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  1. Article: Identification of fungal melanin production and the role of anti-melanin agents.

    Iqbal, Saba / Ismail, Fatima

    Pakistan journal of pharmaceutical sciences

    2023  Volume 36, Issue 5, Page(s) 1483–1488

    Abstract: Accumulation of melanin pigment in some specific areas of human skin leads to various skin disorders. This study includes melanin production and extraction from non-dermatophyte, filamentous fungi (Aspergillus niger). The effect of carbon, nitrogen, pH ... ...

    Abstract Accumulation of melanin pigment in some specific areas of human skin leads to various skin disorders. This study includes melanin production and extraction from non-dermatophyte, filamentous fungi (Aspergillus niger). The effect of carbon, nitrogen, pH and temperature on melanin production was also observed. Qualitative and Quantitative analysis was performed to confirm melanin pigment from A. niger by using solubility test, precipitation test and reaction with oxidizing and reducing agent. Fungus gave maximum melanin production with dextrose, peptone, pH 5.6 at 37
    MeSH term(s) Humans ; Melanins ; Monophenol Monooxygenase ; Flavonoids/pharmacology ; Skin ; Aspergillus niger
    Chemical Substances Melanins ; Monophenol Monooxygenase (EC 1.14.18.1) ; Flavonoids
    Language English
    Publishing date 2023-11-01
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6588: Show issues Location:
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  2. Article ; Online: Discovery of novel inhibitor via molecular dynamics simulations against D-alanyl-D-alanine carboxypeptidase of

    Ahmad, Faisal / Ismail, Saba / Azam, Syed Sikander

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–16

    Abstract: Antibiotics resistance by bacterial pathogens is a major concern to public health worldwide resulting in high health care costs and rising mortality. Subtractive proteomics prioritized D-alanyl-D-alanine carboxypeptidas (DacB) enzyme from Enterobacter ... ...

    Abstract Antibiotics resistance by bacterial pathogens is a major concern to public health worldwide resulting in high health care costs and rising mortality. Subtractive proteomics prioritized D-alanyl-D-alanine carboxypeptidas (DacB) enzyme from Enterobacter cloacae ATCC 13047 as a potential candidate for drugs designing to block pathogen cell wall biosynthesis. Virtual screening of an antibacterial library against the target unraveled a hit compound (2-[(1-methylsulfonylpiperidin-3-yl)methyl]-6-(1H-pyrazol-4-yl) pyrazine) showing high affinity and stability with the target. The N-methyl-N-propyl-methanesulfonamide of the compound is seen as a closed affinity towards domain involving strong hydrogen bonds with Ser41, Lys44, Ser285, and Asn287. The 4-methyl-1H-pyrazole is posed towards the open cavity of domain I and II and formed hydrophobic and hydrophilic contacts. The system is highly stable with average carbon-alpha deviations of 1.69 Å over trajectories of 400-ns. Three vital residues projected: Arg437, Arg438 and Leu400 from enzyme pocket
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2316790
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  3. Article ; Online: Correction to: Exploring Novel 1-Hydroxynaphthalene-2-Carboxanilides Based Inhibitors Against C-Jun N-Terminal Kinases Through Molecular Dynamic Simulation and WaterSwap Analysis.

    Jamal, Syed Babar / Ismail, Saba / Yousaf, Rimsha / Qazi, Asma Saleem / Iftkhar, Saba / Abbasi, Sumra Wajid

    Applied biochemistry and biotechnology

    2023  

    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04720-6
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  4. Article ; Online: The dynamics of India – ASEAN trade with special reference to manufactured exports and their technological composition

    Nikhat KHALID / Saba ISMAIL

    Theoretical and Applied Economics, Vol XXIX, Iss 1, Pp 161-

    2022  Volume 172

    Abstract: India’s trade with Southeast Asia received a significant impetus in the early 1990s, with the launching of Look East Policy, after which the partners have been trading intensively and extensively. The study at hand examines the trend and composition of ... ...

    Abstract India’s trade with Southeast Asia received a significant impetus in the early 1990s, with the launching of Look East Policy, after which the partners have been trading intensively and extensively. The study at hand examines the trend and composition of trade from 1992 to 2019, wherein the composition at both, aggregate and disaggregate level at 1, 2 and 3 digit SITC classification has been studied. The study further lays emphasis on technological composition and sophistication in bilateral trade, wherein trade has been studied in terms of the category of technology at the aggregate and disaggregated embodied technology level. The percentage growth in trade between India and ASEAN is found to be promising; with a two digit growth in export and import from 1992 to 2019. Results elucidate a statistically intense trade relationship between the partners, with export and import intensity indices persistently > 1. India’s exports to ASEAN are found to be highly concentrated in the resource based category, while ASEAN’s exports to India are a lot more diversified, having significant exports from the resource-based, high-technology, and medium-technology categories.
    Keywords asean ; look east policy ; foreign trade ; manufactured export ; Business ; HF5001-6182 ; Economic theory. Demography ; HB1-3840 ; Economics as a science ; HB71-74
    Subject code 381
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher General Association of Economists from Romania
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Exploring Novel 1-Hydroxynaphthalene-2-Carboxanilides Based Inhibitors Against C-Jun N-Terminal Kinases Through Molecular Dynamic Simulation and WaterSwap Analysis.

    Jamal, Syed Babar / Ismail, Saba / Yousaf, Rimsha / Qazi, Asma Saleem / Iftkhar, Saba / Abbasi, Sumra Wajid

    Applied biochemistry and biotechnology

    2023  Volume 196, Issue 4, Page(s) 1803–1819

    Abstract: Cancer is a disease of mutation and lifestyle modifications. A large number of normal genes can transform normal cells to cancer cells due to their deregulations including overexpression and loss of expression. Signal transduction is a complex signaling ... ...

    Abstract Cancer is a disease of mutation and lifestyle modifications. A large number of normal genes can transform normal cells to cancer cells due to their deregulations including overexpression and loss of expression. Signal transduction is a complex signaling process that involves multiple interactions and different functions. C-Jun N-terminal kinases (JNKs) is an important protein involved in signaling process. JNK mediated pathways can detect, integrate, and amplify various external signals that may cause alterations in gene expression, enzyme activities, and different cellular functions that affect cellular behavior like metabolism, proliferation, differentiation, and cell survival. In this study, we performed molecular docking protocol (MOE) to predict the binding interactions of some known anticancer 1-hydroxynaphthalene-2-carboxanilides candidates. A set of 10 active compounds was retrieved after initial screening on the basis of docking scores, binding energies, and number of interactions and was re-docked in the active site of JNK protein. The results were further validated through molecular dynamics simulation and MMPB/GBSA calculations. The active compounds 4p and 5 k were ranked on top. After computationally exploring interactions of 1-hydroxynaphthalene-2-carboxanilides with JNK protein, we believe compounds 4p and 5 k can serve as potential inhibitors of JNK protein. It is believed that the results of current research would help to develop novel and structurally diverse anticancer compounds that will be useful not only treat cancer but also for the medication for the other diseases caused by protein deregulation.
    MeSH term(s) JNK Mitogen-Activated Protein Kinases/metabolism ; JNK Mitogen-Activated Protein Kinases/chemistry ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Molecular Dynamics Simulation ; Humans ; Molecular Docking Simulation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Anilides/pharmacology ; Anilides/chemistry ; Naphthols/chemistry ; Naphthols/pharmacology ; Naphthols/metabolism
    Chemical Substances JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Protein Kinase Inhibitors ; Anilides ; Naphthols
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04638-z
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    Zs.A 3053: Show issues Location:
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  6. Article ; Online: Military Expenditure and Economic Growth in South Asian Countries

    Saba Ismail

    International Journal of Economics and Financial Issues, Vol 7, Iss

    Empirical Evidences

    2017  Volume 3

    Abstract: This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect ...

    Abstract This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect of military expenditure on economic growth but significantly less compared to alternative uses of scare resources as non-military expenditure. This study raises an important issue of huge opportunity cost of military expenditure and foregone opportunity of economic growth. The paper concludes that the boosting of economic growth through higher military expenditure is neither effective nor efficient way of achieving higher growth. Keywords: Military expenditure; Economic growth; Panel Data, South Asia JEL Classifications: H5, O41, O47
    Keywords Business ; HF5001-6182 ; Economics as a science ; HB71-74
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher EconJournals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Military Expenditure and Economic Growth in South Asian Countries

    Saba Ismail

    International Journal of Economics and Financial Issues, Vol 7, Iss

    Empirical Evidences

    2017  Volume 3

    Abstract: This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect ...

    Abstract This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect of military expenditure on economic growth but significantly less compared to alternative uses of scare resources as non-military expenditure. This study raises an important issue of huge opportunity cost of military expenditure and foregone opportunity of economic growth. The paper concludes that the boosting of economic growth through higher military expenditure is neither effective nor efficient way of achieving higher growth. Keywords: Military expenditure; Economic growth; Panel Data, South Asia JEL Classifications: H5, O41, O47
    Keywords Business ; HF5001-6182 ; Economics as a science ; HB71-74
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher EconJournals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Military Expenditure and Economic Growth in South Asian Countries

    Saba Ismail

    International Journal of Economics and Financial Issues, Vol 7, Iss

    Empirical Evidences

    2017  Volume 3

    Abstract: This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect ...

    Abstract This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect of military expenditure on economic growth but significantly less compared to alternative uses of scare resources as non-military expenditure. This study raises an important issue of huge opportunity cost of military expenditure and foregone opportunity of economic growth. The paper concludes that the boosting of economic growth through higher military expenditure is neither effective nor efficient way of achieving higher growth. Keywords: Military expenditure; Economic growth; Panel Data, South Asia JEL Classifications: H5, O41, O47
    Keywords Business ; HF5001-6182 ; Economics as a science ; HB71-74
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher EconJournals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Military Expenditure and Economic Growth in South Asian Countries

    Saba Ismail

    International Journal of Economics and Financial Issues, Vol 7, Iss 3, Pp 318-

    Empirical Evidences

    2017  Volume 325

    Abstract: This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect ...

    Abstract This paper is an attempt to examine the relationship between military expenditure and economic growth in South Asia region. Panel fixed effect model has been estimated using panel data from five South Asian Countries. The results indicate positive effect of military expenditure on economic growth but significantly less compared to alternative uses of scare resources as non-military expenditure. This study raises an important issue of huge opportunity cost of military expenditure and foregone opportunity of economic growth. The paper concludes that the boosting of economic growth through higher military expenditure is neither effective nor efficient way of achieving higher growth.
    Keywords military expenditure ; economic growth ; panel data ; south asia ; Business ; HF5001-6182 ; Economics as a science ; HB71-74
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher EconJournals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Immuno-informatics profiling of monkeypox virus cell surface binding protein for designing a next generation multi-valent peptide-based vaccine.

    Yousaf, Maha / Ismail, Saba / Ullah, Asad / Bibi, Shabana

    Frontiers in immunology

    2022  Volume 13, Page(s) 1035924

    Abstract: Monkeypox is a viral etiological agent with hallmarks analogous to those observed in smallpox cases in the past. The ongoing outbreak of Monkeypox viral infection is becoming a global health problem. Multi-valent peptide based next generation vaccines ... ...

    Abstract Monkeypox is a viral etiological agent with hallmarks analogous to those observed in smallpox cases in the past. The ongoing outbreak of Monkeypox viral infection is becoming a global health problem. Multi-valent peptide based next generation vaccines provides us a promising solution to combat these emerging infectious diseases by eliciting cell-mediated and humoral immune response. Considering the success rate of subtractive proteomics pipeline and reverse vaccinology approach, in this study, we have developed a novel, next-generation, multi-valent,
    MeSH term(s) Humans ; Monkeypox virus ; Molecular Docking Simulation ; Membrane Proteins ; Mpox (monkeypox) ; Vaccines, Subunit ; Epitopes, T-Lymphocyte
    Chemical Substances Membrane Proteins ; Vaccines, Subunit ; Epitopes, T-Lymphocyte
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1035924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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