Article: Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage.
Aging and disease
2021 Volume 12, Issue 3, Page(s) 726–731
Abstract: Osteoarthritis (OA) is the most common and debilitating joint disease of advanced age and has no universally effective therapy. Here, we demonstrate that systemic transplantation of adult multipotent muscle-derived stem/progenitor cells (MDSPCs)-isolated ...
Abstract | Osteoarthritis (OA) is the most common and debilitating joint disease of advanced age and has no universally effective therapy. Here, we demonstrate that systemic transplantation of adult multipotent muscle-derived stem/progenitor cells (MDSPCs)-isolated from young mice-rejuvenates the knee articular cartilage (AC) of naturally aged mice. This intervention reduced expression of pro-inflammatory cytokines ( |
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Language | English |
Publishing date | 2021-06-01 |
Publishing country | United States |
Document type | Journal Article |
ISSN | 2152-5250 |
ISSN | 2152-5250 |
DOI | 10.14336/AD.2020.1118 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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