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  1. Article ; Online: Clinical and pathological changes in a long-term follow-up case of dermatofibrosarcoma protuberans.

    Yamamoto, Yuki / Toyozawa, Seiko / Uede, Koji / Oda, Yoshinao / Nakamura, Yasushi / Furukawa, Fukumi

    The Journal of dermatology

    2011  Volume 38, Issue 2, Page(s) 203–205

    MeSH term(s) Adult ; Antigens, CD34/metabolism ; Biomarkers, Tumor/metabolism ; Dermatofibrosarcoma/metabolism ; Dermatofibrosarcoma/pathology ; Follow-Up Studies ; Humans ; Male ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
    Chemical Substances Antigens, CD34 ; Biomarkers, Tumor
    Language English
    Publishing date 2011-02
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/j.1346-8138.2010.00938.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1950: Show issues Location:
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  2. Article: Chemokine receptor CXCR4 is a novel marker for the progression of cutaneous malignant melanomas.

    Toyozawa, Seiko / Kaminaka, Chikako / Furukawa, Fukumi / Nakamura, Yasushi / Matsunaka, Hiroshi / Yamamoto, Yuki

    Acta histochemica et cytochemica

    2012  Volume 45, Issue 5, Page(s) 293–299

    Abstract: The CXCR4/CXCL12 pathway has recently been reported to be involved in stimulating the metastasis of many different neoplasms, in which CXCR4 activates various phenomena such as chemotaxis, invasion, angiogenesis and proliferation. The purpose of this ... ...

    Abstract The CXCR4/CXCL12 pathway has recently been reported to be involved in stimulating the metastasis of many different neoplasms, in which CXCR4 activates various phenomena such as chemotaxis, invasion, angiogenesis and proliferation. The purpose of this study was to analyze a possible association between the expression of chemokine receptors CXCR4, CCR6 and CCR7 with the clinicopathological features of cutaneous malignant melanoma, and to assess the usefulness of these chemokine receptors for diagnosis and prognosis. In our study, a percentage of immunoexpression of both CXCR4 and its ligands CXCL12 was associated with high clinical risk. In contrast, the patients with a low immunoexpression of CXCR4 and CXCL12 had low clinical risk. CCR6 and CCR7 immunoexpressions were also correlated with some clinical parameters, but seemed no more useful than CXCR4. These data suggest that the assessment of CXCR4 immunoexpression is a novel tool for predicting tumor aggressiveness in malignant melanomas, and in particular, a high immunoexpression percentage of CXCR4 and CXCL12 might be a sign of a poor prognosis.
    Language English
    Publishing date 2012-10-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280005-6
    ISSN 1347-5800 ; 0044-5991
    ISSN (online) 1347-5800
    ISSN 0044-5991
    DOI 10.1267/ahc.12004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Successful treatment with trichloroacetic acid peeling for inflammatory linear verrucous epidermal nevus.

    Toyozawa, Seiko / Yamamoto, Yuki / Kaminaka, Chikako / Kishioka, Akiko / Yonei, Nozomi / Furukawa, Fukumi

    The Journal of dermatology

    2010  Volume 37, Issue 4, Page(s) 384–386

    MeSH term(s) Child, Preschool ; Female ; Humans ; Keratolytic Agents/therapeutic use ; Nevus/drug therapy ; Nevus/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Trichloroacetic Acid/adverse effects ; Trichloroacetic Acid/therapeutic use
    Chemical Substances Keratolytic Agents ; Trichloroacetic Acid (5V2JDO056X)
    Language English
    Publishing date 2010-04
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/j.1346-8138.2010.00822.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1950: Show issues Location:
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  4. Article ; Online: Immunohistochemical analysis of CXCR4 expression in fibrohistiocytic tumors.

    Toyozawa, Seiko / Yamamoto, Yuki / Ishida, Yuko / Kondo, Toshikazu / Nakamura, Yasushi / Furukawa, Fukumi

    Acta histochemica et cytochemica

    2010  Volume 43, Issue 2, Page(s) 45–50

    Abstract: Functional chemokine receptors are expressed in many malignant tumors. These receptors promote tumor growth and metastasis in response to endogenous chemokines. We analyzed the expression of CXCR4, CCR6 and CCR7 in fibrohistiocytic tumors, including ... ...

    Abstract Functional chemokine receptors are expressed in many malignant tumors. These receptors promote tumor growth and metastasis in response to endogenous chemokines. We analyzed the expression of CXCR4, CCR6 and CCR7 in fibrohistiocytic tumors, including dermatofibrosarcoma protuberance (DFSP), malignant fibrous histiocytoma (MFH), dermatofibroma (DF) using immunohistochemistry. We also investigated the relationship between CXCR4 and CD34, the latter of which is an immunohistochemical marker for DFSP. We observed a higher expression of CXCR4 in DFSP and MFH as compared with DF. Interestingly, a significantly higher expression of CXCR4 was detected in relapsed DFSP than in non-relapsed DFSP, but no significant differences were detected between non-relapsed DFSP and DFSP with CD34 immunostaining. Moreover, MFH had strong immunoreactivity for CXCR4, CCR6 and CCR7. These findings suggest that the assessment of CXCR4 immunoreactivity in fibrohistiocytic tumors is a useful tool for predicting tumor aggressiveness.
    Language English
    Publishing date 2010-04-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280005-6
    ISSN 1347-5800 ; 0044-5991
    ISSN (online) 1347-5800
    ISSN 0044-5991
    DOI 10.1267/ahc.10003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Effective treatment of intractable skin ulcers using allogeneic cultured dermal substitutes in patients with systemic lupus erythematosus.

    Toyozawa, Seiko / Yamamoto, Yuki / Kishioka, Akiko / Yonei, Nozomi / Kanazawa, Nobuo / Matsumoto, Yasuhiro / Kuroyanagi, Yoshimitsu / Furukawa, Fukumi

    European journal of dermatology : EJD

    2009  Volume 19, Issue 6, Page(s) 594–596

    Abstract: Skin ulcers in systemic lupus erythematosus (SLE) patients are non-healing or intractable, because various factors or complications, including vasculitis and immunosuppressants, impair wound healing. In the present study, we applied cultured dermal ... ...

    Abstract Skin ulcers in systemic lupus erythematosus (SLE) patients are non-healing or intractable, because various factors or complications, including vasculitis and immunosuppressants, impair wound healing. In the present study, we applied cultured dermal substitutes (CDSs) to 3 cases of SLE skin ulcers because various systemic or topical therapies were ineffective. CDSs are prepared by culturing human fibroblasts on two-layered spongy matrices of hyaluronic acid and atelo-collagen, and they effectively promote the healing of severe skin defects. After using CDSs in the 3 cases, healthy granulation tissues formed within 6 weeks, and skin grafts were successfully performed. These results indicate that allogeneic CDSs provide new therapeutic alternatives as topical therapies for intractable skin ulcers in SLE.
    MeSH term(s) Adult ; Aged ; Female ; Fibroblasts/cytology ; Humans ; Leg/pathology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/pathology ; Lupus Erythematosus, Systemic/surgery ; Severity of Illness Index ; Skin Transplantation ; Skin Ulcer/etiology ; Skin Ulcer/pathology ; Skin Ulcer/surgery ; Tissue Engineering/methods ; Transplantation, Homologous ; Wound Healing
    Language English
    Publishing date 2009-11
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2009.0780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3484: Show issues Location:
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  6. Article ; Online: Case report: a case of pyoderma gangrenosum with intractable leg ulcers treated by allogeneic cultured dermal substitutes.

    Toyozawa, Seiko / Yamamoto, Yuki / Nishide, Takeshi / Kishioka, Akiko / Kanazawa, Nobuo / Matsumoto, Yasuhiro / Kuroyanagi, Yoshimitsu / Furukawa, Fukumi

    Dermatology online journal

    2008  Volume 14, Issue 11, Page(s) 17

    Abstract: Pyoderma gangrenosum (PG) is an idiopathic, inflammatory, ulcerative disease of undetermined cause. Both topical and systemic treatments of corticosteroids and cyclosporine are commonly used for the ulcers of PG, but these ulcers are often intractable ... ...

    Abstract Pyoderma gangrenosum (PG) is an idiopathic, inflammatory, ulcerative disease of undetermined cause. Both topical and systemic treatments of corticosteroids and cyclosporine are commonly used for the ulcers of PG, but these ulcers are often intractable despite treatment. We employed allogeneic cultured dermal substitutes (CDS) in a patient with intractable ulcers due to PG. The CDS was prepared by cultured human fibroblasts on two-layered sponges of extracellular matrix such as hyaluronic acid and atelo-collagen. In the present case, re-epithelization and healthy granulation were induced by the CDS without increasing the dosage of systemic prednisolone. Then the subsequent autologous skin graft was successfully performed. This indicates that CDS is one of the useful tools for the treatment of intractable ulcers in patients with PG.
    MeSH term(s) Aged ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Cells, Cultured/transplantation ; Combined Modality Therapy ; Debridement ; Female ; Fibroblasts/transplantation ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Leg Ulcer/microbiology ; Leg Ulcer/surgery ; Prednisolone/therapeutic use ; Pseudomonas Infections/complications ; Pseudomonas Infections/microbiology ; Pyoderma Gangrenosum/complications ; Pyoderma Gangrenosum/surgery ; Skin Transplantation ; Skin, Artificial ; Surgical Sponges ; Transplantation, Autologous ; Transplantation, Homologous ; Wound Healing
    Chemical Substances Immunosuppressive Agents ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2008-11-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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