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  1. Book: "Dearest G ... yours WO"

    Osler, William / Longo, Lawrence D / Teigen, Philip M

    William Osler's letters from Egypt to Grace Revere Osler

    (Osler Library studies in the history of medicine ; no. 7)

    2002  

    Title variant William Osler's letters from Egypt to Grace Revere Osler
    Institution Osler Library
    Author's details Lawrence D. Longo and Philip M. Teigen ; with a foreword by Charles G. Roland and a postscript by Caroline-Isbelle Caron
    Series title Osler Library studies in the history of medicine ; no. 7
    MeSH term(s) Physicians
    Language English
    Size xii, 129 p. :, ill., ports. ;, 23 cm.
    Publisher Osler Library, McGill University ; American Osler Society
    Publishing place Montreal ; Columbia, S.C.
    Document type Book
    ISBN 9780771706011 ; 0771706014
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article: ProAna Worlds: Affectivity and Echo Chambers Online.

    Osler, Lucy / Krueger, Joel

    Topoi : an international review of philosophy

    2021  , Page(s) 1–11

    Abstract: ... of AN typically frame the disorder in individualistic terms: e.g., genetic predisposition, perceptual disturbances ...

    Abstract Anorexia Nervosa (AN) is an eating disorder characterised by self-starvation. Accounts of AN typically frame the disorder in individualistic terms: e.g., genetic predisposition, perceptual disturbances of body size and shape, experiential bodily disturbances. Without disputing the role these factors may play in
    Language English
    Publishing date 2021-12-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012661-X
    ISSN 1572-8749 ; 0167-7411
    ISSN (online) 1572-8749
    ISSN 0167-7411
    DOI 10.1007/s11245-021-09785-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 25-year trends in first-time hospitalizations for Parkinson's disease and subsequent mortality: A Danish nationwide cohort study.

    Osler, M / Okholm, G T / Jørgensen, T S H / Rozing, M P

    Parkinsonism & related disorders

    2023  Volume 112, Page(s) 105471

    Abstract: Background: In most countries, incidence and mortality for Parkinson's disease (PD) have not been monitored by surveillance registries, although it could demonstrate the need for primary and tertiary prevention.: Objective: To examine 25-year trends ... ...

    Abstract Background: In most countries, incidence and mortality for Parkinson's disease (PD) have not been monitored by surveillance registries, although it could demonstrate the need for primary and tertiary prevention.
    Objective: To examine 25-year trends in first-time hospitalizations for PD in Denmark and subsequent short and long-term mortality.
    Methods: In a nationwide population-based cohort we identified all 34,947 individuals with a first-time hospitalization for PD from 1995 through 2019. We calculated standardized incidence rates of PD and 1-year and 5-year mortality by sex. Mortality rates were compared with a reference cohort randomly selected from the background population matched on sex, age, and index date.
    Results: The annual standardized incidence rate of PD was relatively stable during the study period in both men and women. The incidence of PD was higher in men than in women and with the highest incidence in those aged 70-79 years. One and 5-year mortality risk after first-time hospitalization for PD was similar for men and women, and decreased by around 30% and 20%, respectively, between 1995 and 2019. The matched reference cohort had a similar decline in mortality over time.
    Conclusion: The rate of first-time hospitalization for PD was relatively stable between 1995 and 2019, whereas subsequent short and long-term mortality declined during the period as in the reference cohort.
    MeSH term(s) Male ; Humans ; Female ; Cohort Studies ; Parkinson Disease/epidemiology ; Hospitalization ; Denmark/epidemiology ; Incidence ; Registries
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2023.105471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Body mass index and height in relation to type 2 diabetes by levels of intelligence and education in a large cohort of Danish men.

    Bjerregaard, Lise G / Damborg, Mille L / Osler, Merete / Sørensen, Thorkild I A / Baker, Jennifer L

    European journal of epidemiology

    2020  Volume 35, Issue 12, Page(s) 1167–1175

    Abstract: Socioeconomic status (SES) is inversely associated with risks of type 2 diabetes (T2D). We investigated if young men's cognitive function, measured by intelligence test scores and educational level, as determinants of SES modified associations between ... ...

    Abstract Socioeconomic status (SES) is inversely associated with risks of type 2 diabetes (T2D). We investigated if young men's cognitive function, measured by intelligence test scores and educational level, as determinants of SES modified associations between body mass index (BMI) and height with the risk of T2D. 369 989 young men from the Danish Conscription Database born between 1939 and 1959 with information on measured height, weight, intelligence test scores, and education were linked to the Danish National Patient Register. During follow-up from 1977 through 2015, T2D was recorded in 32 188 men. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated by Cox regressions. BMIs below-average (z-scores ≤ 0) were not related to risks of T2D. For BMIs above-average (z-scores > 0), positive associations between BMI and T2D were slightly stronger among men with higher intelligence test scores or longer educations than among men with lower levels of these factors (p
    MeSH term(s) Adolescent ; Adult ; Aged ; Body Height ; Body Mass Index ; Cognition ; Cohort Studies ; Denmark/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Educational Status ; Humans ; Incidence ; Intelligence ; Intelligence Tests/statistics & numerical data ; Male ; Middle Aged ; Social Class ; Young Adult
    Language English
    Publishing date 2020-05-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632614-6
    ISSN 1573-7284 ; 0393-2990
    ISSN (online) 1573-7284
    ISSN 0393-2990
    DOI 10.1007/s10654-020-00641-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Socioeconomic disparity in cardiovascular disease: Possible biological pathways based on a proteomic approach.

    Shafi, Bilal Hasan / Bøttcher, Morten / Ejupi, Ali / Jensen, Gorm / Osler, Merete / Lange, Theis / Prescott, Eva

    Atherosclerosis

    2022  Volume 352, Page(s) 62–68

    Abstract: Background and aims: Large social disparities in the occurrence of cardiovascular disease (CVD) have been documented but the underlying biological mechanisms are largely unknown. We investigated a panel of biomarkers linked to CVD to improve our ... ...

    Abstract Background and aims: Large social disparities in the occurrence of cardiovascular disease (CVD) have been documented but the underlying biological mechanisms are largely unknown. We investigated a panel of biomarkers linked to CVD to improve our understanding and quantify the biological pathways in socioeconomic disparity in CVD and their mediation through behavioural and biological risk factors.
    Methods: We included 1142 participants from the Copenhagen City Heart Study aged 55-64 years. Socioeconomic position (SEP) was defined by the length of education and household income. Blood samples were analysed for 184 biomarkers (Olink). Pearson's correlation analysis and linear regression with multivariate adjustment for CVD risk factors were performed.
    Results: The median length of education was 10 (IQR 7-11) years and associated with age, sex, BMI, smoking, blood pressure, physical activity and income. 48 biomarkers were significantly correlated (p < 0.05) to the length of education. The strongest negative associations were seen for interleukin-6 (IL-6), metalloproteinase 12, growth/differentiation factor 15 (GDF-15), retinoic acid receptor responder protein 2 (RARRES2), leptin (LEP), von Willebrand factor (vWF), and renin (REN) (all p < 0.0001) while the strongest positive associations were seen for chymotrypsin, paraoxonase, epidermal growth factor receptor (EGFR) and brother of CDO (cell adhesion and platelet activation) (all p < 0.001). Proportion mediated by CVD risk factors ranged from <1% to 100%. After multivariate adjustment, 14 biomarkers remained significantly associated with education.
    Conclusions: SEP was associated with multiple biomarkers, indicating pathways involving inflammation (IL-6, RARRES2), platelet-activation (vWF, IL-6), blood pressure (REN, LEP) and Mitogen-activated protein kinase cascade (GDF-15, EGFR) may contribute to the socioeconomic differences in CVD.
    MeSH term(s) Biomarkers ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Educational Status ; ErbB Receptors ; Growth Differentiation Factor 15 ; Humans ; Interleukin-6 ; Male ; Proteomics ; Risk Factors ; Socioeconomic Factors ; von Willebrand Factor/analysis
    Chemical Substances Biomarkers ; Growth Differentiation Factor 15 ; Interleukin-6 ; von Willebrand Factor ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-05-28
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2022.05.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk Prediction Tools: The Need for Greater Transparency.

    Glance, Laurent G / Dick, Andrew W / Osler, Turner M

    Anesthesiology

    2018  Volume 128, Issue 2, Page(s) 244–246

    MeSH term(s) Risk Assessment ; Risk Factors
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000002021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Current patterns of trauma center proliferation have not led to proportionate improvements in access to care or mortality after injury: An ecologic study.

    Amato, Stas / Benson, Jamie S / Stewart, Barclay / Sarathy, Ashwini / Osler, Turner / Hosmer, David / An, Gary / Cook, Alan / Winchell, Robert J / Malhotra, Ajai K

    The journal of trauma and acute care surgery

    2023  Volume 94, Issue 6, Page(s) 755–764

    Abstract: Background: Timely access to high-level (I/II) trauma centers (HLTCs) is essential to minimize mortality after injury. Over the last 15 years, there has been a proliferation of HLTC nationally. The current study evaluates the impact of additional HLTC ... ...

    Abstract Background: Timely access to high-level (I/II) trauma centers (HLTCs) is essential to minimize mortality after injury. Over the last 15 years, there has been a proliferation of HLTC nationally. The current study evaluates the impact of additional HLTC on population access and injury mortality.
    Methods: A geocoded list of HLTC, with year designated, was obtained from the American Trauma Society, and 60-minute travel time polygons were created using OpenStreetMap data. Census block group population centroids, county population centroids, and American Communities Survey data from 2005 and 2020 were integrated. Age-adjusted nonoverdose injury mortality was obtained from CDC Wide-ranging Online Data for Epidemiologic Research and the Robert Wood Johnson Foundation. Geographically weighted regression models were used to identify independent predictors of HLTC access and injury mortality.
    Results: Over the 15-year (2005-2020) study period, the number of HLTC increased by 31.0% (445 to 583), while population access to HLTC increased by 6.9% (77.5-84.4%). Despite this increase, access was unchanged in 83.1% of counties, with a median change in access of 0.0% (interquartile range, 0.0-1.1%). Population-level age-adjusted injury mortality rates increased by 5.39 per 100,000 population during this time (60.72 to 66.11 per 100,000). Geographically weighted regression controlling for population demography and health indicators found higher median income and higher population density to be positively associated with majority (≥50%) HLTC population coverage and negatively associated with county-level nonoverdose mortality.
    Conclusion: Over the past 15 years, the number of HLTC increased 31%, while population access to HLTC increased only 6.9%. High-level (I/II) trauma center designation is likely driven by factors other than population need. To optimize efficiency and decrease potential oversupply, the designation process should include population level metrics. Geographic information system methodology can be an effective tool to assess optimal placement.
    Level of evidence: Prognostic and Epidemiological; Level IV.
    MeSH term(s) Humans ; United States/epidemiology ; Trauma Centers ; Income ; Geographic Information Systems ; Health Services Accessibility ; Cell Proliferation ; Wounds and Injuries/therapy
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000003940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A trauma mortality prediction model based on the ICD-10-CM lexicon: TMPM-ICD10.

    Osler, Turner M / Glance, Laurent G / Cook, Alan / Buzas, Jeffrey S / Hosmer, David W

    The journal of trauma and acute care surgery

    2019  Volume 86, Issue 5, Page(s) 891–895

    Abstract: Background: Outcome prediction models allow risk adjustment required for trauma research and the evaluation of outcomes. The advent of ICD-10-CM has rendered risk adjustment based on ICD-9-CM codes moot, but as yet no risk adjustment model based on ICD- ... ...

    Abstract Background: Outcome prediction models allow risk adjustment required for trauma research and the evaluation of outcomes. The advent of ICD-10-CM has rendered risk adjustment based on ICD-9-CM codes moot, but as yet no risk adjustment model based on ICD-10-CM codes has been described.
    Methods: The National Trauma Data Bank provided data from 773,388 injured patients who presented to one of 747 trauma centers in 2016 with traumatic injuries ICD-10-CM codes and Injury Severity Score (ISS). We constructed an outcome prediction model using only ICD-10-CM acute injury codes and compared its performance with that of the ISS.
    Results: Compared with ISS, the TMPM-ICD-10 discriminated survivors from non-survivors better (ROC TMPM-ICD-10 = 0.861 [0.860-0.872], ROC [reviever operating curve] ISS = 0.830 [0.823-0.836]), was better calibrated (HL [Hosmer-Lemeshow statistic] TMPM-ICD-10 = 49.01, HL ISS = 788.79), and had a lower Akaike information criteria (AIC TMPM-ICD10 = 30579.49; AIC ISS = 31802.18).
    Conclusions: Because TMPM-ICD10 provides better discrimination and calibration than the ISS and can be computed without recourse to Abbreviated Injury Scale coding, the TMPM-ICD10 should replace the ISS as the standard measure of overall injury severity for data coded in the ICD-10-CM lexicon.
    Level of evidence: Prognostic/Epidemiologic, level II.
    MeSH term(s) Databases, Factual ; Female ; Humans ; Injury Severity Score ; International Classification of Diseases ; Male ; Middle Aged ; Models, Statistical ; ROC Curve ; Reproducibility of Results ; Risk Assessment/methods ; Wounds and Injuries/diagnosis ; Wounds and Injuries/mortality
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000002194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Injury scoring: Then, now, and into the 21st century.

    Osler, Turner / Glance, Laurent G / Buzas, Jeffrey S / Hosmer, David W

    Injury

    2019  Volume 50, Issue 1, Page(s) 2–3

    MeSH term(s) Abbreviated Injury Scale ; History, 20th Century ; History, 21st Century ; Humans ; Injury Severity Score ; Logistic Models ; Quality Improvement ; Trauma Severity Indices ; Traumatology/history ; Traumatology/trends ; Wounds and Injuries/classification ; Wounds and Injuries/diagnosis
    Language English
    Publishing date 2019-01-04
    Publishing country Netherlands
    Document type Editorial ; Historical Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2018.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Local is not lekker.

    Osler, G

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

    2006  Volume 96, Issue 9, Page(s) 758

    MeSH term(s) Humans ; Societies, Medical ; South Africa ; United Kingdom
    Language English
    Publishing date 2006-09
    Publishing country South Africa
    Document type Letter
    ZDB-ID 390968-2
    ISSN 2078-5135 ; 0256-9574 ; 0038-2469
    ISSN (online) 2078-5135
    ISSN 0256-9574 ; 0038-2469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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