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  1. Article ; Online: Total laryngectomy vs. non-surgical organ preservation in advanced laryngeal cancer: a metanalysis.

    Pfuetzenreiter, Elio Gilberto / Ferreron, Gabriela Feltrini / Sadka, Julia Zumerkorn / Souza, Ana Beatriz Pádua de / Matos, Leandro Luongo / Kowalski, Luiz Paulo / Dedivitis, Rogério Aparecido

    Brazilian journal of otorhinolaryngology

    2024  Volume 90, Issue 3, Page(s) 101404

    Abstract: Objective: To compare the oncological results and the functional outcomes of patients undergoing Total Laryngectomy (TL) with the non-surgical treatment (organ preservation protocol) in the treatment of advanced laryngeal carcinomas through systematic ... ...

    Abstract Objective: To compare the oncological results and the functional outcomes of patients undergoing Total Laryngectomy (TL) with the non-surgical treatment (organ preservation protocol) in the treatment of advanced laryngeal carcinomas through systematic review and meta-analysis.
    Methods: A literature survey strategy was employed in order to perform a systematic review of the available evidence. Success rate and functional outomes after oncological treatment of patients with advanced laryngeal carcinomas was evaluated through systematic review and metanalysis, comparing TL and organ preservation protocol.
    Results: The surgical treatment was associated with better survival outcomes. When stratifying by T stage, while patients with T4 staging have less risk of mortality with TL, there is no difference between the different treatments for patients with T3 tumors. Surgery is related to a lower chance of recurrence, late dysphagia and feeding tube dependence.
    Conclusion: Patients with T4 tumors should undergo TL as their treatment of choice. For patients with T3 tumors, there is no differences on the risk of mortality according to the therapeutic option, however, there is a greater chance of recurrence and dysphagia when surgery is not performed.
    Language English
    Publishing date 2024-02-21
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2024.101404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Medical students' and residents' views on euthanasia.

    Dedivitis, Rogério Aparecido / de Matos, Leandro Luongo / de Castro, Mario Augusto Ferrari / de Castro, Andrea Anacleto Ferrari / Giaxa, Renata Rocha / Tempski, Patrícia Zen

    BMC medical ethics

    2023  Volume 24, Issue 1, Page(s) 109

    Abstract: Background: Doctors are increasingly faced with end-of-life decisions. Little is known about how medical students approach euthanasia. The objective of this study was to evaluate, among medical students and residents, the view on euthanasia and its ... ...

    Abstract Background: Doctors are increasingly faced with end-of-life decisions. Little is known about how medical students approach euthanasia. The objective of this study was to evaluate, among medical students and residents, the view on euthanasia and its variants; correlate such a view with empathy and religiosity/spiritualism; and with the stages of medical training in Brazil.
    Methods: This is an exploratory cross-sectional study using an online questionnaire to be filled out on a voluntary basis among medical students and residents, consisting of: socio-demographic data, an empathy questionnaire and questions with elaborate clinical cases that typify situations of the variants of euthanasia.
    Results: From 1550 invitations, 273 volunteer participants responded (17.6%). The percentages of strong agreement/agreement on the concepts were: passive euthanasia (72.9%); active euthanasia (22.3%), orthothanasia (90.1%), dysthanasia (18.7%), assisted suicide (33%) and sedation (82.8%). Passive euthanasia, active euthanasia, dysthanasia and assisted suicide showed greater refusal with increasing length of medical training. Religious belief and degree of empathy did not significantly influence the opinion about the concepts. Strong agreement/agreement were: passive euthanasia (72.9%); active euthanasia (22.3%), orthothanasia (90.1%), dysthanasia (18.7%), assisted suicide (33%) and sedation (82.8%).
    Conclusions: Passive euthanasia, active euthanasia, dysthanasia and assisted suicide showed greater refusal with increasing length of medical training. The external validation of our findings relies on the distinct legal, cultural, and religious frameworks found across various countries.
    MeSH term(s) Humans ; Students, Medical ; Cross-Sectional Studies ; Euthanasia ; Suicide, Assisted ; Death
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041552-7
    ISSN 1472-6939 ; 1472-6939
    ISSN (online) 1472-6939
    ISSN 1472-6939
    DOI 10.1186/s12910-023-00986-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Congenital Midline Cervical Cleft and Thyroglossal Duct Fibrous Cord-Like, is There a Mixed Presentation?

    Kruschewsky, Leonardo de Souza / Matos, Leandro Luongo de / Alonso, Nivaldo / Seidler, Cariline da Silva / Lisboa, Sonyara Rauedys Oliveira / Silva, Roberto Cintra Lomanto Santos / Goldenberg, Dov Charles / Silva, Tatiana Valeria Novais

    The Journal of craniofacial surgery

    2023  Volume 34, Issue 6, Page(s) e546–e549

    Abstract: Introduction: Congenital midline cervical cleft is a rare condition and is frequently misdiagnosed as thyroglossal duct cyst. Otherwise, the combination of congenital midline cervical cleft and thyroglossal duct fibrosis in the same patient is as rare ... ...

    Abstract Introduction: Congenital midline cervical cleft is a rare condition and is frequently misdiagnosed as thyroglossal duct cyst. Otherwise, the combination of congenital midline cervical cleft and thyroglossal duct fibrosis in the same patient is as rare as important to be registered with the intention to inform and offer specific managements details for the literature.
    Case presentation: Eight-year-old boy with simultaneous congenital midline cervical cleft and a thyroglossal duct fibrosis. The anatomic, clinical, radiologic, and pathologic characteristics of the congenital midline cervical cleft are described as well as surgical technique for removal and repair with Z-plasty.
    Conclusion: Congenital midline cervical cleft is a rare condition and when diagnosed must be surgically treated as early as possible. Its differential diagnosis is a clinical challenge.
    MeSH term(s) Male ; Humans ; Child ; Neck/surgery ; Plastic Surgery Procedures ; Skin Abnormalities/surgery ; Craniofacial Abnormalities/surgery ; Thyroglossal Cyst/diagnosis ; Thyroglossal Cyst/surgery
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000009559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of the COVID-19 Pandemic on Brazilian Head and Neck Surgery Centers.

    Alvarenga, Gustavo Fernandes de / Nogueira Leite, Ana Kober / Lehn, Carlos Neutzling / Dedivitis, Rogério Aparecido / Yumi Nakai, Marianne / Cavalheiro, Beatriz Godoi / Vaz Teixeira, Gilberto / De Cicco, Rafael / Kowalski, Luiz Paulo / Matos, Leandro Luongo de

    Brazilian journal of otorhinolaryngology

    2023  Volume 89, Issue 3, Page(s) 456–461

    Abstract: Objective: The outbreak of the COVID-19 pandemic had a considerable impact on the healthcare access, treatment, and follow-up of oncologic patients. The aim of this study was to evaluate how the COVID-19 pandemic has affected consultation and follow-up ... ...

    Abstract Objective: The outbreak of the COVID-19 pandemic had a considerable impact on the healthcare access, treatment, and follow-up of oncologic patients. The aim of this study was to evaluate how the COVID-19 pandemic has affected consultation and follow-up demand as well as treatment volume at Brazilian Head and Neck Surgery centers.
    Methods: An anonymous online questionnaire was used for collection of data across all Brazilian Head and Neck Surgery Centers across a 3-month period (April‒June 2021). This information included the characteristics of each center, and the perceived self-reported impact of the COVID-19 pandemic on academic activities, residency training, and the diagnosis, treatment, and follow-up of patients with Head and Neck diseases between 2019 and 2020.
    Results: The response rate across the 40 registered Brazilian Head and Neck Surgery Centers was 47.5% (n=19). The data showed a significant reduction in the total number of consultations (24.8%) and number of attending patients (20.2%) between 2019 and 2020. The total number of diagnostic exams (31.6%) and surgical procedures (13.0%) conducted over this period also decreased significantly.
    Conclusions: The COVID-19 pandemic had a significant national impact on Brazilian Head and Neck Surgery Centers. Future studies should examine the long-term effects of the pandemic on cancer treatment.
    Level of evidence: Evidence from a single descriptive study.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Brazil/epidemiology ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/surgery
    Language English
    Publishing date 2023-01-28
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2023.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tumor volume as a prognostic factor of locally advanced laryngeal cancer.

    de Andrade, Natália Martins Magacho / Dedivitis, Rogério Aparecido / Ramos, Daniel Marin / Matos, Leandro Luongo / Garcia, Marcio Ricardo Taveira / Conti, Gustavo Gonçalves / Kowalski, Luiz Paulo

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2021  Volume 278, Issue 5, Page(s) 1707

    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Humans ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/therapy ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Tumor Burden
    Language English
    Publishing date 2021-03-11
    Publishing country Germany
    Document type Letter
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-021-06734-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effect of the COVID-19 Pandemic on the Activity of Physicians Working in the Areas of Head and Neck Surgery and Otorhinolaryngology.

    Kowalski, Luiz Paulo / Imamura, Rui / Castro Junior, Gilberto de / Marta, Gustavo Nader / Chaves, Aline Lauda Freitas / Matos, Leandro Luongo / Bento, Ricardo Ferreira

    International archives of otorhinolaryngology

    2020  Volume 24, Issue 3, Page(s) e258–e266

    Abstract: ... ...

    Abstract Introduction
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2578584-9
    ISSN 1809-4864 ; 1809-9777
    ISSN (online) 1809-4864
    ISSN 1809-9777
    DOI 10.1055/s-0040-1712169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Influence of time between surgery and postoperative radiation therapy and total treatment time in locoregional control of patients with head and neck cancer: a single center experience.

    Franco, Rejane / de Matos, Leandro Luongo / Kulcsar, Marco Aurélio Vamondes / de Castro-Júnior, Gilberto / Marta, Gustavo Nader

    Clinics (Sao Paulo, Brazil)

    2020  Volume 75, Page(s) e1615

    Abstract: Objective: This study aimed to evaluate the effect of the delay to initiate postoperative radiation therapy (RT) on locoregional control to head and neck squamous cell carcinoma patients.: Methods: Retrospective cohort study that included patients ... ...

    Abstract Objective: This study aimed to evaluate the effect of the delay to initiate postoperative radiation therapy (RT) on locoregional control to head and neck squamous cell carcinoma patients.
    Methods: Retrospective cohort study that included patients submitted to surgery followed by adjuvant RT (with/without chemotherapy). The time interval between surgery and RT was dichotomized by the receiver operating characteristics curve method at 92 days. Other possible sources of heterogeneity with potential impact on locoregional control were explored by regressive analysis.
    Results: A total of 168 patients were evaluated. The median time for locoregional recurrence (LRR) was 29.7 months. The relapse-free survival rates were 66.4% and 75.4% for patients who initiated RT more than and within 92 postoperative days (p=0.377), respectively. Doses lower than 60Gy were associated with worse rates of locoregional control (HR=6.523; 95%CI:2.266-18.777, p=0.001). Patients whose total treatment time (TTT) was longer than 150 days had LRR rate of 41.8%; no patient with TTT inferior to 150 days had relapses (p=0.001).
    Conclusions: The interval between surgery and RT did not show influence on locoregional control rates. However, doses <60Gy and the total treatment time >150 days were associated with lower locoregional control rates.
    MeSH term(s) Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/surgery ; Humans ; Neoplasm Recurrence, Local ; Postoperative Period ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2020/e1615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Risk Factors for Malignancy in Patients with Multinodular Goiter.

    Fernandes, Guilherme Arruda / Matos, Leandro Luongo de / Dedivitis, Rogério Aparecido

    International archives of otorhinolaryngology

    2022  Volume 27, Issue 1, Page(s) e138–e142

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-06-17
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2578584-9
    ISSN 1809-4864 ; 1809-9777
    ISSN (online) 1809-4864
    ISSN 1809-9777
    DOI 10.1055/s-0042-1748925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Influence of time between surgery and postoperative radiation therapy and total treatment time in locoregional control of patients with head and neck cancer

    Rejane Franco / Leandro Luongo de Matos / Marco Aurélio Vamondes Kulcsar / Gilberto de Castro-Júnior / Gustavo Nader Marta

    Clinics, Vol

    a single center experience

    2020  Volume 75

    Abstract: OBJECTIVE: This study aimed to evaluate the effect of the delay to initiate postoperative radiation therapy (RT) on locoregional control to head and neck squamous cell carcinoma patients. METHODS: Retrospective cohort study that included patients ... ...

    Abstract OBJECTIVE: This study aimed to evaluate the effect of the delay to initiate postoperative radiation therapy (RT) on locoregional control to head and neck squamous cell carcinoma patients. METHODS: Retrospective cohort study that included patients submitted to surgery followed by adjuvant RT (with/without chemotherapy). The time interval between surgery and RT was dichotomized by the receiver operating characteristics curve method at 92 days. Other possible sources of heterogeneity with potential impact on locoregional control were explored by regressive analysis. RESULTS: A total of 168 patients were evaluated. The median time for locoregional recurrence (LRR) was 29.7 months. The relapse-free survival rates were 66.4% and 75.4% for patients who initiated RT more than and within 92 postoperative days (p=0.377), respectively. Doses lower than 60Gy were associated with worse rates of locoregional control (HR=6.523; 95%CI:2.266-18.777, p=0.001). Patients whose total treatment time (TTT) was longer than 150 days had LRR rate of 41.8%; no patient with TTT inferior to 150 days had relapses (p=0.001). CONCLUSIONS: The interval between surgery and RT did not show influence on locoregional control rates. However, doses <60Gy and the total treatment time >150 days were associated with lower locoregional control rates.
    Keywords Head and Neck Neoplasms/Therapy ; Head and Neck Neoplasms/Surgery ; Prognosis ; Adjuvant Chemoradiotherapy ; Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Detection of serum biomarkers of HPV-16 driven oropharynx and oral cavity cancer in Brazil.

    Sichero, Laura / Gonçalves, Milena Giulia / Bettoni, Fabiana / Coser, Elisangela Monteiro / Mota, Giana / Nunes, Rafaella A L / Mercante, Ana Maria da Cunha / Natalino, Renato / Uno, Miyuki / Ferreira Alves, Maria José / Matos, Leandro Luongo / Kowalski, Luiz Paulo / Kulcsar, Marco Aurélio Vamondes / de Alvarenga, Gustavo Fernandes / Höfler, Daniela / Schroeder, Lea / Waterboer, Tim / Tommasino, Massimo / Villa, Luisa Lina

    Oral oncology

    2023  Volume 149, Page(s) 106676

    Abstract: ... from participants treated at the Instituto do Cancer do Estado de Sao Paulo, ICESP, and from whom tumoral HPV DNA ...

    Abstract Background: HPV-16 driven oropharynx/oral cavity squamous cell carcinomas prevalence varies globally. We evaluated the presence of HPV-16 ctDNA and HPV-16 E6 antibodies in samples obtained from participants treated at the Instituto do Cancer do Estado de Sao Paulo, ICESP, and from whom tumoral HPV DNA, HPV-16 E6*I mRNA, and p16
    Methods: HPV was genotyped by PCR-hybridization. All HPV DNA positive and ∼10 % HPV DNA negative cases underwent p16
    Results: The prevalence of HPV-16 in oropharynx carcinoma (OPC) cases was low (8.7 %) when considering solely HPV-16 DNA detection, and even lower (5.2 %) when taken into consideration the concomitant detection of HPV-16 E6*I RNA and/or p16
    Conclusions: Our findings corroborate that serum biomarkers are highly sensitive and specific biomarkers for detection of HPV-associated OPC.
    MeSH term(s) Humans ; Human papillomavirus 16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Papillomavirus Infections ; Brazil/epidemiology ; Oropharyngeal Neoplasms ; Mouth Neoplasms/complications ; Biomarkers ; DNA, Viral/analysis ; RNA ; Head and Neck Neoplasms/complications
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p16 ; Biomarkers ; DNA, Viral ; RNA (63231-63-0)
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2023.106676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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