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Article ; Online: Dorsal cervical approach for recurrent intradural anaplastic ependymoma.

Laws, Maxwell T / Arhin, Martin / Ampie, Leonel / Chittiboina, Prashant

Neurosurgical focus: Video

2023 Volume 9, Issue 2, Page(s) V2

Abstract: The video demonstrates an operative approach to a recurrent cervical anaplastic ependymoma. MYCN-amplified anaplastic ependymomas are locally aggressive, recurrent, and have a high risk of iatrogenic injury. In this case, the patient presented with local, ...

Abstract	The video demonstrates an operative approach to a recurrent cervical anaplastic ependymoma. MYCN-amplified anaplastic ependymomas are locally aggressive, recurrent, and have a high risk of iatrogenic injury. In this case, the patient presented with local, aggressive tumor expansion, arachnoid adhesions, and pial invasion ventral to the spinal cord. Subcapsular decompression minimized cord retraction from a dorsal approach. Removal of the tumor capsule was guided by bipolar stimulation paired with neuromonitoring. Local gross-total resection was achieved, and the patient had a postoperative improvement in his neurological deficits and myelopathy.
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article
ISSN	2643-5217
ISSN (online)	2643-5217
DOI	10.3171/2023.6.FOCVID2396
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Article ; Online: The role of the dura mater in cerebral metastases.

Cozzi, Francesca M / Ampie, Leonel / Laws, Maxwell T / Brown, Desmond A

Neurosurgical focus

2023 Volume 55, Issue 2, Page(s) E17

Abstract: Objective: The objective of this review was to describe the immunological changes that take place in the dura mater in response to metastatic disease that seeds the CNS. The authors hypothesized that the dura's anatomy and resident immune cell ... ...

Abstract	Objective: The objective of this review was to describe the immunological changes that take place in the dura mater in response to metastatic disease that seeds the CNS. The authors hypothesized that the dura's anatomy and resident immune cell population play a role in enabling metastasis to the brain and leptomeninges. Methods: An extensive literature search was conducted to identify evidence that supports the dura's participation in metastasis to the CNS. The authors' hypothesis was informed by a recent upsurge in studies that have investigated the dura's role in metastatic development, CNS infections, and autoimmunity. They reviewed this literature as well as the use of immunotherapy in treating brain metastases and how these therapies change the meningeal immune landscape to overcome and reverse tumor-promoting immunosuppression. Results: Evidence suggests that the unique architecture and immune cell profile of the dura, compared with other immune compartments within the CNS, facilitate entry of metastatic tumor cells into the brain. Once these tumor cells penetrate the dural barrier, they propagate an immunosuppressive tumor microenvironment. Therefore, immunotherapy may serve to overcome this immunosuppressive environment and liberate proinflammatory immune cells in an effort to combat metastatic disease. Conclusions: Within the next few years, the authors expect the addition of several more scientific studies into the literature that further underscore the dura as a chief participant and neuroanatomical barrier in neuro-oncology.
MeSH term(s)	Humans ; Dura Mater/pathology ; Brain Neoplasms/pathology ; Brain ; Supratentorial Neoplasms ; Tumor Microenvironment
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2023.5.FOCUS23229
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Article ; Online: Immunological defense of CNS barriers against infections.

Ampie, Leonel / McGavern, Dorian B

Immunity

2022 Volume 55, Issue 5, Page(s) 781–799

Abstract: Neuroanatomical barriers with physical, chemical, and immunological properties play an essential role in preventing the spread of peripheral infections into the CNS. A failure to contain pathogens within these barriers can result in very serious CNS ... ...

Abstract	Neuroanatomical barriers with physical, chemical, and immunological properties play an essential role in preventing the spread of peripheral infections into the CNS. A failure to contain pathogens within these barriers can result in very serious CNS diseases. CNS barriers are inhabited by an elaborate conglomerate of innate and adaptive immune cells that are highly responsive to environmental challenges. The CNS and its barriers can also be protected by memory T and B cells elicited by prior infection or vaccination. Here, we discuss the different CNS barriers from a developmental, anatomical, and immunological standpoint and summarize our current understanding of how memory cells protect the CNS compartment. We then discuss a contemporary challenge to CNS-barrier system (SARS-CoV-2 infection) and highlight approaches to promote immunological protection of the CNS via vaccination.
MeSH term(s)	B-Lymphocytes ; COVID-19 ; Humans ; SARS-CoV-2 ; Vaccination
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Intramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2022.04.012
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Syngeneic murine glioblastoma models: reactionary immune changes and immunotherapy intervention outcomes.

Letchuman, Vijay / Ampie, Leonel / Shah, Ashish H / Brown, Desmond A / Heiss, John D / Chittiboina, Prashant

Neurosurgical focus

2022 Volume 52, Issue 2, Page(s) E5

Abstract: Glioblastoma is the most common primary malignant brain neoplasm with dismal 10-year survival rates of < 1%. Despite promising preliminary results from several novel therapeutic agents, clinical responses have been modest due to several factors, ... ...

Abstract	Glioblastoma is the most common primary malignant brain neoplasm with dismal 10-year survival rates of < 1%. Despite promising preliminary results from several novel therapeutic agents, clinical responses have been modest due to several factors, including tumor heterogeneity, immunosuppressive tumor microenvironment, and treatment resistance. Novel immunotherapeutics have been developed to reverse tumor-induced immunosuppression in patients with glioblastomas. In order to recapitulate the tumor microenvironment, reliable in vivo syngeneic murine models are critical for the development of new targeted agents as these models demonstrate rapid tumor induction and reliable tumor growth over multiple generations. Despite the clear advantages of murine models, choosing an appropriate model from an immunological perspective can be difficult and have significant ramifications on the translatability of the results from murine to human trials. Herein, the authors reviewed the 4 most commonly used immunocompetent syngeneic murine glioma models (GL261 [C57BL/6], SB28 [C57BL/6], CT-2A [C57BL/6], and SMA-560 [VM/Dk]) and compared their strengths and weaknesses from an immunological standpoint.
MeSH term(s)	Animals ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Glioblastoma ; Glioma/pathology ; Humans ; Immunotherapy ; Mice ; Mice, Inbred C57BL ; Tumor Microenvironment
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2021.11.FOCUS21556
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Article: Glioblastoma may evade immune surveillance through primary cilia-dependent signaling in an IL-6 dependent manner.

Laws, Maxwell T / Walker, Erin N / Cozzi, Francesca M / Ampie, Leonel / Jung, Mi-Yeon / Burton, Eric C / Brown, Desmond A

Frontiers in oncology

2023 Volume 13, Page(s) 1279923

Abstract: Glioblastoma is the most common, malignant primary brain tumor in adults and remains universally fatal. While immunotherapy has vastly improved the treatment of several solid cancers, efficacy in glioblastoma is limited. These challenges are due in part ... ...

Abstract	Glioblastoma is the most common, malignant primary brain tumor in adults and remains universally fatal. While immunotherapy has vastly improved the treatment of several solid cancers, efficacy in glioblastoma is limited. These challenges are due in part to the propensity of glioblastoma to recruit tumor-suppressive immune cells, which act in conjunction with tumor cells to create a pro-tumor immune microenvironment through secretion of several soluble factors. Glioblastoma-derived EVs induce myeloid-derived suppressor cells (MDSCs) and non-classical monocytes (NCMs) from myeloid precursors leading to systemic and local immunosuppression. This process is mediated by IL-6 which contributes to the recruitment of tumor-associated macrophages of the M2 immunosuppressive subtype, which in turn, upregulates anti-inflammatory cytokines including IL-10 and TGF-β. Primary cilia are highly conserved organelles involved in signal transduction and play critical roles in glioblastoma proliferation, invasion, angiogenesis, and chemoradiation resistance. In this perspectives article, we provide preliminary evidence that primary cilia regulate intracellular release of IL-6. This ties primary cilia mechanistically to tumor-mediated immunosuppression in glioblastomas and potentially, in additional neoplasms which have a shared mechanism for cancer-mediated immunosuppression. We propose potentially testable hypotheses of the cellular mechanisms behind this finding.
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1279923
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Article: Dural Convexity Chondroma Mimicking Meningioma in a Young Female.

Sarathy, Danyas / Snyder, Matthew H / Ampie, Leonel / Berry, Debra / Syed, Hasan R

Cureus

2021 Volume 13, Issue 12, Page(s) e20715

Abstract: Intracranial meningeal convexity chondroma is a rare benign lesion hypothesized to stem from remnant chondrocyte precursors of embryonic origin. This lesion often masquerades as meningioma given the similar dural-based attachment and pattern of ... ...

Abstract	Intracranial meningeal convexity chondroma is a rare benign lesion hypothesized to stem from remnant chondrocyte precursors of embryonic origin. This lesion often masquerades as meningioma given the similar dural-based attachment and pattern of calcification. We describe the case of a 26-year-old female with incidentally discovered convexity meningeal chondroma, originally presumed to be a meningioma. In this case, we share our diagnostic and operative intervention and outcome and discuss the unique pathologic findings in this lesion that differentiate it from similar appearing lesions. To the authors' knowledge, there are fewer than 20 cases of convexity meningeal chondroma in the literature; thus, we also provide a brief review of the literature regarding this rare pathology.
Language	English
Publishing date	2021-12-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.20715
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Article ; Online: Experimental animal models for the study of moyamoya disease.

Letchuman, Vijay / Ampie, Leonel / Mastorakos, Panagiotis / Raper, Daniel M S / Kellogg, Ryan T / Park, Min S

Neurosurgical focus

2021 Volume 51, Issue 3, Page(s) E4

Abstract: Moyamoya disease is a rare disorder of the cerebrovascular system affecting individuals in a bimodal age distribution and is characterized by progressive vascular stenosis of the bilateral supraclinoid internal carotid arteries with compensatory ... ...

Abstract	Moyamoya disease is a rare disorder of the cerebrovascular system affecting individuals in a bimodal age distribution and is characterized by progressive vascular stenosis of the bilateral supraclinoid internal carotid arteries with compensatory formation of collateral vessels at the base of the brain. Despite the disease's initial description in the literature in 1957, little progress has been made in the development of medical and surgical therapeutics due to, in no small part, the lack of effective experimental animal models. Currently, there is a poor understanding of the pathophysiological mechanisms behind the development of the moyamoya vasculopathies. Since the description of a genetic association between moyamoya disease, few studies have investigated the impact of genetic manipulation on the development of an animal model for experimentation. To date, no one model recapitulates the precise phenotype of the moyamoya vasculopathies, although development of an appropriate model would allow for an in-depth investigation into the pathological mechanisms underlying the disease. In this review, the authors discuss the immunological, mechanical, and genetic methods used to develop moyamoya experimental models, as well as future perspectives.
MeSH term(s)	Animals ; Brain ; Carotid Artery, Internal ; Disease Models, Animal ; Humans ; Moyamoya Disease/diagnostic imaging ; Moyamoya Disease/genetics ; Moyamoya Disease/surgery
Language	English
Publishing date	2021-08-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2021.5.FOCUS21282
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Article ; Online: Bevacizumab as a surgery-sparing agent for spinal ependymoma in patients with neurofibromatosis type II: Systematic review and case.

Snyder, M Harrison / Ampie, Leonel / DiDomenico, Joseph D / Asthagiri, Ashok R

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2021 Volume 86, Page(s) 79–84

Abstract: Neurofibromatosis type 2 (NF2) is a rare, hereditary tumor syndrome, often requiring repeated surgeries for multiple lesions with significant cumulative morbidity. As such, non-operative management should be considered when possible for this patient ... ...

Abstract	Neurofibromatosis type 2 (NF2) is a rare, hereditary tumor syndrome, often requiring repeated surgeries for multiple lesions with significant cumulative morbidity. As such, non-operative management should be considered when possible for this patient population. The aim of this study is to provide a systematic review of the literature regarding this treatment strategy. A descriptive case of a patient in whom bevacizumab treatments enabled over 15 years of surgical postponement for a symptomatic spinal cord ependymoma is also provided. Evidence suggests that bevacizumab is a reasonable surgery-deferring option for cystic lesions, and it may be especially useful in NF2 patients to reduce cumulative morbidity.
MeSH term(s)	Adult ; Antineoplastic Agents, Immunological/therapeutic use ; Bevacizumab/therapeutic use ; Conservative Treatment/methods ; Conservative Treatment/trends ; Ependymoma/complications ; Ependymoma/diagnostic imaging ; Ependymoma/drug therapy ; Female ; Humans ; Neurofibromatosis 2/complications ; Neurofibromatosis 2/diagnostic imaging ; Neurofibromatosis 2/drug therapy ; Spinal Cord Neoplasms/complications ; Spinal Cord Neoplasms/diagnostic imaging ; Spinal Cord Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents, Immunological ; Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2021-02-01
Publishing country	Scotland
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2021.01.010
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Zs.A 3999: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A Rare Case of Pancreatoblastoma with Intracranial Seeding.

Snyder, M Harrison / Ampie, Leonel / Mandell, James W / Helm, Greg A / Syed, Hasan R

World neurosurgery

2020 Volume 142, Page(s) 334–338

Abstract: Background: Pancreatoblastoma is an extremely rare neoplasm that accounts for 0.5% of all pancreatic exocrine tumors. These rare entities typically manifest in the pediatric population but can rarely occur in adults. Systemic seeding has been described ... ...

Abstract	Background: Pancreatoblastoma is an extremely rare neoplasm that accounts for 0.5% of all pancreatic exocrine tumors. These rare entities typically manifest in the pediatric population but can rarely occur in adults. Systemic seeding has been described before but intracranial metastasis in adults has yet to be described. Case description: A 28-year-old woman with a history of pancreatoblastoma that had been in remission for 51 months after treatment with cisplatin, doxorubicin (Adriamycin), and etoposide had presented to the emergency room with chronic recurrent headaches. Conservative management of the headaches failed, which led to a diagnostic workup with magnetic resonance imaging of the brain. Magnetic resonance imaging demonstrated a well-circumscribed solitary cerebellar lesion. Metastatic disease was suspected, and the patient underwent suboccipital craniotomy for tumor resection with adjuvant gamma knife radiosurgery. Conclusions: Central nervous system seeding of pancreatoblastoma is rare, and the available evidence suggests that the strategy we used could be adequate for treating such occurrences.
MeSH term(s)	Adult ; Cerebellar Neoplasms/diagnostic imaging ; Cerebellar Neoplasms/secondary ; Cerebellar Neoplasms/surgery ; Craniotomy/methods ; Female ; Humans ; Neoplasm Seeding ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/surgery ; Radiosurgery/methods
Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.06.210
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Zs.A 1159: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Conference proceedings: Radiographic and Clinical Outcomes of Pituitary Apoplexy: Comparison of Conservative Management versus Early Surgical Intervention

Shepard, Matthew / Snyder, Harrison / Soldozy, Sauson / Ampie, Leonel / Morales, Saul / Jr, John A. Jane

Journal of Neurological Surgery Part B: Skull Base

2021 Volume 82, Issue S 02

Event/congress	Special Virtual Symposium of the North American Skull Base Society, Online, 2021-02-13
Language	English
Publishing date	2021-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0041-1725362
Database	Thieme publisher's database

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Zs.A 3425: Show issues

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