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Book ; Thesis: Effect of hematocrit on systemic O 2 transport in hypoxic and normoxic exercise in rats

Erwig, Lars-Peter

1994

Author's details	vorgelegt von Lars-Peter Erwig
Language	German ; English
Size	32 Bl. : graph. Darst.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hannover, Med. Hochsch., Diss., 1995
Note	Beitr. teilw. dt., teilw. engl.
HBZ-ID	HT007092733
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Macrophages and hypoxia in human chronic kidney disease.

Erwig, Lars-Peter

Kidney international

2008 Volume 74, Issue 4, Page(s) 405–406

Abstract: Chronic kidney disease is characterized by progressive interstitial fibrosis, reduced blood flow, and tubular atrophy, which present a common pathway of destruction irrespective of the initial underlying pathology. There is comprehensive evidence that ... ...

Abstract	Chronic kidney disease is characterized by progressive interstitial fibrosis, reduced blood flow, and tubular atrophy, which present a common pathway of destruction irrespective of the initial underlying pathology. There is comprehensive evidence that the interactions of infiltrating macrophages with resident tissue cells play a critical role in this process. A new study now describes the correlation between macrophages, capillary density, and interstitial scarring and suggests distinct differences in early and advanced renal disease.
MeSH term(s)	Humans ; Hypoxia/pathology ; Kidney/pathology ; Kidney Failure, Chronic/pathology ; Macrophages/pathology ; Models, Biological ; Nephritis, Interstitial/pathology
Language	English
Publishing date	2008-08
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1038/ki.2008.225
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Zs.A 797: Show issues

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Article ; Online: Novel insights into host-fungal pathogen interactions derived from live-cell imaging.

Bain, Judith / Gow, Neil A R / Erwig, Lars-Peter

Seminars in immunopathology

2014 Volume 37, Issue 2, Page(s) 131–139

Abstract: The theoretical physicist and Nobel laureate Richard Feynman outlined in his 1959 lecture, "There's plenty of room at the bottom", the enormous possibility of producing and visualising things at smaller scales. The advent of advanced scanning and ... ...

Abstract	The theoretical physicist and Nobel laureate Richard Feynman outlined in his 1959 lecture, "There's plenty of room at the bottom", the enormous possibility of producing and visualising things at smaller scales. The advent of advanced scanning and transmission electron microscopy and high-resolution microscopy has begun to open the door to visualise host-pathogen interactions at smaller scales, and spinning disc confocal and two-photon microscopy has improved our ability to study these events in real time in three dimensions. The aim of this review is to illustrate some of the advances in understanding host-fungal interactions that have been made in recent years in particular those relating to the interactions of live fungal pathogens with phagocytes. Dynamic imaging of host-pathogen interactions has recently revealed novel detail and unsuspected mechanistic insights, facilitating the dissection of the phagocytic process into its component parts. Here, we will highlight advances in our knowledge of host-fungal pathogen interactions, including the specific effects of fungal cell viability, cell wall composition and morphogenesis on the phagocytic process and try to define the relative contributions of neutrophils and macrophages to the clearance of fungal pathogens in vitro and the infected host.
MeSH term(s)	Animals ; Fungi/immunology ; Fungi/metabolism ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Macrophages/immunology ; Macrophages/microbiology ; Macrophages/ultrastructure ; Microscopy, Confocal ; Microscopy, Fluorescence ; Mycoses/immunology ; Mycoses/metabolism ; Neutrophils/immunology ; Neutrophils/microbiology ; Neutrophils/ultrastructure ; Phagocytosis/immunology
Language	English
Publishing date	2014-11-15
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2316828-6
ISSN	1863-2300 ; 1863-2297
ISSN (online)	1863-2300
ISSN	1863-2297
DOI	10.1007/s00281-014-0463-3
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Zs.A 1425: Show issues

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Article ; Online: Pathophysiological importance of antineutrophil antibodies in vasculitis.

Basu, Neil / Erwig, Lars-Peter

Current opinion in hematology

2010 Volume 18, Issue 1, Page(s) 25–29

Abstract: Purpose of review: We endeavour to provide a brief overview of the recent advances in understanding of how antineutrophil cytoplasmic antibodies (ANCAs) contribute to the pathophysiology of vasculitis.: Recent findings: Substantial progress has been ... ...

Abstract	Purpose of review: We endeavour to provide a brief overview of the recent advances in understanding of how antineutrophil cytoplasmic antibodies (ANCAs) contribute to the pathophysiology of vasculitis. Recent findings: Substantial progress has been made in our understanding of the immunopathogenesis of ANCA-associated vasculitides. Compelling evidence from in-vitro studies and experimental models in conjunction with clinical trials has confirmed that ANCAs directly contribute to the evolution and progression of the disease process. A new ANCA, directed against human lysosome membrane protein-2 (LAMP-2), has recently been described as a sensitive and specific marker for renal vasculitis and we discuss its potential impact for diagnosis and therapy. Furthermore, high-throughput approaches are starting to identify genetic patterns that may identify patients likely to respond to specific therapy or having a high probability of relapse. Summary: It has become increasingly clear over the last two decades that ANCA IgG is pathogenic in vasculitis. Novel therapies aimed at selected cell populations or blocking specific pathogenic pathways offer hope for more selectively treating this heterogeneous group of patients, while avoiding nonspecific immunosuppression and its adverse effects.
MeSH term(s)	Animals ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Antibody Specificity/immunology ; Complement Activation/immunology ; Complement System Proteins/immunology ; Humans ; Lymphocyte Activation/immunology ; Lysosomal-Associated Membrane Protein 2/immunology ; T-Lymphocyte Subsets/immunology ; Vasculitis/immunology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; LAMP2 protein, human ; Lysosomal-Associated Membrane Protein 2 ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	2010-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1153887-9
ISSN	1531-7048 ; 1065-6251
ISSN (online)	1531-7048
ISSN	1065-6251
DOI	10.1097/MOH.0b013e328340dc2a
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Zs.A 3703: Show issues

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Article ; Online: Rapid recovery of membrane cofactor protein (MCP; CD46) associated atypical haemolytic uraemic syndrome with plasma exchange.

Reid, Victoria Louise / Mullan, Adam / Erwig, Lars-Peter

BMJ case reports

2013 Volume 2013

Abstract: Atypical haemolytic uraemic syndrome (aHUS), unlike typical HUS is due to complement dysregulation. At least one abnormality of the complement system can be identified in 70% of patients. aHUS is associated with a poor prognosis with 25% mortality and 50% ...

Abstract	Atypical haemolytic uraemic syndrome (aHUS), unlike typical HUS is due to complement dysregulation. At least one abnormality of the complement system can be identified in 70% of patients. aHUS is associated with a poor prognosis with 25% mortality and 50% progress to end-stage renal disease. Genetic abnormalities in the complement system, proteins including CFH, CFI, CFB, C3, CFHR1/3 and MCP (CD46) lead to uncontrolled complement activation in aHUS. We presented the second reported case of aHUS associated with a heterozygous c.191G > T mutation in exon 2 of MCP who responded rapidly to plasma exchange.
MeSH term(s)	Adolescent ; Atypical Hemolytic Uremic Syndrome ; Hemolytic-Uremic Syndrome/genetics ; Hemolytic-Uremic Syndrome/therapy ; Humans ; Male ; Membrane Cofactor Protein/genetics ; Mutation ; Plasma Exchange ; Polymorphism, Single Nucleotide
Chemical Substances	CD46 protein, human ; Membrane Cofactor Protein
Language	English
Publishing date	2013-09-04
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2013-200980
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Article ; Online: Differential expression of macrophage and neutrophil phagocytic receptors recognising fungal pathogens in mouse and human.

Bain, Judith M / Lewis, Leanne E / Erwig, Lars-Peter

Immunology and cell biology

2012 Volume 90, Issue 9, Page(s) 837–838

MeSH term(s)	Candida albicans/immunology ; Humans ; Lectins, C-Type/immunology ; Monocytes/immunology ; Neutrophils/immunology ; Receptors, Immunologic/immunology
Chemical Substances	CLEC4D protein, human ; Lectins, C-Type ; Receptors, Immunologic
Language	English
Publishing date	2012-07-17
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1038/icb.2012.38
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Uc I Zs.175: Show issues

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Article: Immunological consequences of apoptotic cell phagocytosis.

Erwig, Lars-Peter / Henson, Peter M

The American journal of pathology

2007 Volume 171, Issue 1, Page(s) 2–8

Abstract: Cells undergo apoptosis in development, tissue homeostasis, and disease and are subsequently cleared by professional and nonprofessional phagocytes. There is now overwhelming evidence that phagocyte function is profoundly altered following apoptotic cell ...

Abstract	Cells undergo apoptosis in development, tissue homeostasis, and disease and are subsequently cleared by professional and nonprofessional phagocytes. There is now overwhelming evidence that phagocyte function is profoundly altered following apoptotic cell uptake, with consequences for the ensuing innate and adaptive immune response. Pathogens and tumors exploit the changes in macrophage function following apoptotic cell uptake. Here, we will outline the consequences of apoptotic cell phagocytosis and illustrate how apoptotic cells could be used to manipulate the immune response for therapeutic gain.
MeSH term(s)	Apoptosis ; Autoimmunity ; Humans ; Immunity, Active ; Immunity, Innate ; Inflammation/immunology ; Lymphocyte Activation ; Macrophages/immunology ; Phagocytosis ; T-Lymphocytes/immunology
Language	English
Publishing date	2007-06-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.2353/ajpath.2007.070135
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Ud II Zs.76: Show issues

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Article: Different Candida parapsilosis clinical isolates and lipase deficient strain trigger an altered cellular immune response.

Tóth, Renáta / Alonso, Maria F / Bain, Judith M / Vágvölgyi, Csaba / Erwig, Lars-Peter / Gácser, Attila

Frontiers in microbiology

2015 Volume 6, Page(s) 1102

Abstract: Numerous human diseases can be associated with fungal infections either as potential causative agents or as a result of changed immune status due to a primary disease. Fungal infections caused by Candida species can vary from mild to severe dependent ... ...

Abstract	Numerous human diseases can be associated with fungal infections either as potential causative agents or as a result of changed immune status due to a primary disease. Fungal infections caused by Candida species can vary from mild to severe dependent upon the site of infection, length of exposure, and past medical history. Patients with impaired immune status are at increased risk for chronic fungal infections. Recent epidemiologic studies have revealed the increasing incidence of candidiasis caused by non-albicans species such as Candida parapsilosis. Due to its increasing relevance we chose two distinct C. parapsilosis strains, to describe the cellular innate immune response toward this species. In the first section of our study we compared the interaction of CLIB 214 and GA1 cells with murine and human macrophages. Both strains are commonly used to investigate C. parapsilosis virulence properties. CLIB 214 is a rapidly pseudohyphae-forming strain and GA1 is an isolate that mainly exists in a yeast form. Our results showed, that the phagocyte response was similar in terms of overall uptake, however differences were observed in macrophage migration and engulfment of fungal cells. As C. parapsilosis releases extracellular lipases in order to promote host invasion we further investigated the role of these secreted components during the distinct stages of the phagocytic process. Using a secreted lipase deficient mutant strain and the parental strain GA1 individually and simultaneously, we confirmed that fungal secreted lipases influence the fungi's virulence by detecting altered innate cellular responses. In this study we report that two isolates of a single species can trigger markedly distinct host responses and that lipase secretion plays a role on the cellular level of host-pathogen interactions.
Language	English
Publishing date	2015-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2015.01102
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Article ; Online: Rab14 regulates maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and outcome of the host-pathogen interaction.

Okai, Blessing / Lyall, Natalie / Gow, Neil A R / Bain, Judith M / Erwig, Lars-Peter

Infection and immunity

2015 Volume 83, Issue 4, Page(s) 1523–1535

Abstract: Avoidance of innate immune defense is an important mechanism contributing to the pathogenicity of microorganisms. The fungal pathogen Candida albicans undergoes morphogenetic switching from the yeast to the filamentous hyphal form following phagocytosis ... ...

Abstract	Avoidance of innate immune defense is an important mechanism contributing to the pathogenicity of microorganisms. The fungal pathogen Candida albicans undergoes morphogenetic switching from the yeast to the filamentous hyphal form following phagocytosis by macrophages, facilitating its escape from the phagosome, which can result in host cell lysis. We show that the intracellular host trafficking GTPase Rab14 plays an important role in protecting macrophages from lysis mediated by C. albicans hyphae. Live-cell imaging of macrophages expressing green fluorescent protein (GFP)-tagged Rab14 or dominant negative Rab14, or with small interfering RNA (siRNA)-mediated knockdown of Rab14, revealed the temporal dynamics of this protein and its influence on the maturation of macrophage phagosomes following the engulfment of C. albicans cells. Phagosomes containing live C. albicans cells became transiently Rab14 positive within 2 min following engulfment. The duration of Rab14 retention on phagosomes was prolonged for hyphal cargo and was directly proportional to hyphal length. Interference with endogenous Rab14 did not affect the migration of macrophages toward C. albicans cells, the rate of engulfment, the overall uptake of fungal cells, or early phagosome processing. However, Rab14 depletion delayed the acquisition of the late phagosome maturation markers LAMP1 and lysosomal cathepsin, indicating delayed formation of a fully bioactive lysosome. This was associated with a significant increase in the level of macrophage killing by C. albicans. Therefore, Rab14 activity promotes phagosome maturation during C. albicans infection but is dysregulated on the phagosome in the presence of the invasive hyphal form, which favors fungal survival and escape.
MeSH term(s)	Animals ; Bone Marrow Cells ; Candida albicans/immunology ; Candida albicans/pathogenicity ; Cathepsins/biosynthesis ; Cell Line ; Green Fluorescent Proteins/genetics ; Host-Pathogen Interactions/immunology ; Hyphae/immunology ; Immune Evasion ; Lysosomal-Associated Membrane Protein 1/biosynthesis ; Lysosomes/immunology ; Lysosomes/microbiology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Phagocytosis/immunology ; Phagosomes/genetics ; Phagosomes/immunology ; Phagosomes/microbiology ; RNA Interference ; RNA, Small Interfering ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/immunology ; rab5 GTP-Binding Proteins/immunology ; rab7 GTP-Binding Proteins
Chemical Substances	Lysosomal-Associated Membrane Protein 1 ; RNA, Small Interfering ; rab7 GTP-Binding Proteins ; Green Fluorescent Proteins (147336-22-9) ; Cathepsins (EC 3.4.-) ; Rab14 protein, mouse (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2) ; rab5 GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2015-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.02917-14
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Zs.A 684: Show issues

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Article: Assessment of apoptotic cell phagocytosis by macrophages.

McPhillips, Kathleen A / Erwig, Lars-Peter

Methods in molecular biology (Clifton, N.J.)

2009 Volume 559, Page(s) 247–256

Abstract: Cells undergo apoptosis during development, tissue homeostasis, and disease, and are rapidly cleared by both professional and nonprofessional phagocytes. In the whole animal, this process is remarkably efficient and usually goes unnoticed. It is ... ...

Abstract	Cells undergo apoptosis during development, tissue homeostasis, and disease, and are rapidly cleared by both professional and nonprofessional phagocytes. In the whole animal, this process is remarkably efficient and usually goes unnoticed. It is estimated that 2 x 10(11) cells are cleared each day and it has been suggested that detection of apoptotic cells in tissues should lead one to at least question the presence of a local clearance defect. For the last two decades, in vitro phagocytosis assays have played a critical role in identifying the receptors and mechanisms involved in the recognition and ingestion of apoptotic cells. The methodology of phagocytosis assays can be broken down into four separate components: apoptosis induction in target cells, preparation of phagocytes, the interaction assay, and the quantitative assessment of apoptotic cell engulfment. Here, we attempt to provide a detailed description of all the individual components of this complex procedure. To date, this has not been done in its entirety but is vital for the accurate assessment of stimuli that influence the clearance process.
MeSH term(s)	Animals ; Apoptosis ; Cytological Techniques ; Humans ; Macrophages/cytology ; Neutrophils/cytology ; Phagocytosis
Language	English
Publishing date	2009-07-17
Publishing country	United States
Document type	Journal Article
ISSN	1064-3745
ISSN	1064-3745
DOI	10.1007/978-1-60327-017-5_17
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