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Article ; Online: Usability testing and satisfaction of "The Patient Access": A mobile health application for patients with venous thromboembolic disease. A pilot study.

Merks, Piotr / Religioni, Urszula / Arciszewska, Karolina / Pankiewicz, Walentyn / Jaguszewski, Miłosz / Vaillancourt, Regis

Cardiology journal

2020 Volume 27, Issue 6, Page(s) 891–893

MeSH term(s)	Humans ; Patient Satisfaction ; Personal Satisfaction ; Pilot Projects ; Telemedicine ; User-Centered Design ; User-Computer Interface
Language	English
Publishing date	2020-09-11
Publishing country	Poland
Document type	Letter
ZDB-ID	2488680-4
ISSN	1898-018X ; 1897-5593
ISSN (online)	1898-018X
ISSN	1897-5593
DOI	10.5603/CJ.a2020.0107
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Article ; Online: Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts.

Jabłońska-Trypuć, Agata / Pankiewicz, Walentyn / Czerpak, Romuald

Lipids

2016 Volume 51, Issue 9, Page(s) 1021–1035

Abstract: Traumatic acid (TA) is a plant hormone (cytokinin) that in terms of chemical structure belongs to the group of fatty acids derivatives. It was isolated from Phaseolus vulgaris. TA activity and its influence on human cells and organism has not previously ... ...

Abstract	Traumatic acid (TA) is a plant hormone (cytokinin) that in terms of chemical structure belongs to the group of fatty acids derivatives. It was isolated from Phaseolus vulgaris. TA activity and its influence on human cells and organism has not previously been the subject of research. The aim of this study was to examine the effects of TA on collagen content and basic oxidative stress parameters, such as antioxidative enzyme activity, reduced glutathione, thiol group content, and lipid peroxidation in physiological conditions. The results show a stimulatory effect of TA on tested parameters. TA caused a decrease in membrane phospholipid peroxidation and exhibited protective properties against ROS production. It also increases protein and collagen biosynthesis and its secretion into the culture medium. The present findings reveal that TA exhibits multiple and complex activity in fibroblast cells in vitro. TA, with its activity similar to unsaturated fatty acids, shows antioxidant and stimulatory effects on collagen biosynthesis. It is a potentially powerful agent with applications in the treatment of many skin diseases connected with oxidative stress and collagen biosynthesis disorders.
MeSH term(s)	Cell Membrane/metabolism ; Cells, Cultured ; Collagen/biosynthesis ; Dicarboxylic Acids/pharmacology ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Humans ; Lipid Peroxidation/drug effects ; Oxidative Stress/drug effects ; Phospholipids/metabolism ; Skin/cytology ; Skin/drug effects
Chemical Substances	Dicarboxylic Acids ; Phospholipids ; Collagen (9007-34-5) ; traumatic acid (L7ND24937H)
Language	English
Publishing date	2016-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	241539-2
ISSN	1558-9307 ; 0024-4201
ISSN (online)	1558-9307
ISSN	0024-4201
DOI	10.1007/s11745-016-4174-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts

JabÅoÅska-TrypuÄ, Agata / Walentyn Pankiewicz / Romuald Czerpak

Lipids. 2016 Sept., v. 51, no. 9

2016

Abstract	Traumatic acid (TA) is a plant hormone (cytokinin) that in terms of chemical structure belongs to the group of fatty acids derivatives. It was isolated from Phaseolus vulgaris. TA activity and its influence on human cells and organism has not previously been the subject of research. The aim of this study was to examine the effects of TA on collagen content and basic oxidative stress parameters, such as antioxidative enzyme activity, reduced glutathione, thiol group content, and lipid peroxidation in physiological conditions. The results show a stimulatory effect of TA on tested parameters. TA caused a decrease in membrane phospholipid peroxidation and exhibited protective properties against ROS production. It also increases protein and collagen biosynthesis and its secretion into the culture medium. The present findings reveal that TA exhibits multiple and complex activity in fibroblast cells in vitro. TA, with its activity similar to unsaturated fatty acids, shows antioxidant and stimulatory effects on collagen biosynthesis. It is a potentially powerful agent with applications in the treatment of many skin diseases connected with oxidative stress and collagen biosynthesis disorders.
Keywords	Phaseolus vulgaris ; antioxidants ; biosynthesis ; chemical structure ; collagen ; culture media ; cytokinins ; enzyme activity ; fibroblasts ; glutathione ; humans ; lipid peroxidation ; oxidative stress ; phospholipids ; plant hormones ; secretion ; skin diseases ; thiols ; unsaturated fatty acids
Language	English
Dates of publication	2016-09
Size	p. 1021-1035.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	241539-2
ISSN	1558-9307 ; 0024-4201
ISSN (online)	1558-9307
ISSN	0024-4201
DOI	10.1007/s11745-016-4174-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Prognostic significance of DAPK and RASSF1A promoter hypermethylation in non-small cell lung cancer (NSCLC).

Niklinska, Wieslawa / Naumnik, Wojciech / Sulewska, Anetta / Kozłowski, Mirosław / Pankiewicz, Walentyn / Milewski, Robert

Folia histochemica et cytobiologica

2009 Volume 47, Issue 2, Page(s) 275–280

Abstract: The epigenetic inactivation of tumor suppressor genes may play an important role in the development and progression of many cancer types, including lung cancer. Therefore, we investigated the association between the aberrant promoter methylation of 2 ... ...

Abstract	The epigenetic inactivation of tumor suppressor genes may play an important role in the development and progression of many cancer types, including lung cancer. Therefore, we investigated the association between the aberrant promoter methylation of 2 genes: the Death-Associated Protein Kinase (DAPK) and the Ras Association Domain Family 1A (RASSF1A) by using methylation-specific PCR, and the clinicopathological features and prognosis in 70 radically resected non-small cell lung cancers (NSCLCs). Hypermethylation of the DAPK and RASSF1A promoters was found in 24 (34%), and in 18 (26%) tumor DNA samples, respectively. Regarding different clinicopathological features of NSCLCs, the DAPK promoter methylation was more frequently observed in squamous cell carcinoma (46%) than in adenocarcinoma (25%) and large cell carcinoma (22%), but there were no significant statistical differences (p=0.3). On the other hand, a statistically significant trend was observed between the RASSF1A methylation and a histological type of tumor (p=0.06). 45% of adenocarcinoma tumors showed RASSF1A promoter methylation in comparison to 17% of squamous cell carcinomas and 22% of large cell carcinomas. When both markers were analyzed according to the tumor-node-metastasis (TNM) staging system, no statistically significant differences were observed between stage I, II and IIIa, and the DAPK (p=0.2) and RASSF1A methylation (p=0.1). In comparison, when stage I and II were grouped together and considered vs. stage IIIa, a significant association between RASSF1A methylation and the TNM was found (p=0.03). The group of patients with tumors showing DAPK promoter methylation had significantly poorer overall survival rates (p=0.02) than the patients with tumors that did not show DAPK promoter methylation. However, the association between the RASSF1A promoter methylation status and the overall survival rates was not statistically significant (p=0.48). In conclusion, this paper supports the importance of epigenetic gene regulation in lung cancer progression and prognosis.
MeSH term(s)	Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Calcium-Calmodulin-Dependent Protein Kinases/genetics ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/physiopathology ; Carcinoma, Non-Small-Cell Lung/surgery ; DNA Methylation ; Death-Associated Protein Kinases ; Humans ; Neoplasm Staging ; Polymerase Chain Reaction ; Prognosis ; Promoter Regions, Genetic ; Tumor Cells, Cultured ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Apoptosis Regulatory Proteins ; RASSF1 protein, human ; Tumor Suppressor Proteins ; Death-Associated Protein Kinases (EC 2.7.11.1) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17)
Language	English
Publishing date	2009
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605761-5
ISSN	1897-5631 ; 0015-5586 ; 0239-8508
ISSN (online)	1897-5631
ISSN	0015-5586 ; 0239-8508
DOI	10.2478/v10042-009-0091-2
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Article ; Online: Prognostic significance of DAPK and RASSF1A promoter hypermethylation in non-small cell lung cancer (NSCLC).

Robert Milewski / Walentyn Pankiewicz / Mirosław Kozłowski / Anetta Sulewska / Wojciech Naumnik / Wieslawa Niklinska

Folia Histochemica et Cytobiologica, Vol 47, Iss 2, Pp 275-

2009 Volume 280

Abstract	The epigenetic inactivation of tumor suppressor genes may play an important role in the development and progression of many cancer types, including lung cancer. Therefore, we investigated the association between the aberrant promoter methylation of 2 genes: the Death-Associated Protein Kinase (DAPK) and the Ras Association Domain Family 1A (RASSF1A) by using methylation-specific PCR, and the clinicopathological features and prognosis in 70 radically resected non-small cell lung cancers (NSCLCs). Hypermethylation of the DAPK and RASSF1A promoters was found in 24 (34%), and in 18 (26%) tumor DNA samples, respectively. Regarding different clinicopathological features of NSCLCs, the DAPK promoter methylation was more frequently observed in squamous cell carcinoma (46%) than in adenocarcinoma (25%) and large cell carcinoma (22%), but there were no significant statistical differences (p=0.3). On the other hand, a statistically significant trend was observed between the RASSF1A methylation and a histological type of tumor (p=0.06). 45% of adenocarcinoma tumors showed RASSF1A promoter methylation in comparison to 17% of squamous cell carcinomas and 22% of large cell carcinomas. When both markers were analyzed according to the tumor-node-metastasis (TNM) staging system, no statistically significant differences were observed between stage I, II and IIIa, and the DAPK (p=0.2) and RASSF1A methylation (p=0.1). In comparison, when stage I and II were grouped together and considered vs. stage IIIa, a significant association between RASSF1A methylation and the TNM was found (p=0.03). The group of patients with tumors showing DAPK promoter methylation had significantly poorer overall survival rates (p=0.02) than the patients with tumors that did not show DAPK promoter methylation. However, the association between the RASSF1A promoter methylation status and the overall survival rates was not statistically significant (p=0.48). In conclusion, this paper supports the importance of epigenetic gene regulation in lung cancer progression and prognosis.
Keywords	Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	570
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	Polish Histochemical and Cytochemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immunoexpression of P16INK4a, Rb and TP53 proteins in bronchiolar columnar cell dysplasia (BCCD) in lungs resected due to primary non-small cell lung cancer.

Pankiewicz, Walentyn / Sulewska, Anetta / Niklinska, Wieslawa / Naumnik, Wojciech / Laudanski, Jerzy / Niklinski, Jacek / Chyczewski, Lech

Folia histochemica et cytobiologica

2008 Volume 46, Issue 1, Page(s) 89–96

Abstract: Lung cancer is the leading cause of death worldwide. High mortality comes out mainly of the fact that majority of the cases are diagnosed in advanced stadium. An expanded diagnostics of precancerous conditions would certainly contribute to lowering the ... ...

Abstract	Lung cancer is the leading cause of death worldwide. High mortality comes out mainly of the fact that majority of the cases are diagnosed in advanced stadium. An expanded diagnostics of precancerous conditions would certainly contribute to lowering the mortality rate. Many of the molecular changes accompanying the multistep cancer development could be observed using the immunohistochemistry method. In this paper we describe the morphology and cell cycle proteins immunoexpression of the novel probable preinvasive lesion - bronchiolar columnar cell dysplasia (BCCD). Thirty cases of BCCD selected out of 193 patients population, treated for primary non-small cell lung cancer were investigated. Loss of P16INK4a protein was observed in 70% of all cases and was statistically significant in patients with adenocarcinoma. Two cases show abnormal cytoplasmic localization of this protein. TP53 protein accumulates in 26.7% of all BCCD. Rb protein was active in 48.3% of the BCCD cases. In two cases we observed differentiation of the cells composing BCCD into multilayer epithelium of the squamous type, which occurs with formation of desmosomes. We suppose that BCCD may be preneoplastic lesion leading to adenocarcinoma as well as to peripheral squamous cell lung cancer.
MeSH term(s)	Adult ; Aged ; Bronchi/pathology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/surgery ; Cell Nucleus/metabolism ; Cell Nucleus/pathology ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cytoplasm/metabolism ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Mitosis ; Precancerous Conditions/metabolism ; Retinoblastoma Protein/metabolism ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Cyclin-Dependent Kinase Inhibitor p16 ; Ki-67 Antigen ; Retinoblastoma Protein ; Tumor Suppressor Protein p53
Language	English
Publishing date	2008
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605761-5
ISSN	1897-5631 ; 0015-5586 ; 0239-8508
ISSN (online)	1897-5631
ISSN	0015-5586 ; 0239-8508
DOI	10.2478/v10042-008-0013-8
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Article ; Online: Immunoexpression of P16INK4a, Rb and TP53 proteins in bronchiolar columnar cell dysplasia (BCCD) in lungs resected due to primary non-small cell lung cancer.

Lech Chyczewski / Jacek Niklinski / Jerzy Laudanski / Wojciech Naumnik / Wieslawa Niklinska / Anetta Sulewska / Walentyn Pankiewicz

Folia Histochemica et Cytobiologica, Vol 46, Iss 1, Pp 89-

2008 Volume 96

Abstract	Lung cancer is the leading cause of death worldwide. High mortality comes out mainly of the fact that majority of the cases are diagnosed in advanced stadium. An expanded diagnostics of precancerous conditions would certainly contribute to lowering the mortality rate. Many of the molecular changes accompanying the multistep cancer development could be observed using the immunohistochemistry method. In this paper we describe the morphology and cell cycle proteins immunoexpression of the novel probable preinvasive lesion - bronchiolar columnar cell dysplasia (BCCD). Thirty cases of BCCD selected out of 193 patients population, treated for primary non-small cell lung cancer were investigated. Loss of P16INK4a protein was observed in 70% of all cases and was statistically significant in patients with adenocarcinoma. Two cases show abnormal cytoplasmic localization of this protein. TP53 protein accumulates in 26.7% of all BCCD. Rb protein was active in 48.3% of the BCCD cases. In two cases we observed differentiation of the cells composing BCCD into multilayer epithelium of the squamous type, which occurs with formation of desmosomes. We suppose that BCCD may be preneoplastic lesion leading to adenocarcinoma as well as to peripheral squamous cell lung cancer.
Keywords	Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	610
Language	English
Publishing date	2008-02-01T00:00:00Z
Publisher	Polish Histochemical and Cytochemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Immunohistochemical markers of cancerogenesis in the lung.

Pankiewicz, Walentyn / Minarowski, Lukasz / Niklińska, Wiesława / Naumnik, Wojciech / Nikliński, Jacek / Chyczewski, Lech

Folia histochemica et cytobiologica

2007 Volume 45, Issue 2, Page(s) 65–74

Abstract: Lung cancer is the leading cause of cancer deaths for people of both sexes worldwide. Early diagnosis of precancer lesions may be of crucial significance to lowering lung cancer mortality. The World Health Organization has defined three preneoplastic ... ...

Abstract	Lung cancer is the leading cause of cancer deaths for people of both sexes worldwide. Early diagnosis of precancer lesions may be of crucial significance to lowering lung cancer mortality. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia and carcinoma in situ, atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively. Apart from WHO classification, two other lesions such as bronchiolization and bronchiolar columnar cell dysplasia (BCCD) can be observed and thought to be preneoplastic lesions leading to adenocarcinoma. In this review we summarize the data of morphological and cell cycle related proteins changes in both central and peripheral compartments of lung. Many molecular changes, which accompany the multistep process of the development of invasive types of cancer, may be observed thanks to the application of immunohistochemical markers. A deeper knowledge of molecular and genetic changes accompanying pre-cancer states may show new directions of early diagnostics of cancer development.
MeSH term(s)	Animals ; Biomarkers, Tumor/analysis ; Disease Progression ; Humans ; Immunohistochemistry ; Lung/metabolism ; Lung/pathology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Precancerous Conditions/metabolism ; Precancerous Conditions/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2007
Publishing country	Poland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605761-5
ISSN	1897-5631 ; 0239-8508 ; 0015-5586
ISSN (online)	1897-5631
ISSN	0239-8508 ; 0015-5586
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunohistochemical markers of cancerogenesis in the lung.

Lech Chyczewski / Jacek Nikliński / Wojciech Naumnik / Wiesława Niklińska / Lukasz Minarowski / Walentyn Pankiewicz

Folia Histochemica et Cytobiologica, Vol 45, Iss 2, Pp 65-

2007 Volume 74

Abstract	Lung cancer is the leading cause of cancer deaths for people of both sexes worldwide. Early diagnosis of precancer lesions may be of crucial significance to lowering lung cancer mortality. The World Health Organization has defined three preneoplastic lesions of the bronchial epithelium: squamous dysplasia and carcinoma in situ, atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. These lesions are believed to progress to squamous cell carcinoma, adenocarcinoma and carcinoid tumors, respectively. Apart from WHO classification, two other lesions such as bronchiolization and bronchiolar columnar cell dysplasia (BCCD) can be observed and thought to be preneoplastic lesions leading to adenocarcinoma. In this review we summarize the data of morphological and cell cycle related proteins changes in both central and peripheral compartments of lung. Many molecular changes, which accompany the multistep process of the development of invasive types of cancer, may be observed thanks to the application of immunohistochemical markers. A deeper knowledge of molecular and genetic changes accompanying pre-cancer states may show new directions of early diagnostics of cancer development.
Keywords	Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	610
Language	English
Publishing date	2007-06-01T00:00:00Z
Publisher	Polish Histochemical and Cytochemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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