LIVIVO - Search results -

Search results

Result 1 - 10 of total 57

Search options

Article ; Online: Genetic mutations in pyoderma gangrenosum, hidradenitis suppurativa, and associated autoinflammatory syndromes: Insights into pathogenic mechanisms and shared pathways.

Moltrasio, Chiara / Tricarico, Paola Maura / Ronald, de Moura Rodrigues / Lucas, Brandão / Sergio, Crovella / Marzano, Angelo Valerio

The Journal of dermatology

2024

Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Letter
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.17230
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1950: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Peptides for Coating TiO

Agrelli, Almerinda / Vasconcelos, Niedja Fittipaldi / Silva, Rayane Cristine Santos da / Mendes-Marques, Carina Lucena / Arruda, Isabel Renata de Souza / Oliveira, Priscilla Stela Santana de / Santos, Luzia Rejane Lisbôa / Andrade, Audrey Nunes de / Moura, Ronald Rodrigues de / Bernardo-Menezes, Lucas Coelho / Silva, Natália Pereira da / Machado, Giovanna

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: Titanium is usually used in the manufacturing of metal implants due to its biocompatibility and high resistance to corrosion. A structural and functional connection between the living bone and the surface of the implant, a process called osseointegration, ...

Abstract	Titanium is usually used in the manufacturing of metal implants due to its biocompatibility and high resistance to corrosion. A structural and functional connection between the living bone and the surface of the implant, a process called osseointegration, is mandatory for avoiding prolonged healing, infections, and tissue loss. Therefore, osseointegration is crucial for the success of the implantation procedure. Osseointegration is a process mediated by bone-matrix progenitor cells' proteins, named integrins. In this study, we used an in silico approach to assemble and test peptides that can be strategically used in sensitizing TiO
MeSH term(s)	Coated Materials, Biocompatible/chemistry ; Titanium/pharmacology ; Titanium/chemistry ; Peptides ; Integrins
Chemical Substances	titanium dioxide (15FIX9V2JP) ; Coated Materials, Biocompatible ; Titanium (D1JT611TNE) ; Peptides ; Integrins
Language	English
Publishing date	2022-11-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232214048
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Increased risk of dizziness in human immunodeficiency virus-infected patients taking zidovudine and efavirenz combination: a Brazilian cohort study.

Valeriano, Josué Jeyzon de Lima Soares / Carvalho-Silva, Wlisses Henrique Veloso / Coelho, Antônio Victor Campos / Moura, Ronald Rodrigues / Arraes, Luiz Cláudio / Brandão, Lucas André Cavalcanti / Crovella, Sergio / Guimarães, Rafael Lima

The Journal of pharmacy and pharmacology

2020 Volume 72, Issue 5, Page(s) 719–727

Abstract: ... detrimental to human immunodeficiency virus (HIV) treatment. Our study aims at evaluating if zidovudine use ...

Abstract	Objectives: Neuropsychiatric adverse effects (NPAE) related to efavirenz, mainly dizziness, is detrimental to human immunodeficiency virus (HIV) treatment. Our study aims at evaluating if zidovudine use potentiates the risk of dizziness related to efavirenz when used together and whether there are significant differences in over time distribution of this NPAE and others relatively frequents regarding efavirenz regimen without zidovudine. Methods: Human immunodeficiency virus-infected patients under efavirenz-containing different therapy were enrolled. A retrospective analysis of official medical records was accomplished to collect clinical data regarding NPAE occurrence and severity. Univariate statistic and statistical model based on survival analyses were performed. Key findings: One hundred sixty-two patients were included, of these seventy-seven (47.5%) had NPAE reported, such as dizziness (more frequent), depression and insomnia. Univariate statistical analysis demonstrated that the combined use of efavirenz with zidovudine increased the NPAE risk (OR: 2.5; P-value: 0.008), mainly dizziness risk (OR: 3.5; P-value: 0.009) and survival analysis showed that such combination is associated with dizziness occurrence faster (HR: 2.9; P-value: 0.02). Conclusions: The results may contribute to clarify the dizziness occurrence dynamics in therapy with efavirenz and zidovudine by identifying susceptibilities and assisting in the choice of combined antiretroviral therapy.
MeSH term(s)	Adult ; Alkynes/adverse effects ; Anti-HIV Agents/adverse effects ; Benzoxazines/adverse effects ; Brazil ; Cyclopropanes/adverse effects ; Depression/chemically induced ; Dizziness/chemically induced ; Drug Therapy, Combination/adverse effects ; Female ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Reverse Transcriptase Inhibitors/adverse effects ; Sleep Initiation and Maintenance Disorders/chemically induced ; Survival Analysis ; Time Factors ; Zidovudine/adverse effects
Chemical Substances	Alkynes ; Anti-HIV Agents ; Benzoxazines ; Cyclopropanes ; Reverse Transcriptase Inhibitors ; Zidovudine (4B9XT59T7S) ; efavirenz (JE6H2O27P8)
Language	English
Publishing date	2020-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1111/jphp.13237
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uf I Zs.149: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Book ; Online: Rob\^oCIn Small Size League Extended Team Description Paper for RoboCup 2023

de Oliveira, Aline Lima / Gomes, Cauê Addae da Silva / da Silva, Cecília Virginia Santos / Alves, Charles Matheus de Sousa / de Souza, Danilo Andrade Martins / Xavier, Driele Pires Ferreira Araújo / da Silva, Edgleyson Pereira / Martins, Felipe Bezerra / Santos, Lucas Henrique Cavalcanti / Maciel, Lucas Dias / Santos, Matheus Paixão Gumercindo dos / Vasconcelos, Matheus Lafayette / Andrade, Matheus Vinícius Teotonio do Nascimento / de Melo, João Guilherme Oliveira Carvalho / de Moura, João Pedro Souza Pereira / da Silva, José Ronald / Cruz, José Victor Silva / de Morais, Pedro Henrique Santana / de Oliveira, Pedro Paulo Salman /

Rodrigues, Riei Joaquim Matos / Fernandes, Roberto Costa / Morais, Ryan Vinicius Santos / Teobaldo, Tamara Mayara Ramos / Silva, Washington Igor dos Santos / Barros, Edna Natividade Silva

2023

Abstract: Rob\^oCIn has participated in RoboCup Small Size League since 2019, won its first world title in 2022 (Division B), and is currently a three-times Latin-American champion. This paper presents our improvements to defend the Small Size League (SSL) ... ...

Abstract	Rob\^oCIn has participated in RoboCup Small Size League since 2019, won its first world title in 2022 (Division B), and is currently a three-times Latin-American champion. This paper presents our improvements to defend the Small Size League (SSL) division B title in RoboCup 2023 in Bordeaux, France. This paper aims to share some of the academic research that our team developed over the past year. Our team has successfully published 2 articles related to SSL at two high-impact conferences: the 25th RoboCup International Symposium and the 19th IEEE Latin American Robotics Symposium (LARS 2022). Over the last year, we have been continuously migrating from our past codebase to Unification. We will describe the new architecture implemented and some points of software and AI refactoring. In addition, we discuss the process of integrating machined components into the mechanical system, our development for participating in the vision blackout challenge last year and what we are preparing for this year.
Keywords	Computer Science - Robotics ; Computer Science - Artificial Intelligence
Publishing date	2023-07-19
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Reanalysis of Gene Expression Profiles of CD4+ T Cells Treated with HIV-1 Latency Reversal Agents.

Campos Coelho, Antonio Victor / Moura, Ronald Rodrigues de / Crovella, Sergio

Microorganisms

2020 Volume 8, Issue 10

Abstract: The human immunodeficiency virus (HIV-1) causes a progressive depletion of CD4+ T cells, hampering immune function. Current experimental strategies to fight the virus focus on the reactivation of latent HIV-1 in the viral reservoir to make the virus ... ...

Abstract	The human immunodeficiency virus (HIV-1) causes a progressive depletion of CD4+ T cells, hampering immune function. Current experimental strategies to fight the virus focus on the reactivation of latent HIV-1 in the viral reservoir to make the virus detectable by the immune system, by searching for latency reversal agents (LRAs). We hypothesize that if common molecular pathways elicited by the presence of LRAs are known, perhaps new, more efficient, "shock-and-kill" strategies can be found. Thus, the objective of the present study is to re-evaluate RNA-Seq assays to find differentially expressed genes (DEGs) during latency reversal via transcriptome analysis. We selected six studies (45 samples altogether: 16 negative controls and 29 LRA-treated CD4+ T cells) and 11 LRA strategies through a systematic search in Gene Expression Omnibus (GEO) and PubMed databases. The raw reads were trimmed, counted, and normalized. Next, we detected consistent DEGs in these independent experiments. AZD5582, romidepsin, and suberanilohydroxamic acid (SAHA) were the LRAs that modulated most genes. We detected 948 DEGs shared by those three LRAs. Gene ontology analysis and cross-referencing with other sources of the literature showed enrichment of cell activation, differentiation and signaling, especially mitogen-activated protein kinase (
Language	English
Publishing date	2020-09-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms8101505
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reanalysis of Gene Expression Profiles of CD4+ T Cells Treated with HIV-1 Latency Reversal Agents

Antonio Victor Campos Coelho / Ronald Rodrigues de Moura / Sergio Crovella

Microorganisms, Vol 8, Iss 1505, p

2020 Volume 1505

Abstract	The human immunodeficiency virus (HIV-1) causes a progressive depletion of CD4+ T cells, hampering immune function. Current experimental strategies to fight the virus focus on the reactivation of latent HIV-1 in the viral reservoir to make the virus detectable by the immune system, by searching for latency reversal agents (LRAs). We hypothesize that if common molecular pathways elicited by the presence of LRAs are known, perhaps new, more efficient, “shock-and-kill” strategies can be found. Thus, the objective of the present study is to re-evaluate RNA-Seq assays to find differentially expressed genes (DEGs) during latency reversal via transcriptome analysis. We selected six studies (45 samples altogether: 16 negative controls and 29 LRA-treated CD4+ T cells) and 11 LRA strategies through a systematic search in Gene Expression Omnibus (GEO) and PubMed databases. The raw reads were trimmed, counted, and normalized. Next, we detected consistent DEGs in these independent experiments. AZD5582, romidepsin, and suberanilohydroxamic acid (SAHA) were the LRAs that modulated most genes. We detected 948 DEGs shared by those three LRAs. Gene ontology analysis and cross-referencing with other sources of the literature showed enrichment of cell activation, differentiation and signaling, especially mitogen-activated protein kinase ( MAPK ) and Rho-GTPases pathways.
Keywords	reservoir ; shock-and-kill ; antiretroviral therapy ; RNA-Seq ; transcriptomics ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: An overview of Zika virus genotypes and their infectivity.

Bernardo-Menezes, Lucas Coêlho / Agrelli, Almerinda / Oliveira, Ana Sofia Lima Estevão de / Moura, Ronald Rodrigues de / Crovella, Sergio / Brandão, Lucas André Cavalcanti

Revista da Sociedade Brasileira de Medicina Tropical

2022 Volume 55, Page(s) e02632022

Abstract: Zika virus (ZIKV) is an enveloped, single-stranded RNA arbovirus belonging to the genus Flavivirus. It was first isolated from a sentinel monkey in Uganda in 1947. More recently, ZIKV has undergone rapid geographic expansion and has been responsible for ... ...

Abstract	Zika virus (ZIKV) is an enveloped, single-stranded RNA arbovirus belonging to the genus Flavivirus. It was first isolated from a sentinel monkey in Uganda in 1947. More recently, ZIKV has undergone rapid geographic expansion and has been responsible for outbreaks in Southeast Asia, the Pacific Islands, and America. In this review, we have highlighted the influence of viral genetic variants on ZIKV pathogenesis. Two major ZIKV genotypes (African and Asian) have been identified. The Asian genotype is subdivided into Southwest Asia, Pacific Island, and American strains, and is responsible for most outbreaks. Non-synonymous mutations in ZIKV proteins C, prM, E, NS1, NS2A, NS2B, NS3, and NS4B were found to have a higher prevalence and association with virulent strains of the Asian genotype. Consequently, the Asian genotype appears to have acquired higher cellular permissiveness, tissue persistence, and viral tropism in human neural cells. Therefore, mutations in specific coding regions of the Asian genotype may enhance ZIKV infectivity. Considering that mutations in the genomes of emerging viruses may lead to new virulent variants in humans, there is a potential for the re-emergence of new ZIKV cases in the future.
MeSH term(s)	Flavivirus/genetics ; Genotype ; Humans ; RNA/metabolism ; Zika Virus/genetics ; Zika Virus Infection/epidemiology
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2022-09-30
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0263-2022
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2726: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Variant Enrichment Analysis to Explore Pathways Functionality in Complex Autoinflammatory Skin Disorders through Whole Exome Sequencing Analysis.

Brandão, Lucas André Cavalcanti / Moura, Ronald Rodrigues de / Marzano, Angelo Valerio / Moltrasio, Chiara / Tricarico, Paola Maura / Crovella, Sergio

International journal of molecular sciences

2022 Volume 23, Issue 4

Abstract: The challenge of unravelling the molecular basis of multifactorial disorders nowadays cannot rely just on association studies searching for potential causative variants shared by groups of patients and not present in healthy individuals; indeed, ... ...

Abstract	The challenge of unravelling the molecular basis of multifactorial disorders nowadays cannot rely just on association studies searching for potential causative variants shared by groups of patients and not present in healthy individuals; indeed, association studies have as a main limitation the lack of information on the interactions between the disease-causing variants. Thus, new genomic analysis tools focusing on disrupted pathways rather than associated gene variants are required to better understand the complexity of a disease. Therefore, we developed the Variant Enrichment Analysis (VEA) workflow, a tool applicable for whole exome sequencing data, able to find differences between the numbers of genetic variants in a given pathway in comparison with a reference dataset. In this study, we applied VEA to discover novel pathways altered in patients with complex autoinflammatory skin disorders, namely PASH (
MeSH term(s)	Cell Movement/genetics ; Endothelial Cells/pathology ; Homeostasis/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Neutrophils/pathology ; Signal Transduction/genetics ; Skin/pathology ; Skin Diseases/genetics ; Skin Diseases/pathology ; Exome Sequencing/methods
Language	English
Publishing date	2022-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23042278
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Meta-analysis of Brazilian genetic admixture and comparison with other Latin America countries.

Moura, Ronald Rodrigues de / Coelho, Antonio Victor Campos / Balbino, Valdir de Queiroz / Crovella, Sergio / Brandão, Lucas André Cavalcanti

American journal of human biology : the official journal of the Human Biology Council

2015 Volume 27, Issue 5, Page(s) 674–680

Abstract: Objectives: This study aims at performing a systematic review and meta-analysis with the studies of genetic admixture inference of Brazilian population and to compare these results with the genetic admixture levels in other Latin American countries.: ... ...

Abstract	Objectives: This study aims at performing a systematic review and meta-analysis with the studies of genetic admixture inference of Brazilian population and to compare these results with the genetic admixture levels in other Latin American countries. Methods: We searched for articles regarding the estimation of Brazilian genetic admixture published between 1980 and 2014 that used autosomal markers. Then, conducted meta-analyses at the whole-country and regional level. Finally, we compared the results of Brazil with other estimates from other South, Central and North American countries. Results: We analyzed data from 25 studies in 38 different Brazilian populations. European (EUR) ancestry is the major contributor to the genetic background of Brazilians, followed by African (AFR), and Amerindian (AMR) ancestries. The pooled ancestry contributions were 0.62 EUR, 0.21 AFR, and 0.17AMR. The Southern region had a greater EUR contribution (0.77) than other regions. Individuals from the Northeast (NE) region had the highest AFR contribution (0.27) whereas individuals from the North regions had more AMR contribution (0.32). In the Latin America context, Brazil has the 5th high EUR contribution, the 12th for the AFR component and the 10th for the AMR ancestry. Conclusions: Admixture proportions vary greatly among Brazilian populations and also through Latin America. More studies in the Center-West, North and NE regions are needed to capture a more complete picture of the genomic ancestry of Brazil.
MeSH term(s)	Brazil ; Ethnic Groups ; Gene Frequency ; Genetic Variation ; Humans
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1025339-7
ISSN	1520-6300 ; 1042-0533
ISSN (online)	1520-6300
ISSN	1042-0533
DOI	10.1002/ajhb.22714
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2567: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Variant Enrichment Analysis to Explore Pathways Functionality in Complex Autoinflammatory Skin Disorders through Whole Exome Sequencing Analysis

Lucas André Cavalcanti Brandão / Ronald Rodrigues de Moura / Angelo Valerio Marzano / Chiara Moltrasio / Paola Maura Tricarico / Sergio Crovella

International Journal of Molecular Sciences, Vol 23, Iss 2278, p

2022 Volume 2278

Abstract	The challenge of unravelling the molecular basis of multifactorial disorders nowadays cannot rely just on association studies searching for potential causative variants shared by groups of patients and not present in healthy individuals; indeed, association studies have as a main limitation the lack of information on the interactions between the disease-causing variants. Thus, new genomic analysis tools focusing on disrupted pathways rather than associated gene variants are required to better understand the complexity of a disease. Therefore, we developed the Variant Enrichment Analysis (VEA) workflow, a tool applicable for whole exome sequencing data, able to find differences between the numbers of genetic variants in a given pathway in comparison with a reference dataset. In this study, we applied VEA to discover novel pathways altered in patients with complex autoinflammatory skin disorders, namely PASH ( n = 9), 3 of whom are overlapping with SAPHO) and PAPASH ( n = 3). With this approach we have been able to identify pathways related to neutrophil and endothelial cells homeostasis/activations, as disrupted in our patients. We hypothesized that unregulated neutrophil transendothelial migration could elicit increased neutrophil infiltration and tissue damage. Based on our findings, VEA, in our experimental dataset, allowed us to predict novel pathways impaired in subjects with autoinflammatory skin disorders.
Keywords	whole exome sequencing ; OMICs ; hidradenitis suppurativa ; PASH ; PAPASH ; SAPHO ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED