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Article ; Online: To read or not to read? Motives for reading negative COVID-19 news.

Niehoff, Esther / Mittenbühler, Maximilian / Oosterwijk, Suzanne

2023 Volume 79, Issue 2, Page(s) 254–267

Abstract: People were confronted with a barrage of negative news during the COVID-19 crisis. This study investigated how anticipated psychological impact predicted decisions to read personalized and factual COVID-19 news. First, participants chose, based on ... ...

Abstract	People were confronted with a barrage of negative news during the COVID-19 crisis. This study investigated how anticipated psychological impact predicted decisions to read personalized and factual COVID-19 news. First, participants chose, based on headlines, whether they wanted to read news articles (or not). Then, all headlines were rated on a set of motivational dimensions. In order to test confirmatory hypotheses, the data were divided into an exploration (
MeSH term(s)	Humans ; COVID-19/psychology ; Emotions ; Morals ; Motivation ; Reading ; Mass Media
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	209464-2
ISSN	1935-990X ; 0003-066X
ISSN (online)	1935-990X
ISSN	0003-066X
DOI	10.1037/amp0001178
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Choosing the negative: A behavioral demonstration of morbid curiosity.

Oosterwijk, Suzanne

PloS one

2017 Volume 12, Issue 7, Page(s) e0178399

Abstract: ... social scenes that involved death, violence or harm (e.g., war scene), or decontextualized, close-ups ... of physical harm (e.g., mutilated face) or natural threat (e.g., attacking shark). The results demonstrated ...

Abstract	This paper examined, with a behavioral paradigm, to what extent people choose to view stimuli that portray death, violence or harm. Based on briefly presented visual cues, participants made choices between highly arousing, negative images and positive or negative alternatives. The negative images displayed social scenes that involved death, violence or harm (e.g., war scene), or decontextualized, close-ups of physical harm (e.g., mutilated face) or natural threat (e.g., attacking shark). The results demonstrated that social negative images were chosen significantly more often than other negative categories. Furthermore, participants preferred social negative images over neutral images. Physical harm images and natural threat images were not preferred over neutral images, but were chosen in about thirty-five percent of the trials. These results were replicated across three different studies, including a study that presented verbal descriptions of images as pre-choice cues. Together, these results show that people deliberately subject themselves to negative images. With this, the present paper demonstrates a dynamic relationship between negative information and behavior and advances new insights into the phenomenon of morbid curiosity.
MeSH term(s)	Adolescent ; Adult ; Aggression/psychology ; Choice Behavior ; Cues ; Exploratory Behavior ; Female ; Humans ; Male ; Photic Stimulation ; Violence/psychology
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0178399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma.

Shimazui, T / Oosterwijk-Wakka, J / Akaza, H / Bringuier, P P / Ruijter, E / Debruyne, F M / Schalken, J A / Oosterwijk, E

European urology

2000 Volume 38, Issue 3, Page(s) 331–338

Abstract: ... integrity. However, during tissue remodeling, e.g., development, adhesion may be modified for morphogenic ... stained immunohistochemically using antibodies against E-cadherin (ECD), cadherin-6 (CAD6) and ...

Abstract	Objectives: Cell-cell adhesion mediated by cadherins is tight and stable and preserves tissue integrity. However, during tissue remodeling, e.g., development, adhesion may be modified for morphogenic movement. Similarly, during carcinogenesis, cell-cell adhesion might alter leading to a more aggressive phenotype. Here we describe cadherin expression patterns in developing, adult, and neoplastic kidney. Methods: Fetal kidneys were obtained from voluntary terminations of pregnancy and 43 renal cell carcinomas (RCC) and normal kidneys were obtained at nephrectomy. Frozen sections of these specimens were stained immunohistochemically using antibodies against E-cadherin (ECD), cadherin-6 (CAD6) and alpha-catenin (alpha-cat). Results: CAD6 was expressed in lower and middle limbs of the S-shaped bodies, structures that will develop into renal proximal tubules, which also express CAD6. Similarly, ECD was expressed in the upper limb of S-shaped bodies, structures which will develop into distal and collecting tubules which also express ECD. Twenty-four out of 43 RCC (55.8%) displayed a CAD6 (+)/ECD (-)/alpha-cat (+) phenotype. The other RCC had a CAD6 (+)/ECD (+)/alpha-cat (+) phenotype (10/43, 23.2%), CAD6 (-)/ECD (+)/alpha-cat (+) phenotype (3/43, 7.0%) or CAD6 (-)/ECD (-)/alpha-cat (+) phenotype (6/43, 14.0%), respectively. On the other hand, normal, heterogeneous, or absent expression of CAD6 was seen in 19, 15, and 9 tumors, whereas in 11, 2, and 30 tumors, respectively, ECD expression was seen. Survival curves showed that abnormal CAD6 expression correlated with a poor prognosis rather than abnormal ECD expression. Conclusions: The combination of cadherin expression appeared to be fixed relatively early during kidney organogenesis. Since almost all RCC originate from proximal tubular epithelial cells (CAD6 (+)/ECD (-)/alpha-cat (+)), only 55. 8% of RCC retained the original cadherin phenotype. Alterations in expression of these molecules may be a reflection of the degree of dedifferentiation from the primary organ. In addition, scoring of expression patterns including heterogeneous expression could be a useful tool to estimate the malignancy potential of the tumor.
MeSH term(s)	Cadherins/biosynthesis ; Carcinoma, Renal Cell/metabolism ; Cytoskeletal Proteins/biosynthesis ; Humans ; Kidney/embryology ; Kidney/metabolism ; Kidney Neoplasms/metabolism ; alpha Catenin
Chemical Substances	CTNNA1 protein, human ; Cadherins ; Cytoskeletal Proteins ; alpha Catenin ; K cadherin (U9G6UFV40X)
Language	English
Publishing date	2000-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	193790-x
ISSN	1421-993X ; 0302-2838
ISSN (online)	1421-993X
ISSN	0302-2838
DOI	10.1159/000020302
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Conference proceedings ; Online: Social Life Cycle Assessment applied to livestock systems in Europe

Oosterwijk, A.A.M. / Goglio, P. / Oosterkamp, E.B.

Book of Abstracts. The 11th Conference on Life Cycle Management

2023

Keywords	Life Science
Language	English
Publishing country	nl
Document type	Article ; Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Carbonic anhydrase expression in kidney and renal cancer: implications for diagnosis and treatment.

Oosterwijk, Egbert

Sub-cellular biochemistry

2014 Volume 75, Page(s) 181–198

Abstract: Four different carbonic anhydrases are expressed in the human nephron, the functional unit of the kidney. These are specifically expressed in different nephron segments, emphasizing the critical role carbonic anhydrases play in maintaining the ... ...

Abstract	Four different carbonic anhydrases are expressed in the human nephron, the functional unit of the kidney. These are specifically expressed in different nephron segments, emphasizing the critical role carbonic anhydrases play in maintaining the homeostasis of this crucial organ.Whereas the localization of carbonic anhydrases in the kidney has been long established, interest in carbonic anhydrases has increased dramatically for renal cancer, in particular for the clear cell variant of renal cell carcinoma (ccRCC) because carbonic anhydrase IX is specifically expressed in ccRCC. Therefore carbonic anhydrase IX is being studied as potential diagnostic and therapeutic target, despite carbonic anhydrase IX expression in non-renal tissues.
MeSH term(s)	Antigens, Neoplasm/biosynthesis ; Antigens, Neoplasm/therapeutic use ; Biomarkers, Tumor ; Carbonic Anhydrase IV/biosynthesis ; Carbonic Anhydrase IV/therapeutic use ; Carbonic Anhydrase IX ; Carbonic Anhydrases/biosynthesis ; Carbonic Anhydrases/therapeutic use ; Clinical Trials as Topic ; Gene Expression Regulation, Enzymologic ; Humans ; Kidney/enzymology ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/enzymology ; Kidney Neoplasms/pathology
Chemical Substances	Antigens, Neoplasm ; Biomarkers, Tumor ; Carbonic Anhydrase IV (EC 4.2.1.-) ; CA9 protein, human (EC 4.2.1.1) ; Carbonic Anhydrase IX (EC 4.2.1.1) ; Carbonic Anhydrases (EC 4.2.1.1) ; carbonic anhydrase XII (EC 4.2.1.1)
Language	English
Publishing date	2014
Publishing country	United States
Document type	Journal Article ; Review
ISSN	0306-0225 ; 0096-8757
ISSN	0306-0225 ; 0096-8757
DOI	10.1007/978-94-007-7359-2_10
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Choosing the negative

Suzanne Oosterwijk

PLoS ONE, Vol 12, Iss 7, p e

A behavioral demonstration of morbid curiosity.

2017 Volume 0178399

Abstract	This paper examined, with a behavioral paradigm, to what extent people choose to view stimuli that portray death, violence or harm. Based on briefly presented visual cues, participants made choices between highly arousing, negative images and positive or negative alternatives. The negative images displayed social scenes that involved death, violence or harm (e.g., war scene), or decontextualized, close-ups of physical harm (e.g., mutilated face) or natural threat (e.g., attacking shark). The results demonstrated that social negative images were chosen significantly more often than other negative categories. Furthermore, participants preferred social negative images over neutral images. Physical harm images and natural threat images were not preferred over neutral images, but were chosen in about thirty-five percent of the trials. These results were replicated across three different studies, including a study that presented verbal descriptions of images as pre-choice cues. Together, these results show that people deliberately subject themselves to negative images. With this, the present paper demonstrates a dynamic relationship between negative information and behavior and advances new insights into the phenomenon of morbid curiosity.
Keywords	Medicine ; R ; Science ; Q
Subject code	150
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Expression of cadherin-6 as a novel diagnostic tool to predict prognosis of patients with E-cadherin-absent renal cell carcinoma.

Shimazui, T / Oosterwijk, E / Akaza, H / Bringuier, P / Ruijter, E / van Berkel, H / Wakka, J O / van Bokhoven, A / Debruyne, F M / Schalken, J A

Clinical cancer research : an official journal of the American Association for Cancer Research

1998 Volume 4, Issue 10, Page(s) 2419–2424

Abstract: In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and ... however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g ... cadherin-6 expression in tumor cells in 43 patients with RCC. Expression of cadherin-6, E-cadherin, and ...

Abstract	In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and cadherin-6 (T. Shimazui et al, Cancer Res., 56: 3234-3237, 1996). Among these cadherins expressed in RCCs, cadherin-6 has been identified as a major cadherin in the renal proximal tubules and in the tumors themselves. Hence, we have investigated the relationship between prognosis and cadherin-6 expression in tumor cells in 43 patients with RCC. Expression of cadherin-6, E-cadherin, and alpha-catenin was detected immunohistochemically and evaluated microscopically as normal, heterogeneous, or absent. Normal, heterogeneous, and absent expression of cadherin-6 were observed in 19, 16, and 8 of 43 cases, respectively. Coexpression of E-cadherin and cadherin-6 was detected in only 10 cases. Among 30 tumors in which E-cadherin expression was absent, 24 expressed cadherin-6. In addition, the expression pattern of alpha-catenin correlated more highly with that of cadherin-6 than it did with E-cadherin (P = 0.0003 versus 0.025). In survival analyses, aberrant expression of cadherin-6 correlated with poor survivals both among all patients (P = 0.0009) and in those with E-cadherin-absent RCC (P = 0.0008). These results suggest that cadherin-6 is a major cadherin playing an essential role in cell-cell adhesion in E-cadherin-absent RCC.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cadherins/analysis ; Carcinoma, Renal Cell/chemistry ; Carcinoma, Renal Cell/mortality ; Female ; Humans ; Kidney/chemistry ; Kidney Neoplasms/chemistry ; Kidney Neoplasms/mortality ; Male ; Middle Aged ; Prognosis
Chemical Substances	Cadherins ; K cadherin (U9G6UFV40X)
Language	English
Publishing date	1998-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4223: Show issues

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Book ; Thesis: Renal cell carcinoma

Oosterwijk, Egbert

diagnostic procedures with monoclonal antibodies

1987

Size	189 S. : Ill., graph. Darst.
Publishing country	Netherlands
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Leiden, Rijksuniv., Diss., 1987
Note	Zsfassung in niederländ. Sprache
HBZ-ID	HT003228851
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
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Article ; Online: Testing, explaining, and exploring models of facial expressions of emotions.

Snoek, Lukas / Jack, Rachael E / Schyns, Philippe G / Garrod, Oliver G B / Mittenbühler, Maximilian / Chen, Chaona / Oosterwijk, Suzanne / Scholte, H Steven

Science advances

2023 Volume 9, Issue 6, Page(s) eabq8421

Abstract: ... provide a noise ceiling to inform the explanatory power and limitations of different factors (e.g., AUs ...

Abstract	Models are the hallmark of mature scientific inquiry. In psychology, this maturity has been reached in a pervasive question-what models best represent facial expressions of emotion? Several hypotheses propose different combinations of facial movements [action units (AUs)] as best representing the six basic emotions and four conversational signals across cultures. We developed a new framework to formalize such hypotheses as predictive models, compare their ability to predict human emotion categorizations in Western and East Asian cultures, explain the causal role of individual AUs, and explore updated, culture-accented models that improve performance by reducing a prevalent Western bias. Our predictive models also provide a noise ceiling to inform the explanatory power and limitations of different factors (e.g., AUs and individual differences). Thus, our framework provides a new approach to test models of social signals, explain their predictive power, and explore their optimization, with direct implications for theory development.
MeSH term(s)	Humans ; Facial Expression ; Emotions ; Face ; Movement
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abq8421
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Alterations in Expression of Cadherin-6 and E-Cadherin during Kidney Development and in Renal Cell Carcinoma

Shimazui, Toru / Oosterwijk-Wakka, Jeannette / Akaza, Hideyuki / Bringuier, Pierre Paul / Ruijter, Emiel / Debruyne, Frans M.J. / Schalken, Jack A. / Oosterwijk, Egbert

European Urology

2000 Volume 38, Issue 3, Page(s) 331–338

Abstract: ... integrity. However, during tissue remodeling, e.g., development, adhesion may be modified for morphogenic ... immunohistochemically using antibodies against E-cadherin (ECD), cadherin-6 (CAD6) and α-catenin (α-cat).Results: CAD6 ...

Abstract	Objectives: Cell-cell adhesion mediated by cadherins is tight and stable and preserves tissue integrity. However, during tissue remodeling, e.g., development, adhesion may be modified for morphogenic movement. Similarly, during carcinogenesis, cell-cell adhesion might alter leading to a more aggressive phenotype. Here we describe cadherin expression patterns in developing, adult, and neoplastic kidney.Methods: Fetal kidneys were obtained from voluntary terminations of pregnancy and 43 renal cell carcinomas (RCC) and normal kidneys were obtained at nephrectomy. Frozen sections of these specimens were stained immunohistochemically using antibodies against E-cadherin (ECD), cadherin-6 (CAD6) and α-catenin (α-cat).Results: CAD6 was expressed in lower and middle limbs of the S-shaped bodies, structures that will develop into renal proximal tubules, which also express CAD6. Similarly, ECD was expressed in the upper limb of S-shaped bodies, structures which will develop into distal and collecting tubules which also express ECD. Twenty-four out of 43 RCC (55.8%) displayed a CAD6 (+)/ECD (-)/α-cat (+) phenotype. The other RCC had a CAD6 (+)/ECD (+)/α-cat (+) phenotype (10/43, 23.2%), CAD6 (-)/ECD (+)/α-cat (+) phenotype (3/43, 7.0%) or CAD6 (-)/ECD (-)/α-cat (+) phenotype (6/43, 14.0%), respectively. On the other hand, normal, heterogeneous, or absent expression of CAD6 was seen in 19, 15, and 9 tumors, whereas in 11, 2, and 30 tumors, respectively, ECD expression was seen. Survival curves showed that abnormal CAD6 expression correlated with a poor prognosis rather than abnormal ECD expression.Conclusions: The combination of cadherin expression appeared to be fixed relatively early during kidney organogenesis. Since almost all RCC originate from proximal tubular epithelial cells (CAD6 (+)/ECD (-)/α-cat (+)), only 55.8% of RCC retained the original cadherin phenotype. Alterations in expression of these molecules may be a reflection of the degree of dedifferentiation from the primary organ. In addition, scoring of expression patterns including heterogeneous expression could be a useful tool to estimate the malignancy potential of the tumor.
Keywords	Cadherin ; Catenin ; Invasion ; Metastasis ; Neoplasm ; Nephron ; Development
Language	English
Publisher	S. Karger AG
Publishing place	Basel
Publishing country	Switzerland
Document type	Article ; Online
ZDB-ID	193790-x
ISSN	1421-993X ; 0302-2838 ; 0302-2838
ISSN (online)	1421-993X
ISSN	0302-2838
DOI	10.1159/000020302
Database	Karger publisher's database

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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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