30, Issue 3, Page(s) 247–255

    Abstract: Unlabelled: The clinical outcomes and survival of tyrosine kinase inhibitor (TKI)-treated patients with chronic myeloid leukemia (CML) have been significantly improved. The aim of this editorial is to outline critical steps of TKI administration ... ...

    Abstract Unlabelled: The clinical outcomes and survival of tyrosine kinase inhibitor (TKI)-treated patients with chronic myeloid leukemia (CML) have been significantly improved. The aim of this editorial is to outline critical steps of TKI administration practices during the long-term clinical course of CML based on data obtained from randomized clinical trials and international recommendations. The efficacy of TKI treatment, TKI side effects, off-target complications, and long-term morbidities due to both the disease and the drug are common arguments in the management of CML. Complete hematological response, early complete cytogenetic response, faster major molecular response, and deeper, more durable molecular responses (MR4, MR4.5, MR5) are the ultimate goals for TKI-receiving patients with CML.
    Conflict of interest: None declared.
    Language English
    Publishing date 2013-09-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/Tjh.2013.0108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Platelet Activation in Ocular Behçet's Patients with Posterior Segment Involvement.

    Citirik, Mehmet / Ozdal, Pinar C / Keles, Ali / Haznedaroglu, Ibrahim C

    Middle East African journal of ophthalmology

    2022  Volume 28, Issue 4, Page(s) 203–207

    Abstract: Purpose: The aim of the present study was to assess platelet activation by analyzing three platelet activation parameters in ocular Behçet's disease (BD): mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).: Methods!# ...

    Abstract Purpose: The aim of the present study was to assess platelet activation by analyzing three platelet activation parameters in ocular Behçet's disease (BD): mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).
    Methods: Twenty-nine patients with active ocular BD (Group 1), 40 patients with inactive ocular BD (Group 2), and 40 healthy adult individuals serving as controls (Group 3) were evaluated. All of the individuals had been performed the complete ophthalmologic evaluation. The levels of MPV, PDW, and PCT were measured in each group.
    Results: The mean MPV level was 8.40 ± 0.97 in Group 1, 8.32 ± 1.04 in Group 2, and 7.77 ± 0.72 in Group 3. The mean PDW level was 15.12 ± 1.09 in Group 1, 14.97 ± 1.02 in Group 2, and 14.52 ± 0.82 in Group 3. The mean PCT level was 0.23 ± 0.07 in Group 1, 0.21 ± 0.04 in Group 2, and 0.18 ± 0.03 in Group 3. MPV, PDW, and PCT levels were significantly higher in ocular BD patients than controls (
    Conclusion: Platelet activation may affect vascular occlusion in ocular Behçet's patients with posterior segment involvement. This result may be important in evaluating ocular BD patients.
    MeSH term(s) Adult ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Humans ; Mean Platelet Volume ; Platelet Activation/physiology
    Language English
    Publishing date 2022-04-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2545467-5
    ISSN 0975-1599 ; 0975-1599
    ISSN (online) 0975-1599
    ISSN 0975-1599
    DOI 10.4103/meajo.MEAJO_324_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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