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  1. Article ; Online: Use of Insecticide-Treated Bed Nets and Incidence of Burkitt Lymphoma.

    Velavan, Thirumalaisamy P / Kremsner, Peter G

    JAMA network open

    2024  Volume 7, Issue 4, Page(s) e247358

    MeSH term(s) Humans ; Burkitt Lymphoma ; Incidence ; Insecticide-Treated Bednets
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2024.7358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A severe case of Plasmodium falciparum malaria in a traveler returning from Kazakhstan, a malaria-free country.

    Velavan, Thirumalaisamy P / Fleischmann, Wim A / Kremsner, Peter G

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  , Page(s) 107026

    Abstract: Following a two-weeks trip to Kazakhstan, a 42-year-old woman presented at the emergency department in Germany with fever, headache, nausea, and neurological symptoms. An infection with Plasmodium falciparum was rapidly diagnosed. The patient was ... ...

    Abstract Following a two-weeks trip to Kazakhstan, a 42-year-old woman presented at the emergency department in Germany with fever, headache, nausea, and neurological symptoms. An infection with Plasmodium falciparum was rapidly diagnosed. The patient was immediately treated with intravenous artesunate and transferred to an intensive care unit. The initial parasite density was as high as 30% infected erythrocytes with 845880 parasites/µL. Since Kazakhstan was declared malaria-free in 2012, molecular testing for Plasmodium has been initiated to identify a possible origin. Genotyping of the msp-1 gene and microsatellite markers showed that the parasites are of African origin, with two different alleles indicating a polyclonal infection. After a hospitalization of 10 days, the patient was discharged in good health. Overall, our results emphasize that malaria must be on the list of differential diagnoses for patients with fever of unknown origin, even if they come from countries where malaria does not commonly occur.
    Language English
    Publishing date 2024-04-05
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107026
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    Zs.A 4516: Show issues Location:
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  3. Book ; Online: In vitro drug sensitivity of Plasmodium falciparum in Acre, Brazil / P. G. Kremsner . [et al.]

    Kremsner, P. G / Zotter, G. M / Feldmeier, Hermann / Graninger, W / Kollaritsch, M / Wiedermann, G / Rocha, R. M / Wernsdorfer, Walther H

    1989  

    Keywords Plasmodium falciparum ; Antimalarials ; Drug resistance ; Brazil ; Parasitic Diseases and their Control ; drug effects ; pharmacology
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: In vitro drug sensitivity of Plasmodium falciparum in Acre, Brazil / P. G. Kremsner . [et al.]

    Kremsner, P. G / Zotter, G. M / Feldmeier, Hermann / Graninger, W / Kollaritsch, M / Wiedermann, G / Rocha, R. M / Wernsdorfer, Walther H

    1989  

    Keywords Plasmodium falciparum ; Antimalarials ; Drug resistance ; Brazil ; Parasitic Diseases and their Control ; drug effects ; pharmacology
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Emergence and geographic dominance of Omicron subvariants XBB/XBB.1.5 and BF.7 - the public health challenges.

    Velavan, Thirumalaisamy P / Ntoumi, Francine / Kremsner, Peter G / Lee, Shui Shan / Meyer, Christian G

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 128, Page(s) 307–309

    MeSH term(s) Humans ; Public Health ; COVID-19/epidemiology ; COVID-19/virology ; SARS-CoV-2/genetics
    Language English
    Publishing date 2023-01-19
    Publishing country Canada
    Document type Editorial
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.01.024
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  6. Article: Gut microbiota in vaccine naïve Gabonese children with rotavirus A gastroenteritis.

    Manouana, Gédéon Prince / Kuk, Salih / Linh, Le Thi Kieu / Pallerla, Srinivas Reddy / Niendorf, Sandra / Kremsner, Peter G / Adegnika, Ayola Akim / Velavan, Thirumalaisamy P

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28727

    Abstract: ... with acute diarrhoea without RVA had low microbial diversity compared to healthy children (p = 0.001 and p ...

    Abstract Background: While the gut microbiome modulates the pathogenesis of enteric viruses, how infections caused by rotavirus A (RVA), with or without diarrhoea, alter the gut microbiota has been sparsely studied.
    Methods: From a cohort of 224 vaccine naïve Gabonese children with and without diarrhoea (n = 177 and n = 67, respectively), 48 stool samples were analysed: (i) RVA with diarrhoea (n = 12); (ii) RVA without diarrhoea (n = 12); (iii) diarrhoea without RVA (n = 12); (iv) healthy controls without diarrhoea and RVA (n = 12). The 16S rRNA metabarcoding using Oxford Nanopore sequencing data was analysed for taxonomic composition, abundance, alpha and beta diversity, and metabolic pathways.
    Findings: Alpha diversity showed that children with acute diarrhoea (with and without RVA infection), and children with acute diarrhoea without RVA had low microbial diversity compared to healthy children (p = 0.001 and p = 0.006, respectively). No significant differences observed when comparing children with RVA with or without diarrhoea. Beta diversity revealed high microbial heterogeneity in children without diarrhoea. Proteobacteria (68%) and Firmicutes (69%) were most common in the diarrhoea and non-diarrhoea groups, respectively. Proteobacteria (53%) were most common in children without RVA, while Firmicutes (55%) were most common with RVA. At the genus level,
    Interpretation: Although host physiology dictates the intestinal milieu, diarrhoea per se can alter a balanced gut microbiota, whereas infectious diarrhoea disrupts the gut microbiome and reduces its diversity.
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28727
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  7. Article ; Online: How to (ab)use a COVID-19 antigen rapid test with soft drinks?

    Velavan, Thirumalaisamy P / Pallerla, Srinivas Reddy / Kremsner, Peter G

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 111, Page(s) 28–30

    Abstract: With reasonably good specificity and sensitivity, the speed and convenience of COVID-19 antigen tests have led to self-testing in schools, offices, and universities in the European Union (EU). Although self-testing can be beneficial and increase the ... ...

    Abstract With reasonably good specificity and sensitivity, the speed and convenience of COVID-19 antigen tests have led to self-testing in schools, offices, and universities in the European Union (EU). Although self-testing can be beneficial and increase the accessibility to testing, there are potential ways to confound a positive COVID-19 lateral flow test. We observed that all soft drinks, energy drinks, alcoholic beverages (vodka, whiskey, and brandy), commercially bottled mineral water, and carbonated mineral water caused the appearance of a red test line. However, when equal volumes of the buffer and the respective beverages are mixed, there are no false-positive test lines. Deceitful methods may easily lead to misuse of COVID-19 antigen rapid tests and lead to false-positive results; however, this does not prove that these tests are unreliable when performed correctly.
    MeSH term(s) Antigens, Viral ; COVID-19 ; COVID-19 Testing ; Carbonated Beverages ; Humans ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemical Substances Antigens, Viral
    Language English
    Publishing date 2021-08-18
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.08.023
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    Zs.A 4516: Show issues Location:
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  8. Article ; Online: Drug repurposing for COVID-19: current evidence from randomized controlled adaptive platform trials and living systematic reviews.

    Augustin, Yolanda / Staines, Henry M / Velavan, Thirumalaisamy P / Kamarulzaman, Adeeba / Kremsner, Peter G / Krishna, Sanjeev

    British medical bulletin

    2023  Volume 147, Issue 1, Page(s) 31–49

    Abstract: Introduction: The coronavirus disease 2019 (COVID-19) pandemic resulted in a race to develop effective treatments largely through drug repurposing via adaptive platform trials on a global scale. Drug repurposing trials have focused on potential ... ...

    Abstract Introduction: The coronavirus disease 2019 (COVID-19) pandemic resulted in a race to develop effective treatments largely through drug repurposing via adaptive platform trials on a global scale. Drug repurposing trials have focused on potential antiviral therapies aimed at preventing viral replication, anti-inflammatory agents, antithrombotic agents and immune modulators through a number of adaptive platform trials. Living systematic reviews have also enabled evidence synthesis and network meta-analysis as clinical trial data emerge globally.
    Sources of data: Recent published literature.
    Areas of agreement: Corticosteroids and immunomodulators that antagonize the interleukin-6 (IL-6) receptor have been shown to play a critical role in modulating inflammation and improving clinical outcomes in hospitalized patients. Inhaled budesonide reduces the time to recovery in older patients with mild-to-moderate COVID-19 managed in the community.
    Areas of controversy: The clinical benefit of remdesivir remains controversial with conflicting evidence from different trials. Remdesivir led to a reduction in time to clinical recovery in the ACTT-1 trial. However, the World Health Organization SOLIDARITY and DISCOVERY trial did not find a significant benefit on 28-day mortality and clinical recovery.
    Growing points: Other treatments currently being investigated include antidiabetic drug empagliflozin, antimalarial drug artesunate, tyrosine kinase inhibitor imatinib, immunomodulatory drug infliximab, antiviral drug favipiravir, antiparasitic drug ivermectin and antidepressant drug fluvoxamine.
    Areas timely for developing research: The timing of therapeutic interventions based on postulated mechanisms of action and the selection of clinically meaningful primary end points remain important considerations in the design and implementation of COVID-19 therapeutic trials.
    MeSH term(s) Aged ; Humans ; Adrenal Cortex Hormones ; Antiviral Agents/therapeutic use ; COVID-19 ; Drug Repositioning ; Imatinib Mesylate ; Randomized Controlled Trials as Topic ; Systematic Reviews as Topic
    Chemical Substances Adrenal Cortex Hormones ; Antiviral Agents ; Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 213294-1
    ISSN 1471-8391 ; 0007-1420
    ISSN (online) 1471-8391
    ISSN 0007-1420
    DOI 10.1093/bmb/ldac037
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  9. Article ; Online: Herd immunity and vaccination of children for COVID-19.

    Velavan, Thirumalaisamy P / Pollard, Andrew J / Kremsner, Peter G

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 98, Page(s) 14–15

    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country Canada
    Document type Editorial
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.06.065
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  10. Article ; Online: Antimalarial treatment in infants.

    Kalkman, Laura C / Hanscheid, Thomas / Krishna, Sanjeev / Kremsner, Peter G / Grobusch, Martin P

    Expert opinion on pharmacotherapy

    2022  Volume 23, Issue 15, Page(s) 1711–1726

    Abstract: Introduction: Malaria in infants is common in high-transmission settings, especially in infants >6 months. Infants undergo physiological changes impacting pharmacokinetics and pharmacodynamics of anti-malarial drugs and, consequently, the safety and ... ...

    Abstract Introduction: Malaria in infants is common in high-transmission settings, especially in infants >6 months. Infants undergo physiological changes impacting pharmacokinetics and pharmacodynamics of anti-malarial drugs and, consequently, the safety and efficacy of malaria treatment. Yet, treatment guidelines and evidence on pharmacological interventions for malaria often fail to address this vulnerable age group. This review aims to summarize the available data on anti-malarial treatment in infants.
    Areas covered: The standard recommended treatments for severe and uncomplicated malaria are generally safe and effective in infants. However, infants have an increased risk of drug-related vomiting and have distinct pharmacokinetic parameters of antimalarials compared with older patients. These include larger volumes of distribution, higher clearance rates, and immature enzyme systems. Consequently, infants with malaria may be at increased risk of treatment failure and drug toxicity.
    Expert opinion: Knowledge expansion to optimize treatment can be achieved by including more infants in antimalarial drug trials and by reporting separately on treatment outcomes in infants. Additional evidence on the efficacy, safety, tolerability, acceptability, and effectiveness of ACTs in infants is needed, as well as population pharmacokinetics studies on antimalarials in the infant population.
    MeSH term(s) Infant ; Humans ; Antimalarials/adverse effects ; Malaria/drug therapy ; Malaria, Falciparum/drug therapy
    Chemical Substances Antimalarials
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2022.2130687
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