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Article ; Online: Factors Influencing Triage to Rehabilitation in Functional Movement Disorder.

Gilmour, Gabriela S / Langer, Laura K / Bhatt, Haseel / MacGillivray, Lindsey / Lidstone, Sarah C

Movement disorders clinical practice

2024

Abstract: Background: Treatment of functional movement disorder (FMD) should be individualized, yet factors determining rehabilitation engagement have not been evaluated. Subspecialty FMD clinics are uniquely poised to explore factors influencing treatment ... ...

Abstract	Background: Treatment of functional movement disorder (FMD) should be individualized, yet factors determining rehabilitation engagement have not been evaluated. Subspecialty FMD clinics are uniquely poised to explore factors influencing treatment suitability and triage. Objectives: To describe our approach and explore factors associated with triage to FMD rehabilitation. Methods: We conducted a retrospective chart review of 158 consecutive patients with FMD seen for integrated assessment by movement disorders neurology and psychiatry, with the purpose of triage to rehabilitation. Demographic and clinical variables were compared between patients triaged to therapy versus no therapy, and logistic regression was used to explore factors predictive of triage outcome. Change in primary outcome scores were analyzed. Results: Sixty-six patients (42%) were triaged to FMD therapy from July 2019 to December 2021. Patients triaged to therapy were more likely to have a constant movement disorder, gait disorder and/or tremor, hyperarousal, readiness for change, and people pleasing traits. Patients triaged to no therapy demonstrated persistent diagnostic disagreement, an inability to appreciate motor symptom inconsistency, low self-agency, a propensity to dissociate, and cluster B traits. 90% of patients triaged to rehabilitation had improved outcomes. Conclusions: The ability to "opt-in" to FMD rehabilitation relies on different factors than those relevant to establishing a diagnosis. Unlike many other neurological disorders, a triage and treatment planning step is recommended to identify those likely to meaningfully engage at that time. Holistic assessment through a transdisciplinary lens, and working collaboratively with the patient is essential to prioritize symptoms, determine engagement, and identify treatment targets.
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2330-1619
ISSN (online)	2330-1619
DOI	10.1002/mdc3.14007
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Article ; Online: Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation.

Barbhuiya, Tabassum Khair / Jayarathna, Dulari K / Gilmour, Raechelle / Smet-Nocca, Caroline / Gandhi, Neha S

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2754, Page(s) 3–31

Abstract: ... modifications, phospho- and glyco-, at C-terminus of Tau protein and its stable conformation over the longer ...

Abstract	The microtubule-associated protein, Tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like Alzheimer's disease. The posttranslational modifications across the Tau protein domains are involved in regulating Tau protein's function and disease onset. Of the various posttranslational modifications at Ser, Thr, and Tyr sites, O-GlcNAcylation and phosphorylation are the most critical ones, playing a vital role in Tau aggregation and tauopathies. To understand the function, it is essential to characterize the structural changes associated with Tau modification. Previous experimental studies have focused on high-resolution nuclear magnetic resonance techniques to structurally characterize the effect of phosphorylation, O-GlcNAcylation, and combination of both PTMs on Tau conformation in small peptides centered on the PHF-1 epitope from amino acid 392 to 411. The structural characterization using atomistic molecular dynamics simulation of such disordered peptides requires long simulation time, proper sampling method, and utilization of appropriate force fields for accurate determination of conformational ensembles, resembling the experimental data. This chapter details the protocol for the structural characterization of modified Tau peptides using the CHARMM36m force field and enhanced sampling methods like Gaussian accelerated molecular dynamics (GaMD) simulation. We have focused on a detailed explanation of the GaMD method and analyses of molecular dynamics trajectories to explain the relationship between two modifications, phospho- and glyco-, at C-terminus of Tau protein and its stable conformation over the longer simulation timeframes. The analyses involve energetics reweighting, clustering of simulation trajectories, and characterization of secondary structure using circular dichroism data from the simulation. The reader can utilize this protocol to investigate the structures of complex proteins, especially the disordered ones.
MeSH term(s)	Humans ; tau Proteins/metabolism ; Molecular Dynamics Simulation ; Peptides/chemistry ; Alzheimer Disease/metabolism ; Tauopathies ; Phosphorylation
Chemical Substances	tau Proteins ; Peptides
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3629-9_1
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Article ; Online: Barriers and facilitating factors to healthcare accessibility among Nepalese migrants during COVID-19 crisis in Japan: an exploratory sequential mixed methods study.

Paudel, Sushila / K C Bhandari, Aliza / Gilmour, Stuart / Lee, Hyeon Ju / Kanbara, Sakiko

BMC public health

2023 Volume 23, Issue 1, Page(s) 1226

Abstract: Background: The COVID-19 pandemic has highlighted the need for global unity and timely access to healthcare for all including multilingual and intercultural societies. This study aimed to identify barriers to healthcare access due to the COVID-19 crisis ...

Abstract	Background: The COVID-19 pandemic has highlighted the need for global unity and timely access to healthcare for all including multilingual and intercultural societies. This study aimed to identify barriers to healthcare access due to the COVID-19 crisis among Nepalese migrants in Japan and explore ways to counter these barriers, both in routine and crisis situations. Methods: This study used an exploratory sequential mixed-methods study design. The researchers conducted 11 focus group discussions including 89 participants and an online survey involving 937 respondents. The integration of focus group discussions and logistic regression analysis from the survey was reported via a 'joint display'. Results: Twenty-six themes on barriers to and six on facilitators of healthcare accessibility were identified by the focus group discussions among which 17 barriers like lack of knowledge of health insurance, language barriers, lack of hotline services, unawareness of available services, fear of discrimination etc. had significant association in our logistic regression analysis after adjusting for all confounders. Similarly, the only facilitator that had a significant impact, according to the multivariable logistic regression analysis, was receiving health information from Nepali healthcare professionals (OR = 1.36, 95% CI = (1.01 - 1.82), p-value < 0.05). Conclusion: The study suggests the need for a crisis information hub which could be coordinated by the Nepal embassy or concerned authorities, flexible policies for active deployment of Nepalese health workers and volunteers, accessible hotlines in the Nepali language, and incorporation of Nepali telehealth services in Japan.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Nepal/epidemiology ; Pandemics ; Transients and Migrants ; Japan/epidemiology ; Health Services Accessibility
Language	English
Publishing date	2023-06-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-16107-7
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Article ; Online: Too stressed to eat: Investigating factors associated with appetite loss in subordinate rainbow trout.

Best, C / Jennings, K / Culbert, B M / Flear, K / Volkoff, H / Gilmour, K M

Molecular and cellular endocrinology

2022 Volume 559, Page(s) 111798

Abstract: Juvenile rainbow trout (Oncorhynchus mykiss) form dominance hierarchies in which subordinates experience chronic social stress and suppression of food intake. Here we tested the hypothesis that inhibition of food intake reflects increased expression of ... ...

Abstract	Juvenile rainbow trout (Oncorhynchus mykiss) form dominance hierarchies in which subordinates experience chronic social stress and suppression of food intake. Here we tested the hypothesis that inhibition of food intake reflects increased expression of anorexigenic (appetite inhibiting) signals and decreased expression of orexigenic (appetite stimulating) signals. Trout were confined in pairs for 1 or 4 days, or were confined in pairs for 4 days and then allowed to recover from social interactions for 2 or 4 days; sham fish were handled identically but held alone. Subordinates did not feed during social interaction and had lower food intake than dominants or shams during recovery. In parallel, plasma cortisol (∼18-26x) and liver leptin (lep-a1) transcript abundance (∼10-14x) were elevated in subordinates during social interaction but not recovery, suggesting that these factors contributed to the suppression of food intake. Fish deemed likely to become subordinate based on inhibition of food intake in response to a mild stressor also showed elevated liver lep-a1 transcript abundance (∼5x). The moderate response in these fish coupled with a correlation between liver lep-a1 and cortisol suggest that stress-induced elevation of cortisol increased liver lep-a1 transcript abundance in subordinate trout, contributing to stress-induced suppression of food intake.
MeSH term(s)	Animals ; Oncorhynchus mykiss/metabolism ; Hydrocortisone/metabolism ; Appetite ; Stress, Psychological/metabolism ; Liver/metabolism
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-10-13
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2022.111798
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Zs.A 1127: Show issues

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Article: Neuropsychiatric phenotypes in functional movement disorder.

Gilmour, Gabriela S / Langer, Laura K / Lang, Anthony E / MacGillivray, Lindsey / Lidstone, Sarah C

CNS spectrums

2023 Volume 28, Issue 6, Page(s) 747–755

Abstract: Objective: Functional movement disorder (FMD), the motor-dominant subtype of functional neurological disorder, is a complex neuropsychiatric condition. Patients with FMD also manifest non-motor symptoms. Given that patients with FMD are diagnosed based ... ...

Abstract	Objective: Functional movement disorder (FMD), the motor-dominant subtype of functional neurological disorder, is a complex neuropsychiatric condition. Patients with FMD also manifest non-motor symptoms. Given that patients with FMD are diagnosed based on motor phenotype, the contribution of non-motor features to the neuropsychiatric syndrome is not well characterized. The objective of this hypothesis-generating study was to explore potential novel, neuropsychiatric FMD phenotypes by combining movement disorder presentations with non-motor comorbidities including somatic symptoms, psychiatric diagnoses, and psychological traits. Methods: This retrospective chart review evaluated 158 consecutive patients with a diagnosis of FMD who underwent deep phenotyping across neurological and psychiatric domains. Demographic, clinical, and self-report features were analyzed. A data-driven approach using cluster analysis was performed to detect patterns when combining the movement disorder presentation with somatic symptoms, psychiatric diagnoses, and psychological factors. These new neuropsychiatric FMD phenotypes were then tested using logistic regression models. Results: Distinct neuropsychiatric FMD phenotypes emerged when stratifying by episodic vs. constant motor symptoms. Episodic FMD was associated with hyperkinetic movements, hyperarousal, anxiety, and history of trauma. In contrast, constant FMD was associated with weakness, gait disorders, fixed dystonia, activity avoidance, and low self-agency. Pain, fatigue, somatic preoccupation, and health anxiety were common across all phenotypes. Conclusion: This study found patterns spanning the neurological-psychiatric interface that indicate that FMD is part of a broader neuropsychiatric syndrome. Adopting a transdisciplinary view of illness reveals readily identifiable clinical factors that are relevant for the development and maintenance of FMD.
MeSH term(s)	Humans ; Retrospective Studies ; Medically Unexplained Symptoms ; Movement Disorders/diagnosis ; Movement Disorders/epidemiology ; Conversion Disorder ; Comorbidity
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2008418-3
ISSN	2165-6509 ; 1092-8529
ISSN (online)	2165-6509
ISSN	1092-8529
DOI	10.1017/S1092852923002353
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Zs.A 5171: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 340: Show issues

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Article ; Online: Patients with XLP type 1 have variable numbers of NKT cells.

Ralph, Elizabeth / Evans, Josie / Booth, Claire / Gilmour, Kimberly

British journal of haematology

2022 Volume 198, Issue 1, Page(s) 151–154

Abstract: X-linked lymphoproliferative disease (XLP1) is a rare primary immunodeficiency that usually presents in early childhood. Patients with XLP1 have been reported to have absent NKT cells, and it has been suggested that this can be diagnostic for the ... ...

Abstract	X-linked lymphoproliferative disease (XLP1) is a rare primary immunodeficiency that usually presents in early childhood. Patients with XLP1 have been reported to have absent NKT cells, and it has been suggested that this can be diagnostic for the disorder. Whilst NKT frequency in adults is variable, little is known about their frequency in children. Therefore, we established a paediatric reference range for these cells. In contrast to previous reports, in our cohort of XLP1 patients, NKT cell numbers were found to be variable, and we would advise against using the finding of NKT cells to exclude a diagnosis of XLP1.
MeSH term(s)	Adult ; Child ; Child, Preschool ; Cohort Studies ; Humans ; Lymphoproliferative Disorders/diagnosis ; Natural Killer T-Cells ; Signaling Lymphocytic Activation Molecule Associated Protein
Chemical Substances	Signaling Lymphocytic Activation Molecule Associated Protein
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18159
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Article: Freshwater protected areas can preserve high-performance phenotypes in populations of a popular sportfish.

Zolderdo, A J / Abrams, A E I / Lawrence, M J / Reid, C H / Suski, C D / Gilmour, K M / Cooke, S J

Conservation physiology

2023 Volume 11, Issue 1, Page(s) coad004

Abstract: Recreational fishing has the potential to cause evolutionary change in fish populations; a phenomenon referred to as fisheries-induced evolution. However, detecting and quantifying the magnitude of recreational fisheries selection in the wild is ... ...

Abstract	Recreational fishing has the potential to cause evolutionary change in fish populations; a phenomenon referred to as fisheries-induced evolution. However, detecting and quantifying the magnitude of recreational fisheries selection in the wild is inherently difficult, largely owing to the challenges associated with variation in environmental factors and, in most cases, the absence of pre-selection or baseline data against which comparisons can be made. However, exploration of recreational fisheries selection in wild populations may be possible in systems where fisheries exclusion zones exist. Lakes that possess intra-lake freshwater protected areas (FPAs) can provide investigative opportunities to evaluate the evolutionary impact(s) of differing fisheries management strategies within the same waterbody. To address this possibility, we evaluated how two physiological characteristics (metabolic phenotype and stress responsiveness) as well as a proxy for angling vulnerability, catch-per-unit-effort (CPUE), differed between populations of largemouth bass (
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2721508-8
ISSN	2051-1434
ISSN	2051-1434
DOI	10.1093/conphys/coad004
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Article ; Online: The Clustering of Health-Related Behaviors in the Adult Japanese Population.

Mawditt, Claire / Sasayama, Kiriko / Katanoda, Kota / Gilmour, Stuart

Journal of epidemiology

2021 Volume 31, Issue 8, Page(s) 471–479

Abstract: Background: Research findings indicate that four health-related behaviors (HRBs), smoking, alcohol, diet, and physical activity, do not co-occur within individuals by chance and therefore cluster. To date, there is a lack of research investigating the ... ...

Abstract	Background: Research findings indicate that four health-related behaviors (HRBs), smoking, alcohol, diet, and physical activity, do not co-occur within individuals by chance and therefore cluster. To date, there is a lack of research investigating the clustering of these HRBs in the Japanese population. Methods: The Japanese National Health and Nutrition Survey 2010 was used, containing information on 8,015 community-dwelling adults. Latent profile analysis identified distinct cluster patterns of four HRBs: smoking status, alcohol consumption, calorie intake, and the number of steps per day. Results: For men, four distinct HRB clusters were identified. The largest cluster (54%) was characterized by drinking more than Japan's recommended alcohol guidelines and walking an inadequate number of steps per day. A small cluster (4%) also emerged, characterized by smoking, high calorie intake, and exceeding alcohol guidelines. Members of these clusters had higher systolic blood pressure than those in the remaining clusters. For women, five distinct HRB clusters were identified. The largest cluster (57%) was characterized by not smoking or drinking and walking an inadequate number of steps per day. For both genders, there was a relationship between cluster membership and age. Cluster membership was associated with income and health status among men but not women. Conclusion: Detecting distinct clusters of HRBs in a Japanese population-based survey provides a person-centered understanding of Japanese lifestyles. This approach can assist policy makers in Japan and overseas to identify new strategies for targeting behavioral risk factors and make health promotion policies more effective in their respective countries.
MeSH term(s)	Adult ; Alcohol Drinking/psychology ; Cluster Analysis ; Diet/psychology ; Exercise/psychology ; Female ; Health Behavior ; Humans ; Japan ; Life Style ; Male ; Nutrition Surveys ; Smoking/psychology
Language	English
Publishing date	2021-02-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1442118-5
ISSN	1349-9092 ; 0917-5040
ISSN (online)	1349-9092
ISSN	0917-5040
DOI	10.2188/jea.JE20200120
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Article ; Online: Cold spots and cold moments: The potential for sediment freezing to depress denitrification in wetland sediments.

Gilmour, Kimberly / Hoggarth, Cameron / Williams, Clayton / Baulch, Helen M

Journal of environmental quality

2022 Volume 51, Issue 5, Page(s) 990–1002

Abstract: Within the north-temperate zone, winters can be long and are associated with conditions of low temperature and potential for sediment freezing. There are critical gaps in our knowledge of biogeochemical cycling during winter and inadequate knowledge of ... ...

Abstract	Within the north-temperate zone, winters can be long and are associated with conditions of low temperature and potential for sediment freezing. There are critical gaps in our knowledge of biogeochemical cycling during winter and inadequate knowledge of how warming winters and changing snowpack might affect biogeochemistry. Here, we assessed the impacts of sediment freeze-thaw cycling and nitrate amendment on denitrification rates in the littoral fringe of four urban wetlands. We demonstrate the potential for experimental sediment freezing to suppress denitrification, although freezing effects were not observed at all sites. Multiple freeze-thaw cycles were assessed, and, although subsequent cycles may affect denitrification, the first instance of our experimental freezing seems the most critical. Although this work demonstrates potential sensitivity of wetland denitrification rates to changing winter conditions, we note nitrate availability has a larger impact upon denitrification rates. This suggests nitrification rates and changing nitrate loads may be more important determinants of nitrate retention than sediment freeze-thaw history. Although there has been great interest in hot spots and moments for biogeochemical cycling, we suggest there is similar need to understand cold spots and moments, as evidenced here. This is particularly important where cold moments may correspond with critical periods of nitrate transport, such as snowmelt.
MeSH term(s)	Denitrification ; Freezing ; Geologic Sediments ; Nitrates/analysis ; Nitrogen ; Wetlands
Chemical Substances	Nitrates ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	120525-0
ISSN	1537-2537 ; 0047-2425
ISSN (online)	1537-2537
ISSN	0047-2425
DOI	10.1002/jeq2.20384
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Article ; Online: Regioselective, catalytic 1,1-difluorination of enynes.

Wang, Zi-Xuan / Livingstone, Keith / Hümpel, Carla / Daniliuc, Constantin G / Mück-Lichtenfeld, Christian / Gilmour, Ryan

Nature chemistry

2023 Volume 15, Issue 11, Page(s) 1515–1522

Abstract: Fluorinated small molecules are prevalent across the functional small-molecule spectrum, but the scarcity of naturally occurring sources creates an opportunity for creative endeavour in developing routes to access these important materials. Iodine(I)/ ... ...

Abstract	Fluorinated small molecules are prevalent across the functional small-molecule spectrum, but the scarcity of naturally occurring sources creates an opportunity for creative endeavour in developing routes to access these important materials. Iodine(I)/iodine(III) catalysis has proven to be particularly well-suited to this task, enabling abundant alkene substrates to be readily intercepted by in situ-generated λ
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2464596-5
ISSN	1755-4349 ; 1755-4330
ISSN (online)	1755-4349
ISSN	1755-4330
DOI	10.1038/s41557-023-01344-5
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