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  1. Article ; Online: Enhancing the vascular surgeon-scientist workforce with diversity and team science.

    Nguyen, Mytien / Dardik, Alan

    Journal of vascular surgery

    2023  Volume 78, Issue 4, Page(s) 852–853

    MeSH term(s) Humans ; Interdisciplinary Research ; Surgeons
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2023.06.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1933: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Looking into the mirror: Pulmonary vein isolation in a patient with dextrocardia, complete situs inversus, and interrupted inferior vena cava.

    Khurshid, Shaan / Nguyen, Tri / Yamada, Kei / Hanley, Alan

    HeartRhythm case reports

    2023  Volume 9, Issue 6, Page(s) 396–400

    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2023.03.014
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  3. Article ; Online: Drug-induced liver injury associated with elexacaftor/tezacaftor/ivacaftor: A pharmacovigilance analysis of the FDA adverse event reporting system (FAERS).

    Shi, Alan / Nguyen, Harold / Kuo, C Benson / Beringer, Paul M

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2024  

    Abstract: Introduction: The efficacy and safety of elexacaftor/tezacaftor/ivacaftor (ETI) have been established in prospective clinical trials. Liver function test elevations were observed in a greater proportion of patients receiving ETI compared with placebo; ... ...

    Abstract Introduction: The efficacy and safety of elexacaftor/tezacaftor/ivacaftor (ETI) have been established in prospective clinical trials. Liver function test elevations were observed in a greater proportion of patients receiving ETI compared with placebo; however, the relatively small number of patients and short duration of study preclude detection of rare but clinically significant associations with drug-induced liver injury (DILI). To address this gap, we assessed the real-world risk of DILI associated with ETI through data mining of the FDA adverse event reporting system (FAERS).
    Methods: Disproportionality analyses were conducted on FAERS data from the fourth quarter of 2019 through the third quarter of 2022. Comparative patient demographics, onset time and outcomes for ETI-DILI were also obtained.
    Results: 452 reports of DILI associated with ETI were found, representing 2.1 % of all adverse event reports for ETI. All disproportionality measures were significant for ETI-DILI at p < 0.05; the reporting odds ratio (ROR) (2.82) was comparable to that of drugs classified by FDA as "Most-DILI concern". The most notable demographic finding was a male majority (5:4 male to female ratio) for ETI-DILI compared to a female majority (4:5 male to female ratio) for non ETI-DILI. Median ETI-DILI onset time was 50.5 days, and hospitalization was the second most common complication.
    Conclusion: Using FAERS data, ETI was found to be disproportionately associated with DILI. Future research is needed to investigate the hepatotoxic mechanisms and assess potential mitigation strategies for ETI-induced hepatotoxicity.
    Language English
    Publishing date 2024-01-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2024.01.001
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    Zs.A 6028: Show issues Location:
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  4. Article ; Online: Optimising the management of peanut allergy by targeting immune plasticity.

    Nguyen, Alan / du Toit, George / Lack, Gideon / Marrs, Tom

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2024  Volume 54, Issue 3, Page(s) 169–184

    Abstract: Randomised controlled trials investigating the efficacy of oral tolerance induction to peanut have enabled detailed comparison of their clinical and immunological success. They have demonstrated that the regular consumption of peanut for at least 2 years ...

    Abstract Randomised controlled trials investigating the efficacy of oral tolerance induction to peanut have enabled detailed comparison of their clinical and immunological success. They have demonstrated that the regular consumption of peanut for at least 2 years by babies who are not allergic enables protection from developing peanut allergy. The LEAP study intervention tested the impact of regular peanut consumption for 4 years and demonstrated a sustained protection against the development of peanut allergy even after 12 months of peanut avoidance from 5 to 6 years of age. The PreventADALL trial introduced multiple allergens into babies' diets from early infancy and reduced the prevalence of food allergy at 3 years, especially by protecting against peanut allergy. Immunological studies from the LEAP cohort demonstrated that regular peanut consumption was associated with a prompt induction of peanut-specific IgG4 and reduced manufacture of peanut and Ara h 2-specific IgE. Even after stopping peanut consumption for 5 years, there continued to be a significant fall in peanut-specific Ara h 2 IgE in the consumption group from 5 to 6 years of age (p < .01). Children who developed peanut allergy by 5 years started to develop increasing sensitisation to linear sequential peanut epitopes from 2.5 years of age, suggesting that putative disease-modifying interventions should commence before 3 years. Data comparing clinical outcomes between children undergoing peanut immunotherapy from infancy suggest that younger children can consume higher portions of peanut without reaction on challenge whilst taking immunotherapy, have fewer side effects and are more likely to enjoy remission of PA. Peanut oral immunotherapy modulates T-cell populations in order to bring about hypo-responsiveness of allergy effector cells. Studies are now needed to characterise and compare different states of immunological tolerance. This will accelerate the design of interventions which can promote primary, secondary and tertiary levels of PA prevention across a range of age groups.
    MeSH term(s) Child ; Infant ; Humans ; Child, Preschool ; Peanut Hypersensitivity/prevention & control ; Food Hypersensitivity ; Immunoglobulin E ; Epitopes ; Arachis ; Allergens ; Antigens, Plant
    Chemical Substances Immunoglobulin E (37341-29-0) ; Epitopes ; Allergens ; Antigens, Plant
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14454
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Arthroscopic Cartilage Transplantation.

    Tewilliager, Tyler / Nguyen, Kevin / Ng, Alan

    Clinics in podiatric medicine and surgery

    2023  Volume 40, Issue 3, Page(s) 483–494

    Abstract: Arthroscopic cartilage repair has made several strides in recent years; however, no gold standard for cartilage restoration has been found. Simple treatment with bone marrow stimulation such as microfracture have shown good short-term results; however, ... ...

    Abstract Arthroscopic cartilage repair has made several strides in recent years; however, no gold standard for cartilage restoration has been found. Simple treatment with bone marrow stimulation such as microfracture have shown good short-term results; however, concerns for long-term stability of cartilage repair as well as the subchondral bone health remain in question. Treatment of these lesions often comes down to surgeon preference, the aim of this study is to discuss some of the current options available on the market to further assist surgeons in their decision-making process.
    MeSH term(s) Humans ; Cartilage, Articular/surgery ; Talus/surgery ; Bone Transplantation ; Arthroscopy/methods ; Ankle Joint/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1323674-x
    ISSN 1558-2302 ; 0742-0668 ; 0891-8422
    ISSN (online) 1558-2302
    ISSN 0742-0668 ; 0891-8422
    DOI 10.1016/j.cpm.2023.02.006
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    Se 931: Show issues Location:
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  6. Article: Where Brain Death Is Concerned-NOT Debate BUT Action.

    DeCock, Christopher A / Sulmasy, Daniel P / Alan Shewmon, D / Camosy, Charlie / Accad, Michel / Nguyen, Doyen

    The Linacre quarterly

    2023  Volume 90, Issue 3, Page(s) 231–233

    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604903-5
    ISSN 2050-8549 ; 0024-3639
    ISSN (online) 2050-8549
    ISSN 0024-3639
    DOI 10.1177/00243639231184030
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  7. Article: The effect of the NH2 substituent on NH3: hydrazine as an alternative for ammonia in hydrogen release in the presence of boranes and alanes.

    Vinh-Son, Nguyen / Swinnen, Saartje / Matus, Myrna H / Nguyen, Minh Tho / Dixon, David A

    Physical chemistry chemical physics : PCCP

    2009  Volume 11, Issue 30, Page(s) 6339–6344

    Abstract: Potential energy surfaces for H(2) release from hydrazine interacting with borane, alane, diborane ... dialane and borane-alane were constructed from MP2/aVTZ geometries and zero point energies with single ... point energies at the CCSD(T)/aug-cc-pVTZ level. With one borane or alane molecule, the energy barrier ...

    Abstract Potential energy surfaces for H(2) release from hydrazine interacting with borane, alane, diborane, dialane and borane-alane were constructed from MP2/aVTZ geometries and zero point energies with single point energies at the CCSD(T)/aug-cc-pVTZ level. With one borane or alane molecule, the energy barrier for H(2)-loss of approximately 38 or 30 kcal mol(-1) does not compete with the B-N or Al-N bond cleavage ( approximately 30 or approximately 28 kcal mol(-1)). The second borane or alane molecule can play the role of a bifunctional catalyst. The barrier energy for H(2)-elimination is reduced from 38 to 23 kcal mol(-1), or 30 to 20 kcal mol(-1) in the presence of diborane or dialane, respectively. The mixed borane-alane dimer reduces the barrier energy for H(2) release from hydrazine to approximately 17 kcal mol(-1). A systematic comparison with the reaction pathways from ammonia borane shows that hydrazine could be an alternative for ammonia in producing borane amine derivatives. The results show a significant effect of the NH(2) substituent on the relevant thermodynamics. The B-N dative bond energy of 31 kcal mol(-1) in NH(2)NH(2)BH(3) is approximately 5 kcal mol(-1) larger than that of the parent BH(3)NH(3). The higher thermodynamic stability could allow hydrazine-borane to be used as a material for certain energetic H(2) storage applications.
    MeSH term(s) Alanine/chemistry ; Ammonia/chemistry ; Boranes/chemistry ; Catalysis ; Chemistry/methods ; Hydrazines/chemistry ; Hydrogen/chemistry ; Molecular Conformation ; Software ; Thermodynamics
    Chemical Substances Boranes ; Hydrazines ; hydrazine (27RFH0GB4R) ; Ammonia (7664-41-7) ; Hydrogen (7YNJ3PO35Z) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2009-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/b823358f
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  8. Article ; Online: Analyzing the Li-Al-O Interphase of Atomic Layer-Deposited Al

    Nguyen, Julie A / Becker, Abigayle / Kanhaiya, Krishan / Heinz, Hendrik / Weimer, Alan W

    ACS applied materials & interfaces

    2023  Volume 16, Issue 1, Page(s) 1861–1875

    Abstract: Alumina surface coatings are commonly applied to layered oxide cathode particles for lithium-ion battery applications. Atomic layer deposition (ALD) is one such surface coating technique, and ultrathin alumina ALD films (<2 nm) are shown to improve the ... ...

    Abstract Alumina surface coatings are commonly applied to layered oxide cathode particles for lithium-ion battery applications. Atomic layer deposition (ALD) is one such surface coating technique, and ultrathin alumina ALD films (<2 nm) are shown to improve the electrochemical performance of LiNi
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c15080
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  9. Article ; Online: Oscillating high aspect ratio micro-channels can effectively atomize liquids into uniform aerosol droplets and dial their size on-demand.

    Le, Nguyen Hoai An / Brenker, Jason / Shenoda, Abanoub / Sheikh, Zara / Gum, Jackson / Ong, Hui Xin / Traini, Daniela / Alan, Tuncay

    Lab on a chip

    2024  Volume 24, Issue 6, Page(s) 1676–1684

    Abstract: Ultrasonic atomization of liquids into micrometer-diameter droplets is crucial across multiple fields, ranging from drug delivery, to spectrometry and printing. Controlling the size and uniformity of the generated droplets on-demand is crucial in all ... ...

    Abstract Ultrasonic atomization of liquids into micrometer-diameter droplets is crucial across multiple fields, ranging from drug delivery, to spectrometry and printing. Controlling the size and uniformity of the generated droplets on-demand is crucial in all these applications. However, existing systems lack the required precision to tune the droplet properties, and the underlying droplet formation mechanism under high-frequency ultrasonic actuation remains poorly understood due to experimental constraints. Here, we present an atomization platform, which overcomes these current limitations. Our device utilizes oscillating high aspect ratio micro-channels to extract liquids from various inlets (ranging from sessile droplets to large beakers), bound them in a precisely defined narrow region, and, controllably atomize them on-demand. The droplet size can be precisely dialled from 3.6 μm to 6.8 μm by simply tuning the actuation parameters. Since the approach does not need nozzles, meshes or impacting jets, stresses exerted on the liquid samples are reduced, hence it is gentler on delicate samples. The precision offered by the technique allows us for the first time to experimentally visualise the oscillating fluid interface at the onset of atomization at MHz frequencies, and demonstrate its applications for targeted respiratory drug delivery.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d3lc00816a
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  10. Article ; Online: A Need for Further Education on Buprenorphine in Pain Medicine.

    Hasoon, Jamal / Nguyen, Anvinh / Urits, Ivan / Robinson, Christopher / Viswanath, Omar / Kaye, Alan D

    Health psychology research

    2023  Volume 11, Page(s) 74958

    Abstract: With the ongoing opioid epidemic in the United States there has been a strong transition towards utilizing multi-modal analgesia, interventional procedures, and non-opioid medications when managing acute and chronic pain. There has also been an increased ...

    Abstract With the ongoing opioid epidemic in the United States there has been a strong transition towards utilizing multi-modal analgesia, interventional procedures, and non-opioid medications when managing acute and chronic pain. There has also been an increased interest in utilizing buprenorphine. Buprenorphine is a novel long-acting analgesic with partial mu-opioid agonist activity that can be utilized for analgesia as well as opioid use disorder. Buprenorphine also has a unique set of side effects as well pharmacodynamic and pharmacokinetic properties that require special attention, especially if these patients require future surgical interventions. Given the increased interest in this medication we believe that there needs to be increased education and awareness regarding this medication amongst physicians, specifically pain management physicians and trainees.
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2709692-0
    ISSN 2420-8124 ; 2420-8124
    ISSN (online) 2420-8124
    ISSN 2420-8124
    DOI 10.52965/001c.74958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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