Article: [Systemic evaluation and Meta-analysis of efficacy and safety of Kangfu Xiaoyan Suppository in treatment of pelvic inflammatory disease].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2019 Volume 44, Issue 22, Page(s) 4962–4974
Abstract: To evaluate the efficacy and safety of Kangfu Xiaoyan Suppository in the treatment ... of Meta-analysis showed that the recurrence rate of Kangfu Xiaoyan Suppository combined with antibiotics was lower ... than that of antibiotics alone. Kangfu Xiaoyan Suppository combined with antibiotics was superior to antibiotics alone ...
Abstract | To evaluate the efficacy and safety of Kangfu Xiaoyan Suppository in the treatment of pelvic inflammatory disease. Four Chinese databases,namely CNKI,VIP,WanFang and SinoMed,and three English databases Cochrane Library,namely Medline,and ClinicalTrail.gov were systematically and comprehensively retrieved from the establishment of each database to June 2018. The quality of the included studies was evaluated by using the risk assessment tools developed by the Cochrane Collaboration,and RevMan 5. 3 software was used for Meta-analysis. A total of 675 articles were retrieved,and finally 56 studies were included. The total sample size was 6 228,the test group included 3 267 cases,and the control group included 2 961 cases. The overall quality of the included studies was generally low. According to the intervention measures and outcome indicators,the included studies were divided into different subgroups for analysis. The main results of Meta-analysis showed that the recurrence rate of Kangfu Xiaoyan Suppository combined with antibiotics was lower than that of antibiotics alone. Kangfu Xiaoyan Suppository combined with antibiotics was superior to antibiotics alone in terms of abdominal pain,leucorrhea abnormality relief time,mass absorption time and pain relief time. In terms of safety,Kangfu Xiaoyan Suppository combined with antibiotics had a lower incidence of adverse reactions than antibiotics alone. Based on the results of this study,it is indicated that Kangfu Xiaoyan Suppository had a certain effect on the treatment of pelvic inflammatory disease,especially with a lower recurrence rate. The long-term effect is remarkable. No serious adverse reaction was observed. Restricted by the quality of the studies included,the above conclusion need to be further verified in high-quality,largesize,multi-center clinical researches. |
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MeSH term(s) | Anti-Bacterial Agents ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Pelvic Inflammatory Disease/drug therapy ; Suppositories |
Chemical Substances | Anti-Bacterial Agents ; Drugs, Chinese Herbal ; Suppositories |
Language | Chinese |
Publishing date | 2019-12-23 |
Publishing country | China |
Document type | Journal Article ; Meta-Analysis |
ZDB-ID | 1004649-5 |
ISSN | 1001-5302 ; 0254-0029 |
ISSN | 1001-5302 ; 0254-0029 |
DOI | 10.19540/j.cnki.cjcmm.20190326.502 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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