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  1. Article ; Online: Optimizing Dose Per Fraction: A New Chapter in the Story of the Abscopal Effect?

    Formenti, Silvia C

    International journal of radiation oncology, biology, physics

    2018  Volume 99, Issue 3, Page(s) 677–679

    MeSH term(s) Animals ; DNA Damage ; Dose Fractionation, Radiation ; Gene Expression Regulation ; Humans ; Interferon Type I/genetics ; Membrane Proteins/metabolism ; Mice ; Radiation Effects
    Chemical Substances Interferon Type I ; Membrane Proteins ; STING1 protein, human
    Language English
    Publishing date 2018-01-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.07.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness.

    Demaria, Sandra / Formenti, Silvia C

    Trends in immunology

    2021  Volume 42, Issue 4, Page(s) 275–277

    Abstract: Allogeneic liver transplants tolerize the immune system, preventing organ rejection from the same donor. A recent article by Yu et al. shows that liver metastases can likewise prevent tumor rejection in immunotherapy-treated murine and human hosts. ... ...

    Abstract Allogeneic liver transplants tolerize the immune system, preventing organ rejection from the same donor. A recent article by Yu et al. shows that liver metastases can likewise prevent tumor rejection in immunotherapy-treated murine and human hosts. Furthermore, radiation can reprogram the liver microenvironment to restore systemic tumor rejection.
    MeSH term(s) Animals ; Humans ; Immunotherapy ; Liver Neoplasms/therapy ; Macrophages ; Mice ; T-Lymphocytes ; Tumor Microenvironment
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids.

    Charpentier, Maud / Bloy, Norma / Formenti, Silvia C / Galluzzi, Lorenzo / Demaria, Sandra

    Journal of visualized experiments : JoVE

    2024  , Issue 206

    Abstract: Radiation therapy (RT) is one of the mainstays of modern clinical cancer management. However, not all cancer types are equally sensitive to irradiation, often (but not always) because of differences in the ability of malignant cells to repair oxidative ... ...

    Abstract Radiation therapy (RT) is one of the mainstays of modern clinical cancer management. However, not all cancer types are equally sensitive to irradiation, often (but not always) because of differences in the ability of malignant cells to repair oxidative DNA damage as elicited by ionizing rays. Clonogenic assays have been employed for decades to assess the sensitivity of cultured cancer cells to ionizing irradiation, largely because irradiated cancer cells often die in a delayed manner that is difficult to quantify with short-term flow cytometry- or microscopy-assisted techniques. Unfortunately, clonogenic assays cannot be employed as such for more complex tumor models, such as patient-derived tumor organoids (PDTOs). Indeed, irradiating established PDTOs may not necessarily abrogate their growth as multicellular units, unless their stem-like compartment is completely eradicated. Moreover, irradiating PDTO-derived single-cell suspensions may not properly recapitulate the sensitivity of malignant cells to RT in the context of established PDTOs. Here, we detail an adaptation of conventional clonogenic assays that involves exposure of established PDTOs to ionizing radiation, followed by single-cell dissociation, replating in suitable culture conditions and live imaging. Non-irradiated (control) PDTO-derived stem-like cells reform growing PDTOs with a PDTO-specific efficiency, which is negatively influenced by irradiation in a dose-dependent manner. In these conditions, PDTO-forming efficiency and growth rate can be quantified as a measure of radiosensitivity on time-lapse images collected until control PDTOs achieve a predefined space occupancy.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/66680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Future of Radiation and Immunotherapy.

    Formenti, Silvia C / Demaria, Sandra

    International journal of radiation oncology, biology, physics

    2020  Volume 108, Issue 1, Page(s) 3–5

    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/radiotherapy ; Radiotherapy
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2020.04.034
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    Zs.A 1218: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Emerging evidence for adapting radiotherapy to immunotherapy.

    Galluzzi, Lorenzo / Aryankalayil, Molykutty J / Coleman, C Norman / Formenti, Silvia C

    Nature reviews. Clinical oncology

    2023  Volume 20, Issue 8, Page(s) 543–557

    Abstract: Immunotherapy has revolutionized the clinical management of many malignancies but is infrequently associated with durable objective responses when used as a standalone treatment approach, calling for the development of combinatorial regimens with ... ...

    Abstract Immunotherapy has revolutionized the clinical management of many malignancies but is infrequently associated with durable objective responses when used as a standalone treatment approach, calling for the development of combinatorial regimens with superior efficacy and acceptable toxicity. Radiotherapy, the most commonly used oncological treatment, has attracted considerable attention as a combination partner for immunotherapy owing to its well-known and predictable safety profile, widespread clinical availability, and potential for immunostimulatory effects. However, numerous randomized clinical trials investigating radiotherapy-immunotherapy combinations have failed to demonstrate a therapeutic benefit compared with either modality alone. Such a lack of interaction might reflect suboptimal study design, choice of end points and/or administration of radiotherapy according to standard schedules and target volumes. Indeed, radiotherapy has empirically evolved towards radiation doses and fields that enable maximal cancer cell killing with manageable toxicity to healthy tissues, without much consideration of potential radiation-induced immunostimulatory effects. Herein, we propose the concept that successful radiotherapy-immunotherapy combinations might require modifications of standard radiotherapy regimens and target volumes to optimally sustain immune fitness and enhance the antitumour immune response in support of meaningful clinical benefits.
    MeSH term(s) Humans ; Combined Modality Therapy ; Radiation Oncology ; Neoplasms/radiotherapy ; Immunotherapy ; Immunization ; Radiotherapy
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-023-00782-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 103: Show issues

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  6. Article: Silvia Formenti on the promise of combining radiotherapy and immunotherapy to treat cancer.

    Formenti, Silvia C

    Oncology (Williston Park, N.Y.)

    2016  Volume 30, Issue 4, Page(s) 289, 292

    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/therapy ; Precision Medicine
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Interview
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3168: Show issues Location:
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    Zs.MO 372: Show issues

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  7. Article ; Online: The Pace of Progress in Radiation and Immunotherapy.

    Formenti, Silvia C

    International journal of radiation oncology, biology, physics

    2016  Volume 95, Issue 4, Page(s) 1257–1258

    Language English
    Publishing date 2016--15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2016.02.063
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    Zs.A 1218: Show issues Location:
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  8. Article: The initial experience of MRI-guided precision prone breast irradiation with daily adaptive planning in treating early stage breast cancer patients.

    Ng, John / Pennell, Ryan / Formenti, Silvia C

    Frontiers in oncology

    2022  Volume 12, Page(s) 1048512

    Abstract: Background: A major challenge in breast radiotherapy is accurately targeting the surgical cavity volume. Application of the emerging MRI-guided radiotherapy (MRgRT) technique in breast radiotherapy may enable more accurate targeting and potentially ... ...

    Abstract Background: A major challenge in breast radiotherapy is accurately targeting the surgical cavity volume. Application of the emerging MRI-guided radiotherapy (MRgRT) technique in breast radiotherapy may enable more accurate targeting and potentially reduce side effects associated with treatment.
    Purpose: To study the feasibility of delivering MRI-guided partial breast radiotherapy or Precision Prone Irradiation (PPI) to treat DCIS and early stage breast cancer patients.
    Materials and methods: Eleven patients with diagnosed DCIS or early stage breast cancer treated with lumpectomy underwent CT-based and MRI-based simulations and treatment planning in the prone position. MRI-guided radiotherapy was utilized to deliver partial breast irradiation. A customized adaptive plan was created for each delivered radiotherapy fraction and the cumulative doses to the target volumes and nearby organs at risk were determined. The CT-based and the MRI-guided radiotherapy plans were compared with respect to target volumes, target volume coverage, and dose to nearby organs.
    Results: All patients receiving PPI successfully completed their treatments as planned. Clinical target volume (CTV) and planning target volume (PTV) dose coverage and organs-at-risk (OAR) dose constraints were met in all fractions planned and delivered and the MRI-guided clinical target volumes were smaller when compared to those of the CT-based partial breast radiotherapy plans for these eleven patients.
    Conclusions: MRI-guided partial breast radiotherapy as a breast radiotherapy technology is feasible and is a potential high clinical impact application of MRgRT. PPI has the potential to improve the therapeutic index of breast radiotherapy by more accurately delivering radiation dose to the cavity target and decreasing toxicities associated with radiation to the surrounding normal tissues. Prospective clinical data and further technical refinements of this novel technology may broaden its clinical implementation.
    Language English
    Publishing date 2022-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1048512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cancer and COVID-19 - potentially deleterious effects of delaying radiotherapy.

    Nagar, Himanshu / Formenti, Silvia C

    Nature reviews. Clinical oncology

    2020  Volume 17, Issue 6, Page(s) 332–334

    MeSH term(s) Breast Neoplasms/complications ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/virology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/radiotherapy ; Coronavirus Infections/virology ; Disease-Free Survival ; Female ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/virology ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/radiotherapy ; Pneumonia, Viral/virology
    Keywords covid19
    Language English
    Publishing date 2020-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-020-0375-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The abscopal effect 67 years later: from a side story to center stage.

    Demaria, Sandra / Formenti, Silvia C

    The British journal of radiology

    2020  Volume 93, Issue 1109, Page(s) 20200042

    Abstract: For over a century, ionising radiation has been used to treat cancer based on its cytotoxic effects on tumour cells. Technical progress has enabled more precise targeting of the tumour to reduce normal tissue toxicity while delivering higher radiation ... ...

    Abstract For over a century, ionising radiation has been used to treat cancer based on its cytotoxic effects on tumour cells. Technical progress has enabled more precise targeting of the tumour to reduce normal tissue toxicity while delivering higher radiation doses per fraction of treatment.In 1953, unexpected regression in lesions outside of the irradiated field were noted by an observant physician, RH Mole, who named such phenomenon "abscopal effect" from the Latin
    MeSH term(s) Animals ; Dendritic Cells/immunology ; Dendritic Cells/radiation effects ; Disease Models, Animal ; Humans ; Immunity/physiology ; Lymphocyte Activation/immunology ; Lymphocyte Activation/radiation effects ; Mice ; Neoplasms/immunology ; Neoplasms/radiotherapy ; T-Lymphocytes/immunology ; T-Lymphocytes/radiation effects
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20200042
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