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  1. Article ; Online: Left atrial appendage closure in a patient with hemophilia C. An option or the only antithrombotic treatment for patients with a rare bleeding disorder?

    Binko, Paweł / Madejczyk, Andrzej / Brzozowski, Wojciech / Zarczuk, Radosław / Lewczuk, Karolina / Waciński, Piotr

    Kardiologia polska

    2023  Volume 81, Issue 7-8, Page(s) 792–793

    MeSH term(s) Humans ; Fibrinolytic Agents/therapeutic use ; Factor XI Deficiency/chemically induced ; Factor XI Deficiency/drug therapy ; Atrial Appendage/surgery ; Hemorrhage/chemically induced ; Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/surgery ; Treatment Outcome ; Stroke/drug therapy
    Chemical Substances Fibrinolytic Agents ; Anticoagulants
    Language English
    Publishing date 2023-05-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2023.0117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.

    Borowicz, Kinga K / Zarczuk, Radosław / Latalski, Michał / Borowicz, Kornel M

    Pharmacological reports : PR

    2014  Volume 66, Issue 3, Page(s) 430–435

    Abstract: Background: Our previous studies revealed that different classes of antidepressant drugs differently affect seizure phenomena. Continuing our research in this field, in the present study we wanted to investigate the influence of acute and chronic ... ...

    Abstract Background: Our previous studies revealed that different classes of antidepressant drugs differently affect seizure phenomena. Continuing our research in this field, in the present study we wanted to investigate the influence of acute and chronic treatment with reboxetine, a selective norepinephrine reuptake inhibitor, on the anticonvulsant action of classical antiepileptic drugs.
    Methods: Experiments were conducted in the model of electroconvulsive threshold and maximal electroshock in mice. Motor coordination was evaluated in the chimney test and long term memory in the step-through passive avoidance task. Brain concentrations of antiepileptic drugs were detected by fluorescence polarization immunoassay.
    Results: Acute treatment with reboxetine (8-16 mg/kg) significantly raised the electroconvulsive threshold. In contrast, chronic reboxetine (2-16 mg/kg) did not affect this parameter. Single administration of the antidepressant applied at its subthreshold doses enhanced the action of valproate, carbamazepine and phenobarbital. The antielectroshock effect of phenytoin was also potentiated by acute reboxetine, but only at doses increasing the threshold. Repeated administration of reboxetine (8-12 mg/kg) enhanced the anticonvulsant action of carbamazepine, but not that of three remaining antiepileptic drugs. Neither acute nor chronic reboxetine changed the brain concentrations of valproate, carbamazepine, phenytoin or phenobarbital. Therefore, all revealed interactions seem to be pharmacodynamic. In terms of undesired effects, acute/chronic reboxetine and its combinations with classical antiepileptic drugs did not significantly impair motor performance or long-term memory in mice.
    Conclusions: As far as the obtained data can be extrapolated into clinical conditions, it seems that reboxetine may be safely used in the treatment of depressive disorders in epileptic patients.
    MeSH term(s) Animals ; Anticonvulsants/pharmacology ; Brain/drug effects ; Carbamazepine/pharmacology ; Disease Models, Animal ; Drug Interactions ; Electroshock/methods ; Epilepsy/drug therapy ; Male ; Memory, Long-Term/drug effects ; Mice ; Morpholines/pharmacology ; Motor Activity/drug effects ; Phenobarbital/pharmacology ; Phenytoin/pharmacology ; Reboxetine ; Valproic Acid/pharmacology
    Chemical Substances Anticonvulsants ; Morpholines ; Carbamazepine (33CM23913M) ; Valproic Acid (614OI1Z5WI) ; Phenytoin (6158TKW0C5) ; Reboxetine (947S0YZ36I) ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2014-04-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1016/j.pharep.2013.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Immunological aspects of epilepsy.

    Zarczuk, Radosław / Łukasik, Dariusz / Jedrych, Marian / Borowicz, Kinga K

    Pharmacological reports : PR

    2010  Volume 62, Issue 4, Page(s) 592–607

    Abstract: In recent years, the concept of an immunological background of some types of epilepsy has been gaining an increasing number of supporters. The following article is an attempt to review the most significant studies that explore irregularities in patients ... ...

    Abstract In recent years, the concept of an immunological background of some types of epilepsy has been gaining an increasing number of supporters. The following article is an attempt to review the most significant studies that explore irregularities in patients with intractable epilepsy, search for and identify the immunological causal factors of seizures and, finally, associate these factors with particular syndromes that manifest in refractory epilepsy. We also discuss the efficacy of immunomodulatory treatment in the recognized syndromes. Last, we focus on the immunological abnormalities found in patients undergoing antiepileptic therapy with classical antiepileptic drugs as well as changes in the immune system that could be provoked by an epileptic seizure itself.
    MeSH term(s) Animals ; Anticonvulsants/therapeutic use ; Drug Resistance ; Encephalitis/complications ; Encephalitis/immunology ; Epilepsy/drug therapy ; Epilepsy/etiology ; Epilepsy/immunology ; Humans ; Immunologic Factors/therapeutic use ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/immunology
    Chemical Substances Anticonvulsants ; Immunologic Factors
    Language English
    Publishing date 2010-09-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1016/s1734-1140(10)70317-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.

    Borowicz, Kinga K / Banach, Monika / Zarczuk, Radosław / Lukasik, Dariusz / Luszczki, Jarogniew J / Czuczwar, Stanislaw J

    Psychopharmacology

    2007  Volume 195, Issue 2, Page(s) 167–174

    Abstract: Rationale: Epilepsy often coexists with depression. Therefore, the probability of simultaneous treatment with antiepileptics and antidepressants and the possibility of interactions between them are relatively high.: Objective: The effects of acute ... ...

    Abstract Rationale: Epilepsy often coexists with depression. Therefore, the probability of simultaneous treatment with antiepileptics and antidepressants and the possibility of interactions between them are relatively high.
    Objective: The effects of acute and chronic administration of mianserin on the protective activity of valproate (VPA), carbamazepine, phenytoin, and phenobarbital were evaluated in the maximal electroshock in mice.
    Materials and methods: Animals were subjected to electroconvulsions. Undesired effects were evaluated in the chimney test (motor impairment) and passive-avoidance task (memory deficit). Brain concentrations of antiepileptic drugs were assessed by immunofluorescence.
    Results: When given acutely, mianserin (at doses greater than or equal to 20 mg/kg) significantly raised the electroconvulsive threshold. The antidepressant, at the subanticonvulsant doses, enhanced the anticonvulsant action of carbamazepine, phenytoin, and VPA. Mianserin administered chronically at 30 mg/kg significantly decreased the electroconvulsive threshold. In contrast to acute treatment, the antidepressant at subeffective doses diminished the anticonvulsant activity of VPA and phenytoin. Mianserin given either acutely or chronically did not affect the brain concentrations of antiepileptic drugs, so a pharmacokinetic contribution to the observed interactions is not probable. Acute and chronic treatment with mianserin and its combinations with antiepileptic drugs did not impair either motor coordination or long-term memory.
    Conclusion: Although acute application of mianserin may potentiate the anticonvulsant action of some antiepileptics, its chronic administration can lead to the opposite effect. Therefore, as far as the presented results can be transferred to clinical conditions, the antidepressant therapy with mianserin should be limited or even avoided in epileptic patients.
    MeSH term(s) Analysis of Variance ; Animals ; Anticonvulsants/pharmacokinetics ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Antidepressive Agents, Second-Generation/administration & dosage ; Antidepressive Agents, Second-Generation/pharmacology ; Antidepressive Agents, Second-Generation/therapeutic use ; Brain/drug effects ; Brain/metabolism ; Carbamazepine/pharmacokinetics ; Carbamazepine/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Synergism ; Electroshock ; Fluorescent Antibody Technique ; Male ; Memory/drug effects ; Mianserin/administration & dosage ; Mianserin/pharmacology ; Mianserin/therapeutic use ; Mice ; Motor Activity/drug effects ; Phenobarbital/pharmacokinetics ; Phenobarbital/pharmacology ; Phenytoin/pharmacokinetics ; Phenytoin/pharmacology ; Seizures/etiology ; Seizures/prevention & control ; Valproic Acid/pharmacokinetics ; Valproic Acid/pharmacology
    Chemical Substances Anticonvulsants ; Antidepressive Agents, Second-Generation ; Mianserin (250PJI13LM) ; Carbamazepine (33CM23913M) ; Valproic Acid (614OI1Z5WI) ; Phenytoin (6158TKW0C5) ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2007-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-007-0878-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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