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  1. Book: Environmental Alteration Leads to Human Disease

    Ingegnoli, Vittorio / La Torre, Giuseppe / Lombardo, Francesco

    A Planetary Health Approach

    (Sustainable Development Goals Series)

    2022  

    Author's details Vittorio Ingegnoli is the founder of the new discipline of Landscape Bionomics. Since 2016 he has been a Visiting Professor of Landscape Bionomics at the Dept. of Environmental Science & Policy at the University of Milan, Italy. His research focuses on environmental alterations in connection with human health. From 2004 to 2008 he was a Member of the Con. Eco. For. (CFS, State Foresters) and ICP European Forest Monitoring; from 2012 to 2014 he was Coordinator of the Research on Suburban Landscapes in Brussels and Milan, KU-Leuven, Belgium, with prof. H. Gulink. Currently, he is a Member of the Planetary Health Alliance (University of Harvard), of the SIPNEI (It. Soc. of Psycho-Neuro-Endocrine-Immunology) and of the Academic Experts for CAI Central Scientific Committee (It. Alpine Club). He has authored more than 150 books and articles.§ Francesco Lombardo is a Visiting Professor at the Royal University of Jordan, Director of the Master in Andrology and Seminology of the University o
    Series title Sustainable Development Goals Series
    Keywords SDG3 ; wellbeing ; Public Health ; Global Health ; systemic medicine ; Ecology ; Landscape Bionomics ; PNEI (Psycho-Neuro-Endocrine-Immunology) ; Wellbeing ; Systemic Medicine
    Language English
    Size 352 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_13
    Format 183 x 260 x 24
    ISBN 9783030831592 ; 3030831590
    Database PDA

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  2. Book ; Online ; E-Book: Environmental Alteration Leads to Human Disease

    Ingegnoli, Vittorio / Lombardo, Francesco / La Torre, Giuseppe

    A Planetary Health Approach

    (Sustainable Development Goals Series,)

    2022  

    Abstract: This book aims to explore the impact of human alterations of Earth’s ecological systems on human health. Human activities are producing fundamental biophysical changes faster than ever before in the history of our species, which are accompanied by ... ...

    Author's details edited by Vittorio Ingegnoli, Francesco Lombardo, Giuseppe La Torre
    Series title Sustainable Development Goals Series,
    Abstract This book aims to explore the impact of human alterations of Earth’s ecological systems on human health. Human activities are producing fundamental biophysical changes faster than ever before in the history of our species, which are accompanied by dangerous health effects. Drawing on advanced ecological principles, the book demonstrates the importance of using systemic medicine to study the effects of ecological alterations on human health. Planetary Health is an interdisciplinary field, but first of all it must be systemic and it needs a preferential relationship between Ecology and Medicine. This relation is to be upgrading, because today both ecology and medicine pursue few systemic characters and few correct interrelations. We need to refer to new principles and methods sustained by the most advanced fields, as Landscape Bionomics and Systemic Medicine. Thus, we will be able to better discover environmental syndromes and their consequences on human health. Environmental transformations proposed by PHA (from biodiversity shifts to climate change) do not consider bionomic dysfunctions which can menace human health. On the contrary, finding advanced diagnostic criteria in landscape syndromes can strongly help to find the effects on human well-being. The passage from sick care to health care can’t avoid the mentioned upgrading.
    Keywords Public health ; Ecology ; Public Health
    Subject code 577
    Language English
    Size 1 online resource (345 pages)
    Edition 1st ed. 2022.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-83160-4 ; 9783030831592 ; 978-3-030-83160-8 ; 3030831590
    DOI 10.1007/978-3-030-83160-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Emerging Role of [

    Nappi, Anna Giulia / Santo, Giulia / Jonghi-Lavarini, Lorenzo / Miceli, Alberto / Lazzarato, Achille / La Torre, Flavia / Dondi, Francesco / Gorica, Joana

    Hematology reports

    2024  Volume 16, Issue 1, Page(s) 32–41

    Abstract: Fluorine-18 fluorodeoxyglucose ([ ...

    Abstract Fluorine-18 fluorodeoxyglucose ([
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2586645-X
    ISSN 2038-8330 ; 2038-8322
    ISSN (online) 2038-8330
    ISSN 2038-8322
    DOI 10.3390/hematolrep16010004
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  4. Article ; Online: Generalized morphea treated with secukinumab.

    Filoni, Angela / Bonamonte, Domenico / Civino, Adele / LA Torre, Francesco / Congedo, Maurizio

    Italian journal of dermatology and venereology

    2023  Volume 158, Issue 4, Page(s) 368–369

    MeSH term(s) Humans ; Scleroderma, Localized/drug therapy ; Scleroderma, Systemic ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-08-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.23.07502-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A SNP-based genotyping strategy to detect the abuse of homologous blood transfusion from dried blood spots.

    Donati, Francesco / Natalucci, Alice / Concetti, Livia / de la Torre, Xavier / Botrè, Francesco

    Drug testing and analysis

    2024  

    Abstract: We performed genotyping analysis of human biallelic polymorphisms (single nucleotide polymorphisms) for the detection of homologous blood transfusion in sports doping. DNA was extracted from dried blood spots and quantified real-time fast PCR. The method ...

    Abstract We performed genotyping analysis of human biallelic polymorphisms (single nucleotide polymorphisms) for the detection of homologous blood transfusion in sports doping. DNA was extracted from dried blood spots and quantified real-time fast PCR. The method was proven to allow the detection of transfusions up to a donor percentage of 1%, with a significant improvement in terms of sensitivity with respect to both the reference cytofluorimetric method and a previously proposed strategy based on the DNA STR-based strategy.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3650
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  6. Article ; Online: What cardiologists should know about sleep.

    Pengo, Martino Francesco / Javaheri, Sogol / Sanchez-de-la-Torre, Manuel / Schwarz, Esther Irene

    European heart journal

    2022  Volume 43, Issue 31, Page(s) 2911–2913

    MeSH term(s) Cardiologists ; Cardiovascular Diseases ; Humans ; Sleep
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac349
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  7. Article: Multi-Inflammatory Syndrome in Children (MIS-C) in 2023: Is It Time to Forget about It?

    La Torre, Francesco / Taddio, Andrea / Conti, Chiara / Cattalini, Marco

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 6

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is defined as a clinically serious condition requiring hospitalization involving fever, multi-system organ dysfunction, and an increase in inflammatory biomarkers. The syndrome was originally ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) is defined as a clinically serious condition requiring hospitalization involving fever, multi-system organ dysfunction, and an increase in inflammatory biomarkers. The syndrome was originally described as a post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which usually causes COVID-19. During the COVID-19 pandemic, not only did the virus undergo mutations but vaccines against SARS-CoV-2 were also developed. Both these conditions led to a decrease in the incidence of MIS-C. This narrative review summarizes the recent updates for MIS-C, particularly regarding the change in incidence, the link between the SARS-CoV-2 vaccine and MIS-C, and new updates of MIS-C treatments.
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10060980
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  8. Article ; Online: Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation.

    Jeong, Mingeum / Cortopassi, Francesco / See, Jia-Xiang / De La Torre, Carolina / Cerwenka, Adelheid / Stojanovic, Ana

    European journal of immunology

    2024  , Page(s) e2250342

    Abstract: Natural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and ...

    Abstract Natural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and nutrients. Vitamin A is an essential micronutrient that plays an indispensable role in embryogenesis and development, but was also reported to regulate immune responses. However, the role of vitamin A in regulating NK cell functions remains poorly understood. Here, we show that the most prevalent vitamin A metabolite, all-trans retinoic acid (atRA), induces transcriptional and functional changes in NK cells leading to altered metabolism and reduced IFN-γ production in response to a wide range of stimuli. atRA-exposed NK cells display a reduced ability to support dendritic cell (DC) maturation and to eliminate immature DCs. Moreover, they support the polarization and proliferation of regulatory T cells. These results imply that in vitamin A-enriched environments, NK cells can acquire functions that might promote tolerogenic immunity and/or immunosuppression.
    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202250342
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  9. Article ; Online: Multidimensional response of Dupilumab in a child affected by Netherton syndrome: Improvement of trichorrhexis invaginata.

    Mastrorilli, Carla / Ambrogio, Francesca / La Torre, Francesco / Foti, Caterina / Bonamonte, Domenico / Serio, Cristina / Cardinale, Fabio

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 7, Page(s) e13997

    MeSH term(s) Humans ; Child ; Netherton Syndrome/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Dermatitis, Exfoliative
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Letter
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13997
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  10. Article ; Online: Long-term treatment for endometriosis with dienogest: efficacy, side effects and tolerability.

    La Torre, Francesco / Vannuccini, Silvia / Toscano, Federico / Gallucci, Ernesto / Orlandi, Gretha / Manzi, Virginia / Petraglia, Felice

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2024  Volume 40, Issue 1, Page(s) 2336121

    Abstract: Background: Dienogest (DNG) improves endometriosis-associated pain (EAP) and patients' quality of life; however, the modern cornerstone of the management of endometriosis is the long-term adherence of the patient to medical treatment.: Objective: To ... ...

    Abstract Background: Dienogest (DNG) improves endometriosis-associated pain (EAP) and patients' quality of life; however, the modern cornerstone of the management of endometriosis is the long-term adherence of the patient to medical treatment.
    Objective: To evaluate DNG as a long-term treatment of endometriosis, focusing on patients' compliance and side effects, also correlating with different phenotypes of endometriosis.
    Methods: This was a cohort study on a group of patients with endometriosis (
    Results: At 12 months, 81% were continuing the DNG treatment, with a significant reduction of dysmenorrhea, dyspareunia, dyschezia, dysuria and chronic pelvic pain. Of the 19% that discontinued the treatment: 62% was due to spotting, reduced sexual drive, vaginal dryness, and mood disorders. The improvement of EAP was significant for all endometriosis phenotypes, especially in patients with the deep infiltrating type. At 36 months, 73% of patients were continuing the treatment, showing a significant reduction of EAP through the follow up, along with an increase of amenorrhea (from 77% at 12 months to 93% at 36 months). In a subgroup of 18 patients with gastrointestinal disorders, DNG was administered vaginally at the same dosage, showing similar results in terms of efficacy and tolerability.
    Conclusions: DNG was an effective long-term treatment for all endometriosis phenotypes, with few side effects that caused the discontinuation of the treatment mainly during the first year. Thus, the course of 1-year treatment is a predictive indicator for long-term treatment adherence.
    MeSH term(s) Female ; Humans ; Endometriosis/complications ; Endometriosis/drug therapy ; Endometriosis/chemically induced ; Treatment Outcome ; Cohort Studies ; Quality of Life ; Pelvic Pain/drug therapy ; Pelvic Pain/etiology ; Nandrolone/adverse effects ; Nandrolone/analogs & derivatives
    Chemical Substances dienogest (46M3EV8HHE) ; Nandrolone (6PG9VR430D)
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2024.2336121
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