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  1. Article: F

    Tanton, Helen / Voronina, Svetlana / Evans, Anthony / Armstrong, Jane / Sutton, Robert / Criddle, David N / Haynes, Lee / Schmid, Michael C / Campbell, Fiona / Costello, Eithne / Tepikin, Alexei V

    Frontiers in physiology

    2018  Volume 9, Page(s) 833

    Abstract: F ...

    Abstract F
    Language English
    Publishing date 2018-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.00833
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  2. Article: Disruption of Prostaglandin F

    Rodriguez, Luis R / Tang, Soon Yew / Barboza, Willy Roque / Murthy, Aditi / Tomer, Yaniv / Cai, Tian-Quan / Iyer, Swati / Chavez, Katrina / Das, Ujjalkumar Subhash / Ghosh, Soumita / Dimopoulos, Thalia / Babu, Apoorva / Connelly, Caitlin / FitzGerald, Garret A / Beers, Michael F

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a chronic parenchymal lung disease characterized by repetitive alveolar cell injury, myofibroblast proliferation, and excessive extracellular matrix deposition for which unmet need persists for effective ... ...

    Abstract Idiopathic Pulmonary Fibrosis (IPF) is a chronic parenchymal lung disease characterized by repetitive alveolar cell injury, myofibroblast proliferation, and excessive extracellular matrix deposition for which unmet need persists for effective therapeutics. The bioactive eicosanoid, prostaglandin F2
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.07.543956
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  3. Article ; Online: Piflufolastat F-18 (

    Voter, Andrew F / Werner, Rudolf A / Pienta, Kenneth J / Gorin, Michael A / Pomper, Martin G / Solnes, Lilja B / Rowe, Steven P

    Expert review of anticancer therapy

    2022  Volume 22, Issue 7, Page(s) 681–694

    Abstract: Introduction: Accurate imaging is essential for staging prostate cancer and guiding management decisions. Conventional imaging modalities are hampered by a limited sensitivity for metastatic disease. Nearly all prostate cancers express prostate-specific ...

    Abstract Introduction: Accurate imaging is essential for staging prostate cancer and guiding management decisions. Conventional imaging modalities are hampered by a limited sensitivity for metastatic disease. Nearly all prostate cancers express prostate-specific membrane antigen (PSMA) and
    Areas covered: This article provides an overview of PSMA, the mechanism of action of
    Expert opinion: The OSPREY and CONDOR clinical trials have demonstrated the superiority of
    MeSH term(s) Humans ; Male ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2022.2081155
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  4. Article ; Online: Cystatin F (

    Daniels, Michael J D / Lefevre, Lucas / Szymkowiak, Stefan / Drake, Alice / McCulloch, Laura / Tzioras, Makis / Barrington, Jack / Dando, Owen R / He, Xin / Mohammad, Mehreen / Sasaguri, Hiroki / Saito, Takashi / Saido, Takaomi C / Spires-Jones, Tara L / McColl, Barry W

    eLife

    2023  Volume 12

    Abstract: Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer's ... ...

    Abstract Microglial endolysosomal (dys)function is strongly implicated in neurodegenerative disease. Transcriptomic studies show that a microglial state characterised by a set of genes involved in endolysosomal function is induced in both mouse Alzheimer's disease (AD) models and human AD brain, and that the emergence of this state is emphasised in females.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Mice ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Cystatins/metabolism ; Disease Models, Animal ; Mice, Transgenic ; Microglia/metabolism ; Neurodegenerative Diseases/pathology
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Cystatins ; cystatin F, mouse
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.85279
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  5. Book ; Thesis: Klinikopathologische Bedeutung von F. nucleatum bei Patienten und Patientinnen mit Magenkarzinom sowie bei präneoplastischen Veränderungen der Magenmukosa

    Böhm, Ellen Teresa / Venerito, Marino / Sigal, Michael

    2023  

    Title variant Fusobacterium nucleatum
    Institution Otto-von-Guericke-Universität Magdeburg
    Author's details von Ellen Teresa Böhm ; Gutachter: Prof. Dr. Marino Venerito ; Prof. Dr. Michael Sigal
    Keywords Magenkrebs ; Bakterielle Infektion
    Subject Bakterienkrankheit ; Bakteriose ; Bakterielle Krankheit ; Carcinoma ventriculi ; Magencarcinom ; Magenkarzinom
    Subject code 610
    Language German
    Size II-IX, 72 Blätter, Illustration, Diagramme
    Publisher Otto-von-Guericke-Universität Magdeburg
    Publishing place Magdeburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Magdeburg, 2024
    HBZ-ID HT030727659
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2024 E 610 order for loan Magazin

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  6. Book ; Online: Zeit in Gesetzen erfasst - G. W. F. Hegels Theorie der Kodifikation

    Müller, Michael W.

    (Recht und Philosophie ; 10)

    2021  

    Series title Recht und Philosophie ; 10
    Keywords Jurisprudence & philosophy of law ; Philosophy: logic ; Georg Wilhelm Friedrich Hegel ; Kodifikation ; Rechtsphilosophie
    Language 0|d
    Size 1 electronic resource (99 pages)
    Publisher Duncker and Humblot
    Publishing place Berlin
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT021610166
    ISBN 978-3-428-58487-1 ; 3-428-58487-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: The F

    Gahura, Ondřej / Šubrtová, Karolína / Váchová, Hana / Panicucci, Brian / Fearnley, Ian M / Harbour, Michael E / Walker, John E / Zíková, Alena

    The FEBS journal

    2017  Volume 285, Issue 3, Page(s) 614–628

    Abstract: The F-ATPases (also called the F ...

    Abstract The F-ATPases (also called the F
    MeSH term(s) Adenosine Triphosphate/metabolism ; Amino Acid Sequence ; Computational Biology ; Conserved Sequence ; Enzyme Stability ; Hydrolysis ; Kinetics ; Membrane Potential, Mitochondrial ; Models, Molecular ; Peptide Mapping ; Protein Conformation ; Protein Multimerization ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/genetics ; Protein Subunits/isolation & purification ; Protein Subunits/metabolism ; Proteolysis ; Proton-Translocating ATPases/antagonists & inhibitors ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/isolation & purification ; Proton-Translocating ATPases/metabolism ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/genetics ; Protozoan Proteins/isolation & purification ; Protozoan Proteins/metabolism ; RNA Interference ; Sequence Alignment ; Sequence Homology, Amino Acid ; Trypanosoma brucei brucei/enzymology ; Trypanosoma brucei brucei/growth & development
    Chemical Substances Protein Subunits ; Protozoan Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; Proton-Translocating ATPases (EC 3.6.3.14)
    Language English
    Publishing date 2017-12-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.14364
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  8. Article ; Online: Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults.

    Papi, Alberto / Ison, Michael G / Langley, Joanne M / Lee, Dong-Gun / Leroux-Roels, Isabel / Martinon-Torres, Federico / Schwarz, Tino F / van Zyl-Smit, Richard N / Campora, Laura / Dezutter, Nancy / de Schrevel, Nathalie / Fissette, Laurence / David, Marie-Pierre / Van der Wielen, Marie / Kostanyan, Lusine / Hulstrøm, Veronica

    The New England journal of medicine

    2023  Volume 388, Issue 7, Page(s) 595–608

    Abstract: Background: Respiratory syncytial virus (RSV) is an important cause of acute respiratory infection, lower respiratory tract disease, clinical complications, and death in older adults. There is currently no licensed vaccine against RSV infection.: ... ...

    Abstract Background: Respiratory syncytial virus (RSV) is an important cause of acute respiratory infection, lower respiratory tract disease, clinical complications, and death in older adults. There is currently no licensed vaccine against RSV infection.
    Methods: In an ongoing, international, placebo-controlled, phase 3 trial, we randomly assigned, in a 1:1 ratio, adults 60 years of age or older to receive a single dose of an AS01
    Results: A total of 24,966 participants received one dose of the RSVPreF3 OA vaccine (12,467 participants) or placebo (12,499). Over a median follow-up of 6.7 months, vaccine efficacy against RT-PCR-confirmed RSV-related lower respiratory tract disease was 82.6% (96.95% confidence interval [CI], 57.9 to 94.1), with 7 cases (1.0 per 1000 participant-years) in the vaccine group and 40 cases (5.8 per 1000 participant-years) in the placebo group. Vaccine efficacy was 94.1% (95% CI, 62.4 to 99.9) against severe RSV-related lower respiratory tract disease (assessed on the basis of clinical signs or by the investigator) and 71.7% (95% CI, 56.2 to 82.3) against RSV-related acute respiratory infection. Vaccine efficacy was similar against the RSV A and B subtypes (for RSV-related lower respiratory tract disease: 84.6% and 80.9%, respectively; for RSV-related acute respiratory infection: 71.9% and 70.6%, respectively). High vaccine efficacy was observed in various age groups and in participants with coexisting conditions. The RSVPreF3 OA vaccine was more reactogenic than placebo, but most adverse events for which reports were solicited were transient, with mild-to-moderate severity. The incidences of serious adverse events and potential immune-mediated diseases were similar in the two groups.
    Conclusions: A single dose of the RSVPreF3 OA vaccine had an acceptable safety profile and prevented RSV-related acute respiratory infection and lower respiratory tract disease and severe RSV-related lower respiratory tract disease in adults 60 years of age or older, regardless of RSV subtype and the presence of underlying coexisting conditions. (Funded by GlaxoSmithKline Biologicals; AReSVi-006 ClinicalTrials.gov number, NCT04886596.).
    MeSH term(s) Aged ; Humans ; Adjuvants, Immunologic/administration & dosage ; Adjuvants, Immunologic/adverse effects ; Adjuvants, Immunologic/therapeutic use ; Antibodies, Viral ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines/administration & dosage ; Respiratory Syncytial Virus Vaccines/adverse effects ; Respiratory Syncytial Virus Vaccines/therapeutic use ; Respiratory Syncytial Virus, Human ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Internationality ; Vaccine Efficacy
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Viral ; Respiratory Syncytial Virus Vaccines
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa2209604
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  9. Article ; Online: [18]F-fluoroethyl-l-tyrosine positron emission tomography for radiotherapy target delineation: Results from a Radiation Oncology credentialing program.

    Barry, Nathaniel / Koh, Eng-Siew / Ebert, Martin A / Moore, Alisha / Francis, Roslyn J / Rowshanfarzad, Pejman / Hassan, Ghulam Mubashar / Ng, Sweet P / Back, Michael / Chua, Benjamin / Pinkham, Mark B / Pullar, Andrew / Phillips, Claire / Sia, Joseph / Gorayski, Peter / Le, Hien / Gill, Suki / Croker, Jeremy / Bucknell, Nicholas /
    Bettington, Catherine / Syed, Farhan / Jung, Kylie / Chang, Joe / Bece, Andrej / Clark, Catherine / Wada, Mori / Cook, Olivia / Whitehead, Angela / Rossi, Alana / Grose, Andrew / Scott, Andrew M

    Physics and imaging in radiation oncology

    2024  Volume 30, Page(s) 100568

    Abstract: Background and purpose: The [18]F-fluoroethyl-l-tyrosine (FET) PET in Glioblastoma (FIG) study is ...

    Abstract Background and purpose: The [18]F-fluoroethyl-l-tyrosine (FET) PET in Glioblastoma (FIG) study is an Australian prospective, multi-centre trial evaluating FET PET for newly diagnosed glioblastoma management. The Radiation Oncology credentialing program aimed to assess the feasibility in Radiation Oncologist (RO) derivation of standard-of-care target volumes (TV
    Materials and methods: Central review and analysis of TV
    Results: Data from 19 ROs across 10 trial sites (54 initial submissions, 8 resubmissions requested, 4 conditional passes) was assessed with an initial pass rate of 77.8 %; all resubmissions passed. TV
    Conclusions: The credentialing program demonstrated feasibility in successful credentialing of 19 ROs across 10 sites, increasing national expertise in TV
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-6316
    ISSN (online) 2405-6316
    DOI 10.1016/j.phro.2024.100568
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  10. Article ; Online: Unraveling Hypothalamus-Pituitary dysregulation: Hypergonadotropism in F

    Navin, Ajit Kumar / Aruldhas, Mariajoseph Michael / Mani, Kathiresh Kumar / Navaneethabalakrishnan, Shobana / Venkatachalam, Sankar / Banu, Sakhila K

    Journal of biochemical and molecular toxicology

    2024  Volume 38, Issue 4, Page(s) e23699

    Abstract: ... in hypergonadotropic hypoandrogenism in F ...

    Abstract The endocrine disruptor hexavalent chromium [Cr(VI)] is a proven reproductive toxicant. We recently demonstrated that prenatal Cr(VI) exposure causes testicular resistance to gonadotropins, resulting in hypergonadotropic hypoandrogenism in F
    MeSH term(s) Female ; Pregnancy ; Humans ; Rats ; Male ; Animals ; Receptors, LHRH/metabolism ; Estrogen Receptor alpha/metabolism ; Aromatase ; Prenatal Exposure Delayed Effects/metabolism ; Hypothalamus ; Gonadotropin-Releasing Hormone/metabolism ; Chromium
    Chemical Substances chromium hexavalent ion (18540-29-9) ; Receptors, LHRH ; Estrogen Receptor alpha ; Aromatase (EC 1.14.14.1) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Chromium (0R0008Q3JB)
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23699
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